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The map label for this gene is cpxA [H]

Identifier: 108763854

GI number: 108763854

Start: 6616052

End: 6617452

Strand: Direct

Name: cpxA [H]

Synonym: MXAN_5314

Alternate gene names: 108763854

Gene position: 6616052-6617452 (Clockwise)

Preceding gene: 108763038

Following gene: 108757166

Centisome position: 72.39

GC content: 73.02

Gene sequence:

>1401_bases
GTGAAACGCGGCAGGCCCCGGGCGCACAAGCGCGGCTGGGACGCGTGGGGCGAGCCGCGCGAATGCGGCCCCTGGGGACA
CCGGCATCCGCCGCACGGTTACTGGCATATGGGCCGCCTGGGCGGCTTCGTGCGCGCCCGGCTGCACCGGCGCCTGTTCA
TGTGGTTCGGCCTGTCCATCCTCGCCACCGGCGCCGTGGTGGCCACGGTGATGAGCCTGGTGGGCGGAGGCACCTGGAAA
CAGGAAGGCGACCGCGTGCGCGCCTTCGTGGGCCACCGCTTCGAGGAGGTCTGGGACGAGCCCGCACGGCGGGACGCGCT
GGTGGCCTCCATCGAGAAGGACTTGCAGGTGGGCGTGGAGTTGCGGGACGCGTCCGGCGCGATGCTGGCGCAGAGCCAGG
TGCCGTGCCGGCGGCCCGAGCTCAACCTGCCCGTGGTTCGCGATGGCATCACCCTGGGCTCGGTGCGCGCTTGCTACGCC
AGCTTCCGTCCGAAGAACCCGCTGCGGATGGTGCTGCCGCTGGCGCTGTCGTGCATGGTGCTGTGGCTGGCCTCGGGGAA
GCTCGCGCGGCGGCTCGCACGGCCCATGGATGCGCTGGTCCGGGCCACGCGAGAGCTGGGCTCGGGCCGGCTGGACTCGC
GCGCGGACGTCGCGCCGCATGTCACGGGAGAGTTCGCCGTGCTGGCGGATGCCTTCAACGACATGGCGGGGCGCATCGAG
AAGCAGGTGGCGGACCAGCGCGAGCTGCTCGCCGCCGTGTCCCACGAGCTGCGCACCCCGCTGGCCCGGCTGCGCGTGCT
GACGGAGCTGCTCCGCGACGGAGGCGGCAACCCGAAGACGTTGGACCAGGTGGACCGCGAGGTGGTGGAGCTGGATGCCC
TGGTGGGGGAGCTGCTGGCCAGCTCCCGGCTGGACTTCGGCCAGCTCACCCCGCGTGTCCTCGATGGCCAGACGCTGGCC
ACGCAGGCCCTGGAGCGCGCGGGGCTGGCGAGCTCCCTGTTGGGTATGGACGTGGAGCGCGCCGGGCTCGTGGGAGACGC
GACGCTGCTGGGCCGCGCCCTGGCCAACCTCCTGGAGAATGCGCGCAAGCACGGCACCGGCGCCGAGGCACTGCGCATCC
AGGAGCGAGGCGAACACCTGGCCTTCTGCGTGGAAGACCGGGGCCCCGGGCTGCAGCCCGGCGAGGACGAGCGCATCTTC
CGGCCCTTCTACCGGAGGGACCAAGGCACCGAAGCGCGCGAGGCGGGCTCCCTGGGCCTGGGTCTGGCGCTGGTCCAGCG
CATCGCGCACGTCCACGGCGGAGACGTCTTCGCGGAGAACCGCCCCGGCGGCGGCGCTCGGGTGGGCTTCACCGTGCGGA
AAAACGGCCCTCCGGCTTCAGAGGGCCGCCCCACCGCGTAG

Upstream 100 bases:

>100_bases
ACGTGCACATCTCCCACCTGCGACAGAAGCTCGGTGACGTGGGCACCCGCCTCATCAAGACGGTGCGCGGCGTGGGCTAC
GTGTTCGCCAAGGAGGGTCC

Downstream 100 bases:

>100_bases
CGCGTTCGTCACTTCTGCGCGGACGCGTCCTCCGCGGAGAAGGAGAACGCGGCCTCGGCCGGCGCGTCGTCCGTCACCGT
GACTTCGGCCGTCTTCGAGC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKRGRPRAHKRGWDAWGEPRECGPWGHRHPPHGYWHMGRLGGFVRARLHRRLFMWFGLSILATGAVVATVMSLVGGGTWK
QEGDRVRAFVGHRFEEVWDEPARRDALVASIEKDLQVGVELRDASGAMLAQSQVPCRRPELNLPVVRDGITLGSVRACYA
SFRPKNPLRMVLPLALSCMVLWLASGKLARRLARPMDALVRATRELGSGRLDSRADVAPHVTGEFAVLADAFNDMAGRIE
KQVADQRELLAAVSHELRTPLARLRVLTELLRDGGGNPKTLDQVDREVVELDALVGELLASSRLDFGQLTPRVLDGQTLA
TQALERAGLASSLLGMDVERAGLVGDATLLGRALANLLENARKHGTGAEALRIQERGEHLAFCVEDRGPGLQPGEDERIF
RPFYRRDQGTEAREAGSLGLGLALVQRIAHVHGGDVFAENRPGGGARVGFTVRKNGPPASEGRPTA

Sequences:

>Translated_466_residues
MKRGRPRAHKRGWDAWGEPRECGPWGHRHPPHGYWHMGRLGGFVRARLHRRLFMWFGLSILATGAVVATVMSLVGGGTWK
QEGDRVRAFVGHRFEEVWDEPARRDALVASIEKDLQVGVELRDASGAMLAQSQVPCRRPELNLPVVRDGITLGSVRACYA
SFRPKNPLRMVLPLALSCMVLWLASGKLARRLARPMDALVRATRELGSGRLDSRADVAPHVTGEFAVLADAFNDMAGRIE
KQVADQRELLAAVSHELRTPLARLRVLTELLRDGGGNPKTLDQVDREVVELDALVGELLASSRLDFGQLTPRVLDGQTLA
TQALERAGLASSLLGMDVERAGLVGDATLLGRALANLLENARKHGTGAEALRIQERGEHLAFCVEDRGPGLQPGEDERIF
RPFYRRDQGTEAREAGSLGLGLALVQRIAHVHGGDVFAENRPGGGARVGFTVRKNGPPASEGRPTA
>Mature_466_residues
MKRGRPRAHKRGWDAWGEPRECGPWGHRHPPHGYWHMGRLGGFVRARLHRRLFMWFGLSILATGAVVATVMSLVGGGTWK
QEGDRVRAFVGHRFEEVWDEPARRDALVASIEKDLQVGVELRDASGAMLAQSQVPCRRPELNLPVVRDGITLGSVRACYA
SFRPKNPLRMVLPLALSCMVLWLASGKLARRLARPMDALVRATRELGSGRLDSRADVAPHVTGEFAVLADAFNDMAGRIE
KQVADQRELLAAVSHELRTPLARLRVLTELLRDGGGNPKTLDQVDREVVELDALVGELLASSRLDFGQLTPRVLDGQTLA
TQALERAGLASSLLGMDVERAGLVGDATLLGRALANLLENARKHGTGAEALRIQERGEHLAFCVEDRGPGLQPGEDERIF
RPFYRRDQGTEAREAGSLGLGLALVQRIAHVHGGDVFAENRPGGGARVGFTVRKNGPPASEGRPTA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=32.5757575757576, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=32.824427480916, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=31.9852941176471, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1789808, Length=268, Percent_Identity=30.5970149253731, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=34.8360655737705, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790551, Length=306, Percent_Identity=29.0849673202614, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786783, Length=261, Percent_Identity=29.8850574712644, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=244, Percent_Identity=29.5081967213115, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=30.0813008130081, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=276, Percent_Identity=26.8115942028986, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787374, Length=344, Percent_Identity=27.3255813953488, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789149, Length=350, Percent_Identity=25.1428571428571, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=27.5, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=29.6296296296296, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=244, Percent_Identity=29.5081967213115, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=244, Percent_Identity=25.8196721311475, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50885; Mature: 50885

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGRPRAHKRGWDAWGEPRECGPWGHRHPPHGYWHMGRLGGFVRARLHRRLFMWFGLSI
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LATGAVVATVMSLVGGGTWKQEGDRVRAFVGHRFEEVWDEPARRDALVASIEKDLQVGVE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCE
LRDASGAMLAQSQVPCRRPELNLPVVRDGITLGSVRACYASFRPKNPLRMVLPLALSCMV
EECCCCCHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LWLASGKLARRLARPMDALVRATRELGSGRLDSRADVAPHVTGEFAVLADAFNDMAGRIE
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KQVADQRELLAAVSHELRTPLARLRVLTELLRDGGGNPKTLDQVDREVVELDALVGELLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SSRLDFGQLTPRVLDGQTLATQALERAGLASSLLGMDVERAGLVGDATLLGRALANLLEN
HCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
ARKHGTGAEALRIQERGEHLAFCVEDRGPGLQPGEDERIFRPFYRRDQGTEAREAGSLGL
HHHCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCHH
GLALVQRIAHVHGGDVFAENRPGGGARVGFTVRKNGPPASEGRPTA
HHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKRGRPRAHKRGWDAWGEPRECGPWGHRHPPHGYWHMGRLGGFVRARLHRRLFMWFGLSI
CCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH
LATGAVVATVMSLVGGGTWKQEGDRVRAFVGHRFEEVWDEPARRDALVASIEKDLQVGVE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCE
LRDASGAMLAQSQVPCRRPELNLPVVRDGITLGSVRACYASFRPKNPLRMVLPLALSCMV
EECCCCCHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
LWLASGKLARRLARPMDALVRATRELGSGRLDSRADVAPHVTGEFAVLADAFNDMAGRIE
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KQVADQRELLAAVSHELRTPLARLRVLTELLRDGGGNPKTLDQVDREVVELDALVGELLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SSRLDFGQLTPRVLDGQTLATQALERAGLASSLLGMDVERAGLVGDATLLGRALANLLEN
HCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
ARKHGTGAEALRIQERGEHLAFCVEDRGPGLQPGEDERIFRPFYRRDQGTEAREAGSLGL
HHHCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCHH
GLALVQRIAHVHGGDVFAENRPGGGARVGFTVRKNGPPASEGRPTA
HHHHHHHHHHHCCCCEEECCCCCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]