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The map label for this gene is pdhB [H]

Identifier: 108798064

GI number: 108798064

Start: 1191332

End: 1192309

Strand: Direct

Name: pdhB [H]

Synonym: Mmcs_1092

Alternate gene names: 108798064

Gene position: 1191332-1192309 (Clockwise)

Preceding gene: 108798063

Following gene: 108798065

Centisome position: 20.88

GC content: 66.16

Gene sequence:

>978_bases
ATGAAGACCAGTTACCGCGCCGCCGTGCACGACGCCCTGCGCGACGCTCTGCGCGACGACGACAGGGTGCTACTCATGGG
TGAGGACGTCGGTCGCTACGGCGGCACTTATGCCGCGTCGAAAGGCTTGCTGGAGGAATTCGGACCGGAGCGGGTCCGCG
ACACCCCGTTGTCGGAGCTCGGCTTCGTCGGAGTCGGAATCGGCGCCGCGCTGGGCGGATTGCGTCCCATCATCGAGATC
ATGACGGTGAATTTCAGCCTGCTCGCGCTCGATCAGATCGTCAACACCGCTGCGGCGCTCAGGCATATGTCCGGTGGACA
ATTCTCGGTGCCGATCGTGGTGCGGATGGCCACCGGAGCCGGCAGGCAGCTGGCGGCCCAGCACTCACACAGCTTGGAGT
GCTGGTATGCACACATCCCGGGGATCAAGGTCGTGGCACCCGCGACGGTGGAGGACGCCTACGGCATGATGACCACCGCG
CTGGCAGACCCGGACCCGGTGATCGTGTTCGAGCATGTCGCGCTTTACAACTCGTCGGCGGATGGCACGACGCTGCACGC
CACCGACATAAGGCATGCGGCGGTTCGTCGCTCCGGATCCGACGTCACCCTGATCACCTACGGTGGGTCGCTGCCGAAGA
CGCTCGACGCTGCCGACCAACTCGCACTCGCCGGCATCGACTGCGAGGTGATCGACCTCCGGGTACTGCGGCCGCTGGAC
ACGGCCACCTTCGTGGAGTCCGTGCGCAGGACCCACCGCGCCGTCGTGGTCGACGAGGCGTGGAAAACCGGAAGTCTGGC
CGCCGAAATCAGTGCCCAGATCGTCGAGAACGCCTTCTACGATCTCGATGCGCCCGTGGCGAGGGTGTGCGGTGCAGAAG
TCCCGGTGCCCTATGCCAAGCACCTCGAGCAGGCCGCCCTACCGCAGGCCGGTCAGATTGCGACCGCGGTCAGGGACCTC
TGCGGCGGCCCAGCATGA

Upstream 100 bases:

>100_bases
ACGAAGTGCAAGAGGCTGTCTCATTCGCCGAGGCCGGAACGTGGGAGGACATCGGCGATCTCGAACGTGACGTGCTCACC
CCGGCACCGAGGAGCATCCG

Downstream 100 bases:

>100_bases
CCGAGTTCCGGATGCCCGCGCTCGGCTCGGACATGGACGAGGGGACCCTCGACCAATGGCTGGTCAAACCGGGCGACACC
GTCACCAGGGGCCAGGTCGT

Product: transketolase central subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKTSYRAAVHDALRDALRDDDRVLLMGEDVGRYGGTYAASKGLLEEFGPERVRDTPLSELGFVGVGIGAALGGLRPIIEI
MTVNFSLLALDQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLECWYAHIPGIKVVAPATVEDAYGMMTTA
LADPDPVIVFEHVALYNSSADGTTLHATDIRHAAVRRSGSDVTLITYGGSLPKTLDAADQLALAGIDCEVIDLRVLRPLD
TATFVESVRRTHRAVVVDEAWKTGSLAAEISAQIVENAFYDLDAPVARVCGAEVPVPYAKHLEQAALPQAGQIATAVRDL
CGGPA

Sequences:

>Translated_325_residues
MKTSYRAAVHDALRDALRDDDRVLLMGEDVGRYGGTYAASKGLLEEFGPERVRDTPLSELGFVGVGIGAALGGLRPIIEI
MTVNFSLLALDQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLECWYAHIPGIKVVAPATVEDAYGMMTTA
LADPDPVIVFEHVALYNSSADGTTLHATDIRHAAVRRSGSDVTLITYGGSLPKTLDAADQLALAGIDCEVIDLRVLRPLD
TATFVESVRRTHRAVVVDEAWKTGSLAAEISAQIVENAFYDLDAPVARVCGAEVPVPYAKHLEQAALPQAGQIATAVRDL
CGGPA
>Mature_325_residues
MKTSYRAAVHDALRDALRDDDRVLLMGEDVGRYGGTYAASKGLLEEFGPERVRDTPLSELGFVGVGIGAALGGLRPIIEI
MTVNFSLLALDQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLECWYAHIPGIKVVAPATVEDAYGMMTTA
LADPDPVIVFEHVALYNSSADGTTLHATDIRHAAVRRSGSDVTLITYGGSLPKTLDAADQLALAGIDCEVIDLRVLRPLD
TATFVESVRRTHRAVVVDEAWKTGSLAAEISAQIVENAFYDLDAPVARVCGAEVPVPYAKHLEQAALPQAGQIATAVRDL
CGGPA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=324, Percent_Identity=41.358024691358, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=38.8888888888889, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=36.7283950617284, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=36.7283950617284, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17538422, Length=319, Percent_Identity=45.141065830721, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17506935, Length=322, Percent_Identity=36.6459627329193, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319698, Length=322, Percent_Identity=41.9254658385093, Blast_Score=272, Evalue=5e-74,
Organism=Drosophila melanogaster, GI21358145, Length=330, Percent_Identity=45.4545454545455, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24650940, Length=330, Percent_Identity=45.4545454545455, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI160714832, Length=317, Percent_Identity=35.9621451104101, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI160714828, Length=317, Percent_Identity=35.9621451104101, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=48.8888888888889, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=48.8888888888889, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34449; Mature: 34449

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTSYRAAVHDALRDALRDDDRVLLMGEDVGRYGGTYAASKGLLEEFGPERVRDTPLSEL
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCHHHHCCCHHHCCCCHHHH
GFVGVGIGAALGGLRPIIEIMTVNFSLLALDQIVNTAAALRHMSGGQFSVPIVVRMATGA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEEECCC
GRQLAAQHSHSLECWYAHIPGIKVVAPATVEDAYGMMTTALADPDPVIVFEHVALYNSSA
CHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEEHEECCCC
DGTTLHATDIRHAAVRRSGSDVTLITYGGSLPKTLDAADQLALAGIDCEVIDLRVLRPLD
CCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHEEECCCEEEEEEEEECCCC
TATFVESVRRTHRAVVVDEAWKTGSLAAEISAQIVENAFYDLDAPVARVCGAEVPVPYAK
HHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHH
HLEQAALPQAGQIATAVRDLCGGPA
HHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTSYRAAVHDALRDALRDDDRVLLMGEDVGRYGGTYAASKGLLEEFGPERVRDTPLSEL
CCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCHHHHCCCHHHCCCCHHHH
GFVGVGIGAALGGLRPIIEIMTVNFSLLALDQIVNTAAALRHMSGGQFSVPIVVRMATGA
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEEECCC
GRQLAAQHSHSLECWYAHIPGIKVVAPATVEDAYGMMTTALADPDPVIVFEHVALYNSSA
CHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEEHEECCCC
DGTTLHATDIRHAAVRRSGSDVTLITYGGSLPKTLDAADQLALAGIDCEVIDLRVLRPLD
CCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHEEECCCEEEEEEEEECCCC
TATFVESVRRTHRAVVVDEAWKTGSLAAEISAQIVENAFYDLDAPVARVCGAEVPVPYAK
HHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHH
HLEQAALPQAGQIATAVRDLCGGPA
HHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]