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The map label for this gene is hemB [H]

Identifier: 108797659

GI number: 108797659

Start: 737684

End: 738655

Strand: Direct

Name: hemB [H]

Synonym: Mmcs_0679

Alternate gene names: 108797659

Gene position: 737684-738655 (Clockwise)

Preceding gene: 108797658

Following gene: 108797660

Centisome position: 12.93

GC content: 69.14

Gene sequence:

>972_bases
ATGCGTCAGCGTCCGCGTAGGTTGCGTTCGACACCGGCCATGCGTCGGCTGGTTGCTGAAACCTCCCTGGAGCCAAGGCA
TCTCGTGCTGCCGATGTTCGTCGCCGACGGGATCGACGAGCCGCGGCCGATCTCGTCGATGCCCGGGGTGGTGCAACACA
CCCGCGACTCGTTGCGCCGCGCGGCCGCCGACGCGGTGGCCGCCGGGGTGGGCGGGCTGATGCTGTTCGGGGTGCCCCGC
GACGAGGACAAGGATCCGCGCGGTTCGATCGGCATGGACCCCGAGGGCATCCTCAACGTCGCGCTGCGCGACCTCGCCAA
GGACCTCGGCGAGGACACCGTGATCATGGCCGACACCTGCCTCGACGAGTTCACCGATCACGGCCACTGCGGGGTGCTGG
ACGACCGGGGTCGGGTCGACAATGACGCGACCAATCAGCAGTACGTGAAACTTGCTGTGGCCCAGGCGCAGTCGGGTGCC
CACGTGGTCGCGCCGAGCGGGATGATGGACGGTCAGGTGGCCGCCATCCGCGACGGGCTGGACGGCGCAGGACACACCGA
CGTGGCGATCCTGGCGTATGCGGCCAAGTTCGCCTCGGCGTTCTACGGCCCGTTCCGCGAAGCCGTCGGATCGAGTCTGC
AGGGCGACCGCCGCACCTATCAGCAGGACAGCGGCAACGCGCGCGAGGCTCTGCGCGAGATCGAACTGGACCTCGCCGAG
GGCGCCGACATGGTGATGGTGAAGCCGGCCATGTCCTACCTGGACGTGGTGCGCGCATGCGCCGACATCTCCCCGGTGCC
GGTCGCGGCGTACCAGATCTCCGGTGAGTACGCGATGATCAGCGCCGCCGCCGCCAACGGCTGGATCGATCTGCAGGCGT
CTGCCCTCGAAGCGCTCACCGGTATCCGGCGGGCCGGTGCGGACATCGTGTTGACCTACTGGGCGGCCGACGTGGCCGGC
TGGCTGGGATGA

Upstream 100 bases:

>100_bases
CGGTCGGTCCGCTGGTGGAGGCGCTCGCCGAGCACGCCGCCCGACTGCGCGCCGAGGGTGCGCTGCCGCCGCCGCGCAAG
AAGAGTCGCCGCCGCTGATC

Downstream 100 bases:

>100_bases
CCGGATCCGCTCCCACCCGGCCGCCTGACGTCGACACCGGGTTCTGGCTGTGGGTGGCCGCGCTGCCGCTGCTGGTCATC
GGCTACCTGATCGACAACCT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRQRPRRLRSTPAMRRLVAETSLEPRHLVLPMFVADGIDEPRPISSMPGVVQHTRDSLRRAAADAVAAGVGGLMLFGVPR
DEDKDPRGSIGMDPEGILNVALRDLAKDLGEDTVIMADTCLDEFTDHGHCGVLDDRGRVDNDATNQQYVKLAVAQAQSGA
HVVAPSGMMDGQVAAIRDGLDGAGHTDVAILAYAAKFASAFYGPFREAVGSSLQGDRRTYQQDSGNAREALREIELDLAE
GADMVMVKPAMSYLDVVRACADISPVPVAAYQISGEYAMISAAAANGWIDLQASALEALTGIRRAGADIVLTYWAADVAG
WLG

Sequences:

>Translated_323_residues
MRQRPRRLRSTPAMRRLVAETSLEPRHLVLPMFVADGIDEPRPISSMPGVVQHTRDSLRRAAADAVAAGVGGLMLFGVPR
DEDKDPRGSIGMDPEGILNVALRDLAKDLGEDTVIMADTCLDEFTDHGHCGVLDDRGRVDNDATNQQYVKLAVAQAQSGA
HVVAPSGMMDGQVAAIRDGLDGAGHTDVAILAYAAKFASAFYGPFREAVGSSLQGDRRTYQQDSGNAREALREIELDLAE
GADMVMVKPAMSYLDVVRACADISPVPVAAYQISGEYAMISAAAANGWIDLQASALEALTGIRRAGADIVLTYWAADVAG
WLG
>Mature_323_residues
MRQRPRRLRSTPAMRRLVAETSLEPRHLVLPMFVADGIDEPRPISSMPGVVQHTRDSLRRAAADAVAAGVGGLMLFGVPR
DEDKDPRGSIGMDPEGILNVALRDLAKDLGEDTVIMADTCLDEFTDHGHCGVLDDRGRVDNDATNQQYVKLAVAQAQSGA
HVVAPSGMMDGQVAAIRDGLDGAGHTDVAILAYAAKFASAFYGPFREAVGSSLQGDRRTYQQDSGNAREALREIELDLAE
GADMVMVKPAMSYLDVVRACADISPVPVAAYQISGEYAMISAAAANGWIDLQASALEALTGIRRAGADIVLTYWAADVAG
WLG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=43.1818181818182, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=48.5804416403785, Blast_Score=286, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6321398, Length=315, Percent_Identity=38.4126984126984, Blast_Score=218, Evalue=9e-58,
Organism=Drosophila melanogaster, GI21358291, Length=324, Percent_Identity=41.358024691358, Blast_Score=236, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 34419; Mature: 34419

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQRPRRLRSTPAMRRLVAETSLEPRHLVLPMFVADGIDEPRPISSMPGVVQHTRDSLRR
CCCCCHHHHCCHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
AAADAVAAGVGGLMLFGVPRDEDKDPRGSIGMDPEGILNVALRDLAKDLGEDTVIMADTC
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHH
LDEFTDHGHCGVLDDRGRVDNDATNQQYVKLAVAQAQSGAHVVAPSGMMDGQVAAIRDGL
HHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCC
DGAGHTDVAILAYAAKFASAFYGPFREAVGSSLQGDRRTYQQDSGNAREALREIELDLAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHC
GADMVMVKPAMSYLDVVRACADISPVPVAAYQISGEYAMISAAAANGWIDLQASALEALT
CCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEHHCCCEEEEHHHHHHHHH
GIRRAGADIVLTYWAADVAGWLG
HHHHCCCCEEEEHHHHHHHHHCC
>Mature Secondary Structure
MRQRPRRLRSTPAMRRLVAETSLEPRHLVLPMFVADGIDEPRPISSMPGVVQHTRDSLRR
CCCCCHHHHCCHHHHHHHHHCCCCCCCEEEHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
AAADAVAAGVGGLMLFGVPRDEDKDPRGSIGMDPEGILNVALRDLAKDLGEDTVIMADTC
HHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHH
LDEFTDHGHCGVLDDRGRVDNDATNQQYVKLAVAQAQSGAHVVAPSGMMDGQVAAIRDGL
HHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCC
DGAGHTDVAILAYAAKFASAFYGPFREAVGSSLQGDRRTYQQDSGNAREALREIELDLAE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHC
GADMVMVKPAMSYLDVVRACADISPVPVAAYQISGEYAMISAAAANGWIDLQASALEALT
CCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEEEHHCCCEEEEHHHHHHHHH
GIRRAGADIVLTYWAADVAGWLG
HHHHCCCCEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]