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The map label for this gene is apqZ [H]

Identifier: 108762920

GI number: 108762920

Start: 6345254

End: 6346090

Strand: Reverse

Name: apqZ [H]

Synonym: MXAN_5069

Alternate gene names: 108762920

Gene position: 6346090-6345254 (Counterclockwise)

Preceding gene: 108764091

Following gene: 108759657

Centisome position: 69.43

GC content: 70.49

Gene sequence:

>837_bases
ATGGATGCATCCAGGGACAGGGCCGCGCTGGCTCGGGCGGGCAACCCCCGCAACAACGACGCCGTCCGGAAGTACGTTGC
GGAGTTCATCGGGACGTTCGTCCTGGTGTTGGGTGGCGTCGGGGCGGCCGTGCTGGCGGGCGACCACATCGGCTTCCAAG
GTGTCGCGCTCGCCTTTGGCCTGTCACTGCTGGCCATGGTGTACGTGATTGGGCCCATCTCGGGCTGCCATGTGAATCCG
GCGGTGACGCTGGGCCTCTTGCTGTCGGGGAAGATGGAGGGCAAGGACGCGGTCGGCTACGTGGTGGCGCAGTGCGCGGG
GGCCATCCTCGGCGCGGGCGTGGTGCTGCTGATTGCCAAGGGCATGCCCGGTGGGTACTCGGCGGTGACCGAGGGACTCG
CGACCAACGGGTACGGCGCCGCTTCACCTGACGGCTTCAACATGGGAGCGGCCTTCCTCACGGAGGTGGCGCTCACCTTC
TTGCTCGTGCTCACGGTGCTGGGCGCGACGGATGCGCGCGCCCCGGTGGGCTTCGCGGGGCTGGCCATTGGCCTGGTGCT
GGCGCTCATCCACTTGGTGGGGATTCCGGTGACGAACACGTCTGTGAATCCGGCGCGCAGCCTGGGGCCGGCGGTGTTCG
CGGGGAGCGTGCCCATGGGGCAGCTCTGGCTGTTCATCGTGGCGCCGCTCCTGGGAGGCGCCACCGCGGCGGCGGTGTAT
CGCACGGTGTTCCGGCCTGCCGTGCCCATCAGCGCGGAGGAGGCCGAGCGGGCGCTGCGGCGCGAGCGTGAGGCGCGAAT
CGCGGAGGATCGGGCGGGCACGCGCGCGCCCGTCTGA

Upstream 100 bases:

>100_bases
GTGACGCGGTGCTTCGCGTTGTCGTCTTCCGGTCCATGCGCAGCGTGCCTGGAAGAATTCGCTGAAGCGCGGCGTCTGGC
CGCGCGAATCGAGGCTGACC

Downstream 100 bases:

>100_bases
TGCTGCGGGTCGCTTTGCTCGGCGGTCTCCGGCAGGTACGGTGACTGGCAATCGGGGCCAGTCGTGCCCCCACTGGAGCC
GCCATGTTCTTCGACCCGAC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MDASRDRAALARAGNPRNNDAVRKYVAEFIGTFVLVLGGVGAAVLAGDHIGFQGVALAFGLSLLAMVYVIGPISGCHVNP
AVTLGLLLSGKMEGKDAVGYVVAQCAGAILGAGVVLLIAKGMPGGYSAVTEGLATNGYGAASPDGFNMGAAFLTEVALTF
LLVLTVLGATDARAPVGFAGLAIGLVLALIHLVGIPVTNTSVNPARSLGPAVFAGSVPMGQLWLFIVAPLLGGATAAAVY
RTVFRPAVPISAEEAERALRREREARIAEDRAGTRAPV

Sequences:

>Translated_278_residues
MDASRDRAALARAGNPRNNDAVRKYVAEFIGTFVLVLGGVGAAVLAGDHIGFQGVALAFGLSLLAMVYVIGPISGCHVNP
AVTLGLLLSGKMEGKDAVGYVVAQCAGAILGAGVVLLIAKGMPGGYSAVTEGLATNGYGAASPDGFNMGAAFLTEVALTF
LLVLTVLGATDARAPVGFAGLAIGLVLALIHLVGIPVTNTSVNPARSLGPAVFAGSVPMGQLWLFIVAPLLGGATAAAVY
RTVFRPAVPISAEEAERALRREREARIAEDRAGTRAPV
>Mature_278_residues
MDASRDRAALARAGNPRNNDAVRKYVAEFIGTFVLVLGGVGAAVLAGDHIGFQGVALAFGLSLLAMVYVIGPISGCHVNP
AVTLGLLLSGKMEGKDAVGYVVAQCAGAILGAGVVLLIAKGMPGGYSAVTEGLATNGYGAASPDGFNMGAAFLTEVALTF
LLVLTVLGATDARAPVGFAGLAIGLVLALIHLVGIPVTNTSVNPARSLGPAVFAGSVPMGQLWLFIVAPLLGGATAAAVY
RTVFRPAVPISAEEAERALRREREARIAEDRAGTRAPV

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=235, Percent_Identity=38.7234042553192, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4502181, Length=262, Percent_Identity=33.969465648855, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4755125, Length=262, Percent_Identity=33.969465648855, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI4502183, Length=266, Percent_Identity=34.5864661654135, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI4502179, Length=273, Percent_Identity=32.967032967033, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI6912506, Length=241, Percent_Identity=34.0248962655602, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI86792455, Length=233, Percent_Identity=36.0515021459227, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4502187, Length=290, Percent_Identity=27.9310344827586, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI4826645, Length=295, Percent_Identity=28.135593220339, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI157266307, Length=271, Percent_Identity=29.520295202952, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22538420, Length=279, Percent_Identity=29.3906810035842, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI45446752, Length=217, Percent_Identity=29.9539170506912, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI297307120, Length=105, Percent_Identity=42.8571428571429, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI297307116, Length=105, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI297307118, Length=105, Percent_Identity=42.8571428571429, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787101, Length=227, Percent_Identity=51.5418502202643, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1790362, Length=276, Percent_Identity=28.6231884057971, Blast_Score=84, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=242, Percent_Identity=30.5785123966942, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994009, Length=297, Percent_Identity=29.96632996633, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71993722, Length=248, Percent_Identity=31.0483870967742, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71992966, Length=243, Percent_Identity=28.3950617283951, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544068, Length=245, Percent_Identity=31.0204081632653, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=278, Percent_Identity=28.7769784172662, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=278, Percent_Identity=28.7769784172662, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71992961, Length=241, Percent_Identity=28.6307053941909, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321054, Length=217, Percent_Identity=33.6405529953917, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6325450, Length=276, Percent_Identity=28.2608695652174, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652747, Length=232, Percent_Identity=36.6379310344828, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551084, Length=232, Percent_Identity=36.6379310344828, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922038, Length=249, Percent_Identity=37.3493975903614, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24652751, Length=251, Percent_Identity=37.4501992031873, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24762342, Length=269, Percent_Identity=28.6245353159851, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550503, Length=268, Percent_Identity=28.3582089552239, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24762344, Length=255, Percent_Identity=27.843137254902, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24762346, Length=255, Percent_Identity=27.843137254902, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24762348, Length=255, Percent_Identity=27.843137254902, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130305, Length=255, Percent_Identity=27.843137254902, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17136672, Length=224, Percent_Identity=30.8035714285714, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922828, Length=199, Percent_Identity=29.6482412060301, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 28131; Mature: 28131

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure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HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]