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The map label for this gene is hemA

Identifier: 108797656

GI number: 108797656

Start: 733701

End: 735044

Strand: Direct

Name: hemA

Synonym: Mmcs_0676

Alternate gene names: 108797656

Gene position: 733701-735044 (Clockwise)

Preceding gene: 108797655

Following gene: 108797657

Centisome position: 12.86

GC content: 70.39

Gene sequence:

>1344_bases
ATGAGCGTGCTGCTGTTCGGGGTTTCGCACCGCAGTGCCCCGGTATCGGTCCTCGAGCAGTTGAGCACCGACGAGTCCGA
CCAGGCCAAGATCGTCGACCAGGTGTTGCAGTCGTCGCTGGTGACAGAGGCGATGGTGCTGTCCACCTGCAACCGCGTCG
AGGTCTATGCCGTGGTCGACGCCTTCCACGGCGGGCTGTCCGTCATCGGCCAGGTCCTCGCCGAGCACTGTGGCATGTCG
CTCAACGATCTGACCAAGTACGCCTACGTGCGCTACGCCGAGGCCGCCGTCGAGCATCTGTTCGCCGTGGCGAGCGGACT
GGACTCCGCGGTCATCGGTGAGCAGCAGGTGCTCGGGCAGGTGCGCCGCGCCTACACCTCCGCCGAGGCCAACCACACCG
TCGGTCGCACGCTGCACGAACTGTCGCAGCGCGCACTGTCGGTCGGCAAGCGGGTGCACTCGGAGACCGGGATCGACGCC
GCGGGCGCCTCGGTCGTCTCGGTGGCCCTCGACATCGCCGAAGCCAAACTCGGCTCGCTGGCCGGTCGTACCGCGGTCGT
CATCGGGGCCGGATCCATGGGCGCCCTGTCGGCCAAACACCTGGTCCGCGCCGGAATCGAACGGGTGCACGTGGTCAACC
GGTCGCTTCCGCGCGCCCGCCGCCTCGCCCAGAGCCTGCTCGACCAGGGTGTCACCGCCGATGCGCACACCCTCGACGAC
ATCGCCCACGCGCTGGCCGACGCCGACGTGGTGATCACCTCCACCGGTGCGGTCCGGCCGGTGGTGTCGCTGGCCGACGC
CCACCGCGGGCTGACCGGCCGTCCTGAGCACCGCCGGCTGGTGATCTGCGACCTGGGCATGCCCCGGGACGTGGAACCGG
CGATCGCCGGGCTGCCGGGTGTCAACGTCATCGACATGGAGCGCATCCAGCGCGAGCCTTCGGCGCGCGCCGCGGCCTCC
GACGCCGACGCCGCCCGCTCCATCGTGGCCGCCGAGGTCGCGAACTACCTCGCCGGACAGCGGATGGCGGAGGTCACCCC
CACCGTCACCGCGTTGCGGCAGCGGGCCGCCGACGTGGTCGAGGCGGAGTTGCTGCGCCTGGACAACAGGTTGCCGGAGC
TCGACGCCGCGCATCGCGCCGAGGTCGCCAAGACGGTCCGCCGGGTCGTCGACAAACTTCTGCACGCCCCGACCGTGCGC
GTCAAACAGCTCGCCAGCGCACCCGGCGGCGACAGCTACGCCGAGGCGCTGCGTGAGCTGTTCGAGCTCGACCAGCAAGC
GGTCGACGCGGTGGCCGCCGGCGAACTGCCCCTGCTGCCAATCGAACTCGACAAGTCTGAGTAA

Upstream 100 bases:

>100_bases
TCTCGGGTGACAGAATCCCGCTTTGGTGACAAAGATGACTAGGTGAAATTTGGTCGGCACGCTCGTGAACGGATACCGTG
GATGACGTGGTGATGAAGCC

Downstream 100 bases:

>100_bases
CGCTTGAGCAACGCCGACACGCCCATCCGGATCGGCACCCGGGCCAGCCTCCTCGCGACGACGCAAGCCGGCACCATCCG
CGACGCGCTGATCGCCAGGG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSVLLFGVSHRSAPVSVLEQLSTDESDQAKIVDQVLQSSLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHCGMS
LNDLTKYAYVRYAEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYTSAEANHTVGRTLHELSQRALSVGKRVHSETGIDA
AGASVVSVALDIAEAKLGSLAGRTAVVIGAGSMGALSAKHLVRAGIERVHVVNRSLPRARRLAQSLLDQGVTADAHTLDD
IAHALADADVVITSTGAVRPVVSLADAHRGLTGRPEHRRLVICDLGMPRDVEPAIAGLPGVNVIDMERIQREPSARAAAS
DADAARSIVAAEVANYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPELDAAHRAEVAKTVRRVVDKLLHAPTVR
VKQLASAPGGDSYAEALRELFELDQQAVDAVAAGELPLLPIELDKSE

Sequences:

>Translated_447_residues
MSVLLFGVSHRSAPVSVLEQLSTDESDQAKIVDQVLQSSLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHCGMS
LNDLTKYAYVRYAEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYTSAEANHTVGRTLHELSQRALSVGKRVHSETGIDA
AGASVVSVALDIAEAKLGSLAGRTAVVIGAGSMGALSAKHLVRAGIERVHVVNRSLPRARRLAQSLLDQGVTADAHTLDD
IAHALADADVVITSTGAVRPVVSLADAHRGLTGRPEHRRLVICDLGMPRDVEPAIAGLPGVNVIDMERIQREPSARAAAS
DADAARSIVAAEVANYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPELDAAHRAEVAKTVRRVVDKLLHAPTVR
VKQLASAPGGDSYAEALRELFELDQQAVDAVAAGELPLLPIELDKSE
>Mature_446_residues
SVLLFGVSHRSAPVSVLEQLSTDESDQAKIVDQVLQSSLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHCGMSL
NDLTKYAYVRYAEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYTSAEANHTVGRTLHELSQRALSVGKRVHSETGIDAA
GASVVSVALDIAEAKLGSLAGRTAVVIGAGSMGALSAKHLVRAGIERVHVVNRSLPRARRLAQSLLDQGVTADAHTLDDI
AHALADADVVITSTGAVRPVVSLADAHRGLTGRPEHRRLVICDLGMPRDVEPAIAGLPGVNVIDMERIQREPSARAAASD
ADAARSIVAAEVANYLAGQRMAEVTPTVTALRQRAADVVEAELLRLDNRLPELDAAHRAEVAKTVRRVVDKLLHAPTVRV
KQLASAPGGDSYAEALRELFELDQQAVDAVAAGELPLLPIELDKSE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=416, Percent_Identity=32.6923076923077, Blast_Score=186, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_MYCSJ (A3PUA3)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001068971.1
- ProteinModelPortal:   A3PUA3
- SMR:   A3PUA3
- STRING:   A3PUA3
- EnsemblBacteria:   EBMYCT00000047599
- GeneID:   4876413
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_0669
- eggNOG:   COG0373
- GeneTree:   EBGT00050000017163
- HOGENOM:   HBG732626
- OMA:   EVRPEHF
- PhylomeDB:   A3PUA3
- ProtClustDB:   PRK00045
- BioCyc:   MSP164757:MJLS_0669-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47273; Mature: 47142

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLLFGVSHRSAPVSVLEQLSTDESDQAKIVDQVLQSSLVTEAMVLSTCNRVEVYAVVD
CCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
AFHGGLSVIGQVLAEHCGMSLNDLTKYAYVRYAEAAVEHLFAVASGLDSAVIGEQQVLGQ
HHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH
VRRAYTSAEANHTVGRTLHELSQRALSVGKRVHSETGIDAAGASVVSVALDIAEAKLGSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AGRTAVVIGAGSMGALSAKHLVRAGIERVHVVNRSLPRARRLAQSLLDQGVTADAHTLDD
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHH
IAHALADADVVITSTGAVRPVVSLADAHRGLTGRPEHRRLVICDLGMPRDVEPAIAGLPG
HHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCHHHCCCCC
VNVIDMERIQREPSARAAASDADAARSIVAAEVANYLAGQRMAEVTPTVTALRQRAADVV
CCEEEHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAELLRLDNRLPELDAAHRAEVAKTVRRVVDKLLHAPTVRVKQLASAPGGDSYAEALREL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHH
FELDQQAVDAVAAGELPLLPIELDKSE
HHHHHHHHHHHHCCCCCEEEEECCCCC
>Mature Secondary Structure 
SVLLFGVSHRSAPVSVLEQLSTDESDQAKIVDQVLQSSLVTEAMVLSTCNRVEVYAVVD
CEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
AFHGGLSVIGQVLAEHCGMSLNDLTKYAYVRYAEAAVEHLFAVASGLDSAVIGEQQVLGQ
HHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH
VRRAYTSAEANHTVGRTLHELSQRALSVGKRVHSETGIDAAGASVVSVALDIAEAKLGSL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AGRTAVVIGAGSMGALSAKHLVRAGIERVHVVNRSLPRARRLAQSLLDQGVTADAHTLDD
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHH
IAHALADADVVITSTGAVRPVVSLADAHRGLTGRPEHRRLVICDLGMPRDVEPAIAGLPG
HHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCHHHCCCCC
VNVIDMERIQREPSARAAASDADAARSIVAAEVANYLAGQRMAEVTPTVTALRQRAADVV
CCEEEHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAELLRLDNRLPELDAAHRAEVAKTVRRVVDKLLHAPTVRVKQLASAPGGDSYAEALREL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHH
FELDQQAVDAVAAGELPLLPIELDKSE
HHHHHHHHHHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA