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The map label for this gene is bioA [H]

Identifier: 108800044

GI number: 108800044

Start: 3251927

End: 3253237

Strand: Reverse

Name: bioA [H]

Synonym: Mmcs_3078

Alternate gene names: 108800044

Gene position: 3253237-3251927 (Counterclockwise)

Preceding gene: 108800049

Following gene: 108800043

Centisome position: 57.02

GC content: 70.25

Gene sequence:

>1311_bases
GTGTCGATTCCCGTGCCCGCGTTGACCCCCGAACAGATCAGGGCCCTGGATGCCGCGCACGTCTGGCATCCCTACAGCAC
GATCGGCGCAGGCGCGTTACCGCCGGTGGTGGCGCTGGCCGCCAAGGGGGTGTGGATCACGATCGATCACCCGGCGGGCG
GGGGACCGGTCGACGTGATCGATGCGATGAGCTCGTGGTGGACGGCGATCCACGGCCACGGCCACCCGGTGCTCGACGCG
GCGATCACCCGGCAGCTCGCCACGATGAACCACGTCATGTTCGGCGGTCTGACCCACGAACCGGCCGTCCGGCTGGCGCA
GCTGCTGGTGCATATCACCCCGCCCGGCTTGGACACGGTCTTCTTCTCCGACTCCGGGTCGGTGTCGGTGGAAGTGGCCG
TGAAGATGGCGCTGCAGTACTGGCGCGCCGCCGGGCGGCCGGGCAAGACCCGCCTGATGACCTGGCGGGGCGGCTACCAC
GGCGACACCTTCACGCCGATGAGCGTGTGCGATCCCGACGGTGGCATGCACTCCCTGTGGACCGACGTGCTGACCCGGCA
GGTGTTCGCCCCGCCGGTGCCGCGCGACTACGACCCCGGGTATGTGGCGGCGTTCGAGCGCCGGCTCGCCGAGCACGCCG
ACGAACTCGCCGCGGTGATCGTCGAACCGGTGGTGCAGGGCGCCGGGGGGATGCGGTTCCACGATCCCCGCTACCTCAGC
GACCTGCGGACGCTGTGTGACCGGCACGGCGTGCTGCTGGTGTTCGACGAGATCGCCACCGGTTTCGGGCGCACCGGTGA
GTTGTTCGCCGCCGACCACGTCGGCGTCAGCCCCGACATCATGTGTGTCGGCAAGGGACTCACCGGCGGCTATCTCACGC
TCGCCGCGACGTTGTGCAGCGCCGAGATCGCGCGGGTCATCAGTACCGGCGAGGCCGGTGCGCTGATGCACGGCCCGACG
TTCATGGCCAACGCGCTGGCCTGCGCGGTCGGCGTCGCCGCCGTCGAACTGCTGCTGGCCGGTGACTGGCGGAGCACCAT
CGCGACGATCGAACGCGGGCTGACCGAGGGTCTGGCGCCGGCGCGTGAGGTGTCCGGGGTCGCCGATGTACGGGTGCTCG
GCGCGATCGGCGTGGTCGAACTGGACCGCCCGGTGGACATGGCGACGGCGACCGCCGCGGCGCTGAGTCACCGGGTGTGG
TTGCGCCCGTTCCGCAACCTCGTCTACGTCATGCCGCCGTACATCTGCACCCCCGAGGAGATCGCACAGATCACCTCGGC
CGTGGTGGGTGTGGCCCGTGCTTTAGCCTGA

Upstream 100 bases:

>100_bases
GTGGGGGGCGAGGGTCATCATGGTCGGCGGCTAATTTACCGAATAACGCCGCACACCTCATGCCGCGCATCGTGGGCGGC
CGCAGTGCGCGGAGGCGTTA

Downstream 100 bases:

>100_bases
ACGGTGTTCAATAGTCGGTTCGCGTCGAGAGGGCACCCGTGACACGCGCTGGTCTTTCGCCCCTGGCCTGGCTCGACGAG
GTCGCCGATCAACGCAGGGC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSIPVPALTPEQIRALDAAHVWHPYSTIGAGALPPVVALAAKGVWITIDHPAGGGPVDVIDAMSSWWTAIHGHGHPVLDA
AITRQLATMNHVMFGGLTHEPAVRLAQLLVHITPPGLDTVFFSDSGSVSVEVAVKMALQYWRAAGRPGKTRLMTWRGGYH
GDTFTPMSVCDPDGGMHSLWTDVLTRQVFAPPVPRDYDPGYVAAFERRLAEHADELAAVIVEPVVQGAGGMRFHDPRYLS
DLRTLCDRHGVLLVFDEIATGFGRTGELFAADHVGVSPDIMCVGKGLTGGYLTLAATLCSAEIARVISTGEAGALMHGPT
FMANALACAVGVAAVELLLAGDWRSTIATIERGLTEGLAPAREVSGVADVRVLGAIGVVELDRPVDMATATAAALSHRVW
LRPFRNLVYVMPPYICTPEEIAQITSAVVGVARALA

Sequences:

>Translated_436_residues
MSIPVPALTPEQIRALDAAHVWHPYSTIGAGALPPVVALAAKGVWITIDHPAGGGPVDVIDAMSSWWTAIHGHGHPVLDA
AITRQLATMNHVMFGGLTHEPAVRLAQLLVHITPPGLDTVFFSDSGSVSVEVAVKMALQYWRAAGRPGKTRLMTWRGGYH
GDTFTPMSVCDPDGGMHSLWTDVLTRQVFAPPVPRDYDPGYVAAFERRLAEHADELAAVIVEPVVQGAGGMRFHDPRYLS
DLRTLCDRHGVLLVFDEIATGFGRTGELFAADHVGVSPDIMCVGKGLTGGYLTLAATLCSAEIARVISTGEAGALMHGPT
FMANALACAVGVAAVELLLAGDWRSTIATIERGLTEGLAPAREVSGVADVRVLGAIGVVELDRPVDMATATAAALSHRVW
LRPFRNLVYVMPPYICTPEEIAQITSAVVGVARALA
>Mature_435_residues
SIPVPALTPEQIRALDAAHVWHPYSTIGAGALPPVVALAAKGVWITIDHPAGGGPVDVIDAMSSWWTAIHGHGHPVLDAA
ITRQLATMNHVMFGGLTHEPAVRLAQLLVHITPPGLDTVFFSDSGSVSVEVAVKMALQYWRAAGRPGKTRLMTWRGGYHG
DTFTPMSVCDPDGGMHSLWTDVLTRQVFAPPVPRDYDPGYVAAFERRLAEHADELAAVIVEPVVQGAGGMRFHDPRYLSD
LRTLCDRHGVLLVFDEIATGFGRTGELFAADHVGVSPDIMCVGKGLTGGYLTLAATLCSAEIARVISTGEAGALMHGPTF
MANALACAVGVAAVELLLAGDWRSTIATIERGLTEGLAPAREVSGVADVRVLGAIGVVELDRPVDMATATAAALSHRVWL
RPFRNLVYVMPPYICTPEEIAQITSAVVGVARALA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=286, Percent_Identity=31.8181818181818, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI284507298, Length=219, Percent_Identity=35.6164383561644, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI13994255, Length=354, Percent_Identity=28.2485875706215, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=24.7395833333333, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI37574042, Length=384, Percent_Identity=24.7395833333333, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI226442705, Length=392, Percent_Identity=24.234693877551, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=25.531914893617, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=52.6315789473684, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI145693181, Length=348, Percent_Identity=31.3218390804598, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=34.4051446945338, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788044, Length=267, Percent_Identity=37.0786516853933, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789016, Length=370, Percent_Identity=28.9189189189189, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787560, Length=340, Percent_Identity=30.8823529411765, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=28.6532951289398, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=342, Percent_Identity=27.7777777777778, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=124, Percent_Identity=41.9354838709677, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=393, Percent_Identity=26.4631043256997, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=396, Percent_Identity=25.5050505050505, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=242, Percent_Identity=27.6859504132231, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=468, Percent_Identity=39.1025641025641, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6323470, Length=428, Percent_Identity=28.5046728971963, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324432, Length=270, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357415, Length=288, Percent_Identity=30.2083333333333, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574759, Length=343, Percent_Identity=27.9883381924198, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161085790, Length=343, Percent_Identity=27.9883381924198, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46199; Mature: 46068

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVPALTPEQIRALDAAHVWHPYSTIGAGALPPVVALAAKGVWITIDHPAGGGPVDVI
CCCCCCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHH
DAMSSWWTAIHGHGHPVLDAAITRQLATMNHVMFGGLTHEPAVRLAQLLVHITPPGLDTV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEE
FFSDSGSVSVEVAVKMALQYWRAAGRPGKTRLMTWRGGYHGDTFTPMSVCDPDGGMHSLW
EECCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
TDVLTRQVFAPPVPRDYDPGYVAAFERRLAEHADELAAVIVEPVVQGAGGMRFHDPRYLS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
DLRTLCDRHGVLLVFDEIATGFGRTGELFAADHVGVSPDIMCVGKGLTGGYLTLAATLCS
HHHHHHHCCCEEEEEHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHH
AEIARVISTGEAGALMHGPTFMANALACAVGVAAVELLLAGDWRSTIATIERGLTEGLAP
HHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
AREVSGVADVRVLGAIGVVELDRPVDMATATAAALSHRVWLRPFRNLVYVMPPYICTPEE
HHHHCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHH
IAQITSAVVGVARALA
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIPVPALTPEQIRALDAAHVWHPYSTIGAGALPPVVALAAKGVWITIDHPAGGGPVDVI
CCCCCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHHH
DAMSSWWTAIHGHGHPVLDAAITRQLATMNHVMFGGLTHEPAVRLAQLLVHITPPGLDTV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEE
FFSDSGSVSVEVAVKMALQYWRAAGRPGKTRLMTWRGGYHGDTFTPMSVCDPDGGMHSLW
EECCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
TDVLTRQVFAPPVPRDYDPGYVAAFERRLAEHADELAAVIVEPVVQGAGGMRFHDPRYLS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
DLRTLCDRHGVLLVFDEIATGFGRTGELFAADHVGVSPDIMCVGKGLTGGYLTLAATLCS
HHHHHHHCCCEEEEEHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHH
AEIARVISTGEAGALMHGPTFMANALACAVGVAAVELLLAGDWRSTIATIERGLTEGLAP
HHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
AREVSGVADVRVLGAIGVVELDRPVDMATATAAALSHRVWLRPFRNLVYVMPPYICTPEE
HHHHCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCHHH
IAQITSAVVGVARALA
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]