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The map label for this gene is nrdA [H]

Identifier: 108757444

GI number: 108757444

Start: 6331039

End: 6333396

Strand: Direct

Name: nrdA [H]

Synonym: MXAN_5057

Alternate gene names: 108757444

Gene position: 6331039-6333396 (Clockwise)

Preceding gene: 108762070

Following gene: 108763495

Centisome position: 69.27

GC content: 66.92

Gene sequence:

>2358_bases
ATGCGGGTGCGTAAGCGCAACGGCGGCACGGAGACGGTGGACCTCAACAAGATTGTGCGCGCCGTGGGCCGCTCCTGCGT
GGGCCTGCCCCGCGTGGACGCGATGCGCGTGGCCACCAAGACGATCTCCGGCCTGTATGACGGCGCGACGACGCGCGAGC
TGGACAGCCTCTCCATCCAGACGGCCGCCGCCCTCATCGTCGAAGAGCCCGAGTACGGCCGCCTCTCCGCGCGCCTGCTG
GCCACCTTCATCCAGAAGGAAGTCAGCAACCAGGACATCCACTCCTTCAGCCAGTCGGTGGCCGCGGGCCACAAGCACGG
GCTCATCGCGGACCGGCTGCTCCAGTTCGTCCAGGCCAACGCGCGCAAGCTCAACGCGGCCATCGACCCGTCGCGCAACG
ACCTCTTCGAGTACTTCGGCCTGCGCACCGTCTACGACCGGTACCTGCTGAAGAACCCGCAGACGCGTGAGGTGCTGGAG
ACGCCGCAGGAGTTCTTCCTCCGCGTGGCCAGCGCGCTCAGCGGCGACAATGTGAATGAGGCCATCGAGCTGTACCGGCT
GTTCAGCTCGCTGGAGTACCTGCCCAGCTCCCCCACCCTGTTCAACTCGGGCACGCGCCACGAGCAGCTTTCGAGCTGCT
TCCTGCTGGACTCGCCCGCGGACGAGCTGGACGCCATCTACAAGAAGTATTCGGACATCGCGATGCTGTCGAAGTTCTCC
GGCGGCATCGGCGTGGCGTACCACCGGGTGCGCGCACGCGGCTCGCTCATCAAGTCCACCAACGGGCACTCCAACGGCAT
CGTCCCCTGGCTGAAGACGCTGGACGCCTCCGTGGCGGCGGTGAACCAGGGCGGCAAGCGCAAGGGCGCGTGCTGCGTGT
ACCTGGAGACGTGGCACGCGGACATCGAGGACTTCCTCGAGCTGCGTGAGAACACCGGCGACGACGCGCGCCGCACGCAC
AACCTGAACCTGGCCAACTGGGTGCCGGACCTCTTCATGAAGCGCGTGGAGGCGGACGGCGACTGGAGCCTGTTCGACCC
GAAGTCCGTCCCCCACTTCACGGACCTGTACGGCGACGCCTTCGAGCAGGCCTACGCGAAGGCCGAGGCCGACGGCCTGG
CCATGCGCAAGGTGAAGGCGCGTGACCTCTACGCCCGGATGATGAAGAGCCTGGCGCAGACGGGTAACGGCTGGATGACC
TTCAAGGACATCAGCAACCGCAAGAGCAACCAGACGGGCAAGGCGGGCAACGTCATCCACCTGTCCAACCTGTGCACCGA
AATCCTGGAGGTGACGAGCCAGGGTGAGACGGCGGTGTGCAATCTGGGCTCGCTGAACCTGAGCCGGATGCTGGTGGACG
GGAAGTTCGACTTCGAGCGGCTGCGCGCCAACGCCCAGCTCGCGATGCGGCAGCTCGACCGCGTCATCGACCTGAACTAC
TACCCCATCCCCACGGCGGCTTCGTCCAACAAGCGCTGGCGCCCGGTGGGCCTGGGCCTGATGGGGCTCCAGGACGTCTT
CTTCCAGCTCAAGCTGGCCTTCGACTCGGCGGAGGCGCGTGCGCTCTCCAAGAAGATTTCGGAGGAGATCTACTTCGCGG
CGCTGACCACGTCCTGCGAGCTGGCCGAGCAGTACGGCGCCCACGAGTCCTTCGCGGAGACGCGGGCGGCCAAGGGCGAG
CTCCAGTTCGACCACTGGGGCGTGGTGCCCGAGGACACGGCGCGCTGGGACGCGCTGCGCCAGCGCATCATGAAGCACGG
CCTGCGCAACTCGCTGATGATTGCCATTGCCCCCACGGCGACGATTGCGTCCATCGTGGGCTGCTACGAGTGCATCGAGC
CGCAGGTGTCCAACCTGTTCAAGCGCGAGACGCTGTCGGGTGACTTCCTCCAGGTGAACCGCTACCTGGTGCGCGACCTC
CAGGCGCTCGGGCTGTGGAACGAGAACATCCGCAACCGCATCAAGATGGCGGAAGGCAGCGTTCAGGACATTACGGAGCT
GCCGGAGAACCTGCGCGCGGTGTACCGCACGGCGTGGGAGCTGCCGATGCGCTCGCTGCTGGACATGGGCGCGGACCGCG
GGGCGTTCATCGACCAGAGCCAGTCGCTCAACCTCTTCGTCGAGACGCCGAACATCGGGAAGCTGTCCTCGATGTACTTC
TACGCGTGGCAGAAGGGCCTGAAGACCACGTACTACCTGCGCTCGCGTCCGGCGACGCGGATTGCCAAGGCCACGGTGGG
CGCGGGTGGTGGCGCCAGCGTGGCGCAGGCGGCCCCTGCTCCGGTGGCGAAGGCGACCGAGGCCGAGGCGGTGGCCTGCT
CGCTGGAGAACCCGGAGGCGTGCGAGGCCTGCCAGTAG

Upstream 100 bases:

>100_bases
CGGTCCGTCCACGCCGGCGACGACGACAGCGCCGACGGGCGCCGCTGCCTCGGGCGCGGTTGCTTCCGAGCCCACGGCGG
GCGACTTCAGCGCCACCTCC

Downstream 100 bases:

>100_bases
GCATGGGACGTTGACGGTTTCGCAGTTGGAAGAACGTTGGAGACACCGCGCCGCAGCGCGAGGAGCACGGAAGCAATGCT
GTTGAACCCTGGCCTGAATC

Product: ribonucleoside-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MRVRKRNGGTETVDLNKIVRAVGRSCVGLPRVDAMRVATKTISGLYDGATTRELDSLSIQTAAALIVEEPEYGRLSARLL
ATFIQKEVSNQDIHSFSQSVAAGHKHGLIADRLLQFVQANARKLNAAIDPSRNDLFEYFGLRTVYDRYLLKNPQTREVLE
TPQEFFLRVASALSGDNVNEAIELYRLFSSLEYLPSSPTLFNSGTRHEQLSSCFLLDSPADELDAIYKKYSDIAMLSKFS
GGIGVAYHRVRARGSLIKSTNGHSNGIVPWLKTLDASVAAVNQGGKRKGACCVYLETWHADIEDFLELRENTGDDARRTH
NLNLANWVPDLFMKRVEADGDWSLFDPKSVPHFTDLYGDAFEQAYAKAEADGLAMRKVKARDLYARMMKSLAQTGNGWMT
FKDISNRKSNQTGKAGNVIHLSNLCTEILEVTSQGETAVCNLGSLNLSRMLVDGKFDFERLRANAQLAMRQLDRVIDLNY
YPIPTAASSNKRWRPVGLGLMGLQDVFFQLKLAFDSAEARALSKKISEEIYFAALTTSCELAEQYGAHESFAETRAAKGE
LQFDHWGVVPEDTARWDALRQRIMKHGLRNSLMIAIAPTATIASIVGCYECIEPQVSNLFKRETLSGDFLQVNRYLVRDL
QALGLWNENIRNRIKMAEGSVQDITELPENLRAVYRTAWELPMRSLLDMGADRGAFIDQSQSLNLFVETPNIGKLSSMYF
YAWQKGLKTTYYLRSRPATRIAKATVGAGGGASVAQAAPAPVAKATEAEAVACSLENPEACEACQ

Sequences:

>Translated_785_residues
MRVRKRNGGTETVDLNKIVRAVGRSCVGLPRVDAMRVATKTISGLYDGATTRELDSLSIQTAAALIVEEPEYGRLSARLL
ATFIQKEVSNQDIHSFSQSVAAGHKHGLIADRLLQFVQANARKLNAAIDPSRNDLFEYFGLRTVYDRYLLKNPQTREVLE
TPQEFFLRVASALSGDNVNEAIELYRLFSSLEYLPSSPTLFNSGTRHEQLSSCFLLDSPADELDAIYKKYSDIAMLSKFS
GGIGVAYHRVRARGSLIKSTNGHSNGIVPWLKTLDASVAAVNQGGKRKGACCVYLETWHADIEDFLELRENTGDDARRTH
NLNLANWVPDLFMKRVEADGDWSLFDPKSVPHFTDLYGDAFEQAYAKAEADGLAMRKVKARDLYARMMKSLAQTGNGWMT
FKDISNRKSNQTGKAGNVIHLSNLCTEILEVTSQGETAVCNLGSLNLSRMLVDGKFDFERLRANAQLAMRQLDRVIDLNY
YPIPTAASSNKRWRPVGLGLMGLQDVFFQLKLAFDSAEARALSKKISEEIYFAALTTSCELAEQYGAHESFAETRAAKGE
LQFDHWGVVPEDTARWDALRQRIMKHGLRNSLMIAIAPTATIASIVGCYECIEPQVSNLFKRETLSGDFLQVNRYLVRDL
QALGLWNENIRNRIKMAEGSVQDITELPENLRAVYRTAWELPMRSLLDMGADRGAFIDQSQSLNLFVETPNIGKLSSMYF
YAWQKGLKTTYYLRSRPATRIAKATVGAGGGASVAQAAPAPVAKATEAEAVACSLENPEACEACQ
>Mature_785_residues
MRVRKRNGGTETVDLNKIVRAVGRSCVGLPRVDAMRVATKTISGLYDGATTRELDSLSIQTAAALIVEEPEYGRLSARLL
ATFIQKEVSNQDIHSFSQSVAAGHKHGLIADRLLQFVQANARKLNAAIDPSRNDLFEYFGLRTVYDRYLLKNPQTREVLE
TPQEFFLRVASALSGDNVNEAIELYRLFSSLEYLPSSPTLFNSGTRHEQLSSCFLLDSPADELDAIYKKYSDIAMLSKFS
GGIGVAYHRVRARGSLIKSTNGHSNGIVPWLKTLDASVAAVNQGGKRKGACCVYLETWHADIEDFLELRENTGDDARRTH
NLNLANWVPDLFMKRVEADGDWSLFDPKSVPHFTDLYGDAFEQAYAKAEADGLAMRKVKARDLYARMMKSLAQTGNGWMT
FKDISNRKSNQTGKAGNVIHLSNLCTEILEVTSQGETAVCNLGSLNLSRMLVDGKFDFERLRANAQLAMRQLDRVIDLNY
YPIPTAASSNKRWRPVGLGLMGLQDVFFQLKLAFDSAEARALSKKISEEIYFAALTTSCELAEQYGAHESFAETRAAKGE
LQFDHWGVVPEDTARWDALRQRIMKHGLRNSLMIAIAPTATIASIVGCYECIEPQVSNLFKRETLSGDFLQVNRYLVRDL
QALGLWNENIRNRIKMAEGSVQDITELPENLRAVYRTAWELPMRSLLDMGADRGAFIDQSQSLNLFVETPNIGKLSSMYF
YAWQKGLKTTYYLRSRPATRIAKATVGAGGGASVAQAAPAPVAKATEAEAVACSLENPEACEACQ

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=795, Percent_Identity=43.1446540880503, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI2367133, Length=809, Percent_Identity=28.3065512978986, Blast_Score=259, Evalue=6e-70,
Organism=Escherichia coli, GI1789030, Length=640, Percent_Identity=27.8125, Blast_Score=213, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17555242, Length=784, Percent_Identity=44.2602040816327, Blast_Score=679, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320914, Length=762, Percent_Identity=43.1758530183727, Blast_Score=644, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322123, Length=783, Percent_Identity=41.3793103448276, Blast_Score=634, Evalue=0.0,
Organism=Drosophila melanogaster, GI17352481, Length=804, Percent_Identity=41.5422885572139, Blast_Score=653, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 87184; Mature: 87184

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRKRNGGTETVDLNKIVRAVGRSCVGLPRVDAMRVATKTISGLYDGATTRELDSLSIQ
CCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TAAALIVEEPEYGRLSARLLATFIQKEVSNQDIHSFSQSVAAGHKHGLIADRLLQFVQAN
HHHHHEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ARKLNAAIDPSRNDLFEYFGLRTVYDRYLLKNPQTREVLETPQEFFLRVASALSGDNVNE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHCCCCHHH
AIELYRLFSSLEYLPSSPTLFNSGTRHEQLSSCFLLDSPADELDAIYKKYSDIAMLSKFS
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHC
GGIGVAYHRVRARGSLIKSTNGHSNGIVPWLKTLDASVAAVNQGGKRKGACCVYLETWHA
CCHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHC
DIEDFLELRENTGDDARRTHNLNLANWVPDLFMKRVEADGDWSLFDPKSVPHFTDLYGDA
CHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
FEQAYAKAEADGLAMRKVKARDLYARMMKSLAQTGNGWMTFKDISNRKSNQTGKAGNVIH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCEEE
LSNLCTEILEVTSQGETAVCNLGSLNLSRMLVDGKFDFERLRANAQLAMRQLDRVIDLNY
HHHHHHHHHHHHCCCCEEEEECCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
YPIPTAASSNKRWRPVGLGLMGLQDVFFQLKLAFDSAEARALSKKISEEIYFAALTTSCE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
LAEQYGAHESFAETRAAKGELQFDHWGVVPEDTARWDALRQRIMKHGLRNSLMIAIAPTA
HHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHH
TIASIVGCYECIEPQVSNLFKRETLSGDFLQVNRYLVRDLQALGLWNENIRNRIKMAEGS
HHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
VQDITELPENLRAVYRTAWELPMRSLLDMGADRGAFIDQSQSLNLFVETPNIGKLSSMYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHH
YAWQKGLKTTYYLRSRPATRIAKATVGAGGGASVAQAAPAPVAKATEAEAVACSLENPEA
HHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCCC
CEACQ
CCCCC
>Mature Secondary Structure
MRVRKRNGGTETVDLNKIVRAVGRSCVGLPRVDAMRVATKTISGLYDGATTRELDSLSIQ
CCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TAAALIVEEPEYGRLSARLLATFIQKEVSNQDIHSFSQSVAAGHKHGLIADRLLQFVQAN
HHHHHEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ARKLNAAIDPSRNDLFEYFGLRTVYDRYLLKNPQTREVLETPQEFFLRVASALSGDNVNE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHHCCCCHHH
AIELYRLFSSLEYLPSSPTLFNSGTRHEQLSSCFLLDSPADELDAIYKKYSDIAMLSKFS
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHC
GGIGVAYHRVRARGSLIKSTNGHSNGIVPWLKTLDASVAAVNQGGKRKGACCVYLETWHA
CCHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHHHC
DIEDFLELRENTGDDARRTHNLNLANWVPDLFMKRVEADGDWSLFDPKSVPHFTDLYGDA
CHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
FEQAYAKAEADGLAMRKVKARDLYARMMKSLAQTGNGWMTFKDISNRKSNQTGKAGNVIH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCEEE
LSNLCTEILEVTSQGETAVCNLGSLNLSRMLVDGKFDFERLRANAQLAMRQLDRVIDLNY
HHHHHHHHHHHHCCCCEEEEECCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
YPIPTAASSNKRWRPVGLGLMGLQDVFFQLKLAFDSAEARALSKKISEEIYFAALTTSCE
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
LAEQYGAHESFAETRAAKGELQFDHWGVVPEDTARWDALRQRIMKHGLRNSLMIAIAPTA
HHHHCCCHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHH
TIASIVGCYECIEPQVSNLFKRETLSGDFLQVNRYLVRDLQALGLWNENIRNRIKMAEGS
HHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
VQDITELPENLRAVYRTAWELPMRSLLDMGADRGAFIDQSQSLNLFVETPNIGKLSSMYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHH
YAWQKGLKTTYYLRSRPATRIAKATVGAGGGASVAQAAPAPVAKATEAEAVACSLENPEA
HHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCCCC
CEACQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]