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The map label for this gene is cobC [C]

Identifier: 108800308

GI number: 108800308

Start: 3542028

End: 3543125

Strand: Reverse

Name: cobC [C]

Synonym: Mmcs_3342

Alternate gene names: 108800308

Gene position: 3543125-3542028 (Counterclockwise)

Preceding gene: 108800309

Following gene: 108800306

Centisome position: 62.1

GC content: 71.86

Gene sequence:

>1098_bases
GTGAAGGTTCTCGTCGAGGCCGACGGCGGCTCGCGGGGCAACCCCGGACCGGCGGGCTACGGCTCGGTGGTCTGGTCGGA
GGACCGGTCGTCGGTGCTCGCCGAGGCCAAACAGTCGATCGGCCGGGCCACCAACAACGTCGCCGAGTACCGCGGGTTGA
TCGCCGGTCTCGAGGAGGCCGCCAACGTCGGCGCCACCGAGGTCGCGGTGTCGATGGACTCCAAACTCATCGTCGAGCAG
ATGGCGGGCCGCTGGCGGGTCAAACACCCCGACCTGATTCCGCTGTATCAGCGGGCGCGGGAACTGGCCGAGGGGTTCGA
CCGCGTCACGTATTCGTGGATTCCGCGGGCCGCCAACGCCCGCGCCGACCGGCTGGCCAACGAGGCGATGGACGCCGCGC
AGGGTATCGACCCCCCGCCGCGCACGGCCGCCCCCGCCGCGTCCACCCACACCCCCACGTCACCGGCCGGCTGGACGGGT
GCGCGGGGGGAGCCGACACGGTTCCTGCTGCTGCGCCACGGACAGACCGAGCTGTCGGTGGAGCGCCGGTACTCCGGGCG
CGGCAACCCGGCGCTGACCGAACTGGGCCGCAGCCAGGCCGGCGCCGCGGCCGCCTACCTCGCGGGTCGGGGCGGCATCG
ACGCCGTCATCACCTCACCGCTGCAGCGCGCCTACGACACCGCGACCGCTGCCGCCAAGACGCTCGGACTGGACGTCACC
GTCGACGAGGATCTGATCGAGACGGATTTCGGCGCCTGGGAAGGGCTGACATTCGGCGAAGCGTCGCAACGGGATCCGGA
GCTGCACGGCCGCTGGCTGCGCGACACCAGCGTCGACCCGCCCGGCGGGGAGAGCTTCGACACCGTCGCCCACCGGGTGC
GGCGGGCCCGCAACCGCATCATCGCCGACCACGGCGCCTCGACGGTGCTGGTGGTCTCCCACGTCACGCCGATCAAGACG
ATGCTGCGGCTGGCGCTCAACGCCGGGGAAGGCATCCTGTACCGGCTGCACCTGGATCTCGCCTCGCTGAGCATCGCGGA
GTTCTACCCCGACGGTGGATCGTCGGTGCGGCTGGTCAACCAGACCGCCCACCTCTAG

Upstream 100 bases:

>100_bases
ACCGGGGCGAGATGGCCCGCATCTCGGCCGCGCCCGACGACGAGGTGCTGCGCTGCCCCGAGTGCAACGCAATTTTGGTG
CGCGCGGAGGGCTTCAAGAA

Downstream 100 bases:

>100_bases
GTGTGCAGGTGGAGGCGCTCGCCGTGCGGGCCGAAGATCCCGATCGCCTCCACCGGGCCGTCGACCACCCCGAACCAGTG
CGGTGTCCACGTCGAGAACT

Product: bifunctional RNase H/acid phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKVLVEADGGSRGNPGPAGYGSVVWSEDRSSVLAEAKQSIGRATNNVAEYRGLIAGLEEAANVGATEVAVSMDSKLIVEQ
MAGRWRVKHPDLIPLYQRARELAEGFDRVTYSWIPRAANARADRLANEAMDAAQGIDPPPRTAAPAASTHTPTSPAGWTG
ARGEPTRFLLLRHGQTELSVERRYSGRGNPALTELGRSQAGAAAAYLAGRGGIDAVITSPLQRAYDTATAAAKTLGLDVT
VDEDLIETDFGAWEGLTFGEASQRDPELHGRWLRDTSVDPPGGESFDTVAHRVRRARNRIIADHGASTVLVVSHVTPIKT
MLRLALNAGEGILYRLHLDLASLSIAEFYPDGGSSVRLVNQTAHL

Sequences:

>Translated_365_residues
MKVLVEADGGSRGNPGPAGYGSVVWSEDRSSVLAEAKQSIGRATNNVAEYRGLIAGLEEAANVGATEVAVSMDSKLIVEQ
MAGRWRVKHPDLIPLYQRARELAEGFDRVTYSWIPRAANARADRLANEAMDAAQGIDPPPRTAAPAASTHTPTSPAGWTG
ARGEPTRFLLLRHGQTELSVERRYSGRGNPALTELGRSQAGAAAAYLAGRGGIDAVITSPLQRAYDTATAAAKTLGLDVT
VDEDLIETDFGAWEGLTFGEASQRDPELHGRWLRDTSVDPPGGESFDTVAHRVRRARNRIIADHGASTVLVVSHVTPIKT
MLRLALNAGEGILYRLHLDLASLSIAEFYPDGGSSVRLVNQTAHL
>Mature_365_residues
MKVLVEADGGSRGNPGPAGYGSVVWSEDRSSVLAEAKQSIGRATNNVAEYRGLIAGLEEAANVGATEVAVSMDSKLIVEQ
MAGRWRVKHPDLIPLYQRARELAEGFDRVTYSWIPRAANARADRLANEAMDAAQGIDPPPRTAAPAASTHTPTSPAGWTG
ARGEPTRFLLLRHGQTELSVERRYSGRGNPALTELGRSQAGAAAAYLAGRGGIDAVITSPLQRAYDTATAAAKTLGLDVT
VDEDLIETDFGAWEGLTFGEASQRDPELHGRWLRDTSVDPPGGESFDTVAHRVRRARNRIIADHGASTVLVVSHVTPIKT
MLRLALNAGEGILYRLHLDLASLSIAEFYPDGGSSVRLVNQTAHL

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=149, Percent_Identity=33.5570469798658, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 39003; Mature: 39003

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVEADGGSRGNPGPAGYGSVVWSEDRSSVLAEAKQSIGRATNNVAEYRGLIAGLEEA
CEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANVGATEVAVSMDSKLIVEQMAGRWRVKHPDLIPLYQRARELAEGFDRVTYSWIPRAANA
HCCCHHHEEEECCHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
RADRLANEAMDAAQGIDPPPRTAAPAASTHTPTSPAGWTGARGEPTRFLLLRHGQTELSV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHH
ERRYSGRGNPALTELGRSQAGAAAAYLAGRGGIDAVITSPLQRAYDTATAAAKTLGLDVT
HHHHCCCCCHHHHHHCCHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
VDEDLIETDFGAWEGLTFGEASQRDPELHGRWLRDTSVDPPGGESFDTVAHRVRRARNRI
ECHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCE
IADHGASTVLVVSHVTPIKTMLRLALNAGEGILYRLHLDLASLSIAEFYPDGGSSVRLVN
EECCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHCCCCCCEEEEEC
QTAHL
CCCCC
>Mature Secondary Structure
MKVLVEADGGSRGNPGPAGYGSVVWSEDRSSVLAEAKQSIGRATNNVAEYRGLIAGLEEA
CEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANVGATEVAVSMDSKLIVEQMAGRWRVKHPDLIPLYQRARELAEGFDRVTYSWIPRAANA
HCCCHHHEEEECCHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
RADRLANEAMDAAQGIDPPPRTAAPAASTHTPTSPAGWTGARGEPTRFLLLRHGQTELSV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHH
ERRYSGRGNPALTELGRSQAGAAAAYLAGRGGIDAVITSPLQRAYDTATAAAKTLGLDVT
HHHHCCCCCHHHHHHCCHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
VDEDLIETDFGAWEGLTFGEASQRDPELHGRWLRDTSVDPPGGESFDTVAHRVRRARNRI
ECHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCE
IADHGASTVLVVSHVTPIKTMLRLALNAGEGILYRLHLDLASLSIAEFYPDGGSSVRLVN
EECCCCCEEEEEECCHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHCCCCCCEEEEEC
QTAHL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]