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The map label for this gene is hisD [H]

Identifier: 108759254

GI number: 108759254

Start: 5187669

End: 5188982

Strand: Reverse

Name: hisD [H]

Synonym: MXAN_4229

Alternate gene names: 108759254

Gene position: 5188982-5187669 (Counterclockwise)

Preceding gene: 108763734

Following gene: 108757852

Centisome position: 56.77

GC content: 72.22

Gene sequence:

>1314_bases
ATGACGGCCTTCCTTGCTTCGTCGACCCTGAGGTACCGCGGTCCTCTGTCCGCTCTTGCTCGGGAGGACGTCCGGCGTCT
GCTGGACCGCGCGACTGGATCCGATGCCCGCGTCGCGCTGCGCGTGCGGGAGATCATCGCCCGCGTGCGAGCGGAAGGGG
ACCAGGCGCTCTTCGAACTCGCGCGGCAGTTCGACCGCGTGGAGCTGACGGCGCTGGAGGTTCCGCGAGAGGTCTGTGCC
GCGGCGCTCGCCGGATTGGAGCCATCGGTCAGGGACGCGCTGGCCCGAGCGGCCCGCAACATCGCCCTGGCGCACGCGCC
GCAGAAGCCGCAATGGGTGGAGGTCGAAACCGAGCCCGGTGTGCTCGTGGGCCGGCGGCCGGATCCGCTGGGCCGCGTGG
GGGTGTATGCACCGGGAGGCCGCGCGGTGTACCCCAGCAGCGTACTGATGGGGGTGGTGCCCGCGAAGGTAGCGGGCGTG
GGCGAGGTCATCGTGTGCTCGCCGCCGGGGCCCGATGGATTGCCACACCCCAGCGTGCTGGCGGCGGCATCTCTGGCGGG
CGCGGACCGAGTCTTCTCGCTGGGCGGCGCTGGCGCGGTGGCGGCCATGGCCCATGGCACGGAAAGCGTGCCGCGCGTGG
ACCGCATCGTGGGGCCGGGCAATGCCTATGTGGCCGAGGCCAAGCTGCAGGTGGTGGGCGCGGTGGCGATTGAAGCACCC
GCGGGCCCCAGTGAAATCCTGGTCGTGGCCGACGACACGGCGAACCCTGCCGCGGTGGCGCGGGAGATGCTGGCTCAGGC
GGAGCATGACCCAGAGGCGGCTTGTGTCACGCTGGCGCTGGGGGACGCGCTGGCGGACGCCATCGCCGCGGAGGTGGAGC
GGCAGGCCGAGCGCGCGAAGCGGTGGGAGATCGTCACGTCGGCCCTGGGCTCTCGCGGCGCGGTGCTGACGGTGGCGTCC
CTGGAGGAAGCCTGGCCCTTCGTGGCGGACTTTGCTCCGGAGCATCTGCTCATCGCCACCGCGTCGCCGCGGGAGGACCT
GGGGCAGGTGCGCAACGCGGGCACCGTCTTCCTGGGTGAGCGCTCGTCGGTGGCCTACGGCGATTACATGACCGGCTCCA
ACCACGTGTTGCCCACGGCGGGGTTGGCGCGGGCGTACTCGGGACTCAACCTGCTCGACTTCTACCGGTGGACCACCTAC
CAGCGCGTCGCGCCCACGGCGGCGGCGTCTCTTGCGGAGGACGTGGGGCGGCTGGCCGACAGTGAAGGTCTCTTCGCGCA
CGCGGACGCCGCGCGCGCCTGGGGGCGGCCATGA

Upstream 100 bases:

>100_bases
ACGCGGTGGTGCCGGCGAAGACCATCTACCGCACCATCAACGCGCTGAAGGCACTGGGCTGCGAGGGCATCCTCGTCACC
CGCATTGAAAGGTTGATGGC

Downstream 100 bases:

>100_bases
TTCCCAGGCGGGCTTCGTATCGGGACATTCCGCTGTACGCGCCTTCGACGCGGCCGTGCCGGGTGGACCTGAGTGACAAC
ACCAACCTCTTTGGCGTTCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTAFLASSTLRYRGPLSALAREDVRRLLDRATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEVPREVCA
AALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVGVYAPGGRAVYPSSVLMGVVPAKVAGV
GEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSLGGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQVVGAVAIEAP
AGPSEILVVADDTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGSRGAVLTVAS
LEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMTGSNHVLPTAGLARAYSGLNLLDFYRWTTY
QRVAPTAAASLAEDVGRLADSEGLFAHADAARAWGRP

Sequences:

>Translated_437_residues
MTAFLASSTLRYRGPLSALAREDVRRLLDRATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEVPREVCA
AALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVGVYAPGGRAVYPSSVLMGVVPAKVAGV
GEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSLGGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQVVGAVAIEAP
AGPSEILVVADDTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGSRGAVLTVAS
LEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMTGSNHVLPTAGLARAYSGLNLLDFYRWTTY
QRVAPTAAASLAEDVGRLADSEGLFAHADAARAWGRP
>Mature_436_residues
TAFLASSTLRYRGPLSALAREDVRRLLDRATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEVPREVCAA
ALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVGVYAPGGRAVYPSSVLMGVVPAKVAGVG
EVIVCSPPGPDGLPHPSVLAAASLAGADRVFSLGGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQVVGAVAIEAPA
GPSEILVVADDTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGSRGAVLTVASL
EEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMTGSNHVLPTAGLARAYSGLNLLDFYRWTTYQ
RVAPTAAASLAEDVGRLADSEGLFAHADAARAWGRP

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=413, Percent_Identity=42.1307506053269, Blast_Score=287, Evalue=9e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=38.6091127098321, Blast_Score=273, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45609; Mature: 45478

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFLASSTLRYRGPLSALAREDVRRLLDRATGSDARVALRVREIIARVRAEGDQALFEL
CCCEECCCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
ARQFDRVELTALEVPREVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPG
HHHHCCEEEHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCC
VLVGRRPDPLGRVGVYAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVL
EEECCCCCCCCCEEEECCCCCEECCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHH
AAASLAGADRVFSLGGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQVVGAVAIEAP
HHHHHCCCHHHEECCCCCHHHHHHCCCCCCCHHHHHCCCCCCEEEEHHEEEEEEEEEECC
AGPSEILVVADDTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAK
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
RWEIVTSALGSRGAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGE
HHHHHHHHHCCCCCEEEEECHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHCCCEEEEEC
RSSVAYGDYMTGSNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLAD
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SEGLFAHADAARAWGRP
CCCCEEECHHHHCCCCC
>Mature Secondary Structure 
TAFLASSTLRYRGPLSALAREDVRRLLDRATGSDARVALRVREIIARVRAEGDQALFEL
CCEECCCCHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
ARQFDRVELTALEVPREVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPG
HHHHCCEEEHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCC
VLVGRRPDPLGRVGVYAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVL
EEECCCCCCCCCEEEECCCCCEECCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHH
AAASLAGADRVFSLGGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQVVGAVAIEAP
HHHHHCCCHHHEECCCCCHHHHHHCCCCCCCHHHHHCCCCCCEEEEHHEEEEEEEEEECC
AGPSEILVVADDTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAK
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
RWEIVTSALGSRGAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGE
HHHHHHHHHCCCCCEEEEECHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHCCCEEEEEC
RSSVAYGDYMTGSNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLAD
CCCEEECCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SEGLFAHADAARAWGRP
CCCCEEECHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA