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The map label for this gene is trpE [H]

Identifier: 108800019

GI number: 108800019

Start: 3230305

End: 3231864

Strand: Reverse

Name: trpE [H]

Synonym: Mmcs_3053

Alternate gene names: 108800019

Gene position: 3231864-3230305 (Counterclockwise)

Preceding gene: 108800021

Following gene: 108800018

Centisome position: 56.65

GC content: 69.81

Gene sequence:

>1560_bases
GTGCAGACGACCGCCGCTTCCGCCTTCGACTCCTCGCGCGAGCGTTCGTCGCTGGCCACGACCACGTCTCGCGAGGACTT
CCGGGCACTGGCAGCCGAGCACCGCGTGGTGCCGGTGGTCCGCAAGGTGCTCGCCGACAGCGAGACCCCGCTGTCGGCGT
ACCGCAAGCTCGCCGCCAACCGGCCCGGCACGTTCCTGCTCGAATCGGCCGAGAACGGCAGGTCGTGGTCGCGGTGGTCG
TTCATCGGGGCGGGCGCACCGTCGGCGCTGACGGTCCGCGACGGCGAGGCGGTGTGGTTGGGCGTGACGCCGAAGGATGC
GCCGAGCGGTGGTGATCCACTGCAGGCACTGCGGTCCACGCTGGCGCTGCTGGAGACCGCGCCGCTGCCGGGCCTGCCGC
CGCTGTCGAGCGGTCTGGTCGGGTTCTTCGCCTATGACATGGTGCGGCAGCTGGAGCGGCTGCCGTCGCTGGCCGTCGAC
GATCTCGGACTGCCCGACATGCTGCTGCTGTTGGCCACCGACATCGCCGCCGTCGACCACCACGAGGGCACCATCACGCT
GATCGCCAACGCGGTGAACTGGAACGGCACCGACGAGAACGTGGACGGCGCGTATGACGACGCCGTCGCCCGGCTCGACG
TGATGACCAAGGCGCTGGGGCAGTCGCTGCCCTCGTCGGTGGCCACGTTCGCCCGGCCGGCCCCGACGCACCGGGCGCAG
CGCACCGTCGAGGAGTACACCGCGATCGTCGAGAAGCTCGTCGGCGACATCGAGGCCGGTGAGGCGTTCCAGGTGGTGCC
GTCGCAACGCTTCGAGATGGACACCGTCGCCGATCCGCTCGATGTGTACCGGATGCTGCGGGTCACCAATCCCAGTCCGT
ACATGTATCTGCTGAACGTGCCGGATGAGACTGGGGGACTGGACTTCTCGGTGGTCGGGTCGAGTCCGGAGGCGCTGGTG
ACCGTCGCCGACGGGAAGGCCACGACGCACCCGATCGCCGGCACCCGCTGGCGCGGCGACACCGAGGAAGAGGACCTGCT
GCTCGAGAAGGAGCTGCTGGCCGACGAGAAGGAACGCGCCGAACACCTGATGCTGGTGGACCTGGGCCGTAACGATCTGG
GCCGGGTGTGTGAACCCGGCACCGTGCGGGTCGAGGACTACAGCCACATCGAGCGGTACAGCCACGTCATGCACCTGGTG
TCGACGGTCACCGGACGTCTCGCCGAGGGCATGACCGCGCTCGACGCGGTGACGGCCTGTTTCCCGGCGGGCACGCTGTC
GGGCGCCCCGAAGGTGCGGGCCATGGAGCTCATCGAGGAGGTCGAGAAGACCCGCCGCGGGCTCTACGGCGGGGTGCTGG
GCTACCTCGACTTCGCGGGCAACGCCGATTTCGCGATCGCCATCCGGACCGCGCTGATGCGCGACGGGGTCGCCTACGTC
CAGGCCGGCGGGGGAGTCGTGGCCGACTCCAACGGGCCGTACGAGTTCAACGAGGCCACCAATAAGGCCAAGGCGGTGCT
GGCCGCCGTCGCCGCCGCCGAAACCCTGCGCGAACCATGA

Upstream 100 bases:

>100_bases
TGCAGTTCGAAATCCTCGACTCGATCACCGCGTTCCATGAGCCGTCACGCTACGCCTCCTGCCGGCGAACGGGCCCGCAC
CGGTCTGGGAGAATCGCCTC

Downstream 100 bases:

>100_bases
CCCGCATCGCCCAGCTCGTCCTCGTCCTCGGCGCCGCGGTGCTGTGGGTGGCGTCGCGGCTGACGTGGGTCGAGGTGCGT
TCGTTCGACGGACTGGGTCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MQTTAASAFDSSRERSSLATTTSREDFRALAAEHRVVPVVRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWS
FIGAGAPSALTVRDGEAVWLGVTPKDAPSGGDPLQALRSTLALLETAPLPGLPPLSSGLVGFFAYDMVRQLERLPSLAVD
DLGLPDMLLLLATDIAAVDHHEGTITLIANAVNWNGTDENVDGAYDDAVARLDVMTKALGQSLPSSVATFARPAPTHRAQ
RTVEEYTAIVEKLVGDIEAGEAFQVVPSQRFEMDTVADPLDVYRMLRVTNPSPYMYLLNVPDETGGLDFSVVGSSPEALV
TVADGKATTHPIAGTRWRGDTEEEDLLLEKELLADEKERAEHLMLVDLGRNDLGRVCEPGTVRVEDYSHIERYSHVMHLV
STVTGRLAEGMTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAGNADFAIAIRTALMRDGVAYV
QAGGGVVADSNGPYEFNEATNKAKAVLAAVAAAETLREP

Sequences:

>Translated_519_residues
MQTTAASAFDSSRERSSLATTTSREDFRALAAEHRVVPVVRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWS
FIGAGAPSALTVRDGEAVWLGVTPKDAPSGGDPLQALRSTLALLETAPLPGLPPLSSGLVGFFAYDMVRQLERLPSLAVD
DLGLPDMLLLLATDIAAVDHHEGTITLIANAVNWNGTDENVDGAYDDAVARLDVMTKALGQSLPSSVATFARPAPTHRAQ
RTVEEYTAIVEKLVGDIEAGEAFQVVPSQRFEMDTVADPLDVYRMLRVTNPSPYMYLLNVPDETGGLDFSVVGSSPEALV
TVADGKATTHPIAGTRWRGDTEEEDLLLEKELLADEKERAEHLMLVDLGRNDLGRVCEPGTVRVEDYSHIERYSHVMHLV
STVTGRLAEGMTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAGNADFAIAIRTALMRDGVAYV
QAGGGVVADSNGPYEFNEATNKAKAVLAAVAAAETLREP
>Mature_519_residues
MQTTAASAFDSSRERSSLATTTSREDFRALAAEHRVVPVVRKVLADSETPLSAYRKLAANRPGTFLLESAENGRSWSRWS
FIGAGAPSALTVRDGEAVWLGVTPKDAPSGGDPLQALRSTLALLETAPLPGLPPLSSGLVGFFAYDMVRQLERLPSLAVD
DLGLPDMLLLLATDIAAVDHHEGTITLIANAVNWNGTDENVDGAYDDAVARLDVMTKALGQSLPSSVATFARPAPTHRAQ
RTVEEYTAIVEKLVGDIEAGEAFQVVPSQRFEMDTVADPLDVYRMLRVTNPSPYMYLLNVPDETGGLDFSVVGSSPEALV
TVADGKATTHPIAGTRWRGDTEEEDLLLEKELLADEKERAEHLMLVDLGRNDLGRVCEPGTVRVEDYSHIERYSHVMHLV
STVTGRLAEGMTALDAVTACFPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAGNADFAIAIRTALMRDGVAYV
QAGGGVVADSNGPYEFNEATNKAKAVLAAVAAAETLREP

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=386, Percent_Identity=40.9326424870466, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788114, Length=458, Percent_Identity=32.3144104803493, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786809, Length=221, Percent_Identity=28.5067873303167, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082077, Length=264, Percent_Identity=25.7575757575758, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320935, Length=482, Percent_Identity=39.4190871369295, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6324361, Length=403, Percent_Identity=23.5732009925558, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 55623; Mature: 55623

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTAASAFDSSRERSSLATTTSREDFRALAAEHRVVPVVRKVLADSETPLSAYRKLAAN
CCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCC
RPGTFLLESAENGRSWSRWSFIGAGAPSALTVRDGEAVWLGVTPKDAPSGGDPLQALRST
CCCCEEEECCCCCCCCCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHH
LALLETAPLPGLPPLSSGLVGFFAYDMVRQLERLPSLAVDDLGLPDMLLLLATDIAAVDH
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
HEGTITLIANAVNWNGTDENVDGAYDDAVARLDVMTKALGQSLPSSVATFARPAPTHRAQ
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHH
RTVEEYTAIVEKLVGDIEAGEAFQVVPSQRFEMDTVADPLDVYRMLRVTNPSPYMYLLNV
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEEC
PDETGGLDFSVVGSSPEALVTVADGKATTHPIAGTRWRGDTEEEDLLLEKELLADEKERA
CCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHH
EHLMLVDLGRNDLGRVCEPGTVRVEDYSHIERYSHVMHLVSTVTGRLAEGMTALDAVTAC
CEEEEEECCCCCHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
FPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAGNADFAIAIRTALMRDGVAYV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEE
QAGGGVVADSNGPYEFNEATNKAKAVLAAVAAAETLREP
ECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTTAASAFDSSRERSSLATTTSREDFRALAAEHRVVPVVRKVLADSETPLSAYRKLAAN
CCCCHHHHHHCHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHCC
RPGTFLLESAENGRSWSRWSFIGAGAPSALTVRDGEAVWLGVTPKDAPSGGDPLQALRST
CCCCEEEECCCCCCCCCCEEEEECCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHH
LALLETAPLPGLPPLSSGLVGFFAYDMVRQLERLPSLAVDDLGLPDMLLLLATDIAAVDH
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
HEGTITLIANAVNWNGTDENVDGAYDDAVARLDVMTKALGQSLPSSVATFARPAPTHRAQ
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCHHHH
RTVEEYTAIVEKLVGDIEAGEAFQVVPSQRFEMDTVADPLDVYRMLRVTNPSPYMYLLNV
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHCCHHHHHHHHHCCCCCCEEEEEEC
PDETGGLDFSVVGSSPEALVTVADGKATTHPIAGTRWRGDTEEEDLLLEKELLADEKERA
CCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHH
EHLMLVDLGRNDLGRVCEPGTVRVEDYSHIERYSHVMHLVSTVTGRLAEGMTALDAVTAC
CEEEEEECCCCCHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
FPAGTLSGAPKVRAMELIEEVEKTRRGLYGGVLGYLDFAGNADFAIAIRTALMRDGVAYV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEE
QAGGGVVADSNGPYEFNEATNKAKAVLAAVAAAETLREP
ECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA