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The map label for this gene is trpC [H]

Identifier: 108800017

GI number: 108800017

Start: 3228809

End: 3229627

Strand: Reverse

Name: trpC [H]

Synonym: Mmcs_3051

Alternate gene names: 108800017

Gene position: 3229627-3228809 (Counterclockwise)

Preceding gene: 108800018

Following gene: 108800016

Centisome position: 56.61

GC content: 70.45

Gene sequence:

>819_bases
ATGAGTTCGGCGACCGTGCTCGACTCCATCATCGAGGGAGTCCGCGCCGACGTTGCCGCTCGAGAGGCCGTGGTCAGCCT
CACCGAGATCAAGGAACGGGCGCAGCGCGCGAAGCCTCCACTGGACGTGATGGCCGCCCTGCGCGAACCCGGCATCGGGG
TCATCGCCGAGGTCAAGCGGGCCAGTCCGTCCCGGGGGGCGCTCGCCCAGATCGGGGATCCCGCCGACCTGGCCCGCGCC
TATCAGGACGGCGGCGCCCGCGTGATCAGCGTGCTGACCGAACAGCGCCGGTTCAACGGTTCGCTCGACGACCTCGACGC
AGTCCGCGCGGCGGTGTCGATCCCGGTCCTGCGGAAGGACTTCATCGTCCGGCCGTATCAGATCCACGAAGCCCGCGCCC
ACGGTGCCGACATGTTGCTGCTCATCGTCGCCGCACTCGAACAGCCCGTGCTCGAGTCGTTGCTGGAGCGCACCGAGTCG
CTCGGGATGACGGCGCTGGTGGAGGTCCACACCGAAGCCGAAGCCGACCGCGCACTGCAGGCCGGTGCCCGGGTGATCGG
CGTCAACGCGCGGAATCTCAAGACCCTCGAGGTGGACCGCGACTGCTTCGCGCGCATCGCCCCGGGACTGCCGTCGAATG
TCATCCGCATCGCGGAGTCCGGCGTGCGCGGCCCTGCCGACCTGCTGGCGTACGCCGGTGCCGGTGCCGACGCCGTGCTC
GTCGGCGAAGGCCTGGTGACCAGCCGCGACCCCCGCAGTGCGGTGGCCGACCTGGTGACCGCCGGAACCCATCCGTCCTG
CCCGAAACCGTCCCGATAG

Upstream 100 bases:

>100_bases
CACGAAGGGCCGGTGACAGGCGATGGGGTCACTGCGACTACCCTTCGATGAGAACCATCCGGCAACTGTCGGCGACGTAC
CAGAGGGGGATCGACGGGCT

Downstream 100 bases:

>100_bases
CGTGGCCGAACTCGTCGACTCGGACCTGCCGCGCTCCAGTGCGGCCGTCGCCGAACCCACCAGCCACGACCCGGACGCCC
GCGGCCACTTCGGCCCGTAC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSSATVLDSIIEGVRADVAAREAVVSLTEIKERAQRAKPPLDVMAALREPGIGVIAEVKRASPSRGALAQIGDPADLARA
YQDGGARVISVLTEQRRFNGSLDDLDAVRAAVSIPVLRKDFIVRPYQIHEARAHGADMLLLIVAALEQPVLESLLERTES
LGMTALVEVHTEAEADRALQAGARVIGVNARNLKTLEVDRDCFARIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
VGEGLVTSRDPRSAVADLVTAGTHPSCPKPSR

Sequences:

>Translated_272_residues
MSSATVLDSIIEGVRADVAAREAVVSLTEIKERAQRAKPPLDVMAALREPGIGVIAEVKRASPSRGALAQIGDPADLARA
YQDGGARVISVLTEQRRFNGSLDDLDAVRAAVSIPVLRKDFIVRPYQIHEARAHGADMLLLIVAALEQPVLESLLERTES
LGMTALVEVHTEAEADRALQAGARVIGVNARNLKTLEVDRDCFARIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
VGEGLVTSRDPRSAVADLVTAGTHPSCPKPSR
>Mature_271_residues
SSATVLDSIIEGVRADVAAREAVVSLTEIKERAQRAKPPLDVMAALREPGIGVIAEVKRASPSRGALAQIGDPADLARAY
QDGGARVISVLTEQRRFNGSLDDLDAVRAAVSIPVLRKDFIVRPYQIHEARAHGADMLLLIVAALEQPVLESLLERTESL
GMTALVEVHTEAEADRALQAGARVIGVNARNLKTLEVDRDCFARIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVLV
GEGLVTSRDPRSAVADLVTAGTHPSCPKPSR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=35.4581673306773, Blast_Score=128, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=272, Percent_Identity=37.5, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28666; Mature: 28535

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSATVLDSIIEGVRADVAAREAVVSLTEIKERAQRAKPPLDVMAALREPGIGVIAEVKR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
ASPSRGALAQIGDPADLARAYQDGGARVISVLTEQRRFNGSLDDLDAVRAAVSIPVLRKD
CCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FIVRPYQIHEARAHGADMLLLIVAALEQPVLESLLERTESLGMTALVEVHTEAEADRALQ
HHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHH
AGARVIGVNARNLKTLEVDRDCFARIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
CCCEEEECCCCCCEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVTSRDPRSAVADLVTAGTHPSCPKPSR
ECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SSATVLDSIIEGVRADVAAREAVVSLTEIKERAQRAKPPLDVMAALREPGIGVIAEVKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHH
ASPSRGALAQIGDPADLARAYQDGGARVISVLTEQRRFNGSLDDLDAVRAAVSIPVLRKD
CCCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FIVRPYQIHEARAHGADMLLLIVAALEQPVLESLLERTESLGMTALVEVHTEAEADRALQ
HHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHH
AGARVIGVNARNLKTLEVDRDCFARIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVL
CCCEEEECCCCCCEEEEECHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCEEE
VGEGLVTSRDPRSAVADLVTAGTHPSCPKPSR
ECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA