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The map label for this gene is bioF [C]

Identifier: 108800043

GI number: 108800043

Start: 3250740

End: 3251888

Strand: Reverse

Name: bioF [C]

Synonym: Mmcs_3077

Alternate gene names: 108800043

Gene position: 3251888-3250740 (Counterclockwise)

Preceding gene: 108800044

Following gene: 108800042

Centisome position: 57.0

GC content: 75.28

Gene sequence:

>1149_bases
GTGACACGCGCTGGTCTTTCGCCCCTGGCCTGGCTCGACGAGGTCGCCGATCAACGCAGGGCCGCCGGGCTGCGCCGCGC
CCTGCGGACCAGGCCGGCCGGCGGGACCGCCGTCGACCTGGCCTCCAACGACTACCTCGGCCTGTCCACGCATCCGCGCG
TCGTCGAGGGTGCGGTGCGCGCGGTGCGCGAATGGGGCGCCGGGTCGACCGGATCGCGGCTGGTCACCGGCAACACCGAA
CTGCACGAAGGTTTCGAGCGGGCACTCGCCGCCTTCACCGGCGCCGAGTCCGCGCTGGTCTTCTCCTCCGGCTACACCGC
CAATCTCGGGGCGGTGGTGGCGCTGTCCGGCCCCGGCTCGCTGCTGGTGTCCGACGCCCTGACCCACGCGTCGCTGGTCG
ACGCCTGCCGGTTGTCGCGGGCCCGCGTCGTGGTCACCCCGCACCGTGACGTCACCGCGATCGAGACCGCGCTGGCCACC
CGCGACGAACAGCGGGCCATCGTGGTGACCGATTCGGTGTTCTCCGCGGACGGTGTGCTCGCGCCGCTGCGGGACATGCA
CGACGTGTGCCGCCGCCACGGTGCGTTGCTGATCGTCGACGAGGCGCACGGCCTCGGCGTCCGCGGCACCGGCGGCCGCG
GGCTGCTCGACGAGGTGGGGCTGGCCGGCGCGCCCGACGTGGTGATGACCACCACGCTGTCCAAGGCGCTGGGCAGCCAG
GGCGGTGTGGTCCTCGGCCCGCTGGCCGTGCGCGACCACCTCATCGACGCCGCCCGCCCGTTCATCTTCGACACCGGCCT
GGCCCCGGCCGCGGTCGGGGCCGCATGGGCGGCGCTGGAGGTGCTCGTCGACGAACCCTCGCGGGCCCGCGCGGTGCTGG
ACAACGCCGCGGCGCTGGCGCAGGCGTGCGACGTCCCGGCCCGGCCCGACTCCGCCGTCGTCTCGGTGATCCTCGGGGAA
CCCGAGGTGGCACTGGCGGCGGCGATCGCATGCCTCGAGCAGGGTCTGCGCGTCGGGTGCTTCCGACCGCCCACCGTGCC
CGCGGGCACCTCCCGGCTCCGCCTGACCGCGCGGGCGTCGCTGACCGACGACGACCTCGACACCGCCCGCCGGGTGCTGG
CCGACGTGTTGACGGCGGCCCGCCGGTGA

Upstream 100 bases:

>100_bases
CCCCCGAGGAGATCGCACAGATCACCTCGGCCGTGGTGGGTGTGGCCCGTGCTTTAGCCTGAACGGTGTTCAATAGTCGG
TTCGCGTCGAGAGGGCACCC

Downstream 100 bases:

>100_bases
GCGTTCTCGTGATCACCGGCACCGACACCGGCGTCGGTAAGACCGTGGCCACCGCGGCGCTGGCCTGCGCCGCCCGGGTG
GCCGGGATCGACGTCGCGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTRAGLSPLAWLDEVADQRRAAGLRRALRTRPAGGTAVDLASNDYLGLSTHPRVVEGAVRAVREWGAGSTGSRLVTGNTE
LHEGFERALAAFTGAESALVFSSGYTANLGAVVALSGPGSLLVSDALTHASLVDACRLSRARVVVTPHRDVTAIETALAT
RDEQRAIVVTDSVFSADGVLAPLRDMHDVCRRHGALLIVDEAHGLGVRGTGGRGLLDEVGLAGAPDVVMTTTLSKALGSQ
GGVVLGPLAVRDHLIDAARPFIFDTGLAPAAVGAAWAALEVLVDEPSRARAVLDNAAALAQACDVPARPDSAVVSVILGE
PEVALAAAIACLEQGLRVGCFRPPTVPAGTSRLRLTARASLTDDDLDTARRVLADVLTAARR

Sequences:

>Translated_382_residues
MTRAGLSPLAWLDEVADQRRAAGLRRALRTRPAGGTAVDLASNDYLGLSTHPRVVEGAVRAVREWGAGSTGSRLVTGNTE
LHEGFERALAAFTGAESALVFSSGYTANLGAVVALSGPGSLLVSDALTHASLVDACRLSRARVVVTPHRDVTAIETALAT
RDEQRAIVVTDSVFSADGVLAPLRDMHDVCRRHGALLIVDEAHGLGVRGTGGRGLLDEVGLAGAPDVVMTTTLSKALGSQ
GGVVLGPLAVRDHLIDAARPFIFDTGLAPAAVGAAWAALEVLVDEPSRARAVLDNAAALAQACDVPARPDSAVVSVILGE
PEVALAAAIACLEQGLRVGCFRPPTVPAGTSRLRLTARASLTDDDLDTARRVLADVLTAARR
>Mature_381_residues
TRAGLSPLAWLDEVADQRRAAGLRRALRTRPAGGTAVDLASNDYLGLSTHPRVVEGAVRAVREWGAGSTGSRLVTGNTEL
HEGFERALAAFTGAESALVFSSGYTANLGAVVALSGPGSLLVSDALTHASLVDACRLSRARVVVTPHRDVTAIETALATR
DEQRAIVVTDSVFSADGVLAPLRDMHDVCRRHGALLIVDEAHGLGVRGTGGRGLLDEVGLAGAPDVVMTTTLSKALGSQG
GVVLGPLAVRDHLIDAARPFIFDTGLAPAAVGAAWAALEVLVDEPSRARAVLDNAAALAQACDVPARPDSAVVSVILGEP
EVALAAAIACLEQGLRVGCFRPPTVPAGTSRLRLTARASLTDDDLDTARRVLADVLTAARR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=363, Percent_Identity=33.6088154269972, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI284448556, Length=353, Percent_Identity=33.9943342776204, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI83977444, Length=327, Percent_Identity=32.7217125382263, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI83977440, Length=327, Percent_Identity=32.7217125382263, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI83977442, Length=327, Percent_Identity=32.7217125382263, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4758668, Length=361, Percent_Identity=27.1468144044321, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4502025, Length=245, Percent_Identity=35.1020408163265, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI40316939, Length=245, Percent_Identity=35.1020408163265, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI119220554, Length=361, Percent_Identity=24.9307479224377, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI5454084, Length=269, Percent_Identity=24.907063197026, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=36.1031518624642, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1790046, Length=345, Percent_Identity=33.9130434782609, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71994529, Length=350, Percent_Identity=32.8571428571429, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI32566772, Length=352, Percent_Identity=26.1363636363636, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71982625, Length=275, Percent_Identity=26.1818181818182, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71982617, Length=275, Percent_Identity=26.1818181818182, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=23.7569060773481, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=23.7569060773481, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=392, Percent_Identity=29.8469387755102, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=362, Percent_Identity=25.9668508287293, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=280, Percent_Identity=27.1428571428571, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24662918, Length=344, Percent_Identity=31.6860465116279, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI17137420, Length=325, Percent_Identity=32, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24653280, Length=389, Percent_Identity=24.1645244215938, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24653276, Length=389, Percent_Identity=24.1645244215938, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24653278, Length=389, Percent_Identity=24.1645244215938, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17136286, Length=261, Percent_Identity=24.904214559387, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 39445; Mature: 39314

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAGLSPLAWLDEVADQRRAAGLRRALRTRPAGGTAVDLASNDYLGLSTHPRVVEGAVR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECCCCCCHHHHHHHH
AVREWGAGSTGSRLVTGNTELHEGFERALAAFTGAESALVFSSGYTANLGAVVALSGPGS
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCC
LLVSDALTHASLVDACRLSRARVVVTPHRDVTAIETALATRDEQRAIVVTDSVFSADGVL
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
APLRDMHDVCRRHGALLIVDEAHGLGVRGTGGRGLLDEVGLAGAPDVVMTTTLSKALGSQ
HHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCC
GGVVLGPLAVRDHLIDAARPFIFDTGLAPAAVGAAWAALEVLVDEPSRARAVLDNAAALA
CCEEECHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QACDVPARPDSAVVSVILGEPEVALAAAIACLEQGLRVGCFRPPTVPAGTSRLRLTARAS
HHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEEECC
LTDDDLDTARRVLADVLTAARR
CCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRAGLSPLAWLDEVADQRRAAGLRRALRTRPAGGTAVDLASNDYLGLSTHPRVVEGAVR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECCCCCCHHHHHHHH
AVREWGAGSTGSRLVTGNTELHEGFERALAAFTGAESALVFSSGYTANLGAVVALSGPGS
HHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEECCCCC
LLVSDALTHASLVDACRLSRARVVVTPHRDVTAIETALATRDEQRAIVVTDSVFSADGVL
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
APLRDMHDVCRRHGALLIVDEAHGLGVRGTGGRGLLDEVGLAGAPDVVMTTTLSKALGSQ
HHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCC
GGVVLGPLAVRDHLIDAARPFIFDTGLAPAAVGAAWAALEVLVDEPSRARAVLDNAAALA
CCEEECHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
QACDVPARPDSAVVSVILGEPEVALAAAIACLEQGLRVGCFRPPTVPAGTSRLRLTARAS
HHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCEEEEEEECC
LTDDDLDTARRVLADVLTAARR
CCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA