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The map label for this gene is hemD [H]

Identifier: 108797658

GI number: 108797658

Start: 736017

End: 737681

Strand: Direct

Name: hemD [H]

Synonym: Mmcs_0678

Alternate gene names: 108797658

Gene position: 736017-737681 (Clockwise)

Preceding gene: 108797657

Following gene: 108797659

Centisome position: 12.9

GC content: 72.97

Gene sequence:

>1665_bases
ATGACTCGGCAGGAGAGCGGGCGTGGGCGCAAGATGAAGCCCGGCCGCATCACCTTCGTGGGCTCGGGCCCGGGCGACCC
CGGCCTGTTGACCGCACGGGCCCACAGTGTGCTCGTCAATGCCGCGCTGGTCTTCACCGACCCCGACGTCCCCGAGGCGG
TGCTGTCCCTGGTGGGCGCGCACCTGCCCCCACCGTCGGGCCCTGAACCGGCCGAGCCGGCGGACGCCGCCGACGAGCAG
GCGGGCTCGACCATCCCCGGCGGCCCGGACATCCGGCCCGCGCTGGGCGATCCGGCCGAGGTGGCCAAGGTCCTGGCCGG
TGAGGCCAAGCACGGTGTGGACGTGGTTCGGCTGGTGGCCGGCGACCCGCTGTCGGTCGACGCCGTCATCGCCGAGGTGA
ACGCGCTGGCCAAGAGCCACGCCAACTTCGAGATCGTGCCCGGCCTGCCGAACACCACCGCGGTCCCGACGTACGCCGGC
CTGCCGCTGGGTTCCACCCACACCGTCGCCGATGTGCGCGACCCGAACGTGGACTGGGCGGCCCTGGCCGCCGCGCCCGG
CCCGCTGATCCTGCACGCGACCGCCTCGCATCTGCCCGACGCCGCGCGCACGCTGATCGAGTACGGCCTGGCCGAGACCA
CCCCGGCGGTGGTCACCGCCAACGGCACCACCTGCCAGCAGCGCTCGGTCGAGTCGACGCTGTCCGGGCTGCTCGACAAG
GCCGCGCTGACCGCACCGGACGCGACCGGTGCACCCGCCGCACCGCTGGCCGGCCCGCTGGTCGTGACGCTCGGCCGCAC
CGTCACCAACCGGGCCCGCCTGAACTGGTGGGAGAGCCGCGCACTGTACGGCTGGACGGTGCTGGTGCCGCGGACCAAGG
ATCAGGCCGGGGAGATGAGCGACAAGCTCGTCGGCCACGGCGCCCTGCCGATCGAGGTGCCCACCATCGCCGTCGAACCG
CCGCGCAGCCCCGCGCAGATGGAGCGTGCGGTCAAGGGTCTGGTCGACGGCCGGTTCCAGTGGGTCGTGTTCACCTCCAC
CAACGCGGTGCGCGCGGTGTGGGAGAAGTTCAACGAGTTCGGGCTCGACGCCCGCGCGTTCTCCGGTGTGAAGATCGCCT
GCGTCGGTCAGGCGACGGCAGAGCGGGTGCGCGCGTTCGGGATCAACCCCGAGCTGGTTCCGACGGGGGAGCAGTCCTCG
CTGGGTCTGCTCGACGAGTTCCCGCCGTACGACGACATTTTCGATCCGGTGAACCGGGTGCTGCTGCCGCGCGCCGACAT
CGCCACCGAGACGCTGGCCGAGGGGCTGCGCGAACGCGGTTGGGAGATCGAGGACGTCACCGCCTACCGGACGGTGCGTG
CCGCACCGCCGCCGGCCTCGACGCGCGAGATGATCAAGACGGGCGGCTTCGACGCGGTGTGCTTCACGTCGAGCTCGACG
GTGCGCAACCTGGTCGGCATCGCCGGTAAGCCGCACGCCCGCACGATCGTCGCCTGCATCGGGCCCAAGACCGCGGAGAC
GGCAGCGGAGTTCGGCCTGCGCGTCGACGTGCAGCCCGAGGTGGCCGCGGTCGGTCCGCTGGTGGAGGCGCTCGCCGAGC
ACGCCGCCCGACTGCGCGCCGAGGGTGCGCTGCCGCCGCCGCGCAAGAAGAGTCGCCGCCGCTGA

Upstream 100 bases:

>100_bases
CGCAGACCTCGGGGTCTCGGTGGCCGCGGAACTGTTCGAACTGGGTGCGCGAGAGCTCATTGCGGATCACCACTGAGCTG
TAGAGCGGAGTGAGCGACAA

Downstream 100 bases:

>100_bases
TCATGCGTCAGCGTCCGCGTAGGTTGCGTTCGACACCGGCCATGCGTCGGCTGGTTGCTGAAACCTCCCTGGAGCCAAGG
CATCTCGTGCTGCCGATGTT

Product: uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTRQESGRGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSGPEPAEPADAADEQ
AGSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVDVVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAG
LPLGSTHTVADVRDPNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTLSGLLDK
AALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKDQAGEMSDKLVGHGALPIEVPTIAVEP
PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSS
LGLLDEFPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVCFTSSST
VRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR

Sequences:

>Translated_554_residues
MTRQESGRGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSGPEPAEPADAADEQ
AGSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVDVVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAG
LPLGSTHTVADVRDPNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTLSGLLDK
AALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKDQAGEMSDKLVGHGALPIEVPTIAVEP
PRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSS
LGLLDEFPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVCFTSSST
VRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR
>Mature_553_residues
TRQESGRGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGAHLPPPSGPEPAEPADAADEQA
GSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVDVVRLVAGDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGL
PLGSTHTVADVRDPNVDWAALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTLSGLLDKA
ALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKDQAGEMSDKLVGHGALPIEVPTIAVEPP
RSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSL
GLLDEFPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVCFTSSSTV
RNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRAEGALPPPRKKSRRR

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=273, Percent_Identity=26.3736263736264, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 58006; Mature: 57875

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQESGRGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGA
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEHHHHHEEEEEEEEEECCCHHHHHHHHHHC
HLPPPSGPEPAEPADAADEQAGSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVDVVRLVA
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEC
GDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVRDPNVDWA
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEE
ALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTLSGLLDK
EEECCCCCEEEEECHHHCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
AALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKDQAGEMS
HHHCCCCCCCCCCCCCCCCEEEEECCHHHCHHHCCHHHCCCEEEEEEEEECCCCHHHHHH
DKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEF
HHHHCCCCCCEEECEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
GLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRV
CCCHHHCCCEEEEEECHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHH
LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVCFTSSST
HCCCCHHHHHHHHHHHHHCCCCCEEEHHHEEEECCCCCCHHHHHHHCCCCCEEEEECCHH
VRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRA
HHHHHHCCCCCCCCEEEEEECCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
EGALPPPRKKSRRR
CCCCCCCCHHCCCC
>Mature Secondary Structure 
TRQESGRGRKMKPGRITFVGSGPGDPGLLTARAHSVLVNAALVFTDPDVPEAVLSLVGA
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEHHHHHEEEEEEEEEECCCHHHHHHHHHHC
HLPPPSGPEPAEPADAADEQAGSTIPGGPDIRPALGDPAEVAKVLAGEAKHGVDVVRLVA
CCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEC
GDPLSVDAVIAEVNALAKSHANFEIVPGLPNTTAVPTYAGLPLGSTHTVADVRDPNVDWA
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEE
ALAAAPGPLILHATASHLPDAARTLIEYGLAETTPAVVTANGTTCQQRSVESTLSGLLDK
EEECCCCCEEEEECHHHCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
AALTAPDATGAPAAPLAGPLVVTLGRTVTNRARLNWWESRALYGWTVLVPRTKDQAGEMS
HHHCCCCCCCCCCCCCCCCEEEEECCHHHCHHHCCHHHCCCEEEEEEEEECCCCHHHHHH
DKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEF
HHHHCCCCCCEEECEEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
GLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDEFPPYDDIFDPVNRV
CCCHHHCCCEEEEEECHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHH
LLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIKTGGFDAVCFTSSST
HCCCCHHHHHHHHHHHHHCCCCCEEEHHHEEEECCCCCCHHHHHHHCCCCCEEEEECCHH
VRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPEVAAVGPLVEALAEHAARLRA
HHHHHHCCCCCCCCEEEEEECCCHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
EGALPPPRKKSRRR
CCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]