Click here to switch to the map view.

The map label for this gene is pcaA [H]

Identifier: 108799701

GI number: 108799701

Start: 2881026

End: 2881910

Strand: Reverse

Name: pcaA [H]

Synonym: Mmcs_2735

Alternate gene names: 108799701

Gene position: 2881910-2881026 (Counterclockwise)

Preceding gene: 108799706

Following gene: 108799697

Centisome position: 50.51

GC content: 64.41

Gene sequence:

>885_bases
GTGCCAGAAACAAGCAGTGATGCCCAGGGGTTGACGCCTCACTTCGAGGATGTCCAGGCGCATTACGACCTGTCCGACGA
ATTCTTCCGGCTGTTCCTCGACCCGACGCAGACCTACAGCTGCGCCTACTTCGAACGCGACGACATGACGCTGGAAGAGG
CGCAGCTCGCCAAGATCGACCTGTCACTGGGCAAGCTCGGGCTGCAGCCCGGGATGACCCTGCTCGACGTGGGCTGCGGC
TGGGGCGCCACGATCAACCGTGCGCTCGAGAAGTACGACGTCAACGTCGTCGGCCTGACGCTGTCGCGTAACCAGCAGGC
GCACGTGCAGCGACTCCTGGACAACCAGGGCAGCCCGCGCAGCAAGCGGGTGCTCCTGCAGGGCTGGGAGCAGTTCGACG
AGAAGGTCGACCGCATCGTGTCCATCGGCGCCTTCGAACACTTCGGGCGTGACCGCTACACCGACTTCTTCAAGATGGCC
TACGACGCGCTGCCGGACGACGGCGTGATGATGCTCCACACCATCATCAAGCCGAGCGACGAGGAATTCGCCGAGCGCGG
ACTGCCTCTGACGATGAACAAGCTGCGCTTCTTCAAATTCATCATGGACGAGATCTTCCCCGGCGGTGACCTGCCCCAGG
CGCGCGCCGTCACCGACCACGCGACCAAGGCGGGCTTCGAGGTCAAGCTGGTGCAGCCGCTGCGCCTGCACTACGCCAAG
ACGCTCGACATCTGGGCGGCCGCGCTGGAGTCGCGTAAGGACGAGGCGCTCGCGCTGCAGGGTCAGGAGGTCTACGACCG
GTACATGAAGTACCTGACCGGTTGCGCCGACCTGTTCCGCGAGGGCTACACCGACGTCGCGCAGTTCACCCTGACCAAGG
GCTGA

Upstream 100 bases:

>100_bases
GGCGTTGCCTGTTCGGGTAGTGTGCGCAGACGACGGGGGCGGCTCTCGAAAACGGAGGAGCGCCGAACCAACCACGAACA
ACGACGTCAGAGGCTGTACC

Downstream 100 bases:

>100_bases
GTCACCGGGCGGGCGGACCGGGCTGGGCGCCCGCGGCGTCGCGCCTGCGGGCCGCCATCCCGGCCAGCGCTTCGAACACC
ACCCGGTGCGCGGCGTTGAC

Product: cyclopropane-fatty-acyl-phospholipid synthase

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MPETSSDAQGLTPHFEDVQAHYDLSDEFFRLFLDPTQTYSCAYFERDDMTLEEAQLAKIDLSLGKLGLQPGMTLLDVGCG
WGATINRALEKYDVNVVGLTLSRNQQAHVQRLLDNQGSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYTDFFKMA
YDALPDDGVMMLHTIIKPSDEEFAERGLPLTMNKLRFFKFIMDEIFPGGDLPQARAVTDHATKAGFEVKLVQPLRLHYAK
TLDIWAAALESRKDEALALQGQEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG

Sequences:

>Translated_294_residues
MPETSSDAQGLTPHFEDVQAHYDLSDEFFRLFLDPTQTYSCAYFERDDMTLEEAQLAKIDLSLGKLGLQPGMTLLDVGCG
WGATINRALEKYDVNVVGLTLSRNQQAHVQRLLDNQGSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYTDFFKMA
YDALPDDGVMMLHTIIKPSDEEFAERGLPLTMNKLRFFKFIMDEIFPGGDLPQARAVTDHATKAGFEVKLVQPLRLHYAK
TLDIWAAALESRKDEALALQGQEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG
>Mature_293_residues
PETSSDAQGLTPHFEDVQAHYDLSDEFFRLFLDPTQTYSCAYFERDDMTLEEAQLAKIDLSLGKLGLQPGMTLLDVGCGW
GATINRALEKYDVNVVGLTLSRNQQAHVQRLLDNQGSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYTDFFKMAY
DALPDDGVMMLHTIIKPSDEEFAERGLPLTMNKLRFFKFIMDEIFPGGDLPQARAVTDHATKAGFEVKLVQPLRLHYAKT
LDIWAAALESRKDEALALQGQEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG

Specific function: Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of an alpha mycolic acid via the transfers of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell en

COG id: COG2230

COG function: function code M; Cyclopropane fatty acid synthase and related methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=277, Percent_Identity=32.4909747292419, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI133904226, Length=286, Percent_Identity=31.8181818181818, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 33446; Mature: 33315

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETSSDAQGLTPHFEDVQAHYDLSDEFFRLFLDPTQTYSCAYFERDDMTLEEAQLAKID
CCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHH
LSLGKLGLQPGMTLLDVGCGWGATINRALEKYDVNVVGLTLSRNQQAHVQRLLDNQGSPR
HHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCCCCH
SKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYTDFFKMAYDALPDDGVMMLHTIIKPSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCH
EEFAERGLPLTMNKLRFFKFIMDEIFPGGDLPQARAVTDHATKAGFEVKLVQPLRLHYAK
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHH
TLDIWAAALESRKDEALALQGQEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG
HHHHHHHHHHCCCCHHEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCC
>Mature Secondary Structure 
PETSSDAQGLTPHFEDVQAHYDLSDEFFRLFLDPTQTYSCAYFERDDMTLEEAQLAKID
CCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHH
LSLGKLGLQPGMTLLDVGCGWGATINRALEKYDVNVVGLTLSRNQQAHVQRLLDNQGSPR
HHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHCCCCCCH
SKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYTDFFKMAYDALPDDGVMMLHTIIKPSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCH
EEFAERGLPLTMNKLRFFKFIMDEIFPGGDLPQARAVTDHATKAGFEVKLVQPLRLHYAK
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHH
TLDIWAAALESRKDEALALQGQEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG
HHHHHHHHHHCCCCHHEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]