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The map label for this gene is mvk [H]

Identifier: 108761374

GI number: 108761374

Start: 6273785

End: 6274717

Strand: Reverse

Name: mvk [H]

Synonym: MXAN_5019

Alternate gene names: 108761374

Gene position: 6274717-6273785 (Counterclockwise)

Preceding gene: 108759501

Following gene: 108762661

Centisome position: 68.65

GC content: 72.67

Gene sequence:

>933_bases
GTGGCTCCTCGTCCTGAATCCTTGTCGGCCTTTGGCGCCGGCAAGGTCATCCTGTTGGGTGAGCACAGCGTCGTGTACGG
GCACCCGGCCCTGGCCGGGCCGTTGTCGCAGGGCGTGACGGCGCGCGCCGTGCCCGCGAAGGCGTGTCAGCTCGCGTTGC
CCTCCACGCTCAGCCGCCCGCAGCGGGCGCAGCTCACGGCGGCGTTCGCCCGTGCGGCGGAGGTGACGGGCGCGCCGCCG
GTGAAGGTGTCGCTGGAGGCGGACCTGCCGCTGGCGGTGGGCCTGGGAAGCTCGGCGGCGCTGTCGGTGGCGTGCGCGCG
GTTGCTGCTCCAGGCGGCGGGGAAGGTGCCCACACCGAAGGACGCGGCGCGTGTGGCGTGGGCGATGGAGCAGGAGTTCC
ACGGCACGCCGTCCGGCGTGGACCACACCACCAGCGCCGCGGAGCAACTGGTCCTCTACTGGCGCAAGCCGGGGGCCGCC
AAGGGGACGGGGCAGGTCGTGGAGAGCCCCAGGCCCTTGCACGTGGTGGTGACGCTCGCGGGTGAGCGCAGCCCCACGAA
GAAGACGGTGGGCGCGCTGCGGGAGCGGCAGGCTCGCTGGCCGTCGCGCTACGAGCGCCTGTTCGCGGAGATTGGACGGG
TGTCCTCGGAGGGCGCGAAGGCGGTGGCGGCGGGAGATTTGGAGGCACTGGGCGACGCGATGAACGTCAACCAGGGCCTG
CTCGCGGCGCTGGGCCTGTCGTCGCCGCCGTTGGAAGAGATGGTCTACCGGTTGCGGGAGCTGGGGGCGCTGGGCGCCAA
GCTGACCGGAGCTGGTGGAGATGGTGGGGCCGTCATTGGCCTGTTCCTGGAGCCCAAGCCCGTGGTGACGAAGCTCACCC
GGATGGGCGTGCGCTGCTTCAGCAGCCAGCTCGCGGGACCGCGGGCGTCGTGA

Upstream 100 bases:

>100_bases
GTGAAGGCGGGCCACGTGAAGGTGGAGAAGGCCCGCGAGCTGCTGGCCAGCCTCCCCGCCGAGGATGCCGCGGCCGCGAC
CGGCACCACGGTCTGACGCC

Downstream 100 bases:

>100_bases
GTCTTCCCATGAAAGCCACAGCTCTGGCGCATCCCAACATCGCCCTGGTGAAGTACTGGGGGAAGCGGGATGACGCGTTG
ATTCTGCCGCACCAGTCCAG

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MAPRPESLSAFGAGKVILLGEHSVVYGHPALAGPLSQGVTARAVPAKACQLALPSTLSRPQRAQLTAAFARAAEVTGAPP
VKVSLEADLPLAVGLGSSAALSVACARLLLQAAGKVPTPKDAARVAWAMEQEFHGTPSGVDHTTSAAEQLVLYWRKPGAA
KGTGQVVESPRPLHVVVTLAGERSPTKKTVGALRERQARWPSRYERLFAEIGRVSSEGAKAVAAGDLEALGDAMNVNQGL
LAALGLSSPPLEEMVYRLRELGALGAKLTGAGGDGGAVIGLFLEPKPVVTKLTRMGVRCFSSQLAGPRAS

Sequences:

>Translated_310_residues
MAPRPESLSAFGAGKVILLGEHSVVYGHPALAGPLSQGVTARAVPAKACQLALPSTLSRPQRAQLTAAFARAAEVTGAPP
VKVSLEADLPLAVGLGSSAALSVACARLLLQAAGKVPTPKDAARVAWAMEQEFHGTPSGVDHTTSAAEQLVLYWRKPGAA
KGTGQVVESPRPLHVVVTLAGERSPTKKTVGALRERQARWPSRYERLFAEIGRVSSEGAKAVAAGDLEALGDAMNVNQGL
LAALGLSSPPLEEMVYRLRELGALGAKLTGAGGDGGAVIGLFLEPKPVVTKLTRMGVRCFSSQLAGPRAS
>Mature_309_residues
APRPESLSAFGAGKVILLGEHSVVYGHPALAGPLSQGVTARAVPAKACQLALPSTLSRPQRAQLTAAFARAAEVTGAPPV
KVSLEADLPLAVGLGSSAALSVACARLLLQAAGKVPTPKDAARVAWAMEQEFHGTPSGVDHTTSAAEQLVLYWRKPGAAK
GTGQVVESPRPLHVVVTLAGERSPTKKTVGALRERQARWPSRYERLFAEIGRVSSEGAKAVAAGDLEALGDAMNVNQGLL
AALGLSSPPLEEMVYRLRELGALGAKLTGAGGDGGAVIGLFLEPKPVVTKLTRMGVRCFSSQLAGPRAS

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI167001643, Length=386, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI4557769, Length=386, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI78707210, Length=361, Percent_Identity=27.4238227146814, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 31951; Mature: 31820

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS00627 GHMP_KINASES_ATP ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRPESLSAFGAGKVILLGEHSVVYGHPALAGPLSQGVTARAVPAKACQLALPSTLSRP
CCCCCCCCHHCCCCCEEEEECCEEEECCCCCCCHHHCCCEECCCCHHHHHHHCCHHHCCC
QRAQLTAAFARAAEVTGAPPVKVSLEADLPLAVGLGSSAALSVACARLLLQAAGKVPTPK
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
DAARVAWAMEQEFHGTPSGVDHTTSAAEQLVLYWRKPGAAKGTGQVVESPRPLHVVVTLA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCHHHCCCCCEEEEEEEE
GERSPTKKTVGALRERQARWPSRYERLFAEIGRVSSEGAKAVAAGDLEALGDAMNVNQGL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCHH
LAALGLSSPPLEEMVYRLRELGALGAKLTGAGGDGGAVIGLFLEPKPVVTKLTRMGVRCF
HHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
SSQLAGPRAS
HHHCCCCCCC
>Mature Secondary Structure 
APRPESLSAFGAGKVILLGEHSVVYGHPALAGPLSQGVTARAVPAKACQLALPSTLSRP
CCCCCCCHHCCCCCEEEEECCEEEECCCCCCCHHHCCCEECCCCHHHHHHHCCHHHCCC
QRAQLTAAFARAAEVTGAPPVKVSLEADLPLAVGLGSSAALSVACARLLLQAAGKVPTPK
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCC
DAARVAWAMEQEFHGTPSGVDHTTSAAEQLVLYWRKPGAAKGTGQVVESPRPLHVVVTLA
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEECCCCCCCCCCHHHCCCCCEEEEEEEE
GERSPTKKTVGALRERQARWPSRYERLFAEIGRVSSEGAKAVAAGDLEALGDAMNVNQGL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHCCCCHH
LAALGLSSPPLEEMVYRLRELGALGAKLTGAGGDGGAVIGLFLEPKPVVTKLTRMGVRCF
HHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHH
SSQLAGPRAS
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA