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The map label for this gene is nrdB [H]

Identifier: 108763495

GI number: 108763495

Start: 6333433

End: 6334482

Strand: Direct

Name: nrdB [H]

Synonym: MXAN_5058

Alternate gene names: 108763495

Gene position: 6333433-6334482 (Clockwise)

Preceding gene: 108757444

Following gene: 108757633

Centisome position: 69.3

GC content: 64.67

Gene sequence:

>1050_bases
TTGGAGACACCGCGCCGCAGCGCGAGGAGCACGGAAGCAATGCTGTTGAACCCTGGCCTGAATCTCACGCTGCGCCCGAT
GGCGTATCCGCAGTTCTTCGAGATGTACCGGAACGCCATCAAGAACACCTGGACCGTGGAGGAGGTGGACTTCTCCACGG
ACCTGGTGGACCTGCGCTCGAAGATGACGGACGCGGAGCGCCACCTCATCCACCGGCTGGTGGCGTTCTTCGCGACGGGT
GACAGCATCGTCGGCAACAACCTGGTGCTGAACCTCTACAAGCACCTGAACGCCCCTGAGGCGCGGATGTACCTGTCGCG
CCAGCTCTACGAGGAGGCGCTGCACGTCCAGTTCTACCTGACGCTGCTGGACACCTACGTGCCGGACCCGGCGGAGCGGG
CGATGGCCTTCGCGGCCGTCGACAACATCCCCTCCATCCAGCGCAAGGCGCAGTTCTGCATGAAGTGGATGGACAGCATC
CAGGGGCTGGACACGCTGCAGACGAAGGCGCACCGGCGGCAGTTCCTGCTGAACCTCATCTGCTTCGCGGGCTGCATTGA
GGGCCTCTTCTTCTTCGCAGCCTTCGCCTACGTGTACTTCCTGCGCAGCAAGGGCCTGTTGAACGGCCTGGCGGCGGGTA
CCAACTGGGTGTTCCGGGACGAGAGCGCCCACATGGCGTTCGCGTTCGAATCCATCCAGGTGGCACGCAAGGAAGAGCCG
GACCTCTTCGACGCACAGATGGAGCGCGACGTGGTGGCCATGCTCCGCGAGGCCGTGGAGTGCGAGACGCAGTTCGCCCA
GGACCTGCTGAGCGGCGGTGTCATGGGCCTGTCCGTACAGGACATGCGCGGCTACCTGGAGTACGTGGCGGACCAGCGGC
TCCAGATGCTGGGCATGACGCCGGTGTTCGGCACGAAGAACCCGCTGCACTTCATGGACCTGCAGGACGTGCAGGAGCTC
ACGAACTTCTTCGAGCGCCGCGTGTCGTCGTACCAGGTGGCCGTGGGTGTTGGCGCGGCCACGGACGTCGTGCTCGACGC
GGCGTTCTGA

Upstream 100 bases:

>100_bases
GACCGAGGCCGAGGCGGTGGCCTGCTCGCTGGAGAACCCGGAGGCGTGCGAGGCCTGCCAGTAGGCATGGGACGTTGACG
GTTTCGCAGTTGGAAGAACG

Downstream 100 bases:

>100_bases
GCGGCTGTGCGCTGTGTCCCGGGGCGCGGTTTACGCGCCCCCGTTGAGGTCACGGGGGGCCATCAGTGACTCTCAGGTTG
CCATCAGCCTCGGCTGGGCC

Product: ribonucleoside-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
METPRRSARSTEAMLLNPGLNLTLRPMAYPQFFEMYRNAIKNTWTVEEVDFSTDLVDLRSKMTDAERHLIHRLVAFFATG
DSIVGNNLVLNLYKHLNAPEARMYLSRQLYEEALHVQFYLTLLDTYVPDPAERAMAFAAVDNIPSIQRKAQFCMKWMDSI
QGLDTLQTKAHRRQFLLNLICFAGCIEGLFFFAAFAYVYFLRSKGLLNGLAAGTNWVFRDESAHMAFAFESIQVARKEEP
DLFDAQMERDVVAMLREAVECETQFAQDLLSGGVMGLSVQDMRGYLEYVADQRLQMLGMTPVFGTKNPLHFMDLQDVQEL
TNFFERRVSSYQVAVGVGAATDVVLDAAF

Sequences:

>Translated_349_residues
METPRRSARSTEAMLLNPGLNLTLRPMAYPQFFEMYRNAIKNTWTVEEVDFSTDLVDLRSKMTDAERHLIHRLVAFFATG
DSIVGNNLVLNLYKHLNAPEARMYLSRQLYEEALHVQFYLTLLDTYVPDPAERAMAFAAVDNIPSIQRKAQFCMKWMDSI
QGLDTLQTKAHRRQFLLNLICFAGCIEGLFFFAAFAYVYFLRSKGLLNGLAAGTNWVFRDESAHMAFAFESIQVARKEEP
DLFDAQMERDVVAMLREAVECETQFAQDLLSGGVMGLSVQDMRGYLEYVADQRLQMLGMTPVFGTKNPLHFMDLQDVQEL
TNFFERRVSSYQVAVGVGAATDVVLDAAF
>Mature_349_residues
METPRRSARSTEAMLLNPGLNLTLRPMAYPQFFEMYRNAIKNTWTVEEVDFSTDLVDLRSKMTDAERHLIHRLVAFFATG
DSIVGNNLVLNLYKHLNAPEARMYLSRQLYEEALHVQFYLTLLDTYVPDPAERAMAFAAVDNIPSIQRKAQFCMKWMDSI
QGLDTLQTKAHRRQFLLNLICFAGCIEGLFFFAAFAYVYFLRSKGLLNGLAAGTNWVFRDESAHMAFAFESIQVARKEEP
DLFDAQMERDVVAMLREAVECETQFAQDLLSGGVMGLSVQDMRGYLEYVADQRLQMLGMTPVFGTKNPLHFMDLQDVQEL
TNFFERRVSSYQVAVGVGAATDVVLDAAF

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=342, Percent_Identity=33.9181286549708, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI289177074, Length=340, Percent_Identity=34.1176470588235, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4557845, Length=340, Percent_Identity=32.0588235294118, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI260064013, Length=326, Percent_Identity=32.8220858895706, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI289177076, Length=305, Percent_Identity=34.4262295081967, Blast_Score=173, Evalue=2e-43,
Organism=Escherichia coli, GI1788567, Length=317, Percent_Identity=22.397476340694, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17551968, Length=323, Percent_Identity=32.1981424148607, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI193206379, Length=311, Percent_Identity=29.2604501607717, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17567153, Length=221, Percent_Identity=32.1266968325792, Blast_Score=120, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322434, Length=332, Percent_Identity=34.9397590361446, Blast_Score=193, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321619, Length=338, Percent_Identity=25.4437869822485, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18079279, Length=342, Percent_Identity=34.2105263157895, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 39754; Mature: 39754

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METPRRSARSTEAMLLNPGLNLTLRPMAYPQFFEMYRNAIKNTWTVEEVDFSTDLVDLRS
CCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
KMTDAERHLIHRLVAFFATGDSIVGNNLVLNLYKHLNAPEARMYLSRQLYEEALHVQFYL
HHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TLLDTYVPDPAERAMAFAAVDNIPSIQRKAQFCMKWMDSIQGLDTLQTKAHRRQFLLNLI
HHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
CFAGCIEGLFFFAAFAYVYFLRSKGLLNGLAAGTNWVFRDESAHMAFAFESIQVARKEEP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCC
DLFDAQMERDVVAMLREAVECETQFAQDLLSGGVMGLSVQDMRGYLEYVADQRLQMLGMT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PVFGTKNPLHFMDLQDVQELTNFFERRVSSYQVAVGVGAATDVVLDAAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHCCCC
>Mature Secondary Structure
METPRRSARSTEAMLLNPGLNLTLRPMAYPQFFEMYRNAIKNTWTVEEVDFSTDLVDLRS
CCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
KMTDAERHLIHRLVAFFATGDSIVGNNLVLNLYKHLNAPEARMYLSRQLYEEALHVQFYL
HHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TLLDTYVPDPAERAMAFAAVDNIPSIQRKAQFCMKWMDSIQGLDTLQTKAHRRQFLLNLI
HHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
CFAGCIEGLFFFAAFAYVYFLRSKGLLNGLAAGTNWVFRDESAHMAFAFESIQVARKEEP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCC
DLFDAQMERDVVAMLREAVECETQFAQDLLSGGVMGLSVQDMRGYLEYVADQRLQMLGMT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PVFGTKNPLHFMDLQDVQELTNFFERRVSSYQVAVGVGAATDVVLDAAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]