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The map label for this gene is srrB [H]

Identifier: 108762656

GI number: 108762656

Start: 68306

End: 70582

Strand: Direct

Name: srrB [H]

Synonym: MXAN_0060

Alternate gene names: 108762656

Gene position: 68306-70582 (Clockwise)

Preceding gene: 108760360

Following gene: 108762854

Centisome position: 0.75

GC content: 70.09

Gene sequence:

>2277_bases
GTGGCACGTCCGTGGACGTTCGCGCAGCGCGCGGGCGCCGGCTTCATCATCTCGTTGGTGGTGGCGCTCGTGCTGGCGGG
AACGTCCGTGGTGGCGCTGCTCTCCGTGCGGGCCAATCACAAGGCGCGCATCCTGGAGCTGTCCCGGGACGTGCTGGACA
TCAAACAACTGGAGCGGACCTTCAACGACAAGGTCGTCAGTGGCCGGGGCTTCGCTTTGTCGGGAGATACCTTCTTCGCC
CAGGACATGTCCGTCGCGCGCGAGCGCTTCATCGCCACCTACGAAGCCCTGAAGCGCCGGCTCACCCAGGAGCCCCTGGC
CACTCAATTGGAGGCCGTCTCCCACGCGGAGCTGGAGCACGAGGAGGCCATGCAGGCGCTCATCATGGAGCGCGAGGACG
GCGTGCCCCGCCAGCGGCTGGAGCAGATTTTCGACGGCCACGTGGCGGACACGCGCCGCCGTGTCATGGACAGCCTCCGG
ATGCTCCACCAGCAGACGGAGACCCGGCTGTCCGAGGGCATTCATGAGAGCCTGGCCACGGACCGCAGCGCGCTTGGGCT
GTCCCTGCTCGCGGGGAGCCTGGGCCTCGCGGGCGCCACGATGCTGGCGTGGACGCTGACGCGCAAGCTGCGGCCCATCC
AACAGGAGGCCGAGGCCAGCGCCGAGCGCTTTCAGCTCCTCGTGGAGGGGGTGCGCGACTACGCCTTGTTCCTGCTGGAT
GCGCGGGGCCGGGTGGAGAGCTGGAACCCGGGCGCGGAGCGCATCATGGGCTACCGGGAGGCGGAAATCCTGGGCCAGCC
CTCCAGCGTCTTCTACCCGCCGGATGCGGTTGCGGCGGGGATTCCGGACAAGGACCTGGTGCGGGCCCGGAAGGATGGGC
GGCTGCACACGGAGGGCTGGCGAGTGAGGAAGGACGGCTCGCGCTATCTGGCGGACGTCAACGTCACCGTGCTCCAGGAC
GCGCGCGGGCTGCCGCGCGGCTTCGCCAAGGTGACGCGCGACATCACCGAGCGGCGCCGGGCCGAGCGCACGCAGCAACT
GCTGGCGGAGGCGGGAGGCCTCTTCCACCAGTTCCAGGACCCAGACCAGACGGTGGCCGAGCTGACGCGCATCATGGTGC
CGGAGGTGGCGGACGCCTGCCTGCTCTACCTGCTGTCGGCCAGTGGTGACCTCTGGCCTCGCGCGGTGGCGCACGCGATG
CCGGAGAAGGAGGCGTGGCTATGGGACGCGGCGCGGCGCTTTCCGCCGCCACCAGAGTCTCCATGGGGCATCTGGCAGGT
GATGCGCACGGGGCGCTCCGAGCTCAAGAGCGACGTGTCTCCGGAGACCCTGGCCCGGGGGCTGGTGGGCCCCGAGCACC
TCTCGTTGATGGAGAAGGTGGGCGTGCGCTCCTACCTCGGCGTGCCGCTGCGGGTGGGGCGGCAGACTCGCGGGGTGTTT
GTGCTGCTGACGTCCGCGCCGGAGCGCCGGCTGACGGTGACGGACCAGGTCTTCGTGGAGGAGGTGGCGGGACGTGCCGC
GCTCGCGCTGGACAACGCCCGGCTCTGGAGCGAGGCGCAGGACGCGGTGGAGCTCATCGGCGTGGCCGCGCACGACTTGG
GCAATCCGTTGAACACGCTGCAGTTGCTCCTGCGAAGGCTTCAGCGGATGGAACTCGCGGAGGAGCAGAAGGCGCGCGAC
GGGCTGGCGGCGGCGCTGAAGCAGACGCAGCGGCTGGGGCAGCTGCTGCACAACTTGCTGGACCTGTCGCGGCTGTCATC
GGGAAAGCTGATGCTGGACGTGGCGCCGGTGGACCTGTCGGACCTGGTGCACGAGGTGGTGGAGCGCTTCGCCGAACAGG
CTGCGGAGGCGGGCTGCAAGCTGGAGTTCGGCGCGGAATTGGGGCTGGTGGGCCGGTGGGACCGGCTGCGGTTGGACCGG
GTGGTGACGAACCTCTTGTCCAACGCGCTGAAGTTCGGGAGGGGGCGGCCGGTGGAGGTCCGGGTGGAGCACGCGGGCGT
GGCGCGGGCGCGGCTGTGCGTGAGAGACCACGGCGTGGGCATTGCCCCGGAGGCGCAGCGGCGCATCTTCGAGCGCTTCG
AAAGAGAGCCCTCCGGCGGCCAGCATGCGGGCTTCGGGCTCGGGCTCTACATCGTCCGGCAGTTGGTGGAGGCGCACGGC
GGCACCATCCGCGTGGAGAGTGCCCCCAGCGAGGGCGCCACCTTCATCGTGGAGTTGCCGCTGATGCTGCTGGGCTCGGA
GCTGCGTGAGCCACCCGATATTCCCCTGCACTCGTGA

Upstream 100 bases:

>100_bases
CCAACGTTCGCGTCACCCGGCGAGCCCCCTGGATTCAGGGTGCGGAGCGCTTCACCCTGCCCGAGGGCATGGGCGGTGGA
CCGTCTGGGGAGGAGGGGAG

Downstream 100 bases:

>100_bases
GCCCGCCCGTCACGCGTGCAGCGGCGGCCGGGTGTCCACGAAGGTCCGCAGGGGCGACCGCTCAGGCGCTTTCTCCTGCT
CCTCCAGCAGCTCGAACTCC

Product: sensory box histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MARPWTFAQRAGAGFIISLVVALVLAGTSVVALLSVRANHKARILELSRDVLDIKQLERTFNDKVVSGRGFALSGDTFFA
QDMSVARERFIATYEALKRRLTQEPLATQLEAVSHAELEHEEAMQALIMEREDGVPRQRLEQIFDGHVADTRRRVMDSLR
MLHQQTETRLSEGIHESLATDRSALGLSLLAGSLGLAGATMLAWTLTRKLRPIQQEAEASAERFQLLVEGVRDYALFLLD
ARGRVESWNPGAERIMGYREAEILGQPSSVFYPPDAVAAGIPDKDLVRARKDGRLHTEGWRVRKDGSRYLADVNVTVLQD
ARGLPRGFAKVTRDITERRRAERTQQLLAEAGGLFHQFQDPDQTVAELTRIMVPEVADACLLYLLSASGDLWPRAVAHAM
PEKEAWLWDAARRFPPPPESPWGIWQVMRTGRSELKSDVSPETLARGLVGPEHLSLMEKVGVRSYLGVPLRVGRQTRGVF
VLLTSAPERRLTVTDQVFVEEVAGRAALALDNARLWSEAQDAVELIGVAAHDLGNPLNTLQLLLRRLQRMELAEEQKARD
GLAAALKQTQRLGQLLHNLLDLSRLSSGKLMLDVAPVDLSDLVHEVVERFAEQAAEAGCKLEFGAELGLVGRWDRLRLDR
VVTNLLSNALKFGRGRPVEVRVEHAGVARARLCVRDHGVGIAPEAQRRIFERFEREPSGGQHAGFGLGLYIVRQLVEAHG
GTIRVESAPSEGATFIVELPLMLLGSELREPPDIPLHS

Sequences:

>Translated_758_residues
MARPWTFAQRAGAGFIISLVVALVLAGTSVVALLSVRANHKARILELSRDVLDIKQLERTFNDKVVSGRGFALSGDTFFA
QDMSVARERFIATYEALKRRLTQEPLATQLEAVSHAELEHEEAMQALIMEREDGVPRQRLEQIFDGHVADTRRRVMDSLR
MLHQQTETRLSEGIHESLATDRSALGLSLLAGSLGLAGATMLAWTLTRKLRPIQQEAEASAERFQLLVEGVRDYALFLLD
ARGRVESWNPGAERIMGYREAEILGQPSSVFYPPDAVAAGIPDKDLVRARKDGRLHTEGWRVRKDGSRYLADVNVTVLQD
ARGLPRGFAKVTRDITERRRAERTQQLLAEAGGLFHQFQDPDQTVAELTRIMVPEVADACLLYLLSASGDLWPRAVAHAM
PEKEAWLWDAARRFPPPPESPWGIWQVMRTGRSELKSDVSPETLARGLVGPEHLSLMEKVGVRSYLGVPLRVGRQTRGVF
VLLTSAPERRLTVTDQVFVEEVAGRAALALDNARLWSEAQDAVELIGVAAHDLGNPLNTLQLLLRRLQRMELAEEQKARD
GLAAALKQTQRLGQLLHNLLDLSRLSSGKLMLDVAPVDLSDLVHEVVERFAEQAAEAGCKLEFGAELGLVGRWDRLRLDR
VVTNLLSNALKFGRGRPVEVRVEHAGVARARLCVRDHGVGIAPEAQRRIFERFEREPSGGQHAGFGLGLYIVRQLVEAHG
GTIRVESAPSEGATFIVELPLMLLGSELREPPDIPLHS
>Mature_757_residues
ARPWTFAQRAGAGFIISLVVALVLAGTSVVALLSVRANHKARILELSRDVLDIKQLERTFNDKVVSGRGFALSGDTFFAQ
DMSVARERFIATYEALKRRLTQEPLATQLEAVSHAELEHEEAMQALIMEREDGVPRQRLEQIFDGHVADTRRRVMDSLRM
LHQQTETRLSEGIHESLATDRSALGLSLLAGSLGLAGATMLAWTLTRKLRPIQQEAEASAERFQLLVEGVRDYALFLLDA
RGRVESWNPGAERIMGYREAEILGQPSSVFYPPDAVAAGIPDKDLVRARKDGRLHTEGWRVRKDGSRYLADVNVTVLQDA
RGLPRGFAKVTRDITERRRAERTQQLLAEAGGLFHQFQDPDQTVAELTRIMVPEVADACLLYLLSASGDLWPRAVAHAMP
EKEAWLWDAARRFPPPPESPWGIWQVMRTGRSELKSDVSPETLARGLVGPEHLSLMEKVGVRSYLGVPLRVGRQTRGVFV
LLTSAPERRLTVTDQVFVEEVAGRAALALDNARLWSEAQDAVELIGVAAHDLGNPLNTLQLLLRRLQRMELAEEQKARDG
LAAALKQTQRLGQLLHNLLDLSRLSSGKLMLDVAPVDLSDLVHEVVERFAEQAAEAGCKLEFGAELGLVGRWDRLRLDRV
VTNLLSNALKFGRGRPVEVRVEHAGVARARLCVRDHGVGIAPEAQRRIFERFEREPSGGQHAGFGLGLYIVRQLVEAHGG
TIRVESAPSEGATFIVELPLMLLGSELREPPDIPLHS

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=30.5882352941176, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=27.2321428571429, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=30.0884955752212, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=288, Percent_Identity=30.5555555555556, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1786783, Length=220, Percent_Identity=30.9090909090909, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=28.90625, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=215, Percent_Identity=30.6976744186047, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=32.15859030837, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=228, Percent_Identity=27.1929824561404, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=30.4147465437788, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=220, Percent_Identity=31.3636363636364, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=29.5652173913043, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1789808, Length=229, Percent_Identity=28.82096069869, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=32.5242718446602, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI87081816, Length=189, Percent_Identity=30.1587301587302, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84094; Mature: 83962

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPWTFAQRAGAGFIISLVVALVLAGTSVVALLSVRANHKARILELSRDVLDIKQLERT
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FNDKVVSGRGFALSGDTFFAQDMSVARERFIATYEALKRRLTQEPLATQLEAVSHAELEH
HCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EEAMQALIMEREDGVPRQRLEQIFDGHVADTRRRVMDSLRMLHQQTETRLSEGIHESLAT
HHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DRSALGLSLLAGSLGLAGATMLAWTLTRKLRPIQQEAEASAERFQLLVEGVRDYALFLLD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
ARGRVESWNPGAERIMGYREAEILGQPSSVFYPPDAVAAGIPDKDLVRARKDGRLHTEGW
CCCCCCCCCCCHHHHHCHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCC
RVRKDGSRYLADVNVTVLQDARGLPRGFAKVTRDITERRRAERTQQLLAEAGGLFHQFQD
EEECCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
PDQTVAELTRIMVPEVADACLLYLLSASGDLWPRAVAHAMPEKEAWLWDAARRFPPPPES
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
PWGIWQVMRTGRSELKSDVSPETLARGLVGPEHLSLMEKVGVRSYLGVPLRVGRQTRGVF
CHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCHHHHCCCCHHCCCCCCCEE
VLLTSAPERRLTVTDQVFVEEVAGRAALALDNARLWSEAQDAVELIGVAAHDLGNPLNTL
EEEECCCCCCEEHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QLLLRRLQRMELAEEQKARDGLAAALKQTQRLGQLLHNLLDLSRLSSGKLMLDVAPVDLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHH
DLVHEVVERFAEQAAEAGCKLEFGAELGLVGRWDRLRLDRVVTNLLSNALKFGRGRPVEV
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
RVEHAGVARARLCVRDHGVGIAPEAQRRIFERFEREPSGGQHAGFGLGLYIVRQLVEAHG
EEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
GTIRVESAPSEGATFIVELPLMLLGSELREPPDIPLHS
CEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ARPWTFAQRAGAGFIISLVVALVLAGTSVVALLSVRANHKARILELSRDVLDIKQLERT
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FNDKVVSGRGFALSGDTFFAQDMSVARERFIATYEALKRRLTQEPLATQLEAVSHAELEH
HCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
EEAMQALIMEREDGVPRQRLEQIFDGHVADTRRRVMDSLRMLHQQTETRLSEGIHESLAT
HHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DRSALGLSLLAGSLGLAGATMLAWTLTRKLRPIQQEAEASAERFQLLVEGVRDYALFLLD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
ARGRVESWNPGAERIMGYREAEILGQPSSVFYPPDAVAAGIPDKDLVRARKDGRLHTEGW
CCCCCCCCCCCHHHHHCHHHHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCCCCCC
RVRKDGSRYLADVNVTVLQDARGLPRGFAKVTRDITERRRAERTQQLLAEAGGLFHQFQD
EEECCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
PDQTVAELTRIMVPEVADACLLYLLSASGDLWPRAVAHAMPEKEAWLWDAARRFPPPPES
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
PWGIWQVMRTGRSELKSDVSPETLARGLVGPEHLSLMEKVGVRSYLGVPLRVGRQTRGVF
CHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCHHHHCCCCHHCCCCCCCEE
VLLTSAPERRLTVTDQVFVEEVAGRAALALDNARLWSEAQDAVELIGVAAHDLGNPLNTL
EEEECCCCCCEEHHHHHHHHHHCCCHHEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QLLLRRLQRMELAEEQKARDGLAAALKQTQRLGQLLHNLLDLSRLSSGKLMLDVAPVDLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHH
DLVHEVVERFAEQAAEAGCKLEFGAELGLVGRWDRLRLDRVVTNLLSNALKFGRGRPVEV
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
RVEHAGVARARLCVRDHGVGIAPEAQRRIFERFEREPSGGQHAGFGLGLYIVRQLVEAHG
EEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCC
GTIRVESAPSEGATFIVELPLMLLGSELREPPDIPLHS
CEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA