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The map label for this gene is nhaA

Identifier: 108763283

GI number: 108763283

Start: 4688594

End: 4689943

Strand: Direct

Name: nhaA

Synonym: MXAN_3898

Alternate gene names: 108763283

Gene position: 4688594-4689943 (Clockwise)

Preceding gene: 108758977

Following gene: 108762347

Centisome position: 51.3

GC content: 70.37

Gene sequence:

>1350_bases
ATGGCGCAGACACCCCCTACCTCAGAGGCCCGGCCCCGGCCTCCAGTCCCCACGCTCTTCCGCGTGGCCCTGGCTCCCAT
CCAGGCCTTCTTCCGCCTGGAGGCGGCCAGCGGCATCCTGCTCGCGCTGTGCGCCGTGGCCGCCATGGTGTGGGCCAACT
CGCCGTGGGCCGCCACCTACTCCGCCGTGTTCGACGCCCGCATGACGGTGGGCCTGGCGGGCGTCCACGCGGGCTTCACC
ATCCGCGAGTTCATCAACGACGGGCTGATGACGCTGTTCTTCTTCGTCGTCGGCATGGAAATCAAGCGCGAGCTGAGCTC
GGGTGAGCTGCGCACCTTCTCCCGCGCGGTGCTGCCGCTCATCGCCGCGATGGGCGGCATGATTGTCCCCGCCGCGCTCT
ACGCCGCCTTCAACCAGGGGACGCCCGCGCAGGCGGGCTGGGCCATCCCCATGGCCACCGACATCGCCTTCTCCATTGGC
TGCCTCACGCTGGTCAAGACGCGCGTGAGCCACGGGCTGGTCGTGTTCCTCACGGCGCTGGCCATCTTCGATGACATCGG
CGGAATCCTCGTCATCGCGCTCTTCTACGGCTCGGGGCTCCACGTCAGCTGGCTCGTGGGAGCCCTGGGCGTGCTTGCCG
TGCTGGCGTGCCTCAACCACTTCCAGGTGCGCAACGGCGTGGCGTACGCGCTGGCGGGCGCGGCGCTCTGGTACACGATG
CACCACGGCGGCATCCACGCCACGCTGTCGGGCGTGGTGCTGGGCCTGTTCATGCCCGCCCGGCCCCTGCGTCCGGGCCG
CCACGTGCTGGAGGAACTGCGCCTCTACGTGGACCGGGCGCTCCAGACGGCGATGGACGAGGCGACGCGGGGCGCGCAGA
TTCTCTACCTCGAGGAGCGCCTGGAGGAGCTGGAGCCGCCGCTCAACCGCTTCGTCCACCTGTGGCACGTGCCCGTGGCG
TACGGCATCGTCCCCCTCTTCGCCCTGGCCAACTCGGGCATCTCCCTGGAGGGCATGGGCTGGGCGGACCTGCTCCGGCC
GCTGCCGCTGGGCATCATCGCCGGCCTCTTCGTGGGCAAGCAGGTGGGCATCTTCCTGTTCACCTGGGGCTCGCTGAAGC
TGGGCGTGGCCGACCGGCCCGGCGGTGCGACGCTGCCGCAGCTTCACGGCGTCGCGGTGGTGGCGGGCATTGGCTTCACG
GTGGCCCTGTTCGTGGCGGGGCTGGCCTTCCCCACCCAGCCGGAGCTGCTCACGGAGGCCAAGCTGGGCATTCTGGTGGG
CTCGCTGCTTTCCGCGGTGGTGGGCTACGCACTCTTGCGCTTCGTGGCGAAACCGGCCGTCCCGGCGTAA

Upstream 100 bases:

>100_bases
TACCCGCCGAGTTCCCTTACCACCCCCCGCCGACATTCCACCCACCCCACCGCTGAAAACGGGTGTCAGACCCGGCGACG
CGGGGCATCGTGCGCGCCGC

Downstream 100 bases:

>100_bases
CGTAGAGGACAGGAACGCTCGTGATTCTCCAAGACCTCAACCGCGTGCGGCAAATCACCGTCATCGCGGCACGCCACGGC
TTTGGCGAGCTGGCGGAGCG

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAQTPPTSEARPRPPVPTLFRVALAPIQAFFRLEAASGILLALCAVAAMVWANSPWAATYSAVFDARMTVGLAGVHAGFT
IREFINDGLMTLFFFVVGMEIKRELSSGELRTFSRAVLPLIAAMGGMIVPAALYAAFNQGTPAQAGWAIPMATDIAFSIG
CLTLVKTRVSHGLVVFLTALAIFDDIGGILVIALFYGSGLHVSWLVGALGVLAVLACLNHFQVRNGVAYALAGAALWYTM
HHGGIHATLSGVVLGLFMPARPLRPGRHVLEELRLYVDRALQTAMDEATRGAQILYLEERLEELEPPLNRFVHLWHVPVA
YGIVPLFALANSGISLEGMGWADLLRPLPLGIIAGLFVGKQVGIFLFTWGSLKLGVADRPGGATLPQLHGVAVVAGIGFT
VALFVAGLAFPTQPELLTEAKLGILVGSLLSAVVGYALLRFVAKPAVPA

Sequences:

>Translated_449_residues
MAQTPPTSEARPRPPVPTLFRVALAPIQAFFRLEAASGILLALCAVAAMVWANSPWAATYSAVFDARMTVGLAGVHAGFT
IREFINDGLMTLFFFVVGMEIKRELSSGELRTFSRAVLPLIAAMGGMIVPAALYAAFNQGTPAQAGWAIPMATDIAFSIG
CLTLVKTRVSHGLVVFLTALAIFDDIGGILVIALFYGSGLHVSWLVGALGVLAVLACLNHFQVRNGVAYALAGAALWYTM
HHGGIHATLSGVVLGLFMPARPLRPGRHVLEELRLYVDRALQTAMDEATRGAQILYLEERLEELEPPLNRFVHLWHVPVA
YGIVPLFALANSGISLEGMGWADLLRPLPLGIIAGLFVGKQVGIFLFTWGSLKLGVADRPGGATLPQLHGVAVVAGIGFT
VALFVAGLAFPTQPELLTEAKLGILVGSLLSAVVGYALLRFVAKPAVPA
>Mature_448_residues
AQTPPTSEARPRPPVPTLFRVALAPIQAFFRLEAASGILLALCAVAAMVWANSPWAATYSAVFDARMTVGLAGVHAGFTI
REFINDGLMTLFFFVVGMEIKRELSSGELRTFSRAVLPLIAAMGGMIVPAALYAAFNQGTPAQAGWAIPMATDIAFSIGC
LTLVKTRVSHGLVVFLTALAIFDDIGGILVIALFYGSGLHVSWLVGALGVLAVLACLNHFQVRNGVAYALAGAALWYTMH
HGGIHATLSGVVLGLFMPARPLRPGRHVLEELRLYVDRALQTAMDEATRGAQILYLEERLEELEPPLNRFVHLWHVPVAY
GIVPLFALANSGISLEGMGWADLLRPLPLGIIAGLFVGKQVGIFLFTWGSLKLGVADRPGGATLPQLHGVAVVAGIGFTV
ALFVAGLAFPTQPELLTEAKLGILVGSLLSAVVGYALLRFVAKPAVPA

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=366, Percent_Identity=45.6284153005465, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA1_MYXXD (Q1D5J5)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632078.1
- ProteinModelPortal:   Q1D5J5
- SMR:   Q1D5J5
- STRING:   Q1D5J5
- GeneID:   4107038
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3898
- TIGR:   MXAN_3898
- eggNOG:   COG3004
- HOGENOM:   HBG665619
- OMA:   KISSAHE
- PhylomeDB:   Q1D5J5
- ProtClustDB:   CLSK955472
- BioCyc:   MXAN246197:MXAN_3898-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 47617; Mature: 47486

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19bba204)-; HASH(0x1af06898)-; HASH(0x1aefa63c)-; HASH(0x1ac97d94)-; HASH(0x1ac9b0b4)-; HASH(0x1af0511c)-; HASH(0x1ac8f7f8)-; HASH(0x1ac9b0d8)-; HASH(0x1aeffdb4)-; HASH(0x1d465a60)-; HASH(0x1af03ca8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQTPPTSEARPRPPVPTLFRVALAPIQAFFRLEAASGILLALCAVAAMVWANSPWAATY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
SAVFDARMTVGLAGVHAGFTIREFINDGLMTLFFFVVGMEIKRELSSGELRTFSRAVLPL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IAAMGGMIVPAALYAAFNQGTPAQAGWAIPMATDIAFSIGCLTLVKTRVSHGLVVFLTAL
HHHHCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIFDDIGGILVIALFYGSGLHVSWLVGALGVLAVLACLNHFQVRNGVAYALAGAALWYTM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
HHGGIHATLSGVVLGLFMPARPLRPGRHVLEELRLYVDRALQTAMDEATRGAQILYLEER
HCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
LEELEPPLNRFVHLWHVPVAYGIVPLFALANSGISLEGMGWADLLRPLPLGIIAGLFVGK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QVGIFLFTWGSLKLGVADRPGGATLPQLHGVAVVAGIGFTVALFVAGLAFPTQPELLTEA
HCCEEEEEECCEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KLGILVGSLLSAVVGYALLRFVAKPAVPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
AQTPPTSEARPRPPVPTLFRVALAPIQAFFRLEAASGILLALCAVAAMVWANSPWAATY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHH
SAVFDARMTVGLAGVHAGFTIREFINDGLMTLFFFVVGMEIKRELSSGELRTFSRAVLPL
HHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IAAMGGMIVPAALYAAFNQGTPAQAGWAIPMATDIAFSIGCLTLVKTRVSHGLVVFLTAL
HHHHCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AIFDDIGGILVIALFYGSGLHVSWLVGALGVLAVLACLNHFQVRNGVAYALAGAALWYTM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
HHGGIHATLSGVVLGLFMPARPLRPGRHVLEELRLYVDRALQTAMDEATRGAQILYLEER
HCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
LEELEPPLNRFVHLWHVPVAYGIVPLFALANSGISLEGMGWADLLRPLPLGIIAGLFVGK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QVGIFLFTWGSLKLGVADRPGGATLPQLHGVAVVAGIGFTVALFVAGLAFPTQPELLTEA
HCCEEEEEECCEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KLGILVGSLLSAVVGYALLRFVAKPAVPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA