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The map label for this gene is caiD [H]

Identifier: 108762601

GI number: 108762601

Start: 2365107

End: 2365868

Strand: Direct

Name: caiD [H]

Synonym: MXAN_2034

Alternate gene names: 108762601

Gene position: 2365107-2365868 (Clockwise)

Preceding gene: 108762098

Following gene: 108763360

Centisome position: 25.88

GC content: 72.44

Gene sequence:

>762_bases
ATGAGCGTGCGCGTCGAGAAGAACGGCCTCGTCACCACCGTCATCCTGGACCGCCCGGAGGTGCGCAACGCCGTGGATGG
CGCCACCGCCCAGGCGCTGGCGGAGGCCTTCCGCGCCTTCGACGCGGACCCGGATGCGCGGGTGGGCGTGCTCCATGGAG
AAGGGGGTACCTTCTGCGCCGGGGCGGACCTGAAGGCCGTCTCCGAGGGCCGGATGCCCCGCCTGGAGCTGGACGGGGAT
GGACCCATGGGCCCCTCGCGCATGGTGCTGTCCAAGCCCGTCATCGCGTCCATCGGCGGCCATGCCGTGGCGGGCGGCTT
GGAGCTGGCGTTGTGGTGCGACTTGCGCGTGGCCGAGGAGGACGCCGTCCTGGGCGTCTTCTGCCGCCGCTGGGGTGTGC
CCCTCATCGACGGGGGGACGGTGCGGCTGCCCCGGCTCATTGGCCTTTCGCGCGCGCTGGACCTCATCCTCACGGGCCGG
CCTGTGTCCGCCCAGGAGGCGCTGGCCATGGGGCTGGTCAACCGTGTGGTGCCCCGGGGGCAGGCGCGCGAGGCCGCGGA
GGCTCTGGCGCGCGAGGTGGCCGCCTTCCCGCAGGCGTGCATGAACGCGGACCGGCGCTCCGCCTACACCCAGGCGGGGC
TGGGCACCGAGGAGGCACTGCGTCAGGAGTTCGCCCGCGGTGTCAAGGTACTGGAGTCGGAGTCCATTGCTGGCGCCACG
CGTTTTGCCCAAGGGGCGGGGCGTCACGGGAAGTTCGAATAG

Upstream 100 bases:

>100_bases
ATCCACGGCCTGTCGGAAGGGGAGGGCGCGCACGCGCCCATGTAAGGAGGCACCGCGGCGGGATTGCGGTCCGGACGCGA
GGGAAGAAGACTCCGCCGCC

Downstream 100 bases:

>100_bases
GCGGGTCCTGCTGCGGGCAGGGAGGGACTGTGTTAGTTCCCCCGGCATGCGCTTCGACACGCTTGCCATCCACGCCGGTC
AGGAGCCGGATCCCACCACC

Product: enoyl-CoA hydratase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSVRVEKNGLVTTVILDRPEVRNAVDGATAQALAEAFRAFDADPDARVGVLHGEGGTFCAGADLKAVSEGRMPRLELDGD
GPMGPSRMVLSKPVIASIGGHAVAGGLELALWCDLRVAEEDAVLGVFCRRWGVPLIDGGTVRLPRLIGLSRALDLILTGR
PVSAQEALAMGLVNRVVPRGQAREAAEALAREVAAFPQACMNADRRSAYTQAGLGTEEALRQEFARGVKVLESESIAGAT
RFAQGAGRHGKFE

Sequences:

>Translated_253_residues
MSVRVEKNGLVTTVILDRPEVRNAVDGATAQALAEAFRAFDADPDARVGVLHGEGGTFCAGADLKAVSEGRMPRLELDGD
GPMGPSRMVLSKPVIASIGGHAVAGGLELALWCDLRVAEEDAVLGVFCRRWGVPLIDGGTVRLPRLIGLSRALDLILTGR
PVSAQEALAMGLVNRVVPRGQAREAAEALAREVAAFPQACMNADRRSAYTQAGLGTEEALRQEFARGVKVLESESIAGAT
RFAQGAGRHGKFE
>Mature_252_residues
SVRVEKNGLVTTVILDRPEVRNAVDGATAQALAEAFRAFDADPDARVGVLHGEGGTFCAGADLKAVSEGRMPRLELDGDG
PMGPSRMVLSKPVIASIGGHAVAGGLELALWCDLRVAEEDAVLGVFCRRWGVPLIDGGTVRLPRLIGLSRALDLILTGRP
VSAQEALAMGLVNRVVPRGQAREAAEALAREVAAFPQACMNADRRSAYTQAGLGTEEALRQEFARGVKVLESESIAGATR
FAQGAGRHGKFE

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=189, Percent_Identity=33.8624338624339, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI31542718, Length=230, Percent_Identity=30, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI68989263, Length=172, Percent_Identity=37.7906976744186, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI70995211, Length=185, Percent_Identity=33.5135135135135, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4502327, Length=197, Percent_Identity=35.5329949238579, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI20127408, Length=187, Percent_Identity=32.0855614973262, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI221142681, Length=250, Percent_Identity=34.4, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787659, Length=229, Percent_Identity=34.4978165938865, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788682, Length=200, Percent_Identity=35, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=31.5508021390374, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788597, Length=200, Percent_Identity=29, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787660, Length=225, Percent_Identity=32.4444444444444, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560910, Length=245, Percent_Identity=50.6122448979592, Blast_Score=225, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17540714, Length=189, Percent_Identity=33.8624338624339, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17534483, Length=188, Percent_Identity=35.6382978723404, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25145438, Length=218, Percent_Identity=33.0275229357798, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=182, Percent_Identity=32.4175824175824, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17554946, Length=202, Percent_Identity=32.6732673267327, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17540306, Length=221, Percent_Identity=30.316742081448, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=181, Percent_Identity=35.3591160220994, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=181, Percent_Identity=35.3591160220994, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=181, Percent_Identity=35.3591160220994, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25141363, Length=200, Percent_Identity=29, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357171, Length=213, Percent_Identity=50.7042253521127, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24650670, Length=222, Percent_Identity=48.1981981981982, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24653139, Length=197, Percent_Identity=33.502538071066, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI20129971, Length=172, Percent_Identity=34.8837209302326, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653477, Length=172, Percent_Identity=34.8837209302326, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583077, Length=193, Percent_Identity=32.6424870466321, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583079, Length=193, Percent_Identity=32.6424870466321, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921000, Length=193, Percent_Identity=32.6424870466321, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922422, Length=225, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920382, Length=188, Percent_Identity=30.8510638297872, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 26637; Mature: 26506

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRVEKNGLVTTVILDRPEVRNAVDGATAQALAEAFRAFDADPDARVGVLHGEGGTFCA
CCEEEECCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
GADLKAVSEGRMPRLELDGDGPMGPSRMVLSKPVIASIGGHAVAGGLELALWCDLRVAEE
CCCCHHHHCCCCCEEEECCCCCCCCCCHHHCCCHHHHCCCCCHHCCEEEEEEEEEEECCC
DAVLGVFCRRWGVPLIDGGTVRLPRLIGLSRALDLILTGRPVSAQEALAMGLVNRVVPRG
CHHHHHHHHHCCCCEECCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
QAREAAEALAREVAAFPQACMNADRRSAYTQAGLGTEEALRQEFARGVKVLESESIAGAT
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
RFAQGAGRHGKFE
HHHHCCCCCCCCC
>Mature Secondary Structure 
SVRVEKNGLVTTVILDRPEVRNAVDGATAQALAEAFRAFDADPDARVGVLHGEGGTFCA
CEEEECCCCEEEEEECCCHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
GADLKAVSEGRMPRLELDGDGPMGPSRMVLSKPVIASIGGHAVAGGLELALWCDLRVAEE
CCCCHHHHCCCCCEEEECCCCCCCCCCHHHCCCHHHHCCCCCHHCCEEEEEEEEEEECCC
DAVLGVFCRRWGVPLIDGGTVRLPRLIGLSRALDLILTGRPVSAQEALAMGLVNRVVPRG
CHHHHHHHHHCCCCEECCCCEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
QAREAAEALAREVAAFPQACMNADRRSAYTQAGLGTEEALRQEFARGVKVLESESIAGAT
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
RFAQGAGRHGKFE
HHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA