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The map label for this gene is mutT3 [H]

Identifier: 108797523

GI number: 108797523

Start: 602907

End: 603431

Strand: Direct

Name: mutT3 [H]

Synonym: Mmcs_0543

Alternate gene names: 108797523

Gene position: 602907-603431 (Clockwise)

Preceding gene: 108797519

Following gene: 108797525

Centisome position: 10.57

GC content: 72.76

Gene sequence:

>525_bases
TTGGGTGCGCCCTATCCTGTACGGGTGCGTGGCGACGGTGACGGCTGGGTGTTCTCCGAGGGCGGCGGCCGCTACTGGGG
CAGGCACGGTGCCGCCGGCCTGCTGCTGCGTGCACCGCAGTCCGACGGTTCGGCCGCAGTGTTGTTGCAGCACCGCGCGC
CCTGGAGCCATCAGGGCGGGACGTGGGGCCTGCCGGGCGGCGCCCGCGACAGCCACGAGACACCCGAACAGGCCGCCGTA
CGCGAGGCGCACGAGGAAGCGGGGCTCTCGGTCGAGCAGCTGACCGTGCGGACCACGGTGGTCACCGCCGAGGTCGTCGG
CTCCGGTGGCGCGTCGTGGACCTACACCACGGTGATCGCCGACGCGCCCGCACTGCTGCACACCGTGCCCAACCGGGAGA
GCGCCGAACTGCGCTGGGTCGCCGAGGAGGACGTCGACTCCCTGCCGCTGCACCCGGGTTTCGCCGCGAGCTGGGACCGA
CTGCGGACCGTCACCGCGGCTTTTCCGCTGCTGGTCAGCGACTGA

Upstream 100 bases:

>100_bases
GGTCCTCATCTCTCCGGCAACTTCCCGACCGTCCGACTCTATAAAAGAATCCTAAGAGGTTCTGTCACGGCTCGCGCCCA
ATCGAGCGGAGCCGTACAGG

Downstream 100 bases:

>100_bases
CGAGCGCATCCTTCAGCCGGCGAGCCGCCGCCTTCGGATCGTCGGCCGCCGTGATCGCGCGGACCACGACGATGCGGCGG
GCGCCGGCGTCGAGCACCTC

Product: NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MGAPYPVRVRGDGDGWVFSEGGGRYWGRHGAAGLLLRAPQSDGSAAVLLQHRAPWSHQGGTWGLPGGARDSHETPEQAAV
REAHEEAGLSVEQLTVRTTVVTAEVVGSGGASWTYTTVIADAPALLHTVPNRESAELRWVAEEDVDSLPLHPGFAASWDR
LRTVTAAFPLLVSD

Sequences:

>Translated_174_residues
MGAPYPVRVRGDGDGWVFSEGGGRYWGRHGAAGLLLRAPQSDGSAAVLLQHRAPWSHQGGTWGLPGGARDSHETPEQAAV
REAHEEAGLSVEQLTVRTTVVTAEVVGSGGASWTYTTVIADAPALLHTVPNRESAELRWVAEEDVDSLPLHPGFAASWDR
LRTVTAAFPLLVSD
>Mature_173_residues
GAPYPVRVRGDGDGWVFSEGGGRYWGRHGAAGLLLRAPQSDGSAAVLLQHRAPWSHQGGTWGLPGGARDSHETPEQAAVR
EAHEEAGLSVEQLTVRTTVVTAEVVGSGGASWTYTTVIADAPALLHTVPNRESAELRWVAEEDVDSLPLHPGFAASWDRL
RTVTAAFPLLVSD

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 18483; Mature: 18351

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPYPVRVRGDGDGWVFSEGGGRYWGRHGAAGLLLRAPQSDGSAAVLLQHRAPWSHQGG
CCCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCC
TWGLPGGARDSHETPEQAAVREAHEEAGLSVEQLTVRTTVVTAEVVGSGGASWTYTTVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEHHEEEEEEEEEEEEECCCCCCEEEEEEEE
DAPALLHTVPNRESAELRWVAEEDVDSLPLHPGFAASWDRLRTVTAAFPLLVSD
CCCHHEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEECC
>Mature Secondary Structure 
GAPYPVRVRGDGDGWVFSEGGGRYWGRHGAAGLLLRAPQSDGSAAVLLQHRAPWSHQGG
CCCCEEEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCC
TWGLPGGARDSHETPEQAAVREAHEEAGLSVEQLTVRTTVVTAEVVGSGGASWTYTTVIA
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEHHEEEEEEEEEEEEECCCCCCEEEEEEEE
DAPALLHTVPNRESAELRWVAEEDVDSLPLHPGFAASWDRLRTVTAAFPLLVSD
CCCHHEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]