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The map label for this gene is zraS [H]

Identifier: 108763850

GI number: 108763850

Start: 5159123

End: 5160457

Strand: Direct

Name: zraS [H]

Synonym: MXAN_4203

Alternate gene names: 108763850

Gene position: 5159123-5160457 (Clockwise)

Preceding gene: 108758934

Following gene: 108763024

Centisome position: 56.45

GC content: 69.96

Gene sequence:

>1335_bases
ATGCCTGAGAGTCCTCGACCGCTGGCGCTGGAGCAGATGGCGCAGCGGGTGCTGTCCGACGCTTCGAACGAGGGCGAAGC
GCTGGTCAGCGGGGGCCGGATTGTCTTCTGTGCCCTCATCCTGACGCGCTTCCTGGCGCTGGGTGGCGCCCACGCCGAGG
GCGGTGCCGCGGCGGCATGGCTCCAGCTTCCCCTGCTGCTGGGCAGCATCGCGGCGTCAGTGATGGCGCTGTGGGCGGCT
CGGCGGCGGATGTTCGGCGCGAAGCTGCTCGTGGCCTCCACGGTGCTGGACGCCGTCTTCGCCCATGCGTCCCTCCTCTC
CACGGTGCTCTGGCATGGCCCTCACTACACCGGCCTGCTGCGAATGCCAGACCCCGCGGCGGCCATCGCGGTGGCCTTCA
TCACCGCGCTGCGGCTGTCGCCCTCGGCCGCTTGGATTGGGACGGCGGCCAACCTCCTGTTGATGGCGGGTCTGACGGCG
GTCGACCTCCACGTCAATGCAGGGCAGTCCACCTACGGGGCGAAGGAGCTGATGCTCCTGTTCATCTTCATCGGCAGCGC
GGGCGTCTTCGCCTCGGTGATTTGTGGCATTGCACGGCGGCTGGTCCTGGAGGCCGGAACCGCGAGTGTCCACATGGAGC
GTGCACGCACGAACCTGCGCGCGCTGCTGCGCGAGCACCATGACGTGCGCACGTTGCTGTCCGCGGCGAGGCTGCGCGCC
GACCTCCTCCTCCGCGAGCCCCTGAGCGCCAGCGCGCCCGGCCATGCGAGCGCCCTGGTCGAGGACCTGGGAGAGCTGAG
CAGCTTCATCGAGAGCGTGAAGGCCCGGACCCTGAGCGAGCTGACTGTGATTGAAGATGCGACGGCGGTGAACGTGGGCG
CCACGCTGCGCCGTGCCATGGAGGTCGTCCAGGCGAGGTTCGCCCGGGTCCGGTTCGAGTTGGAAGGAACAGCGGGCCTG
GCGCGTGCCGCCGCCAACGACGTCAGCGTCCGGATTGTCGGTGGAGAGCGAGGGCTCACGCACGTGGTCACCAACCTGTT
CGTGAACGCCTGTGAGGGTGATGGCCGGCAAGGCGCGCGCACGGTTCGAATCAGCGTGGAGCCGAACCCGGCGCTGCACC
GCGTCCTGCTCAGCGTGAGCGATGATGGACCGGGCTTCCGACCGGGGCTGCTGGAGGGGGAACGCCCCCGGGCCGGTACG
ACCAAGCCAGAGGGCGCTGGGCTGGGCATGCTCCTGGTGAGCGGGCTCGTCGAGGCAAGCGGCGGCACCTTGCGCGCCTG
CAACCCGCCCGAGGGAGGCGCGCGGGTCGAAGTCACACTGCCCACCAGCGGGTAG

Upstream 100 bases:

>100_bases
GCGAGAGCGCAACGCCTCCTCGATCGCACGCGCAAGACGCGTGGCGTCCTCGACGACCAGGAGATGTCGGACCCGCCCCA
CCCATGGCAACTTACCATGA

Downstream 100 bases:

>100_bases
AGCCGCGGGCCCCTTCCCTCGCCCCGGCGGCAGGAGCAGGCGCCGTGGATGGCCGGCGCAACCGCCAGGCGTGAGCGAGC
CCCAGTCCGAGGTTCGCCAC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPESPRPLALEQMAQRVLSDASNEGEALVSGGRIVFCALILTRFLALGGAHAEGGAAAAWLQLPLLLGSIAASVMALWAA
RRRMFGAKLLVASTVLDAVFAHASLLSTVLWHGPHYTGLLRMPDPAAAIAVAFITALRLSPSAAWIGTAANLLLMAGLTA
VDLHVNAGQSTYGAKELMLLFIFIGSAGVFASVICGIARRLVLEAGTASVHMERARTNLRALLREHHDVRTLLSAARLRA
DLLLREPLSASAPGHASALVEDLGELSSFIESVKARTLSELTVIEDATAVNVGATLRRAMEVVQARFARVRFELEGTAGL
ARAAANDVSVRIVGGERGLTHVVTNLFVNACEGDGRQGARTVRISVEPNPALHRVLLSVSDDGPGFRPGLLEGERPRAGT
TKPEGAGLGMLLVSGLVEASGGTLRACNPPEGGARVEVTLPTSG

Sequences:

>Translated_444_residues
MPESPRPLALEQMAQRVLSDASNEGEALVSGGRIVFCALILTRFLALGGAHAEGGAAAAWLQLPLLLGSIAASVMALWAA
RRRMFGAKLLVASTVLDAVFAHASLLSTVLWHGPHYTGLLRMPDPAAAIAVAFITALRLSPSAAWIGTAANLLLMAGLTA
VDLHVNAGQSTYGAKELMLLFIFIGSAGVFASVICGIARRLVLEAGTASVHMERARTNLRALLREHHDVRTLLSAARLRA
DLLLREPLSASAPGHASALVEDLGELSSFIESVKARTLSELTVIEDATAVNVGATLRRAMEVVQARFARVRFELEGTAGL
ARAAANDVSVRIVGGERGLTHVVTNLFVNACEGDGRQGARTVRISVEPNPALHRVLLSVSDDGPGFRPGLLEGERPRAGT
TKPEGAGLGMLLVSGLVEASGGTLRACNPPEGGARVEVTLPTSG
>Mature_443_residues
PESPRPLALEQMAQRVLSDASNEGEALVSGGRIVFCALILTRFLALGGAHAEGGAAAAWLQLPLLLGSIAASVMALWAAR
RRMFGAKLLVASTVLDAVFAHASLLSTVLWHGPHYTGLLRMPDPAAAIAVAFITALRLSPSAAWIGTAANLLLMAGLTAV
DLHVNAGQSTYGAKELMLLFIFIGSAGVFASVICGIARRLVLEAGTASVHMERARTNLRALLREHHDVRTLLSAARLRAD
LLLREPLSASAPGHASALVEDLGELSSFIESVKARTLSELTVIEDATAVNVGATLRRAMEVVQARFARVRFELEGTAGLA
RAAANDVSVRIVGGERGLTHVVTNLFVNACEGDGRQGARTVRISVEPNPALHRVLLSVSDDGPGFRPGLLEGERPRAGTT
KPEGAGLGMLLVSGLVEASGGTLRACNPPEGGARVEVTLPTSG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46381; Mature: 46250

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESPRPLALEQMAQRVLSDASNEGEALVSGGRIVFCALILTRFLALGGAHAEGGAAAAW
CCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LQLPLLLGSIAASVMALWAARRRMFGAKLLVASTVLDAVFAHASLLSTVLWHGPHYTGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
RMPDPAAAIAVAFITALRLSPSAAWIGTAANLLLMAGLTAVDLHVNAGQSTYGAKELMLL
ECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHH
FIFIGSAGVFASVICGIARRLVLEAGTASVHMERARTNLRALLREHHDVRTLLSAARLRA
HHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLLREPLSASAPGHASALVEDLGELSSFIESVKARTLSELTVIEDATAVNVGATLRRAM
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
EVVQARFARVRFELEGTAGLARAAANDVSVRIVGGERGLTHVVTNLFVNACEGDGRQGAR
HHHHHHHHHHEEEECCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCE
TVRISVEPNPALHRVLLSVSDDGPGFRPGLLEGERPRAGTTKPEGAGLGMLLVSGLVEAS
EEEEEECCCHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GGTLRACNPPEGGARVEVTLPTSG
CCEEEECCCCCCCCEEEEEECCCC
>Mature Secondary Structure 
PESPRPLALEQMAQRVLSDASNEGEALVSGGRIVFCALILTRFLALGGAHAEGGAAAAW
CCCCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
LQLPLLLGSIAASVMALWAARRRMFGAKLLVASTVLDAVFAHASLLSTVLWHGPHYTGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
RMPDPAAAIAVAFITALRLSPSAAWIGTAANLLLMAGLTAVDLHVNAGQSTYGAKELMLL
ECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHH
FIFIGSAGVFASVICGIARRLVLEAGTASVHMERARTNLRALLREHHDVRTLLSAARLRA
HHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLLLREPLSASAPGHASALVEDLGELSSFIESVKARTLSELTVIEDATAVNVGATLRRAM
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHH
EVVQARFARVRFELEGTAGLARAAANDVSVRIVGGERGLTHVVTNLFVNACEGDGRQGAR
HHHHHHHHHHEEEECCCHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCE
TVRISVEPNPALHRVLLSVSDDGPGFRPGLLEGERPRAGTTKPEGAGLGMLLVSGLVEAS
EEEEEECCCHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GGTLRACNPPEGGARVEVTLPTSG
CCEEEECCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]