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The map label for this gene is pyrG [H]

Identifier: 108799910

GI number: 108799910

Start: 3102389

End: 3104128

Strand: Reverse

Name: pyrG [H]

Synonym: Mmcs_2944

Alternate gene names: 108799910

Gene position: 3104128-3102389 (Counterclockwise)

Preceding gene: 108799911

Following gene: 108799909

Centisome position: 54.41

GC content: 67.41

Gene sequence:

>1740_bases
TTGCCCGCGCTACGCAAGCATCCGCAAACGGCCACAAAGCACCTCTTCGTCACGGGCGGCGTCGTCTCCTCCCTGGGCAA
GGGTCTGACGGGCTCGAGTCTCGGACAGTTGTTGACTGCCAGGGGCCTGCAGGTGACGATGCAGAAGCTCGACCCCTATC
TCAACGTCGACCCCGGCACCATGAACCCGTTCCAGCACGGTGAGGTGTTCGTCACCGAGGACGGCGCCGAGACCGACCTC
GACGTCGGGCACTACGAACGGTTCCTCGACCGGAACCTGTCGGGGTCCGCGAACGTCACCACGGGGCAGATCTATTCGTC
GGTGATCGCCAAGGAACGCCGCGGGGAGTACCTCGGTGACACCGTGCAGGTGATCCCGCACATCACCGACGAGATCAAGA
GCCGCATCCTCGCGATGGCCGCGCCGGACGAGCACGGCAACCGTCCGGACGTGGTGATCACCGAAGTCGGCGGCACGGTC
GGCGACATCGAATCCCTGCCCTTCCTTGAGGCCGCGCGCCAGGTGCGCCACGAGGTCGGCCGCGAGAACTGCTTCTTCCT
GCACTGCTCGCTGGTGCCCTACATGGCGCCGTCGGGTGAGCTCAAGACCAAACCCACGCAGCATTCGGTCGCCGCACTGC
GCAGCATCGGCATCCAGCCGGACGCCCTGATCCTGCGCTGCGACCGGGACGTGCCCGAGGCGCTGAAGAACAAGATCGCG
CTGATGTGCGACGTCGACATCGACGGGGTCATCTCGACGCCGGACGCACCGTCGATCTACGACATCCCCAAGGTGCTGCA
CCGGGAGGAACTCGACGCCTACGTGGTGCGCCGGTTGAACCTGCCGTTCCGCGACGTGGACTGGACCCAGTGGAACGATC
TCCTCAAGCGGGTGCACGAACCGCACGAGACGGTCCGGATCGCGCTGGTGGGCAAGTACATCGACCTCTCCGATGCGTAC
CTGTCGGTGACCGAGGCGCTGCGTGCGGGCGGGTTCTTCCACCACGCCAAGGTCGAGATGCGGTGGGTGGCCTCCGACGA
CTGCGAACTCGACAGCGGTGCGGCCGCGGCGCTGGCCGACGTCGACGGGGTGCTGATCCCCGGCGGGTTCGGCATCCGCG
GTATCGAAGGCAAGATCGGTGCGATCAGCTACGCCCGCAAACGCGGCCTGCCGGTGCTCGGGCTGTGCCTCGGGTTGCAG
TGCATCGTGATCGAGGCGGCCCGCTCGGTGGGCATCACCGGAGCGAACTCCGCCGAATTCGATCCGGCCACCCCCGACCC
GGTCATCTCGACGATGGCCGACCAGCGCGACGCCGTGGCCGGTGCGGCCGATCTGGGCGGCACCATGCGGTTGGGTGCCT
ATCCGGCTGTGCTGGAGGAAGATTCGATCGTCGCGCGTGCCTACCAGGCGACCGAGGTCTCCGAACGGCACCGGCACCGC
TACGAGGTCAACAACGCCTACCGCGACCGCATCGCCGAGAGTGGGCTGCGCTTCTCGGGCACGTCGCCCGACGGACATCT
GGTCGAGTTCGTCGAGTACGACGCCGAGCAGCATCCGTTCCTCGTCGGCACCCAGGCGCATCCCGAACTCAAGAGCCGGC
CCACCCGTCCGCACCCGCTGTTCGCCGCGTTCATCGGCGCGGCGCTCGACTACAAGGCCGCCGAGCGGCTGCCGGTCGAG
ATTCCCGAGCAACGGTCCAACGGGGTGGAGCTGCTGCAAGAACCCGCGTCCCGTGGCTGA

Upstream 100 bases:

>100_bases
TCGGAGTCGGTGTTAGGGTGGGGTTCCGTGGGTCGGCAGGCCCCAAAGCTAGGAGCAAGCCTAGAAAAGTAAGCCCTGCC
CGTCGTCACGGAGGTTGTTC

Downstream 100 bases:

>100_bases
GCACGACTTCGAAACCGTCACCAGCGAGACCGTCTACGTCGGCAACATCTTCGCGCTGCGCGCCGACGAGGTGCGGATGC
CGGGCGGCGGCACCGCCCGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 579; Mature: 578

Protein sequence:

>579_residues
MPALRKHPQTATKHLFVTGGVVSSLGKGLTGSSLGQLLTARGLQVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDL
DVGHYERFLDRNLSGSANVTTGQIYSSVIAKERRGEYLGDTVQVIPHITDEIKSRILAMAAPDEHGNRPDVVITEVGGTV
GDIESLPFLEAARQVRHEVGRENCFFLHCSLVPYMAPSGELKTKPTQHSVAALRSIGIQPDALILRCDRDVPEALKNKIA
LMCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTQWNDLLKRVHEPHETVRIALVGKYIDLSDAY
LSVTEALRAGGFFHHAKVEMRWVASDDCELDSGAAAALADVDGVLIPGGFGIRGIEGKIGAISYARKRGLPVLGLCLGLQ
CIVIEAARSVGITGANSAEFDPATPDPVISTMADQRDAVAGAADLGGTMRLGAYPAVLEEDSIVARAYQATEVSERHRHR
YEVNNAYRDRIAESGLRFSGTSPDGHLVEFVEYDAEQHPFLVGTQAHPELKSRPTRPHPLFAAFIGAALDYKAAERLPVE
IPEQRSNGVELLQEPASRG

Sequences:

>Translated_579_residues
MPALRKHPQTATKHLFVTGGVVSSLGKGLTGSSLGQLLTARGLQVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDL
DVGHYERFLDRNLSGSANVTTGQIYSSVIAKERRGEYLGDTVQVIPHITDEIKSRILAMAAPDEHGNRPDVVITEVGGTV
GDIESLPFLEAARQVRHEVGRENCFFLHCSLVPYMAPSGELKTKPTQHSVAALRSIGIQPDALILRCDRDVPEALKNKIA
LMCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTQWNDLLKRVHEPHETVRIALVGKYIDLSDAY
LSVTEALRAGGFFHHAKVEMRWVASDDCELDSGAAAALADVDGVLIPGGFGIRGIEGKIGAISYARKRGLPVLGLCLGLQ
CIVIEAARSVGITGANSAEFDPATPDPVISTMADQRDAVAGAADLGGTMRLGAYPAVLEEDSIVARAYQATEVSERHRHR
YEVNNAYRDRIAESGLRFSGTSPDGHLVEFVEYDAEQHPFLVGTQAHPELKSRPTRPHPLFAAFIGAALDYKAAERLPVE
IPEQRSNGVELLQEPASRG
>Mature_578_residues
PALRKHPQTATKHLFVTGGVVSSLGKGLTGSSLGQLLTARGLQVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLD
VGHYERFLDRNLSGSANVTTGQIYSSVIAKERRGEYLGDTVQVIPHITDEIKSRILAMAAPDEHGNRPDVVITEVGGTVG
DIESLPFLEAARQVRHEVGRENCFFLHCSLVPYMAPSGELKTKPTQHSVAALRSIGIQPDALILRCDRDVPEALKNKIAL
MCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTQWNDLLKRVHEPHETVRIALVGKYIDLSDAYL
SVTEALRAGGFFHHAKVEMRWVASDDCELDSGAAAALADVDGVLIPGGFGIRGIEGKIGAISYARKRGLPVLGLCLGLQC
IVIEAARSVGITGANSAEFDPATPDPVISTMADQRDAVAGAADLGGTMRLGAYPAVLEEDSIVARAYQATEVSERHRHRY
EVNNAYRDRIAESGLRFSGTSPDGHLVEFVEYDAEQHPFLVGTQAHPELKSRPTRPHPLFAAFIGAALDYKAAERLPVEI
PEQRSNGVELLQEPASRG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=554, Percent_Identity=44.9458483754513, Blast_Score=474, Evalue=1e-133,
Organism=Homo sapiens, GI28559085, Length=553, Percent_Identity=43.2188065099458, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=553, Percent_Identity=43.2188065099458, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=553, Percent_Identity=43.2188065099458, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=549, Percent_Identity=52.2768670309654, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25148299, Length=603, Percent_Identity=37.3134328358209, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=42.756183745583, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=564, Percent_Identity=41.8439716312057, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=557, Percent_Identity=44.3447037701975, Blast_Score=446, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21357815, Length=502, Percent_Identity=43.2270916334661, Blast_Score=381, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 63033; Mature: 62902

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALRKHPQTATKHLFVTGGVVSSLGKGLTGSSLGQLLTARGLQVTMQKLDPYLNVDPGT
CCCCCCCCCCHHCEEEEECHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCEECCCCC
MNPFQHGEVFVTEDGAETDLDVGHYERFLDRNLSGSANVTTGQIYSSVIAKERRGEYLGD
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
TVQVIPHITDEIKSRILAMAAPDEHGNRPDVVITEVGGTVGDIESLPFLEAARQVRHEVG
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
RENCFFLHCSLVPYMAPSGELKTKPTQHSVAALRSIGIQPDALILRCDRDVPEALKNKIA
CCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCEE
LMCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTQWNDLLKRVHE
EEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
PHETVRIALVGKYIDLSDAYLSVTEALRAGGFFHHAKVEMRWVASDDCELDSGAAAALAD
CHHEEEEEEEECEECCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCHHHHHC
VDGVLIPGGFGIRGIEGKIGAISYARKRGLPVLGLCLGLQCIVIEAARSVGITGANSAEF
CCCEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DPATPDPVISTMADQRDAVAGAADLGGTMRLGAYPAVLEEDSIVARAYQATEVSERHRHR
CCCCCCHHHHHHHHHHHHHHCHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YEVNNAYRDRIAESGLRFSGTSPDGHLVEFVEYDAEQHPFLVGTQAHPELKSRPTRPHPL
HHHHHHHHHHHHHCCCEECCCCCCCCEEHHHHCCCCCCCEEEECCCCCHHHCCCCCCCHH
FAAFIGAALDYKAAERLPVEIPEQRSNGVELLQEPASRG
HHHHHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
PALRKHPQTATKHLFVTGGVVSSLGKGLTGSSLGQLLTARGLQVTMQKLDPYLNVDPGT
CCCCCCCCCHHCEEEEECHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCEECCCCC
MNPFQHGEVFVTEDGAETDLDVGHYERFLDRNLSGSANVTTGQIYSSVIAKERRGEYLGD
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
TVQVIPHITDEIKSRILAMAAPDEHGNRPDVVITEVGGTVGDIESLPFLEAARQVRHEVG
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
RENCFFLHCSLVPYMAPSGELKTKPTQHSVAALRSIGIQPDALILRCDRDVPEALKNKIA
CCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCEE
LMCDVDIDGVISTPDAPSIYDIPKVLHREELDAYVVRRLNLPFRDVDWTQWNDLLKRVHE
EEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
PHETVRIALVGKYIDLSDAYLSVTEALRAGGFFHHAKVEMRWVASDDCELDSGAAAALAD
CHHEEEEEEEECEECCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCCCCHHHHHC
VDGVLIPGGFGIRGIEGKIGAISYARKRGLPVLGLCLGLQCIVIEAARSVGITGANSAEF
CCCEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DPATPDPVISTMADQRDAVAGAADLGGTMRLGAYPAVLEEDSIVARAYQATEVSERHRHR
CCCCCCHHHHHHHHHHHHHHCHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YEVNNAYRDRIAESGLRFSGTSPDGHLVEFVEYDAEQHPFLVGTQAHPELKSRPTRPHPL
HHHHHHHHHHHHHCCCEECCCCCCCCEEHHHHCCCCCCCEEEECCCCCHHHCCCCCCCHH
FAAFIGAALDYKAAERLPVEIPEQRSNGVELLQEPASRG
HHHHHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA