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The map label for this gene is pepP [H]

Identifier: 108763789

GI number: 108763789

Start: 2355844

End: 2357394

Strand: Reverse

Name: pepP [H]

Synonym: MXAN_2026

Alternate gene names: 108763789

Gene position: 2357394-2355844 (Counterclockwise)

Preceding gene: 108757437

Following gene: 108760653

Centisome position: 25.79

GC content: 68.6

Gene sequence:

>1551_bases
TTGTCCATGGCCACGACCCGTTCTTCCGCCGCCGCTCAGCCCGCCCTGGGCGAGCAACAGCCGATTGTCACCTCCGAGGA
GCAGGCCCCCGCGGCAGCGCCCGCGAAGCCCGCCACGCACGACACGGTGCCACCGCCGGCCCTGCTCGACTTCATGATGA
AGTCGTGGAAGCCGCGCTCGAAGAAGCTGCCCCCGAAAATCAAGCAGGCGGAGGCCTTCAAAGCCCGCCGCCGGGCGCTC
TCCAAGCTGTTCCCCGGCGAGACGCTCATCATTCCCACCGGCCACGAGAAGGTGCGCGCCAACGACACCAACTTCCGTTT
CCGGCCGGGCAGCGACTTCTACTACCTCACCGGCAACCTGGAGCCGGACTGCGTCCTCGTCCTCCAGCCCAAGGAGAAGG
GTGGCCACACCGACGTGCTCTTCGTGGAGCCGAACCCGGGCCGCACCGACGCCACGTTCTTCACCGACCGCGTGAAGGGG
GAGCTGTGGGAAGGCCCCCGCCTGGGCGTGAAGGAGAGTCAGGCCCGCTACGGCGTGGACCAGGCCCGGAGCCTCAACGA
GCTGCCGGCCTTCCTCTCCGGCCTCAGCGGCGCGGAGAGCCGTCCCACGCGCTTGCTGCGCGGCCTGTCGCCCAAGGTGG
ACGGCGCCGTCCCGGCGCCGGGTGAGAAGGACAAGGGGCTGGCCCAAGCGCTGTCGGAGATGCGGCTGCTCAAGGACGCG
CAGGAGCTGCGTGAACTCCAGACGTCCATCGACTCCACGCACCGCGGCTTCGAGGACGTCATCCGTGGCCTGAAGACGGC
GAAGACGGAGCGCTACGTGGAGGGCATCTTCAACCTCCGCGCCCGCGTGGAAGGCAACGACGTGGGCTACCGCACCATCG
CCGCCTCCGGCGCCCATGCGTGCATCCTGCACTGGCACCACAATGACGGGCCGCTCGTTCCCGGCGACCTGCTGCTGCTG
GACGCGGGCGTGGAGGGCCAGACGCTCTACACCGCGGACATCACCCGCACCCTGCCCATCTCCGGGAAGTTCTCCAAGGA
GCAGCGCGAAATCTACGAGCTGGTGCTGGAGGCGCAGGACGCGGCCTTCGCCGAGGTGAAGCCGGGCAACGACTTCATGG
AGCCCAACCGCGCGGCCATGCGCGTGCTCGCGGAGGGCCTGGAGGCCCTGGGCATCCTCGAGGACGCCGAGGAGGCGCTC
AAGGACGAGCACCAGTTCTACAAGCGCTACTCGCTCCACAACGTCAGCCACATGCTGGGCCTGGACGTGCACGACTGCGC
CCAGGCGCGGCAGGAGACCTACAAGTACGGGAAGCTCCAGGCCGGCATGGTGCTGACGGTGGAGCCTGGCCTCTACTTCC
AGATGGACGACCTCACCGTGCCCAAGCGCTACCGGGGCATCGGCGTGCGCATCGAGGACGACGTCGTCGTCACCGCGCGC
GGCTGCAAGGTCCTCTCCGCCGACATCCCCCGCAAGGCGAAGGATGTGGAGGCGTGGATGAAGTCCCTCTGGGCGGCGGA
CAAGGCCGCCCGGAAGGGCAAGAAGAAGTAG

Upstream 100 bases:

>100_bases
GTGCCCGCCCTCCTGGGGCAGGTGGCGCTTCTTCGGGAGGACATTGCGGCACCGCCCGCGACAACTCTGACTTGAAGGCG
CGCCGTGGTCGGGTGAAGAG

Downstream 100 bases:

>100_bases
GCCCGGCGCGCTACTTCGGCTTCGGCGCGGCGGTGGCGGGTTTCGCCGCCGCGGCCGCGGCCCGCTCCTGCCACTCCGAC
AGCGCCAGAGGCTTCACGTC

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase I; Aminopeptidase P I; APP; PEPP I; X-Pro aminopeptidase I; Xaa-Pro aminopeptidase I [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSMATTRSSAAAQPALGEQQPIVTSEEQAPAAAPAKPATHDTVPPPALLDFMMKSWKPRSKKLPPKIKQAEAFKARRRAL
SKLFPGETLIIPTGHEKVRANDTNFRFRPGSDFYYLTGNLEPDCVLVLQPKEKGGHTDVLFVEPNPGRTDATFFTDRVKG
ELWEGPRLGVKESQARYGVDQARSLNELPAFLSGLSGAESRPTRLLRGLSPKVDGAVPAPGEKDKGLAQALSEMRLLKDA
QELRELQTSIDSTHRGFEDVIRGLKTAKTERYVEGIFNLRARVEGNDVGYRTIAASGAHACILHWHHNDGPLVPGDLLLL
DAGVEGQTLYTADITRTLPISGKFSKEQREIYELVLEAQDAAFAEVKPGNDFMEPNRAAMRVLAEGLEALGILEDAEEAL
KDEHQFYKRYSLHNVSHMLGLDVHDCAQARQETYKYGKLQAGMVLTVEPGLYFQMDDLTVPKRYRGIGVRIEDDVVVTAR
GCKVLSADIPRKAKDVEAWMKSLWAADKAARKGKKK

Sequences:

>Translated_516_residues
MSMATTRSSAAAQPALGEQQPIVTSEEQAPAAAPAKPATHDTVPPPALLDFMMKSWKPRSKKLPPKIKQAEAFKARRRAL
SKLFPGETLIIPTGHEKVRANDTNFRFRPGSDFYYLTGNLEPDCVLVLQPKEKGGHTDVLFVEPNPGRTDATFFTDRVKG
ELWEGPRLGVKESQARYGVDQARSLNELPAFLSGLSGAESRPTRLLRGLSPKVDGAVPAPGEKDKGLAQALSEMRLLKDA
QELRELQTSIDSTHRGFEDVIRGLKTAKTERYVEGIFNLRARVEGNDVGYRTIAASGAHACILHWHHNDGPLVPGDLLLL
DAGVEGQTLYTADITRTLPISGKFSKEQREIYELVLEAQDAAFAEVKPGNDFMEPNRAAMRVLAEGLEALGILEDAEEAL
KDEHQFYKRYSLHNVSHMLGLDVHDCAQARQETYKYGKLQAGMVLTVEPGLYFQMDDLTVPKRYRGIGVRIEDDVVVTAR
GCKVLSADIPRKAKDVEAWMKSLWAADKAARKGKKK
>Mature_515_residues
SMATTRSSAAAQPALGEQQPIVTSEEQAPAAAPAKPATHDTVPPPALLDFMMKSWKPRSKKLPPKIKQAEAFKARRRALS
KLFPGETLIIPTGHEKVRANDTNFRFRPGSDFYYLTGNLEPDCVLVLQPKEKGGHTDVLFVEPNPGRTDATFFTDRVKGE
LWEGPRLGVKESQARYGVDQARSLNELPAFLSGLSGAESRPTRLLRGLSPKVDGAVPAPGEKDKGLAQALSEMRLLKDAQ
ELRELQTSIDSTHRGFEDVIRGLKTAKTERYVEGIFNLRARVEGNDVGYRTIAASGAHACILHWHHNDGPLVPGDLLLLD
AGVEGQTLYTADITRTLPISGKFSKEQREIYELVLEAQDAAFAEVKPGNDFMEPNRAAMRVLAEGLEALGILEDAEEALK
DEHQFYKRYSLHNVSHMLGLDVHDCAQARQETYKYGKLQAGMVLTVEPGLYFQMDDLTVPKRYRGIGVRIEDDVVVTARG
CKVLSADIPRKAKDVEAWMKSLWAADKAARKGKKK

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=462, Percent_Identity=31.6017316017316, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI149589008, Length=473, Percent_Identity=28.5412262156448, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI260593665, Length=313, Percent_Identity=31.9488817891374, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI260593663, Length=461, Percent_Identity=27.9826464208243, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1789275, Length=454, Percent_Identity=34.8017621145374, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788728, Length=259, Percent_Identity=30.8880308880309, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=29.3333333333333, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=467, Percent_Identity=26.338329764454, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71989583, Length=288, Percent_Identity=27.4305555555556, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320922, Length=467, Percent_Identity=27.8372591006424, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321118, Length=480, Percent_Identity=28.125, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI19920384, Length=424, Percent_Identity=31.6037735849057, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21357079, Length=481, Percent_Identity=29.9376299376299, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 57018; Mature: 56886

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMATTRSSAAAQPALGEQQPIVTSEEQAPAAAPAKPATHDTVPPPALLDFMMKSWKPRS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
KKLPPKIKQAEAFKARRRALSKLFPGETLIIPTGHEKVRANDTNFRFRPGSDFYYLTGNL
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEECCCCCEEEEECCC
EPDCVLVLQPKEKGGHTDVLFVEPNPGRTDATFFTDRVKGELWEGPRLGVKESQARYGVD
CCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCHH
QARSLNELPAFLSGLSGAESRPTRLLRGLSPKVDGAVPAPGEKDKGLAQALSEMRLLKDA
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QELRELQTSIDSTHRGFEDVIRGLKTAKTERYVEGIFNLRARVEGNDVGYRTIAASGAHA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCE
CILHWHHNDGPLVPGDLLLLDAGVEGQTLYTADITRTLPISGKFSKEQREIYELVLEAQD
EEEEEECCCCCCCCCCEEEEECCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHCC
AAFAEVKPGNDFMEPNRAAMRVLAEGLEALGILEDAEEALKDEHQFYKRYSLHNVSHMLG
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDVHDCAQARQETYKYGKLQAGMVLTVEPGLYFQMDDLTVPKRYRGIGVRIEDDVVVTAR
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCHHHCCCCEEEECCEEEEEC
GCKVLSADIPRKAKDVEAWMKSLWAADKAARKGKKK
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SMATTRSSAAAQPALGEQQPIVTSEEQAPAAAPAKPATHDTVPPPALLDFMMKSWKPRS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
KKLPPKIKQAEAFKARRRALSKLFPGETLIIPTGHEKVRANDTNFRFRPGSDFYYLTGNL
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEECCCCCEEEEECCC
EPDCVLVLQPKEKGGHTDVLFVEPNPGRTDATFFTDRVKGELWEGPRLGVKESQARYGVD
CCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHCCHH
QARSLNELPAFLSGLSGAESRPTRLLRGLSPKVDGAVPAPGEKDKGLAQALSEMRLLKDA
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
QELRELQTSIDSTHRGFEDVIRGLKTAKTERYVEGIFNLRARVEGNDVGYRTIAASGAHA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCE
CILHWHHNDGPLVPGDLLLLDAGVEGQTLYTADITRTLPISGKFSKEQREIYELVLEAQD
EEEEEECCCCCCCCCCEEEEECCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHCC
AAFAEVKPGNDFMEPNRAAMRVLAEGLEALGILEDAEEALKDEHQFYKRYSLHNVSHMLG
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LDVHDCAQARQETYKYGKLQAGMVLTVEPGLYFQMDDLTVPKRYRGIGVRIEDDVVVTAR
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCHHHCCCCEEEECCEEEEEC
GCKVLSADIPRKAKDVEAWMKSLWAADKAARKGKKK
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]