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The map label for this gene is hisG [H]

Identifier: 108763734

GI number: 108763734

Start: 5188979

End: 5189839

Strand: Reverse

Name: hisG [H]

Synonym: MXAN_4230

Alternate gene names: 108763734

Gene position: 5189839-5188979 (Counterclockwise)

Preceding gene: 108758672

Following gene: 108759254

Centisome position: 56.78

GC content: 67.36

Gene sequence:

>861_bases
ATGCTGCTGAAGATTGCTCTGCCCAACAAAGGCCGCCTCTCGGACGAAGTACGGGAGTTGTTCAATGACGCGGGCCTGGA
GGTGCGGGCCCGGGGTGAGCGCGCGCTCACCGCGTCATTGGGCGGAGAGTTCGAGGCCATCTTCGTCCGCGCCCAGGACA
TCCCGGAGTTCGTGGCGGACGGCGCCGCGCATGCGGGTGTCACCGGTTGGGACCTGGTGTGTGAGTCCGGACGTGAGCTG
GACCTGCTGATGGACCTGGAGTTCGGCAGGTGTCGCCTGGTGGTGGCGGCGCGGGAGGAGGGCGGCTTCGCCTCGCCGGA
AGACGTGAAGGAGGGCATGCGGGTCGCGTCCTGCTTCCCCCGGCTGACGCAGGAGTTCTTCGCCAGGCGCGGGCAGCGGG
TGGCGGTGGTACCAGTATCGGGCGCGGCGGAGATTGCGCCCCATCTGGGCATCGCGGACATCGTCGTGGACCTGACGTCC
ACCGGCTCCACGCTGAAGATGAATGGCCTGCGCGAGGTCGGCACGGTGCTGGAGTCCAGCGCGCGGCTGGTGGCGTGCAA
GGGCAATCCGGTGGACACCCAGCAGAAGCTGGACGAGCTGAAGCAGGCGCTGGGCTCGGTGTTGGCGGCGCGCGACAAGC
GCTACCTGATGGCCAACGTGCCGAAGGATTCGCTCATCCGGGTGCGCGAAGTCCTCCCGGGCCTCAATGGTCCCACCGTG
GTGGACGTGCTGGACGGTGGTGACTTCGTGGCCGTGCACGCGGTGGTGCCGGCGAAGACCATCTACCGCACCATCAACGC
GCTGAAGGCACTGGGCTGCGAGGGCATCCTCGTCACCCGCATTGAAAGGTTGATGGCATGA

Upstream 100 bases:

>100_bases
CCACCTCGGCACCTGCCGCAGCGACCGAAGGCCCGTCCCCCCAGGACGGGCCTTTTTTCGTTTTCGGGCCGTTGTCTCCT
CGCAGTCTCGAAGGTCCCCC

Downstream 100 bases:

>100_bases
CGGCCTTCCTTGCTTCGTCGACCCTGAGGTACCGCGGTCCTCTGTCCGCTCTTGCTCGGGAGGACGTCCGGCGTCTGCTG
GACCGCGCGACTGGATCCGA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLLKIALPNKGRLSDEVRELFNDAGLEVRARGERALTASLGGEFEAIFVRAQDIPEFVADGAAHAGVTGWDLVCESGREL
DLLMDLEFGRCRLVVAAREEGGFASPEDVKEGMRVASCFPRLTQEFFARRGQRVAVVPVSGAAEIAPHLGIADIVVDLTS
TGSTLKMNGLREVGTVLESSARLVACKGNPVDTQQKLDELKQALGSVLAARDKRYLMANVPKDSLIRVREVLPGLNGPTV
VDVLDGGDFVAVHAVVPAKTIYRTINALKALGCEGILVTRIERLMA

Sequences:

>Translated_286_residues
MLLKIALPNKGRLSDEVRELFNDAGLEVRARGERALTASLGGEFEAIFVRAQDIPEFVADGAAHAGVTGWDLVCESGREL
DLLMDLEFGRCRLVVAAREEGGFASPEDVKEGMRVASCFPRLTQEFFARRGQRVAVVPVSGAAEIAPHLGIADIVVDLTS
TGSTLKMNGLREVGTVLESSARLVACKGNPVDTQQKLDELKQALGSVLAARDKRYLMANVPKDSLIRVREVLPGLNGPTV
VDVLDGGDFVAVHAVVPAKTIYRTINALKALGCEGILVTRIERLMA
>Mature_286_residues
MLLKIALPNKGRLSDEVRELFNDAGLEVRARGERALTASLGGEFEAIFVRAQDIPEFVADGAAHAGVTGWDLVCESGREL
DLLMDLEFGRCRLVVAAREEGGFASPEDVKEGMRVASCFPRLTQEFFARRGQRVAVVPVSGAAEIAPHLGIADIVVDLTS
TGSTLKMNGLREVGTVLESSARLVACKGNPVDTQQKLDELKQALGSVLAARDKRYLMANVPKDSLIRVREVLPGLNGPTV
VDVLDGGDFVAVHAVVPAKTIYRTINALKALGCEGILVTRIERLMA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=293, Percent_Identity=33.1058020477816, Blast_Score=156, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320896, Length=290, Percent_Identity=33.7931034482759, Blast_Score=139, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 30717; Mature: 30717

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKIALPNKGRLSDEVRELFNDAGLEVRARGERALTASLGGEFEAIFVRAQDIPEFVAD
CEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCEEEEHHCCCCEEEEEEEHHHHHHHHHC
GAAHAGVTGWDLVCESGRELDLLMDLEFGRCRLVVAAREEGGFASPEDVKEGMRVASCFP
CCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
RLTQEFFARRGQRVAVVPVSGAAEIAPHLGIADIVVDLTSTGSTLKMNGLREVGTVLESS
HHHHHHHHHCCCEEEEEECCCHHHHHCCCCHHHHHEECCCCCCEEEECCHHHHHHHHHCC
ARLVACKGNPVDTQQKLDELKQALGSVLAARDKRYLMANVPKDSLIRVREVLPGLNGPTV
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEE
VDVLDGGDFVAVHAVVPAKTIYRTINALKALGCEGILVTRIERLMA
EEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MLLKIALPNKGRLSDEVRELFNDAGLEVRARGERALTASLGGEFEAIFVRAQDIPEFVAD
CEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCEEEEHHCCCCEEEEEEEHHHHHHHHHC
GAAHAGVTGWDLVCESGRELDLLMDLEFGRCRLVVAAREEGGFASPEDVKEGMRVASCFP
CCCCCCCCHHHHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
RLTQEFFARRGQRVAVVPVSGAAEIAPHLGIADIVVDLTSTGSTLKMNGLREVGTVLESS
HHHHHHHHHCCCEEEEEECCCHHHHHCCCCHHHHHEECCCCCCEEEECCHHHHHHHHHCC
ARLVACKGNPVDTQQKLDELKQALGSVLAARDKRYLMANVPKDSLIRVREVLPGLNGPTV
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEE
VDVLDGGDFVAVHAVVPAKTIYRTINALKALGCEGILVTRIERLMA
EEEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA