The gene/protein map for NC_008146 is currently unavailable.
Definition Mycobacterium sp. MCS chromosome, complete genome.
Accession NC_008146
Length 5,705,448

Click here to switch to the map view.

The map label for this gene is pntA [H]

Identifier: 108797082

GI number: 108797082

Start: 115664

End: 117187

Strand: Reverse

Name: pntA [H]

Synonym: Mmcs_0101

Alternate gene names: 108797082

Gene position: 117187-115664 (Counterclockwise)

Preceding gene: 108797083

Following gene: 108797081

Centisome position: 2.05

GC content: 69.36

Gene sequence:

>1524_bases
ATGCTCATCGCGATACCGCGCGAGTCTCAGCCCGGCGAGACACGCGTAGCCGCCACACCGCAGACGGTCGGGCAGATCAC
CAAGCTCGGATACTCGGTCGTCGTCGAATCCGGCGCCGGAGTGGCCTCCAGTTTCCCCGACGCCGCCTACGTCGAGGCCG
GGGCGGAGATAGGCGATCCGTGGTCGGCAGATGTGGTGCTGAAGGTCAACGCACCCACCGACGCCGAGATCGCGGCGCTG
CGAGACGGGGCGACCCTCGTCGGTCTGATCTCGCCGGCGCTGAACCCCGAGCTCGTCGAGAAGATGTCGACGCGCCGGAT
CACCGTGCTGGCCATGGACGCCGTCCCACGGATCTCGCGGGCACAGTCACTCGACGTGCTGTCGTCGATGGCCAACATCG
CGGGCTACCGCGCGGTGGTCGAGGCCGCGCACACCTTCGGCCGGTTCTTCACCGGTCAGGTCACCGCCGCGGGCAAGGTG
CCGCCGGCCAAGGTGCTCGTCGTCGGCGCCGGCGTGGCGGGTCTGGCCGCCATCGGCGCCGCGGGCAGCCTCGGGGCGAT
CGTGCGGGCCACCGATCCACGCCCGGAGGTCGCCGATCAGGTCGCGTCCCTGGGCGGGGAGTACCTGGCCGTCGACCCGG
CGGCCGCGGAGGTGTCGGCCACCGGTTACGCCAAGGAGATGGGCGAGGACTACAAGGTCCGCGAGGCGGCGCTGTACGCC
GAGCAGTGCAAGGACGTCGACATCATCATCACCACCGCGCTCATCCCGGGCCGGCCGGCCCCGCGGATCATCACCGCCGA
CATGGTGGCCTCGATGAAGTCGGGCAGCGTGATCGTCGACATGGCCGCGGCCAACGGCGGCAACGTCGAGGGCACCGTGA
AGGACCAGGCGATCGTGACCGACAACGGGGTGACGATCATCGGCTACACCGACCTGGCCGGGCGGCTGCCCGCCACGGCT
TCCCAGCTCTACGCCACCAACCTGGTCAACCTGCTCAAACTGCTCACCCCCAACAAGGACGGGCAGCTCACGCTCGACTT
CGACGACGTGGTGCAGCGCTCGGTGACCGTGATCCGCGACGGCGAGGTCACCTGGCCGCCGCCACCGGTGCAGGTGTCGG
CCGCACCGGCCGCCAAGGCCGCGGCGCCTGTCGAGCACAAACCCGCCAAGCAGCCGATGTCGATGGGCCGCCGACTGGGC
ATCACCTTCGCCGCCGCCGCGGCGCTGTTCGTGCTCATCGCCCTTTCACCGGCCGCACTCCAGGTCCACCTGACGGTTTT
CGCGCTGGCCATCGTCATCGGCTACTACGTGATCGGCAACGTGCACCATGCCCTGCACACCCCGCTGATGTCGGTGACCA
ACGCGATCTCCGGGATCATCGTCGTCGGCGCCCTCCTGCAGATCGGGCACGGCGATCCGGTGGTCACCGCAATCGCCACG
GTGGCGATCCTGCTCGCCAGCATCAACGTCTTCGGTGGGTTCTCCGTGACCCGCCGCATGCTGGCCATGTTCTCGAGGAG
CTGA

Upstream 100 bases:

>100_bases
CGAGCATCGTCTACGTTGGTAAGACCGACTATCTGATGACCGCCTGACCGGCGGCGAGGGCGGCCACGCATTCCGCTCCC
GCGGATGCCAAACTGTGCCG

Downstream 100 bases:

>100_bases
GGAATGTTGTCACTGGAAACCACCGCGACGGCGGCCTACGTCGTCGCGGCCATCCTGTTCATCCTCGCCCTGGCCGGACT
GTCCAAGCACGAGACCTCGA

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha; Pyridine nucleotide transhydrogenase subunit alpha [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MLIAIPRESQPGETRVAATPQTVGQITKLGYSVVVESGAGVASSFPDAAYVEAGAEIGDPWSADVVLKVNAPTDAEIAAL
RDGATLVGLISPALNPELVEKMSTRRITVLAMDAVPRISRAQSLDVLSSMANIAGYRAVVEAAHTFGRFFTGQVTAAGKV
PPAKVLVVGAGVAGLAAIGAAGSLGAIVRATDPRPEVADQVASLGGEYLAVDPAAAEVSATGYAKEMGEDYKVREAALYA
EQCKDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGGNVEGTVKDQAIVTDNGVTIIGYTDLAGRLPATA
SQLYATNLVNLLKLLTPNKDGQLTLDFDDVVQRSVTVIRDGEVTWPPPPVQVSAAPAAKAAAPVEHKPAKQPMSMGRRLG
ITFAAAAALFVLIALSPAALQVHLTVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHGDPVVTAIAT
VAILLASINVFGGFSVTRRMLAMFSRS

Sequences:

>Translated_507_residues
MLIAIPRESQPGETRVAATPQTVGQITKLGYSVVVESGAGVASSFPDAAYVEAGAEIGDPWSADVVLKVNAPTDAEIAAL
RDGATLVGLISPALNPELVEKMSTRRITVLAMDAVPRISRAQSLDVLSSMANIAGYRAVVEAAHTFGRFFTGQVTAAGKV
PPAKVLVVGAGVAGLAAIGAAGSLGAIVRATDPRPEVADQVASLGGEYLAVDPAAAEVSATGYAKEMGEDYKVREAALYA
EQCKDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGGNVEGTVKDQAIVTDNGVTIIGYTDLAGRLPATA
SQLYATNLVNLLKLLTPNKDGQLTLDFDDVVQRSVTVIRDGEVTWPPPPVQVSAAPAAKAAAPVEHKPAKQPMSMGRRLG
ITFAAAAALFVLIALSPAALQVHLTVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHGDPVVTAIAT
VAILLASINVFGGFSVTRRMLAMFSRS
>Mature_507_residues
MLIAIPRESQPGETRVAATPQTVGQITKLGYSVVVESGAGVASSFPDAAYVEAGAEIGDPWSADVVLKVNAPTDAEIAAL
RDGATLVGLISPALNPELVEKMSTRRITVLAMDAVPRISRAQSLDVLSSMANIAGYRAVVEAAHTFGRFFTGQVTAAGKV
PPAKVLVVGAGVAGLAAIGAAGSLGAIVRATDPRPEVADQVASLGGEYLAVDPAAAEVSATGYAKEMGEDYKVREAALYA
EQCKDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGGNVEGTVKDQAIVTDNGVTIIGYTDLAGRLPATA
SQLYATNLVNLLKLLTPNKDGQLTLDFDDVVQRSVTVIRDGEVTWPPPPVQVSAAPAAKAAAPVEHKPAKQPMSMGRRLG
ITFAAAAALFVLIALSPAALQVHLTVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHGDPVVTAIAT
VAILLASINVFGGFSVTRRMLAMFSRS

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=532, Percent_Identity=46.8045112781955, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI122939153, Length=532, Percent_Identity=46.8045112781955, Blast_Score=415, Evalue=1e-116,
Organism=Escherichia coli, GI1787887, Length=511, Percent_Identity=63.013698630137, Blast_Score=621, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17550456, Length=515, Percent_Identity=46.4077669902913, Blast_Score=428, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR004571 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 52186; Mature: 52186

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00836 ALADH_PNT_1 ; PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAIPRESQPGETRVAATPQTVGQITKLGYSVVVESGAGVASSFPDAAYVEAGAEIGDP
CEEEECCCCCCCCCEEEECHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCC
WSADVVLKVNAPTDAEIAALRDGATLVGLISPALNPELVEKMSTRRITVLAMDAVPRISR
CCCCEEEEECCCCCCHHEEECCCCEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCHHH
AQSLDVLSSMANIAGYRAVVEAAHTFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCHHHHHHHCC
AGSLGAIVRATDPRPEVADQVASLGGEYLAVDPAAAEVSATGYAKEMGEDYKVREAALYA
CCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCHHHCCCCHHHHHHHHHH
EQCKDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGGNVEGTVKDQAIVT
HHCCCCEEEEEEEECCCCCCCCEEEHHHHHHCCCCCEEEEEEECCCCCCCEEECCCEEEE
DNGVTIIGYTDLAGRLPATASQLYATNLVNLLKLLTPNKDGQLTLDFDDVVQRSVTVIRD
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHEEEEEC
GEVTWPPPPVQVSAAPAAKAAAPVEHKPAKQPMSMGRRLGITFAAAAALFVLIALSPAAL
CEEECCCCCCEEECCCCHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCHHH
QVHLTVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHGDPVVTAIAT
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VAILLASINVFGGFSVTRRMLAMFSRS
HHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIAIPRESQPGETRVAATPQTVGQITKLGYSVVVESGAGVASSFPDAAYVEAGAEIGDP
CEEEECCCCCCCCCEEEECHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCC
WSADVVLKVNAPTDAEIAALRDGATLVGLISPALNPELVEKMSTRRITVLAMDAVPRISR
CCCCEEEEECCCCCCHHEEECCCCEEEEECCCCCCHHHHHHHCCCEEEEEEECCCCCHHH
AQSLDVLSSMANIAGYRAVVEAAHTFGRFFTGQVTAAGKVPPAKVLVVGAGVAGLAAIGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCHHHHHHHCC
AGSLGAIVRATDPRPEVADQVASLGGEYLAVDPAAAEVSATGYAKEMGEDYKVREAALYA
CCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCHHHCCCCHHHHHHHHHH
EQCKDVDIIITTALIPGRPAPRIITADMVASMKSGSVIVDMAAANGGNVEGTVKDQAIVT
HHCCCCEEEEEEEECCCCCCCCEEEHHHHHHCCCCCEEEEEEECCCCCCCEEECCCEEEE
DNGVTIIGYTDLAGRLPATASQLYATNLVNLLKLLTPNKDGQLTLDFDDVVQRSVTVIRD
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHEEEEEC
GEVTWPPPPVQVSAAPAAKAAAPVEHKPAKQPMSMGRRLGITFAAAAALFVLIALSPAAL
CEEECCCCCCEEECCCCHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCHHH
QVHLTVFALAIVIGYYVIGNVHHALHTPLMSVTNAISGIIVVGALLQIGHGDPVVTAIAT
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VAILLASINVFGGFSVTRRMLAMFSRS
HHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3525165; 1633824; 9097039; 9278503; 1932078 [H]