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The map label for this gene is gabP [H]

Identifier: 108800337

GI number: 108800337

Start: 3572022

End: 3573842

Strand: Reverse

Name: gabP [H]

Synonym: Mmcs_3371

Alternate gene names: 108800337

Gene position: 3573842-3572022 (Counterclockwise)

Preceding gene: 108800338

Following gene: 108800336

Centisome position: 62.64

GC content: 66.83

Gene sequence:

>1821_bases
ATGAGTGCAGCACCCACCTTGAAAAAGGCGCTCAACCAGCGCCAACTGCGGATGATCGCCATCGGCGGCGTCATCGGCGC
CGGACTGTTCGTGGGGTCCGGGGTGGTGATCGCCGACACCGGGCCCGGCTCTTTCCTCACCTACGCGATGAGTGGCGTGC
TCATCATCATGGTGATGCGGATGCTCGCCGAGATGGCGGTGGCCAATCCGTCCACGGGCTCGTTCGCCGACTACTCGCGC
AACGCCCTGGGCAACTGGGCGGGTTTCTCCGTCGGGTGGCTCTACTGGTACTTCTGGGTCATCGTCGTCGGATTCGAGGC
GATCGCGGGCGCGAAGATCATCCAGTACTGGATCGACGTCCCGCTGTGGGCGTCCTCGCTGGTGTTCATGGTGCTGATGA
CGGCGACCAACCTGTTCTCGGTGAAGTCCTACGGCGAGTTCGAGTTCTGGTTCGCCGGGATCAAGGTCGCCGCGATCGTG
GCCTTCATCGCGCTCGGTGCGCTGTTCGTGGTGGGGCTGTGGCCGGGTAAGGACGCCGACTTCTCGAATCTGACCGCGCA
CGGCGGCTTCATGCCGATGGGCTTCGGGGTGATCACCGTGGGGATCGTGACGGTGATCTTCTCGATGGTGGGCGCCGAGA
TCGCGACGATCGCGGCCGCCGAGTCGGCGGACCCCGAGCGGGCGGTGTCCAAGGCCGCGAACTCGGTGATCGTGCGCATC
CTGCTGTTCTACGTGGGCTCCGCGCTGCTGCTCGTGACGATCCTGCCGTGGAACGACGAGGGGATCGCTGCGTCACCGTT
CGTCGCGGCGTTCACCGAGATGGGCATTCCCTATGCCGACCACGTGATGAACGCCGTCGTGCTCACCGCGGTGCTGAGCT
GTCTGAACTCCGGGATGTACACGGCGTCGCGCATGCTGTTCGTCCTCGCCGCCCGGCGGGAAGCGCCGCCCTCGCTGGTC
CGGGTGACCCGCAGGGGAGTGCCGGCACAGGCGATCCTGGCGTCGTCGGTGGTCGGGTTCCTGTGCGTGATCGCCGCGGC
GGTGTCACCGGACACCATCTTCGCGTTCCTGCTCAACTCCAGCGGCGCCATCATCCTGTTCGTCTACCTGCTCATCGCCG
TCTCCCAGATCATCCTGCGCAGGCGCACACCGGATTCCGAACTGCGCGTGAAGATGTGGCTCTTCCCGGTGCTGTCGGTG
CTCACCGCGGTCGGGATCGTGGCGATCCTGGTGCAGATGTTCATCGACGACGCGCTGCGGTCCCAGTTGGTGCTGAGCCT
GCTGTCCTGGGGAGTGGTGCTGTTGCTCTACTTCGCCAACAAGCACTTCCTCAAGCGCCGGCCGACCAAGGCAGGGGTCA
CCGGCACCGGCAAACCGCATCGGGTCCTCGTGCTGGCCAACCAGACCGTCAACTCGACGGAGCTGCTCGACGAGCTGCAC
CGGATCGGCGCCGATCAGGAGACGCACTACTTCGTGGTGGTGCCGGTCAGCCCGATCGAGACGGGCACGGCCGAGACGCA
CGGACCGCTCGACGTCGAGGAGGCCACCCAGAAGGCCGCCTCCGAACGCCTCGACCTGACGCTGAACGCGTTGCGCGGGC
ACGACTTCACCGCCGACGGCGAGCTCGGCGACCGCCGGCCGCTGCGGGCGCTGGCCGACGCCGTCGAGAGTTTCGACCCC
GACCAGATCGTCATCTCGACGCTGCCGCCCGAGAAGTCGGTGTGGCAGCGCTTCGACGTCGTCGACCGGGCCCGCGCACA
GCACAGGGTTCCGGTGACCCACGTGGTCGCCACGGGCGCCGAAGCCACGGCCACGCCATGA

Upstream 100 bases:

>100_bases
GCCTCGTCGAGGACGACCGCAACCGTGCGCTGCAGGTGGCGAAGGAGTTCGTCGACGCACTTGTGGAGTGACGGCGGTCA
CATCTGGGTATCCGTGCCGG

Downstream 100 bases:

>100_bases
CGATCGTCGCCGGGTTCAGCGCCAGCCGGCAGGGCAGCGCACCGCTGCATCTGGCGGCCGAGATCGCCCGGTGCACCTTC
GACCGGATCATCGCCGCGGC

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 606; Mature: 605

Protein sequence:

>606_residues
MSAAPTLKKALNQRQLRMIAIGGVIGAGLFVGSGVVIADTGPGSFLTYAMSGVLIIMVMRMLAEMAVANPSTGSFADYSR
NALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQYWIDVPLWASSLVFMVLMTATNLFSVKSYGEFEFWFAGIKVAAIV
AFIALGALFVVGLWPGKDADFSNLTAHGGFMPMGFGVITVGIVTVIFSMVGAEIATIAAAESADPERAVSKAANSVIVRI
LLFYVGSALLLVTILPWNDEGIAASPFVAAFTEMGIPYADHVMNAVVLTAVLSCLNSGMYTASRMLFVLAARREAPPSLV
RVTRRGVPAQAILASSVVGFLCVIAAAVSPDTIFAFLLNSSGAIILFVYLLIAVSQIILRRRTPDSELRVKMWLFPVLSV
LTAVGIVAILVQMFIDDALRSQLVLSLLSWGVVLLLYFANKHFLKRRPTKAGVTGTGKPHRVLVLANQTVNSTELLDELH
RIGADQETHYFVVVPVSPIETGTAETHGPLDVEEATQKAASERLDLTLNALRGHDFTADGELGDRRPLRALADAVESFDP
DQIVISTLPPEKSVWQRFDVVDRARAQHRVPVTHVVATGAEATATP

Sequences:

>Translated_606_residues
MSAAPTLKKALNQRQLRMIAIGGVIGAGLFVGSGVVIADTGPGSFLTYAMSGVLIIMVMRMLAEMAVANPSTGSFADYSR
NALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQYWIDVPLWASSLVFMVLMTATNLFSVKSYGEFEFWFAGIKVAAIV
AFIALGALFVVGLWPGKDADFSNLTAHGGFMPMGFGVITVGIVTVIFSMVGAEIATIAAAESADPERAVSKAANSVIVRI
LLFYVGSALLLVTILPWNDEGIAASPFVAAFTEMGIPYADHVMNAVVLTAVLSCLNSGMYTASRMLFVLAARREAPPSLV
RVTRRGVPAQAILASSVVGFLCVIAAAVSPDTIFAFLLNSSGAIILFVYLLIAVSQIILRRRTPDSELRVKMWLFPVLSV
LTAVGIVAILVQMFIDDALRSQLVLSLLSWGVVLLLYFANKHFLKRRPTKAGVTGTGKPHRVLVLANQTVNSTELLDELH
RIGADQETHYFVVVPVSPIETGTAETHGPLDVEEATQKAASERLDLTLNALRGHDFTADGELGDRRPLRALADAVESFDP
DQIVISTLPPEKSVWQRFDVVDRARAQHRVPVTHVVATGAEATATP
>Mature_605_residues
SAAPTLKKALNQRQLRMIAIGGVIGAGLFVGSGVVIADTGPGSFLTYAMSGVLIIMVMRMLAEMAVANPSTGSFADYSRN
ALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQYWIDVPLWASSLVFMVLMTATNLFSVKSYGEFEFWFAGIKVAAIVA
FIALGALFVVGLWPGKDADFSNLTAHGGFMPMGFGVITVGIVTVIFSMVGAEIATIAAAESADPERAVSKAANSVIVRIL
LFYVGSALLLVTILPWNDEGIAASPFVAAFTEMGIPYADHVMNAVVLTAVLSCLNSGMYTASRMLFVLAARREAPPSLVR
VTRRGVPAQAILASSVVGFLCVIAAAVSPDTIFAFLLNSSGAIILFVYLLIAVSQIILRRRTPDSELRVKMWLFPVLSVL
TAVGIVAILVQMFIDDALRSQLVLSLLSWGVVLLLYFANKHFLKRRPTKAGVTGTGKPHRVLVLANQTVNSTELLDELHR
IGADQETHYFVVVPVSPIETGTAETHGPLDVEEATQKAASERLDLTLNALRGHDFTADGELGDRRPLRALADAVESFDPD
QIVISTLPPEKSVWQRFDVVDRARAQHRVPVTHVVATGAEATATP

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=337, Percent_Identity=24.0356083086053, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI186910308, Length=426, Percent_Identity=25.1173708920188, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI186910306, Length=426, Percent_Identity=25.1173708920188, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI186910304, Length=426, Percent_Identity=25.1173708920188, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4507047, Length=433, Percent_Identity=21.9399538106236, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789017, Length=423, Percent_Identity=46.5721040189125, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI1786302, Length=416, Percent_Identity=39.6634615384615, Blast_Score=298, Evalue=9e-82,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=37.219730941704, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87081708, Length=432, Percent_Identity=37.037037037037, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1788480, Length=397, Percent_Identity=38.7909319899244, Blast_Score=268, Evalue=1e-72,
Organism=Escherichia coli, GI1790653, Length=440, Percent_Identity=35, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI87081915, Length=385, Percent_Identity=39.2207792207792, Blast_Score=257, Evalue=2e-69,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=34.338747099768, Blast_Score=250, Evalue=2e-67,
Organism=Escherichia coli, GI1786602, Length=392, Percent_Identity=36.4795918367347, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17532491, Length=410, Percent_Identity=24.6341463414634, Blast_Score=79, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=435, Percent_Identity=34.4827586206897, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=435, Percent_Identity=33.5632183908046, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=34.624145785877, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322892, Length=403, Percent_Identity=34.7394540942928, Blast_Score=191, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324924, Length=480, Percent_Identity=29.1666666666667, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=30.5764411027569, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320717, Length=399, Percent_Identity=30.8270676691729, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=386, Percent_Identity=33.9378238341969, Blast_Score=173, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=380, Percent_Identity=32.6315789473684, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=386, Percent_Identity=28.2383419689119, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=30.3482587064677, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=390, Percent_Identity=28.7179487179487, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=28.3950617283951, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=398, Percent_Identity=29.1457286432161, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=390, Percent_Identity=29.7435897435897, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=31.6455696202532, Blast_Score=143, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=494, Percent_Identity=24.4939271255061, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=499, Percent_Identity=21.2424849699399, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24667468, Length=328, Percent_Identity=21.6463414634146, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 65159; Mature: 65028

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPTLKKALNQRQLRMIAIGGVIGAGLFVGSGVVIADTGPGSFLTYAMSGVLIIMVMR
CCCCCHHHHHHCHHHEEHEEEHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
MLAEMAVANPSTGSFADYSRNALGNWAGFSVGWLYWYFWVIVVGFEAIAGAKIIQYWIDV
HHHHHHHCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLWASSLVFMVLMTATNLFSVKSYGEFEFWFAGIKVAAIVAFIALGALFVVGLWPGKDAD
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FSNLTAHGGFMPMGFGVITVGIVTVIFSMVGAEIATIAAAESADPERAVSKAANSVIVRI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LLFYVGSALLLVTILPWNDEGIAASPFVAAFTEMGIPYADHVMNAVVLTAVLSCLNSGMY
HHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHH
TASRMLFVLAARREAPPSLVRVTRRGVPAQAILASSVVGFLCVIAAAVSPDTIFAFLLNS
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
SGAIILFVYLLIAVSQIILRRRTPDSELRVKMWLFPVLSVLTAVGIVAILVQMFIDDALR
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQLVLSLLSWGVVLLLYFANKHFLKRRPTKAGVTGTGKPHRVLVLANQTVNSTELLDELH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHH
RIGADQETHYFVVVPVSPIETGTAETHGPLDVEEATQKAASERLDLTLNALRGHDFTADG
HCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ELGDRRPLRALADAVESFDPDQIVISTLPPEKSVWQRFDVVDRARAQHRVPVTHVVATGA
CCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHEECCC
EATATP
CCCCCC
>Mature Secondary Structure 
SAAPTLKKALNQRQLRMIAIGGVIGAGLFVGSGVVIADTGPGSFLTYAMSGVLIIMVMR
CCCCHHHHHHCHHHEEHEEEHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH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CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]