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The map label for this gene is hemC [H]

Identifier: 108797657

GI number: 108797657

Start: 735048

End: 735992

Strand: Direct

Name: hemC [H]

Synonym: Mmcs_0677

Alternate gene names: 108797657

Gene position: 735048-735992 (Clockwise)

Preceding gene: 108797656

Following gene: 108797658

Centisome position: 12.88

GC content: 69.63

Gene sequence:

>945_bases
TTGAGCAACGCCGACACGCCCATCCGGATCGGCACCCGGGCCAGCCTCCTCGCGACGACGCAAGCCGGCACCATCCGCGA
CGCGCTGATCGCCAGGGGGCATGCCGCCGAACTGGTGCTCATCTCCACCGAGGGTGACCGCAACCAGGGCCCGATCGCCG
ACATCGGCGTCGGGGTGTTCACCGCCGCTTTGCGCGAGGCGATCCACGACGGTCGCGTCGACGCTGCCGTGCACTCCTAC
AAGGATTTGCCGACGGCGGCCGACGAGCGGTTCACGATTCCCGCGATCCCGCGCCGTGAGGACCCGAGGGACGCCCTGGT
GGCCCGCGACGGGCTGGTGCTGGGGGAGTTGCCGGCCGGTTCCACGGTCGGCACGTCGAGCCCGCGCCGGGCCGCGCAGC
TTAGAGCACTGGGTCTCGGTTTGGAAATCCGCCCCCTAAGAGGCAACCTAGATACCAGGTTGAACAGGGTCGGCAACGGT
GAGCTCGACGGCATCGTGGTCGCCCGGGCGGGTCTGGCCCGCATCGGACGGCTGGGCGATGTCACCGAGACTCTCGAGCC
GGTGCAGATGTTGCCAGCGCCGGCTCAGGGTGCCCTCGCGGTCGAGTGCCGCGCAGGTGACACCGGACTGATCGCGCTAC
TGGCGGAGTTGGACGACGCCGACACGCGCGCGGCAGTCACCGCTGAACGGGTCCTGCTCGCCGAACTGGAGGCGGGTTGC
TCCGCACCGGTGGGCGCGATCGCCGAGGTGGTCGAGTCTATCGATGAGGACGGCCGCGTCTTCGAAGAGGTGTCGCTTCG
CGGGTGCGTGGCGGCGCTGGACGGATCCGACGTGATCCGTGCGTCTGGCATCGGAACTCCCGGCCGGGCCGCAGACCTCG
GGGTCTCGGTGGCCGCGGAACTGTTCGAACTGGGTGCGCGAGAGCTCATTGCGGATCACCACTGA

Upstream 100 bases:

>100_bases
GCTGCGTGAGCTGTTCGAGCTCGACCAGCAAGCGGTCGACGCGGTGGCCGCCGGCGAACTGCCCCTGCTGCCAATCGAAC
TCGACAAGTCTGAGTAACGC

Downstream 100 bases:

>100_bases
GCTGTAGAGCGGAGTGAGCGACAAATGACTCGGCAGGAGAGCGGGCGTGGGCGCAAGATGAAGCCCGGCCGCATCACCTT
CGTGGGCTCGGGCCCGGGCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MSNADTPIRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVFTAALREAIHDGRVDAAVHSY
KDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNG
ELDGIVVARAGLARIGRLGDVTETLEPVQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGC
SAPVGAIAEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGARELIADHH

Sequences:

>Translated_314_residues
MSNADTPIRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVFTAALREAIHDGRVDAAVHSY
KDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNG
ELDGIVVARAGLARIGRLGDVTETLEPVQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGC
SAPVGAIAEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGARELIADHH
>Mature_313_residues
SNADTPIRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVFTAALREAIHDGRVDAAVHSYK
DLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAGSTVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGE
LDGIVVARAGLARIGRLGDVTETLEPVQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGCS
APVGAIAEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAELFELGARELIADHH

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=296, Percent_Identity=40.8783783783784, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI20149500, Length=296, Percent_Identity=40.8783783783784, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI48994974, Length=314, Percent_Identity=43.312101910828, Blast_Score=205, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319996, Length=258, Percent_Identity=34.1085271317829, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI20130425, Length=290, Percent_Identity=41.0344827586207, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32476; Mature: 32345

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNADTPIRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVF
CCCCCCCEEECCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHH
TAALREAIHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCCCHHHHHHCCCEEEECCCCC
STVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGD
CCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEHHHHHHHCCCCC
VTETLEPVQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGC
HHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHCCC
SAPVGAIAEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAE
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEECCCCCCCCHHHHHHHHHHH
LFELGARELIADHH
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SNADTPIRIGTRASLLATTQAGTIRDALIARGHAAELVLISTEGDRNQGPIADIGVGVF
CCCCCCEEECCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHH
TAALREAIHDGRVDAAVHSYKDLPTAADERFTIPAIPRREDPRDALVARDGLVLGELPAG
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCCCHHHHHHCCCEEEECCCCC
STVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVGNGELDGIVVARAGLARIGRLGD
CCCCCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEHHHHHHHCCCCC
VTETLEPVQMLPAPAQGALAVECRAGDTGLIALLAELDDADTRAAVTAERVLLAELEAGC
HHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHCCC
SAPVGAIAEVVESIDEDGRVFEEVSLRGCVAALDGSDVIRASGIGTPGRAADLGVSVAAE
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEECCCCCCCCHHHHHHHHHHH
LFELGARELIADHH
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA