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The map label for this gene is tdcB [H]

Identifier: 108799697

GI number: 108799697

Start: 2877974

End: 2878909

Strand: Reverse

Name: tdcB [H]

Synonym: Mmcs_2731

Alternate gene names: 108799697

Gene position: 2878909-2877974 (Counterclockwise)

Preceding gene: 108799701

Following gene: 108799696

Centisome position: 50.46

GC content: 72.01

Gene sequence:

>936_bases
GTGCAACTCGTCTCGATCGACGACATCCGCGCGGCGGCCGCACGTATCCGCGACGACGTCCTGCGGACCCCGCTGATCCC
CGCGGCCTGGGCCGGAACGCTGTGGCTCAAACCCGAGAACCTGCAAGCCATCGGGGCGTTCAAGGTTCGTGGCGCGTTCA
ACGCGATCGCCCGACTGGATCCGGCTGTCCGGGCCCGCGGCGTGGTGGCGTACTCCAGTGGCAACCACGCTCAGGCCGTC
GCGTACGCGGCCGCCCGGTACGGAATCTCGGCGCACATCGTGATGCCCGAGGAGACGCCGCGGATCAAGGTCGACGCGAC
CCGCGCGCACGGCGCCGAGGTGGTGCTGTGCGCTGCCGGCCGGCGAGAGGCGGTCGCCGCCGAGGTCGTCGAGCGCACCG
GCGCCGTGCTCGTCCCGCCCTTCGACCACCCCGACATCATCGCCGGCCAGGGGACGGCGGGGCTGGAGATCGCCGAGGAC
CTGCCCGACGTCGAGCACGTCTTCATCCCGGTGAGTGGCGGAGGGCTGGCCTCTGGCATCGGCACGGCGATCAAGGCGCT
GTGCCCGGGTGCGAGGGTGTACGGGGTGGAGCCGGAACTGGCGGGCGATACGGCCGAGGGTCTGCGGTGTGGGCACCGCG
TGGACTGGTCGATCGAAGACCGCAACCGCACCATCGCCGACGGCTTGCGCTCGCAGCCGTCGGACCTGACGTTCGCGCAC
CTGCAGCGGGTGCTCGACGACACCGTCACCGTCACCGAGGGCGAAATCCGTTCGGCCGTATTCGATCTGGCGCTTCGCGC
GCATCTGGTCAGCGAGCCCAGCGGGGCGGTGGCGCTGGCCGGCTACCGGCGGGTGGCACCCACCGGCCGGGCCGTGGCGG
TGGTGTCGGGCGGCAACATCGAGAGCGCCCTGCTGCGGGAGATCCTCGCGGGCTGA

Upstream 100 bases:

>100_bases
CACGCGACGAACCTACGACCGCTCGAGCATAACCCTCGGAGGTCGCGCGACCCTCCCACCCCGAGGGCCGCGGCGGGCGT
GCGCCGGGCAGACTGACCGG

Downstream 100 bases:

>100_bases
GCGGGCCGGTGCGCGCGGCTATCCTCGCGGAGGTGACCGCGTCCGACGTCTCCCGGGCGGCGCCGCTGCTGCGGACCGCG
CTTCGGCTGTCGATCATCGC

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MQLVSIDDIRAAAARIRDDVLRTPLIPAAWAGTLWLKPENLQAIGAFKVRGAFNAIARLDPAVRARGVVAYSSGNHAQAV
AYAAARYGISAHIVMPEETPRIKVDATRAHGAEVVLCAAGRREAVAAEVVERTGAVLVPPFDHPDIIAGQGTAGLEIAED
LPDVEHVFIPVSGGGLASGIGTAIKALCPGARVYGVEPELAGDTAEGLRCGHRVDWSIEDRNRTIADGLRSQPSDLTFAH
LQRVLDDTVTVTEGEIRSAVFDLALRAHLVSEPSGAVALAGYRRVAPTGRAVAVVSGGNIESALLREILAG

Sequences:

>Translated_311_residues
MQLVSIDDIRAAAARIRDDVLRTPLIPAAWAGTLWLKPENLQAIGAFKVRGAFNAIARLDPAVRARGVVAYSSGNHAQAV
AYAAARYGISAHIVMPEETPRIKVDATRAHGAEVVLCAAGRREAVAAEVVERTGAVLVPPFDHPDIIAGQGTAGLEIAED
LPDVEHVFIPVSGGGLASGIGTAIKALCPGARVYGVEPELAGDTAEGLRCGHRVDWSIEDRNRTIADGLRSQPSDLTFAH
LQRVLDDTVTVTEGEIRSAVFDLALRAHLVSEPSGAVALAGYRRVAPTGRAVAVVSGGNIESALLREILAG
>Mature_311_residues
MQLVSIDDIRAAAARIRDDVLRTPLIPAAWAGTLWLKPENLQAIGAFKVRGAFNAIARLDPAVRARGVVAYSSGNHAQAV
AYAAARYGISAHIVMPEETPRIKVDATRAHGAEVVLCAAGRREAVAAEVVERTGAVLVPPFDHPDIIAGQGTAGLEIAED
LPDVEHVFIPVSGGGLASGIGTAIKALCPGARVYGVEPELAGDTAEGLRCGHRVDWSIEDRNRTIADGLRSQPSDLTFAH
LQRVLDDTVTVTEGEIRSAVFDLALRAHLVSEPSGAVALAGYRRVAPTGRAVAVVSGGNIESALLREILAG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=314, Percent_Identity=36.624203821656, Blast_Score=185, Evalue=6e-47,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=38.3647798742138, Blast_Score=190, Evalue=8e-50,
Organism=Escherichia coli, GI1790207, Length=311, Percent_Identity=39.2282958199357, Blast_Score=162, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=32.2784810126582, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71991565, Length=317, Percent_Identity=34.0694006309148, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17537387, Length=316, Percent_Identity=30.379746835443, Blast_Score=111, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322631, Length=315, Percent_Identity=36.8253968253968, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320930, Length=286, Percent_Identity=38.8111888111888, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=293, Percent_Identity=27.9863481228669, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=33.5423197492163, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24645328, Length=218, Percent_Identity=32.1100917431193, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 32583; Mature: 32583

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLVSIDDIRAAAARIRDDVLRTPLIPAAWAGTLWLKPENLQAIGAFKVRGAFNAIARLD
CCEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEECHHHHHHHHCC
PAVRARGVVAYSSGNHAQAVAYAAARYGISAHIVMPEETPRIKVDATRAHGAEVVLCAAG
HHHHHCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECC
RREAVAAEVVERTGAVLVPPFDHPDIIAGQGTAGLEIAEDLPDVEHVFIPVSGGGLASGI
CCHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCHHHHCCCCEEEEEEECCCCHHHHH
GTAIKALCPGARVYGVEPELAGDTAEGLRCGHRVDWSIEDRNRTIADGLRSQPSDLTFAH
HHHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCCEEECCCCCCHHHHHCCCCCCCHHHH
LQRVLDDTVTVTEGEIRSAVFDLALRAHLVSEPSGAVALAGYRRVAPTGRAVAVVSGGNI
HHHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCEEEEEECCCH
ESALLREILAG
HHHHHHHHHCC
>Mature Secondary Structure
MQLVSIDDIRAAAARIRDDVLRTPLIPAAWAGTLWLKPENLQAIGAFKVRGAFNAIARLD
CCEECCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEEECHHHHHHHHCC
PAVRARGVVAYSSGNHAQAVAYAAARYGISAHIVMPEETPRIKVDATRAHGAEVVLCAAG
HHHHHCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCEEEEEECC
RREAVAAEVVERTGAVLVPPFDHPDIIAGQGTAGLEIAEDLPDVEHVFIPVSGGGLASGI
CCHHHHHHHHHHCCCEEECCCCCCCEEECCCCCCCCHHHHCCCCEEEEEEECCCCHHHHH
GTAIKALCPGARVYGVEPELAGDTAEGLRCGHRVDWSIEDRNRTIADGLRSQPSDLTFAH
HHHHHHHCCCCEEEECCCCCCCCCHHHHHCCCCCCEEECCCCCCHHHHHCCCCCCCHHHH
LQRVLDDTVTVTEGEIRSAVFDLALRAHLVSEPSGAVALAGYRRVAPTGRAVAVVSGGNI
HHHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCEEEEEECCCH
ESALLREILAG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]