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The map label for this gene is mvaD

Identifier: 108762661

GI number: 108762661

Start: 6272790

End: 6273788

Strand: Reverse

Name: mvaD

Synonym: MXAN_5018

Alternate gene names: NA

Gene position: 6273788-6272790 (Counterclockwise)

Preceding gene: 108761374

Following gene: 108763233

Centisome position: 68.64

GC content: 70.67

Gene sequence:

>999_bases
GTGAGTCTTCCCATGAAAGCCACAGCTCTGGCGCATCCCAACATCGCCCTGGTGAAGTACTGGGGGAAGCGGGATGACGC
GTTGATTCTGCCGCACCAGTCCAGCCTGTCCCTCACGCTGTCACCGCTGTCGGTGACGACCACGGTGGAGTTCGGCGCCG
CGAGCGACCAGGTGGAGCTCAACGGGCACACCGCGAAGGGCAGCGAGCGCGACCGCGTGCTGCGGCTTCTGGAGTTGGTG
CGCGCCCAGGCGAAGGCCGACCTGGGCCCCGCGAAGGTGGTGTCTCGCGGGGACTTCCCCATGGCGGCGGGGTTGGCCAG
CAGCGCGGCGGGCTTCGCGGCGCTGGCGGTGGCGGGACGCGCAGCGGCGGGGTTGCCGTCGGAGCCCCGCGCGGCCAGCA
TCCTGGCGCGCATGGGCAGCGGCTCGGCGTGCCGGAGCGTGCAGGGTGGGTTCTGCGAGTGGCAGCGCGGCGAACGTCCG
GATGGAGAGGACAGCTTCGCGGTGCAGCGCTTCGACGCGGCCCACTGGCCGGACGTGCGCATGGTGGTGGCGATTCTCGA
CCGCGGCGAGAAAGAGGTGAAGTCGCGGGACGGGATGAAGCTCACGGTGGACACCAGCCCGTACTACCCGGCGTGGGTGA
AGGACGCCGAGGTGGAGGTCGTGCAGGTGCGCGAGCACATCGCCAGGCGCGACCTGCAGGCCCTGGGTGAGCTGTGTGAG
CGCAACGCGTGGCGGATGCACGCGACGTCGTTCGCCGCGAATCCGCCGCTGAGCTACATGAGCCCCGGCACGCTGGCGCT
CATCCTGCACCTGAAGGAGCAGCGCAAGAAGGGCATCCCGGTGTGGTTCACGCTGGACGCGGGGCCAAACCCGGTGCTGC
TGACGGACGCCGCGCACGAGGTGGCCGCGGAGGCGCTGGCCCGCGCGTGCGGCGCGCTGGATGTGATTCGCTGCGTGCCC
GGCGGTGACGCGGAGCTGAAGGCGGAGCACCTCTTCTGA

Upstream 100 bases:

>100_bases
CCGTCATTGGCCTGTTCCTGGAGCCCAAGCCCGTGGTGACGAAGCTCACCCGGATGGGCGTGCGCTGCTTCAGCAGCCAG
CTCGCGGGACCGCGGGCGTC

Downstream 100 bases:

>100_bases
TGGAGCGCGCCCTCTCCGCGCCGGGGAAGCTGTTCCTCTCCGGGGAGTACGCCGTGCTGTGGGGCGGCGTGGCGCGGTTG
GCCGCGGTGGCGCCGCGCAC

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; Phosphomevalonate Kinase; GHMP Kinase Domain-Containing Protein; Ghmp Kinase

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSLPMKATALAHPNIALVKYWGKRDDALILPHQSSLSLTLSPLSVTTTVEFGAASDQVELNGHTAKGSERDRVLRLLELV
RAQAKADLGPAKVVSRGDFPMAAGLASSAAGFAALAVAGRAAAGLPSEPRAASILARMGSGSACRSVQGGFCEWQRGERP
DGEDSFAVQRFDAAHWPDVRMVVAILDRGEKEVKSRDGMKLTVDTSPYYPAWVKDAEVEVVQVREHIARRDLQALGELCE
RNAWRMHATSFAANPPLSYMSPGTLALILHLKEQRKKGIPVWFTLDAGPNPVLLTDAAHEVAAEALARACGALDVIRCVP
GGDAELKAEHLF

Sequences:

>Translated_332_residues
MSLPMKATALAHPNIALVKYWGKRDDALILPHQSSLSLTLSPLSVTTTVEFGAASDQVELNGHTAKGSERDRVLRLLELV
RAQAKADLGPAKVVSRGDFPMAAGLASSAAGFAALAVAGRAAAGLPSEPRAASILARMGSGSACRSVQGGFCEWQRGERP
DGEDSFAVQRFDAAHWPDVRMVVAILDRGEKEVKSRDGMKLTVDTSPYYPAWVKDAEVEVVQVREHIARRDLQALGELCE
RNAWRMHATSFAANPPLSYMSPGTLALILHLKEQRKKGIPVWFTLDAGPNPVLLTDAAHEVAAEALARACGALDVIRCVP
GGDAELKAEHLF
>Mature_331_residues
SLPMKATALAHPNIALVKYWGKRDDALILPHQSSLSLTLSPLSVTTTVEFGAASDQVELNGHTAKGSERDRVLRLLELVR
AQAKADLGPAKVVSRGDFPMAAGLASSAAGFAALAVAGRAAAGLPSEPRAASILARMGSGSACRSVQGGFCEWQRGERPD
GEDSFAVQRFDAAHWPDVRMVVAILDRGEKEVKSRDGMKLTVDTSPYYPAWVKDAEVEVVQVREHIARRDLQALGELCER
NAWRMHATSFAANPPLSYMSPGTLALILHLKEQRKKGIPVWFTLDAGPNPVLLTDAAHEVAAEALARACGALDVIRCVPG
GDAELKAEHLF

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=312, Percent_Identity=37.1794871794872, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17537201, Length=310, Percent_Identity=36.4516129032258, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17537203, Length=164, Percent_Identity=33.5365853658537, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324371, Length=342, Percent_Identity=35.9649122807018, Blast_Score=156, Evalue=5e-39,
Organism=Drosophila melanogaster, GI28571205, Length=310, Percent_Identity=36.1290322580645, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35601; Mature: 35470

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPMKATALAHPNIALVKYWGKRDDALILPHQSSLSLTLSPLSVTTTVEFGAASDQVEL
CCCCCCCCEECCCCEEEEEEECCCCCEEEEECCCCCEEEEECEEEEEEEEECCCCCEEEE
NGHTAKGSERDRVLRLLELVRAQAKADLGPAKVVSRGDFPMAAGLASSAAGFAALAVAGR
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
AAAGLPSEPRAASILARMGSGSACRSVQGGFCEWQRGERPDGEDSFAVQRFDAAHWPDVR
HHCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHH
MVVAILDRGEKEVKSRDGMKLTVDTSPYYPAWVKDAEVEVVQVREHIARRDLQALGELCE
HHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RNAWRMHATSFAANPPLSYMSPGTLALILHLKEQRKKGIPVWFTLDAGPNPVLLTDAAHE
CCCCEEEECCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCEEEEECCCCCCEEEECCHHH
VAAEALARACGALDVIRCVPGGDAELKAEHLF
HHHHHHHHHHCHHHEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SLPMKATALAHPNIALVKYWGKRDDALILPHQSSLSLTLSPLSVTTTVEFGAASDQVEL
CCCCCCCEECCCCEEEEEEECCCCCEEEEECCCCCEEEEECEEEEEEEEECCCCCEEEE
NGHTAKGSERDRVLRLLELVRAQAKADLGPAKVVSRGDFPMAAGLASSAAGFAALAVAGR
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
AAAGLPSEPRAASILARMGSGSACRSVQGGFCEWQRGERPDGEDSFAVQRFDAAHWPDVR
HHCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHH
MVVAILDRGEKEVKSRDGMKLTVDTSPYYPAWVKDAEVEVVQVREHIARRDLQALGELCE
HHHHHHHCCHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RNAWRMHATSFAANPPLSYMSPGTLALILHLKEQRKKGIPVWFTLDAGPNPVLLTDAAHE
CCCCEEEECCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCEEEEECCCCCCEEEECCHHH
VAAEALARACGALDVIRCVPGGDAELKAEHLF
HHHHHHHHHHCHHHEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA