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The map label for this gene is gnd [H]

Identifier: 108762961

GI number: 108762961

Start: 1092457

End: 1093881

Strand: Reverse

Name: gnd [H]

Synonym: MXAN_0951

Alternate gene names: 108762961

Gene position: 1093881-1092457 (Counterclockwise)

Preceding gene: 108763790

Following gene: 108756875

Centisome position: 11.97

GC content: 69.12

Gene sequence:

>1425_bases
ATGAGTGAGTCAGCGGGCGCGCAGTTCGGCGTGGCGGGAATGGGCGTCATGGGGGCGAGCCTCGCCCTCAACATCGCGGA
CCACGGCTTCCGGGTGGCCGTGTGGGACAGGCATGCGGAGCGCATCGATGAGATGCACCGCAAACACGGACACCCCGAGG
TCTGGGGCACCGAGTCGCTGGAGGCCTTCGTTCAGCGACTGGAGCGCCCGCGCAAGGTGCTGCTGATGGTGACGGCGGGC
GCGGCGGTGGACTCCATGCTGGAGCGCCTGCTGCCGCTGATGGCGGAAGGCGACGTCATCATGGACGCCGGCAACTCGTG
GTTCCTGGACACGCGCCGCCGCGAGGAGCAGTGCAAGGCCAAGGGCATCCACTTCCTGGGCGTCGGCGTGTCCGGCGGCG
AGGAGGGCGCGCGCAACGGCCCCTCCATCATGCCGGGCGGTGCTCCCTCGGCGTACGAGCTGGTGCGTCCGGTATTCGAA
GCCATCGCCGCGAATACGGACATGGGGCCGTGTGTCACCTACGTGGGGGCGGACGGTGCCGGGCACTTCGTGAAGATGGT
GCACAACGGCATCGAGTACGCGGACATGCAGTTGCTCGCGGAAACGTACGACGTGCTGCGCCGCGGGCTCGGGCTGGACG
CGGACGCGTTGGCGGACCTGCTGTCCCAGTGGGACCACGGCATCGCCGGCTCGTTCCTGCTGGAGACCACCATCAAGGTG
CTGCGCCAGAAGGACCCGGAGACGGGCAAGCCGCTGGTGGACCTGGTGTTGGACAAGGCGGGCCAGAAGGGCACCGGCAA
GTGGACGGTGCAGGTGGCGCTGGATTTGGGCGTCCCGATTCCCTCCATCGCCGCGTCACTGGACGCACGCATCCTGTCCT
CCATGAAGGACGAACGCGTGGCCGCCGCGCCGAAGCTGAACGGCCCGGTGGGGCAGCTCAGCAAGGAGGAGCGAGCGCAA
CTGGCGGCGTGGACGCACGACGCGCTCTACGCGGCACGGGTGGTGACGTATGCGCAGGGCATGCGGCTCATCCAGGCGGC
GTCCCAGGAGTATCAGTGGAACATCAGCCTGGCGGAGCTGGCGCGCATCTGGCGGGGGGGCTGCATCATCCGCGCGAAGC
TGCTCACGCCGCTGCGTGAGGCCTTCCAGCAGCAGCCGACGCTGCCCAACCTGATGGTGTCCGACGCCTTCGCGCCGGTG
CTGGAGCGCATGGCCCCCGCGTGGCGGCAGGTGGTGGGCGTGGCCACGCGCGTGGGCATCCCCGTGCCGGTGTTCAGCTC
CTCGCTGGCGTACCTGGACAGCTACCGCACCGCGGAGCTGCCGCAGAACCTCACCCAGGCACAGCGTGACGCCTTCGGCG
CGCACACGTATCAGCGCAAGGACAGACCGGAAGCGGGCTTCGTCCACACGGAGTGGGGCAAGTAG

Upstream 100 bases:

>100_bases
CTCCCCGCCGCCCGGGTGACGAATTCGGAGTGGATGCTGGACCCCGCCGCCGCCGGGCGGTGAGGGCTCCCAGTCGCGAA
CCTTCCAGGAGGAACCAACG

Downstream 100 bases:

>100_bases
CACGGGGCCTGCTTGACCCGGGCGTTCACCCGAACGCCCGGGCCGCGAACACGGCAATTCCTGCTCATCGAATGCCCTGG
CGCGCAGGACCTGAAAGCAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSESAGAQFGVAGMGVMGASLALNIADHGFRVAVWDRHAERIDEMHRKHGHPEVWGTESLEAFVQRLERPRKVLLMVTAG
AAVDSMLERLLPLMAEGDVIMDAGNSWFLDTRRREEQCKAKGIHFLGVGVSGGEEGARNGPSIMPGGAPSAYELVRPVFE
AIAANTDMGPCVTYVGADGAGHFVKMVHNGIEYADMQLLAETYDVLRRGLGLDADALADLLSQWDHGIAGSFLLETTIKV
LRQKDPETGKPLVDLVLDKAGQKGTGKWTVQVALDLGVPIPSIAASLDARILSSMKDERVAAAPKLNGPVGQLSKEERAQ
LAAWTHDALYAARVVTYAQGMRLIQAASQEYQWNISLAELARIWRGGCIIRAKLLTPLREAFQQQPTLPNLMVSDAFAPV
LERMAPAWRQVVGVATRVGIPVPVFSSSLAYLDSYRTAELPQNLTQAQRDAFGAHTYQRKDRPEAGFVHTEWGK

Sequences:

>Translated_474_residues
MSESAGAQFGVAGMGVMGASLALNIADHGFRVAVWDRHAERIDEMHRKHGHPEVWGTESLEAFVQRLERPRKVLLMVTAG
AAVDSMLERLLPLMAEGDVIMDAGNSWFLDTRRREEQCKAKGIHFLGVGVSGGEEGARNGPSIMPGGAPSAYELVRPVFE
AIAANTDMGPCVTYVGADGAGHFVKMVHNGIEYADMQLLAETYDVLRRGLGLDADALADLLSQWDHGIAGSFLLETTIKV
LRQKDPETGKPLVDLVLDKAGQKGTGKWTVQVALDLGVPIPSIAASLDARILSSMKDERVAAAPKLNGPVGQLSKEERAQ
LAAWTHDALYAARVVTYAQGMRLIQAASQEYQWNISLAELARIWRGGCIIRAKLLTPLREAFQQQPTLPNLMVSDAFAPV
LERMAPAWRQVVGVATRVGIPVPVFSSSLAYLDSYRTAELPQNLTQAQRDAFGAHTYQRKDRPEAGFVHTEWGK
>Mature_473_residues
SESAGAQFGVAGMGVMGASLALNIADHGFRVAVWDRHAERIDEMHRKHGHPEVWGTESLEAFVQRLERPRKVLLMVTAGA
AVDSMLERLLPLMAEGDVIMDAGNSWFLDTRRREEQCKAKGIHFLGVGVSGGEEGARNGPSIMPGGAPSAYELVRPVFEA
IAANTDMGPCVTYVGADGAGHFVKMVHNGIEYADMQLLAETYDVLRRGLGLDADALADLLSQWDHGIAGSFLLETTIKVL
RQKDPETGKPLVDLVLDKAGQKGTGKWTVQVALDLGVPIPSIAASLDARILSSMKDERVAAAPKLNGPVGQLSKEERAQL
AAWTHDALYAARVVTYAQGMRLIQAASQEYQWNISLAELARIWRGGCIIRAKLLTPLREAFQQQPTLPNLMVSDAFAPVL
ERMAPAWRQVVGVATRVGIPVPVFSSSLAYLDSYRTAELPQNLTQAQRDAFGAHTYQRKDRPEAGFVHTEWGK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=44.468085106383, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788341, Length=466, Percent_Identity=48.9270386266094, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI1786719, Length=202, Percent_Identity=28.7128712871287, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=45.6659619450317, Blast_Score=442, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321695, Length=471, Percent_Identity=43.7367303609342, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321977, Length=474, Percent_Identity=44.7257383966245, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24639279, Length=474, Percent_Identity=47.0464135021097, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51580; Mature: 51448

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESAGAQFGVAGMGVMGASLALNIADHGFRVAVWDRHAERIDEMHRKHGHPEVWGTESL
CCCCCCCCCCCHHHHHHHHHHEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCHHH
EAFVQRLERPRKVLLMVTAGAAVDSMLERLLPLMAEGDVIMDAGNSWFLDTRRREEQCKA
HHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEEECCHHHHHHHHH
KGIHFLGVGVSGGEEGARNGPSIMPGGAPSAYELVRPVFEAIAANTDMGPCVTYVGADGA
CCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
GHFVKMVHNGIEYADMQLLAETYDVLRRGLGLDADALADLLSQWDHGIAGSFLLETTIKV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
LRQKDPETGKPLVDLVLDKAGQKGTGKWTVQVALDLGVPIPSIAASLDARILSSMKDERV
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AAAPKLNGPVGQLSKEERAQLAAWTHDALYAARVVTYAQGMRLIQAASQEYQWNISLAEL
HCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCHHHH
ARIWRGGCIIRAKLLTPLREAFQQQPTLPNLMVSDAFAPVLERMAPAWRQVVGVATRVGI
HHHHCCCCEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVPVFSSSLAYLDSYRTAELPQNLTQAQRDAFGAHTYQRKDRPEAGFVHTEWGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEECCCCC
>Mature Secondary Structure 
SESAGAQFGVAGMGVMGASLALNIADHGFRVAVWDRHAERIDEMHRKHGHPEVWGTESL
CCCCCCCCCCHHHHHHHHHHEEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCHHH
EAFVQRLERPRKVLLMVTAGAAVDSMLERLLPLMAEGDVIMDAGNSWFLDTRRREEQCKA
HHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCEEECCHHHHHHHHH
KGIHFLGVGVSGGEEGARNGPSIMPGGAPSAYELVRPVFEAIAANTDMGPCVTYVGADGA
CCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
GHFVKMVHNGIEYADMQLLAETYDVLRRGLGLDADALADLLSQWDHGIAGSFLLETTIKV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
LRQKDPETGKPLVDLVLDKAGQKGTGKWTVQVALDLGVPIPSIAASLDARILSSMKDERV
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AAAPKLNGPVGQLSKEERAQLAAWTHDALYAARVVTYAQGMRLIQAASQEYQWNISLAEL
HCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCHHHH
ARIWRGGCIIRAKLLTPLREAFQQQPTLPNLMVSDAFAPVLERMAPAWRQVVGVATRVGI
HHHHCCCCEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PVPVFSSSLAYLDSYRTAELPQNLTQAQRDAFGAHTYQRKDRPEAGFVHTEWGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]