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The map label for this gene is purM

Identifier: 108763087

GI number: 108763087

Start: 3151821

End: 3152858

Strand: Reverse

Name: purM

Synonym: MXAN_2701

Alternate gene names: 108763087

Gene position: 3152858-3151821 (Counterclockwise)

Preceding gene: 108756885

Following gene: 108763836

Centisome position: 34.5

GC content: 69.46

Gene sequence:

>1038_bases
GTGGGAACGACCTACAAGCAGTCCGGAGTAGACATCGAGGCCGGCGACGCGTTCGTCGAGCGCATCAAGCCCCATGCCGC
GCGCACCATGCGCCCTGAAGTCATGGGCGGAGTGGGTGGATTCGGCGGCCTGTTCGCCCTGCCACCAGGCAAGTACCAGC
AGCCAGTGCTGGTGGCCGGCACGGACGGCGTGGGCACCAAGCTGAAGGTGGCCTTCGCCGCTGGACGCCATGGGACGGTG
GGCATCGACCTGGTGGCCATGTCGGTGAACGACATCCTCACCTGCGGCGCCGAGCCCCTCTTCTTCCTCGACTACTTCGC
CACCGGGCGCCTGGAGGTCGACGACGCCGCCGAGGTGGTGAAGGGCATCGCCCTGGGCTGCGAGCAGGCCGGGTGCGCCC
TGCTGGGCGGCGAGACGGCGGAGATGCCAGGCTTCTACGCGCGCGGCGAATACGACCTCGCGGGCTTCTGCGTGGGCGTG
GTGGAGCGCGCGGCCATCATCGACGGCAAGAGCGTGAAGCCGGGTGACGCGCTCATCGGGCTCCCCTCCTCTGGCCTGCA
CAGCAACGGCTATTCGCTGGCGCGCAAGGTGCTGCTGGACGACGGAAAGCTGGCCCTGGACGCGACGCCCGAGGGCCTGG
ACCGGCCGCTCGTGGACGCGCTACTGGAGCCCACGCGCATCTACGTGAAGGACGTGCTGGCGCTGCTCCAGGCGGTGAAG
GTGAAGGGCCTGGCGCACATCACCGGCAGCGGCATTCCAGGCAACCTGCCCCGCTGCCTGCCGGACGGCACGCGCGCGGT
GCTGAGTGAGCAGACTTGGCCCAAGCCGCCCATCTTCGACCTCATCGCGAAGCTGGGGAGCGTGGCCCGCGACGAGATGT
TCAACACGTTCAACATGGGCCTGGGGCTCATCCTCGTCGTGGCGAAGGAAGACGTCGCCCAGGCGCTGAGCGTGCTGAGC
GGCCGGGGCGTGCAGGCCTTCGAGGTCGGCCGCGTGGAAGCGGGCCAGGGCGAGGCCACGGCGGTCATCGACCCATGA

Upstream 100 bases:

>100_bases
CCCACACTCGCCCGGTCAAATTCCCTTTTCTGTGCGCACCGGTGGGACAGCCGCCACGCCACGCGAGACACCGGCGCGGG
GGCCGGGTAGAAGGCCGCCC

Downstream 100 bases:

>100_bases
GCGGCCAGCGAGTCCGCCTGGGCGTGCTCGTGTCCGGCAGCGGGAGCAACCTCCAGGCGCTGCTGGACGCCTGTGCGCGG
GAGGACTTTCCCGCCGAGGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAGTDGVGTKLKVAFAAGRHGTV
GIDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVVKGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGV
VERAAIIDGKSVKPGDALIGLPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVK
VKGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMGLGLILVVAKEDVAQALSVLS
GRGVQAFEVGRVEAGQGEATAVIDP

Sequences:

>Translated_345_residues
MGTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAGTDGVGTKLKVAFAAGRHGTV
GIDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVVKGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGV
VERAAIIDGKSVKPGDALIGLPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVK
VKGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMGLGLILVVAKEDVAQALSVLS
GRGVQAFEVGRVEAGQGEATAVIDP
>Mature_344_residues
GTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAGTDGVGTKLKVAFAAGRHGTVG
IDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVVKGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGVV
ERAAIIDGKSVKPGDALIGLPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVKV
KGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMGLGLILVVAKEDVAQALSVLSG
RGVQAFEVGRVEAGQGEATAVIDP

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=333, Percent_Identity=48.6486486486487, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI209869995, Length=333, Percent_Identity=48.6486486486487, Blast_Score=302, Evalue=3e-82,
Organism=Homo sapiens, GI209869993, Length=333, Percent_Identity=48.6486486486487, Blast_Score=302, Evalue=3e-82,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=55.2631578947368, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=40.0576368876081, Blast_Score=238, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=46.2686567164179, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24582400, Length=316, Percent_Identity=44.9367088607595, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_MYXXD (Q1D8V5)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630918.1
- ProteinModelPortal:   Q1D8V5
- SMR:   Q1D8V5
- STRING:   Q1D8V5
- GeneID:   4106841
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2701
- TIGR:   MXAN_2701
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   Q1D8V5
- ProtClustDB:   PRK05385
- BioCyc:   MXAN246197:MXAN_2701-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 35859; Mature: 35728

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAG
CCCCCCCCCCEEECCHHHHHHHCHHHHHHCCHHHHCCCCCCCCEEECCCCCCCCCEEEEC
TDGVGTKLKVAFAAGRHGTVGIDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVV
CCCCCCEEEEEEECCCCCCEEEEEEEEEHHHHHHCCCCHHEEEHHHHCCCEECHHHHHHH
KGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGVVERAAIIDGKSVKPGDALIG
HHHHHCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVK
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
VKGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMG
HCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LGLILVVAKEDVAQALSVLSGRGVQAFEVGRVEAGQGEATAVIDP
CEEEEEEEHHHHHHHHHHHCCCCCEEEEECCEECCCCCEEEEECC
>Mature Secondary Structure 
GTTYKQSGVDIEAGDAFVERIKPHAARTMRPEVMGGVGGFGGLFALPPGKYQQPVLVAG
CCCCCCCCCEEECCHHHHHHHCHHHHHHCCHHHHCCCCCCCCEEECCCCCCCCCEEEEC
TDGVGTKLKVAFAAGRHGTVGIDLVAMSVNDILTCGAEPLFFLDYFATGRLEVDDAAEVV
CCCCCCEEEEEEECCCCCCEEEEEEEEEHHHHHHCCCCHHEEEHHHHCCCEECHHHHHHH
KGIALGCEQAGCALLGGETAEMPGFYARGEYDLAGFCVGVVERAAIIDGKSVKPGDALIG
HHHHHCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LPSSGLHSNGYSLARKVLLDDGKLALDATPEGLDRPLVDALLEPTRIYVKDVLALLQAVK
CCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
VKGLAHITGSGIPGNLPRCLPDGTRAVLSEQTWPKPPIFDLIAKLGSVARDEMFNTFNMG
HCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LGLILVVAKEDVAQALSVLSGRGVQAFEVGRVEAGQGEATAVIDP
CEEEEEEEHHHHHHHHHHHCCCCCEEEEECCEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA