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The map label for this gene is hpt [H]

Identifier: 108764091

GI number: 108764091

Start: 6346462

End: 6346995

Strand: Reverse

Name: hpt [H]

Synonym: MXAN_5070

Alternate gene names: 108764091

Gene position: 6346995-6346462 (Counterclockwise)

Preceding gene: 108762470

Following gene: 108762920

Centisome position: 69.44

GC content: 62.36

Gene sequence:

>534_bases
TTGGCGTTCTACGAGCAGGAAGTCGGTGTCCTGATTTCCGAGGACAAGTTGCAGGCGCGCGTGCGCGAGCTCGCGGCGGA
GATTACGCGCGACTACGCGGGCAAGGACCTGACGCTCATCTGCGTGTTGAAGGGCTCGGCGTTTTTCGCCATCGACCTGG
CGAAGTACATCGACCTGCCGGTGAAGTTGGAGTTCCTGGGCGTCTCCAGCTACCAGGGCGGCACGGAGTCCACGGGCGAG
GTGCGCATCACCACCGACGTCAGCAAGCCGATGGCTGGCAAGCACCTGCTCATCATCGAGGACATCATCGACACCGGGCT
CACCATGCAGTTCCTGCTGGAGAACCTGCGCGCTCGGCACCCCGCGTCGCTGAAGGTGTGCACGCTGCTGGAGAAGCCCT
CGCGCGCCCGGACGAAGGTGGACATCGACTACAAGGGCTTCGTCATCGATGACCTCTTCGTCGTGGGCTACGGGCTCGAC
TTTGGCGAGGTGTACCGGAACATCCCCTTCATCGGGGTGATGAAGAACAAGTAG

Upstream 100 bases:

>100_bases
GGGAGAAGGAGCGGGGCCTGGATGACCGGCAGTACATCGTCCCCGGAGGCGGCGGCTTCGGGGAGATCATGAACAACGCG
TACGTGTAGCGGAGGAATCC

Downstream 100 bases:

>100_bases
TCCCGGCCGGGTGCTGGCGCCGCCCTCGTGCGCGGCGCCGCACCGGTCTTCAGGTGATGCTCGGAACGGGCAGCGGCGCT
CCACGCCGCCGCACTGGATG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MAFYEQEVGVLISEDKLQARVRELAAEITRDYAGKDLTLICVLKGSAFFAIDLAKYIDLPVKLEFLGVSSYQGGTESTGE
VRITTDVSKPMAGKHLLIIEDIIDTGLTMQFLLENLRARHPASLKVCTLLEKPSRARTKVDIDYKGFVIDDLFVVGYGLD
FGEVYRNIPFIGVMKNK

Sequences:

>Translated_177_residues
MAFYEQEVGVLISEDKLQARVRELAAEITRDYAGKDLTLICVLKGSAFFAIDLAKYIDLPVKLEFLGVSSYQGGTESTGE
VRITTDVSKPMAGKHLLIIEDIIDTGLTMQFLLENLRARHPASLKVCTLLEKPSRARTKVDIDYKGFVIDDLFVVGYGLD
FGEVYRNIPFIGVMKNK
>Mature_176_residues
AFYEQEVGVLISEDKLQARVRELAAEITRDYAGKDLTLICVLKGSAFFAIDLAKYIDLPVKLEFLGVSSYQGGTESTGEV
RITTDVSKPMAGKHLLIIEDIIDTGLTMQFLLENLRARHPASLKVCTLLEKPSRARTKVDIDYKGFVIDDLFVVGYGLDF
GEVYRNIPFIGVMKNK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=176, Percent_Identity=35.7954545454545, Blast_Score=103, Evalue=8e-23,
Organism=Homo sapiens, GI4504483, Length=175, Percent_Identity=36, Blast_Score=101, Evalue=4e-22,
Organism=Escherichia coli, GI87081689, Length=170, Percent_Identity=41.7647058823529, Blast_Score=143, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17510817, Length=175, Percent_Identity=34.2857142857143, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19755; Mature: 19624

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFYEQEVGVLISEDKLQARVRELAAEITRDYAGKDLTLICVLKGSAFFAIDLAKYIDLP
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEHHHHCCCC
VKLEFLGVSSYQGGTESTGEVRITTDVSKPMAGKHLLIIEDIIDTGLTMQFLLENLRARH
EEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCC
PASLKVCTLLEKPSRARTKVDIDYKGFVIDDLFVVGYGLDFGEVYRNIPFIGVMKNK
CCCEEEEEEECCCCCCCEEEEECCCCEEEECEEEEEECCCHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
AFYEQEVGVLISEDKLQARVRELAAEITRDYAGKDLTLICVLKGSAFFAIDLAKYIDLP
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEEHHHHCCCC
VKLEFLGVSSYQGGTESTGEVRITTDVSKPMAGKHLLIIEDIIDTGLTMQFLLENLRARH
EEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCCC
PASLKVCTLLEKPSRARTKVDIDYKGFVIDDLFVVGYGLDFGEVYRNIPFIGVMKNK
CCCEEEEEEECCCCCCCEEEEECCCCEEEECEEEEEECCCHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA