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The map label for this gene is folD [H]

Identifier: 108798175

GI number: 108798175

Start: 1302996

End: 1303742

Strand: Direct

Name: folD [H]

Synonym: Mmcs_1204

Alternate gene names: 108798175

Gene position: 1302996-1303742 (Clockwise)

Preceding gene: 108798168

Following gene: 108798176

Centisome position: 22.84

GC content: 69.75

Gene sequence:

>747_bases
GTGCTGGTCGGTGACGATCCGGGTTCTCAGGCTTACGTACGCGGTAAGCACTCCGACTGCGCGAAGGTCGGCATCAATTC
GATCCGCCGCGACCTGCCCGCCGACATCAGCCAGGCCGAACTCGACGCGACGATCGACGAGCTCAACGCCAACCCCGAAT
GCACCGGCTACATCGTGCAGCTGCCACTGCCCAAGCACCTGGACGAGAACGCGGCGCTCGAACGCATCGACCCGGGGAAG
GACGCCGACGGTCTGCATCCGACCAACCTGGGCCGGCTGGTGCTCAACGAACCCGCACCTCTGCCGTGCACGCCGCGGGG
GATCGTGCACCTGCTGCGCCGGTACGAGGTCGAGATCGCAGGCGCGCACGTGGTGGTGATCGGCCGCGGCGTGACGGTCG
GGCGGCCACTCGGGCTGCTGCTGACCCGCCGCTCGGAGAACGCCACAGTCACCCTGTGCCACACCGCAACCCGGCATCTG
CCGCAGTTCACCCGCGAGGCCGACATCATCGTCGCCGCGGCGGGGGTGCCGCACATGGTGACCGCGGAGATGGTGCGACC
GGGTGCGGCGGTGATCGATGTCGGGGTCAGCCGCGACGACAACGGCAAGCTCGTCGGCGACGTCGCGCCCGACGTGTGGG
AGGTGGCCGGACACGTGTCGCCCAACCCGGGTGGCGTGGGTCCGCTGACGCGGGCGTTCCTGCTGACAAACGTCGTCGAA
CGCGCCGAGGCTCTCGCGCGCGGGTGA

Upstream 100 bases:

>100_bases
AACGCTCGATGGGAAAGCCACGCGGGACGAGATCTTCGTCGACCTCAAGGAACGGGTGGCGGCGCTCACCGAACAGGGGC
GCACACCGGGACTCGGCACC

Downstream 100 bases:

>100_bases
CCGTCAAGGACTTCGCCCGCAAGGTCTTCGCGGGGCAGTGGCCGATCCTGGTGGTCGGCCTGATCTTCGTGGCCGCGTTC
GCCCTTGTGATCGCCGGTTA

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGK
DADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHL
PQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVE
RAEALARG

Sequences:

>Translated_248_residues
MLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGK
DADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHL
PQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVE
RAEALARG
>Mature_248_residues
MLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQLPLPKHLDENAALERIDPGK
DADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHL
PQFTREADIIVAAAGVPHMVTAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVE
RAEALARG

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate [H]

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family [H]

Homologues:

Organism=Homo sapiens, GI222418558, Length=259, Percent_Identity=42.4710424710425, Blast_Score=184, Evalue=4e-47,
Organism=Homo sapiens, GI94721354, Length=261, Percent_Identity=42.1455938697318, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI222136639, Length=255, Percent_Identity=40.3921568627451, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI36796743, Length=174, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786741, Length=241, Percent_Identity=45.643153526971, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17568735, Length=252, Percent_Identity=38.4920634920635, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319558, Length=250, Percent_Identity=40.8, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321643, Length=254, Percent_Identity=39.7637795275591, Blast_Score=161, Evalue=9e-41,
Organism=Drosophila melanogaster, GI17136816, Length=256, Percent_Identity=43.359375, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17136818, Length=256, Percent_Identity=43.359375, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24645718, Length=250, Percent_Identity=44, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17137370, Length=250, Percent_Identity=44, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI62472483, Length=250, Percent_Identity=44, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45551871, Length=250, Percent_Identity=44, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631 [H]

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C [H]

EC number: =1.5.1.5; =3.5.4.9 [H]

Molecular weight: Translated: 26289; Mature: 26289

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQ
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEE
LPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIA
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCEEEC
GAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQFTREADIIVAAAGVPHMV
CEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCCCCHH
TAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVE
HHHHHCCCCEEEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RAEALARG
HHHHHHCC
>Mature Secondary Structure
MLVGDDPGSQAYVRGKHSDCAKVGINSIRRDLPADISQAELDATIDELNANPECTGYIVQ
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEE
LPLPKHLDENAALERIDPGKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYEVEIA
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCEEEC
GAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTATRHLPQFTREADIIVAAAGVPHMV
CEEEEEEECCCCCCCCCEEEEEECCCCCEEEEEEHHHHHHHHHCCCCCEEEEECCCCCHH
TAEMVRPGAAVIDVGVSRDDNGKLVGDVAPDVWEVAGHVSPNPGGVGPLTRAFLLTNVVE
HHHHHCCCCEEEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RAEALARG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA