Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 108800049

GI number: 108800049

Start: 3261679

End: 3262959

Strand: Reverse

Name: ilvA [H]

Synonym: Mmcs_3083

Alternate gene names: 108800049

Gene position: 3262959-3261679 (Counterclockwise)

Preceding gene: 108800050

Following gene: 108800044

Centisome position: 57.19

GC content: 68.93

Gene sequence:

>1281_bases
GTGTCCGCTGAACTGAGCCAGACCCCTCGTACGTCGCCGATCACCGCGGCTGACATCGACGAGGCGGCCCAGCGGATCGT
CGACGTCGTCGTGCGCACACCGCTGCAGTTTTCGGAGCGACTGTCGGAGGTCACCGGCGCGCAGGTCTACCTCAAGCGCG
AAGACCTGCAGGCGGTGCGGTCCTACAAGCTGCGCGGGGCGTTCAACCTGATCTCGCAGCTCACGGAGGAGGAGATCGCC
GCGGGCGTGGTCTGCTCGTCCGCAGGCAACCACGCCCAGGGGTTCGCCATGGCGTGCCGGACGATGGGCATCAAGGGCCG
CGTCTACATCCCGGCCAAGACTCCGAAGCAGAAGCGCGACCGCATCCGCTACCACGGCCGCGAGTTCATCGAGCTGATCG
CCGTCGGGACCACCTACGATCTGGCGGCCGCGGCGGCGATCGACGACGTCGCGCGCACCGGCGCCACCCTCGTCCCGCCC
TATGACGACGTGCGCACCATGGCCGGGCAGGGCACCATCGCCGCCGAGATCCTCGACGACCTCGACGCCGAACCGGATCT
GGTGATCGTCCCGGTGGGCGGCGGCGGCTGTATCGCAGGCATCACCACCTACCTTGCTGAACGCACGTCCGGCACCGCGG
TGCTGGGTGTGGAACCGGCCGGGGCGGCGTCGATGATCGCGGCGCTGAGCGCCGGTGAACCGGTCACCCTCGACCACGTC
GACCAGTTCGTCGACGGCGCGGCGGTCAACCGCGCCGGACGCCTGCCGTTCGCCGCGCTGCAGGCCGCGGGCGACATGGT
GTCGCTGACCACCGTCGACGAGGGTGCGGTCTGCTCCGCGATGCTCGACCTGTACCAGAACGAGGGCATCATCGCCGAAC
CCGCGGGCGCGCTGTCGGTCGCCGGGCTGCTCGAGAACAACGTCGAACCGGGCTCGACGGTCGTCTGCCTGATCTCCGGC
GGGAACAACGACGTATCGCGCTACGGCGAGATCCTCGAGCGCTCGTTGGTGCACCTCGGGCTCAAGCACTACTTCCTGGT
CGACTTCCCGCAGGAGCCCGGTGCGCTGCGCCGGTTCCTCGACGAGGTGCTCGGCCCGAACGACGACATCACGTTGTTCG
AGTACGTCAAGCGCAACAACCGGGAGACGGGGGAGGCGCTCGTCGGGATCGAACTCGGCTCGGCCGCCGACTTCGACGGT
CTGCTCACCCGGATGCGCTCCTCCGACATGCACGTCGAGGCGCTGGAACCGGATTCGCCGGCCTACCGCTACCTGCTCTG
A

Upstream 100 bases:

>100_bases
TTACCAGAAGAAGACCGACCGCGAGATCCCGGTCTTCGTGCTGACCCCGGTCGAATAAAGCGGATTTTCTCCCTGAAGGC
CGCAGTGGCACCATTGACCG

Downstream 100 bases:

>100_bases
GTCCGCACGACGGCGAACGAGTGACCCGCCAGGCTCATCCCGTCACCCTCGGGCGCCGGTTCCCCCCAGGCGAGCACGAC
GTCACCGGTGACCGGCACGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSAELSQTPRTSPITAADIDEAAQRIVDVVVRTPLQFSERLSEVTGAQVYLKREDLQAVRSYKLRGAFNLISQLTEEEIA
AGVVCSSAGNHAQGFAMACRTMGIKGRVYIPAKTPKQKRDRIRYHGREFIELIAVGTTYDLAAAAAIDDVARTGATLVPP
YDDVRTMAGQGTIAAEILDDLDAEPDLVIVPVGGGGCIAGITTYLAERTSGTAVLGVEPAGAASMIAALSAGEPVTLDHV
DQFVDGAAVNRAGRLPFAALQAAGDMVSLTTVDEGAVCSAMLDLYQNEGIIAEPAGALSVAGLLENNVEPGSTVVCLISG
GNNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADFDG
LLTRMRSSDMHVEALEPDSPAYRYLL

Sequences:

>Translated_426_residues
MSAELSQTPRTSPITAADIDEAAQRIVDVVVRTPLQFSERLSEVTGAQVYLKREDLQAVRSYKLRGAFNLISQLTEEEIA
AGVVCSSAGNHAQGFAMACRTMGIKGRVYIPAKTPKQKRDRIRYHGREFIELIAVGTTYDLAAAAAIDDVARTGATLVPP
YDDVRTMAGQGTIAAEILDDLDAEPDLVIVPVGGGGCIAGITTYLAERTSGTAVLGVEPAGAASMIAALSAGEPVTLDHV
DQFVDGAAVNRAGRLPFAALQAAGDMVSLTTVDEGAVCSAMLDLYQNEGIIAEPAGALSVAGLLENNVEPGSTVVCLISG
GNNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADFDG
LLTRMRSSDMHVEALEPDSPAYRYLL
>Mature_425_residues
SAELSQTPRTSPITAADIDEAAQRIVDVVVRTPLQFSERLSEVTGAQVYLKREDLQAVRSYKLRGAFNLISQLTEEEIAA
GVVCSSAGNHAQGFAMACRTMGIKGRVYIPAKTPKQKRDRIRYHGREFIELIAVGTTYDLAAAAAIDDVARTGATLVPPY
DDVRTMAGQGTIAAEILDDLDAEPDLVIVPVGGGGCIAGITTYLAERTSGTAVLGVEPAGAASMIAALSAGEPVTLDHVD
QFVDGAAVNRAGRLPFAALQAAGDMVSLTTVDEGAVCSAMLDLYQNEGIIAEPAGALSVAGLLENNVEPGSTVVCLISGG
NNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFLDEVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADFDGL
LTRMRSSDMHVEALEPDSPAYRYLL

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=325, Percent_Identity=27.3846153846154, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI33469958, Length=306, Percent_Identity=29.0849673202614, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI19923959, Length=332, Percent_Identity=29.8192771084337, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1790207, Length=347, Percent_Identity=38.328530259366, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789505, Length=323, Percent_Identity=36.8421052631579, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537387, Length=381, Percent_Identity=32.0209973753281, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71991565, Length=326, Percent_Identity=34.6625766871166, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17508781, Length=320, Percent_Identity=27.1875, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320930, Length=372, Percent_Identity=34.4086021505376, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322631, Length=319, Percent_Identity=30.4075235109718, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21355833, Length=346, Percent_Identity=34.393063583815, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=33.2, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 45299; Mature: 45168

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELSQTPRTSPITAADIDEAAQRIVDVVVRTPLQFSERLSEVTGAQVYLKREDLQAVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEHHHHHHHH
SYKLRGAFNLISQLTEEEIAAGVVCSSAGNHAQGFAMACRTMGIKGRVYIPAKTPKQKRD
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHH
RIRYHGREFIELIAVGTTYDLAAAAAIDDVARTGATLVPPYDDVRTMAGQGTIAAEILDD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHH
LDAEPDLVIVPVGGGGCIAGITTYLAERTSGTAVLGVEPAGAASMIAALSAGEPVTLDHV
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEHHHH
DQFVDGAAVNRAGRLPFAALQAAGDMVSLTTVDEGAVCSAMLDLYQNEGIIAEPAGALSV
HHHHCCHHHCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEECCCCHHHH
AGLLENNVEPGSTVVCLISGGNNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFL
HHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHH
DEVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADFDGLLTRMRSSDMHVEALEPDSP
HHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCC
AYRYLL
CCCCCC
>Mature Secondary Structure 
SAELSQTPRTSPITAADIDEAAQRIVDVVVRTPLQFSERLSEVTGAQVYLKREDLQAVR
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEHHHHHHHH
SYKLRGAFNLISQLTEEEIAAGVVCSSAGNHAQGFAMACRTMGIKGRVYIPAKTPKQKRD
HHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHH
RIRYHGREFIELIAVGTTYDLAAAAAIDDVARTGATLVPPYDDVRTMAGQGTIAAEILDD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHH
LDAEPDLVIVPVGGGGCIAGITTYLAERTSGTAVLGVEPAGAASMIAALSAGEPVTLDHV
CCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCEEHHHH
DQFVDGAAVNRAGRLPFAALQAAGDMVSLTTVDEGAVCSAMLDLYQNEGIIAEPAGALSV
HHHHCCHHHCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEECCCCHHHH
AGLLENNVEPGSTVVCLISGGNNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFL
HHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHHHHH
DEVLGPNDDITLFEYVKRNNRETGEALVGIELGSAADFDGLLTRMRSSDMHVEALEPDSP
HHHCCCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCC
AYRYLL
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]