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The map label for this gene is lon

Identifier: 108763928

GI number: 108763928

Start: 2346497

End: 2348950

Strand: Direct

Name: lon

Synonym: MXAN_2017

Alternate gene names: 108763928

Gene position: 2346497-2348950 (Clockwise)

Preceding gene: 108760729

Following gene: 108762323

Centisome position: 25.67

GC content: 64.1

Gene sequence:

>2454_bases
ATGTTCTTCGGACGTGACGACAAGAAGGAAGCCCAGAAGCGGGGTTTGACGGTCCCGCTCTTGCCCCTTCGGGACATCAT
CGTGTTCCCGCACATGGTGGTGCCGTTGTTCGTCGGCCGGGAGAAGTCCATCGCGGCGTTGAAGGACGCGATGGCGCACA
AGGGGCCGGACGACAAGGCCGTCATCCTGCTGGCCGCGCAGAAGAAGGCCAAGACGAACGACCCTACCCCCGACGACATC
TTTCACTTCGGTACGCTGGGCCACGTCATCCAGCTCCTCCCGCTGCCCGACGGCACGGTGAAGGTGCTGGTGGAAGGCGT
GCGCCGCGCCAAGGTGAAGAAGTTCCACCCCAACGACGCCTTCTTCATGGTCGAGGTGGAGGAGGTGGAGGAGCAGACGG
AGAAGACGGTGGAGCTGGAGGCGCTCGTTCGCAGCGTCCACTCCGTCTTCGAGGCCTTCGTCAAGCTCAACAAGCGCATC
CCGCCTGAGATGCTGATGCAGGTGGCCAGCATCGACGACCCGGCGCGGCTGGCCGACACCATCGTCGCGCACCTCTCCCT
GAAGCTGAACGACAAGCAGGCCCTGCTCGAGACGGAGTCCCCGGCCAAGCGCCTGGAGAAGCTCTACGAGCTGATGCAGG
GTGAGATCGAGATTCTCCAGGTGGAGAAGAAGATCCGCACGCGCGTCAAGAAGCAGATGGAGAAGACCCAGAAGGAGTAC
TACCTGAATGAGCAGATGCAGGCCATTCAGAAGGAGCTGGGTGAGCGCGACGAGTTCAAGAACGAGATTCAGGAGATTGA
AGAGAAGCTGAAGAACAAGCGGATGAGCAAGGAGGCCACGCTCAAGGTCAAGAAGGAGCTGAAGAAGCTCCGGATGATGA
GCCCGATGAGCGCCGAGGCCACCGTCGTCCGCAACTACATCGACTGGATCATCAGCCTCCCCTGGTACGACGAGACGCAG
GACCGTCTGGACGTCACTGAGGCGGAGACGGTGCTCAACGAGGACCACTACGGCTTGAAGAAGCCGAAGGAGCGCATCCT
CGAGTACCTGGCCGTGCAGCAACTGGTGAAGAAGCTCAAGGGCCCCGTGCTGTGCTTCGTCGGTCCTCCGGGCGTCGGCA
AGACGTCGCTGGCGCGCTCCATTGCTCGGGCCACCGGCCGCAAGTTCGTGCGCCTGTCGCTGGGCGGCGTTCGTGACGAG
GCGGAGATTCGTGGCCACCGGCGCACGTACATCGGCGCGATGCCGGGCAAGCTCATCCAGTCGCTGAAGAAGGCGGGCAG
CAACAACCCCGTCTTCCTGCTCGATGAAATCGACAAGATGTCCACGGACTTCCGTGGCGATCCGAGCGCGGCGCTGCTGG
AGGTGCTGGACCCCGAGCAGAACCACACCTTCAACGACCACTACCTGGACCTCGACTACGACCTGTCCAAGGTGATGTTC
ATCTGCACCGCGAACACGATGCACAACATCCCCGGTCCGCTGCAGGACCGCATGGAAGTGATTCGCATCGCGGGGTACAC
GGAGCCGGAGAAGCTCTCCATCGCCCGCCGATACCTCATCCCGAAGGAGCAGGAGGCCAACGGGCTGTCGGACCTCAAGG
TGGACATCTCCGACCCGGCGCTGCGGACCATCATCCACCGCTACACGCGGGAGTCGGGCGTGCGCTCGCTCGAGCGTGAG
ATTGGCGGCGTGTTCCGCAAGATTGCCCGCGACGTGCTGAAGAACGGCAAGCGGGACATCGACGTGGACCGGAAGATGGC
CATGAAGTTCCTGGGCACGCCCCGCTACCGTTACGGCATGGCGGAGGCCGAGGATCAGGTGGGCATCGTCACGGGCCTGG
CGTGGACGGAGCTGGGCGGTGAAATCCTCACCACCGAGGCCACCATCATGCCGGGCAAGGGCAAGCTCATCATCACTGGC
AAGCTGGGTGAGGTGATGCAGGAGTCCGCGCAGGCGGCCATGTCCTACGTGCGCAGCCGCGCCGAGCGCTTCGGCATCGA
CCGCAAGGTGTTCGAGAACTACGACATCCACGTCCACTTGCCGGAGGGCGCGATTCCGAAGGACGGTCCGTCCGCCGGCG
TCACCATCTGCACCGCACTGGTGAGCGCGCTCACCCGCGTGCTCATCCGCCGCGACGTGGCGATGACGGGTGAAATCACC
CTGCGTGGGCGGGTGCTCCCCATTGGCGGCTTGAAGGAGAAGACGCTGGCCGCGCACCGGGCGGGCATCAAGACGGTCCT
CATCCCGAAGGCGAACAAGAAGGACCTGAAGGACATCCCGCTGAAGATTCGCAAGCAGCTGCGCATCGTCCCGGTGGAGT
TCGTGGACGACGTGCTGCGCGAGGCGCTGGTGCTGGAGAAGCCGGAGGAGTTCGGCCGCAAGCCGACGACGGACGGCGGC
AAGCTGGGTGGCACCACGGAGCTGCCGGCCTCGCCGGCCGTGGCCCCGGCCTAG

Upstream 100 bases:

>100_bases
GTTATAGAACTGCTGCATCCCGTACGAATGCTCGGCGAGCGAGCAGACGGGCAACTCTTCTAGGGGCCTGCAACTCCGAG
GGCCCGCAGGTGGCGGATAC

Downstream 100 bases:

>100_bases
CGGAGACAGACAGCACCCGGTGGGCCGCCGCGCCTGTCGGGCCGAGCTGAAGGGAAGCCAGGACGCCGGACGACCAAGGT
CGCCGGGTTCCTGGCTTCTC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1

Number of amino acids: Translated: 817; Mature: 817

Protein sequence:

>817_residues
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDI
FHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRI
PPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEY
YLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQ
DRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDE
AEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMF
ICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLERE
IGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITG
KLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEIT
LRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGG
KLGGTTELPASPAVAPA

Sequences:

>Translated_817_residues
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDI
FHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRI
PPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEY
YLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQ
DRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDE
AEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMF
ICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLERE
IGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITG
KLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEIT
LRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGG
KLGGTTELPASPAVAPA
>Mature_817_residues
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKAVILLAAQKKAKTNDPTPDDI
FHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDAFFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRI
PPEMLMQVASIDDPARLADTIVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEY
YLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEATVVRNYIDWIISLPWYDETQ
DRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLKGPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDE
AEIRGHRRTYIGAMPGKLIQSLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMF
ICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPALRTIIHRYTRESGVRSLERE
IGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGMAEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITG
KLGEVMQESAQAAMSYVRSRAERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEIT
LRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLREALVLEKPEEFGRKPTTDGG
KLGGTTELPASPAVAPA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=48.1349911190053, Blast_Score=549, Evalue=1e-156,
Organism=Homo sapiens, GI21396489, Length=683, Percent_Identity=42.4597364568082, Blast_Score=541, Evalue=1e-153,
Organism=Escherichia coli, GI1786643, Length=769, Percent_Identity=59.6879063719116, Blast_Score=919, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=701, Percent_Identity=39.5149786019972, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=535, Percent_Identity=42.803738317757, Blast_Score=457, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319449, Length=738, Percent_Identity=37.940379403794, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=680, Percent_Identity=43.2352941176471, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24666867, Length=680, Percent_Identity=43.2352941176471, Blast_Score=531, Evalue=1e-151,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON1_MYXXA (P36773)

Other databases:

- EMBL:   D12923
- EMBL:   AF127082
- PIR:   A49844
- ProteinModelPortal:   P36773
- MEROPS:   S16.001
- BRENDA:   3.4.21.53
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91816; Mature: 91816

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 691-691 ACT_SITE 734-734

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKA
CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCE
VILLAAQKKAKTNDPTPDDIFHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDA
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
FFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADT
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
IVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEY
HHHHHHEEECCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHH
TVVRNYIDWIISLPWYDETQDRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLK
HHHHHHHHHHEECCCCCCCHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQ
CCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCCHHEECCCCHHHHH
SLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMF
HHHHCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHEEE
ICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPA
EEECCHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCHH
LRTIIHRYTRESGVRSLEREIGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHCCC
AEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSR
CCCCCCCEEEECHHHHHCCCEEEEECEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHH
AERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEIT
HHHHCCCHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECEEE
LRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLR
EEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCHHHCCHHHHHHHEECCHHHHHHHHH
EALVLEKPEEFGRKPTTDGGKLGGTTELPASPAVAPA
HHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFFGRDDKKEAQKRGLTVPLLPLRDIIVFPHMVVPLFVGREKSIAALKDAMAHKGPDDKA
CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCE
VILLAAQKKAKTNDPTPDDIFHFGTLGHVIQLLPLPDGTVKVLVEGVRRAKVKKFHPNDA
EEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCC
FFMVEVEEVEEQTEKTVELEALVRSVHSVFEAFVKLNKRIPPEMLMQVASIDDPARLADT
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
IVAHLSLKLNDKQALLETESPAKRLEKLYELMQGEIEILQVEKKIRTRVKKQMEKTQKEY
HHHHHHEEECCHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YLNEQMQAIQKELGERDEFKNEIQEIEEKLKNKRMSKEATLKVKKELKKLRMMSPMSAEA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHH
TVVRNYIDWIISLPWYDETQDRLDVTEAETVLNEDHYGLKKPKERILEYLAVQQLVKKLK
HHHHHHHHHHEECCCCCCCHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC
GPVLCFVGPPGVGKTSLARSIARATGRKFVRLSLGGVRDEAEIRGHRRTYIGAMPGKLIQ
CCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCCCHHEECCCCHHHHH
SLKKAGSNNPVFLLDEIDKMSTDFRGDPSAALLEVLDPEQNHTFNDHYLDLDYDLSKVMF
HHHHCCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCHHHEEE
ICTANTMHNIPGPLQDRMEVIRIAGYTEPEKLSIARRYLIPKEQEANGLSDLKVDISDPA
EEECCHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCHH
LRTIIHRYTRESGVRSLEREIGGVFRKIARDVLKNGKRDIDVDRKMAMKFLGTPRYRYGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHCCC
AEAEDQVGIVTGLAWTELGGEILTTEATIMPGKGKLIITGKLGEVMQESAQAAMSYVRSR
CCCCCCCEEEECHHHHHCCCEEEEECEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHH
AERFGIDRKVFENYDIHVHLPEGAIPKDGPSAGVTICTALVSALTRVLIRRDVAMTGEIT
HHHHCCCHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECEEE
LRGRVLPIGGLKEKTLAAHRAGIKTVLIPKANKKDLKDIPLKIRKQLRIVPVEFVDDVLR
EEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCCHHHCCHHHHHHHEECCHHHHHHHHH
EALVLEKPEEFGRKPTTDGGKLGGTTELPASPAVAPA
HHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468287