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The map label for this gene is metC [H]

Identifier: 108763360

GI number: 108763360

Start: 2365915

End: 2367060

Strand: Direct

Name: metC [H]

Synonym: MXAN_2035

Alternate gene names: 108763360

Gene position: 2365915-2367060 (Clockwise)

Preceding gene: 108762601

Following gene: 108763418

Centisome position: 25.89

GC content: 66.58

Gene sequence:

>1146_bases
ATGCGCTTCGACACGCTTGCCATCCACGCCGGTCAGGAGCCGGATCCCACCACCGGCGCCATCATGACGCCCGTCTACCT
GACGTCCACCTACGTCCAGGACGGCCCCGGAGAGCACAAGGGCTACGAGTACAGCCGGACGCAGAACCCCACCCGCAAGG
CGCTCCAGGACTGTCTGGCCGCGCTCGAGGGGGCGAAGTACGGCGCGGCCTTCGCCTCCGGCCTGGCGGGTACGGACATG
CTGATGCACATGCTGGACTCGGGCGACCACGTGGTCGTCTCGGACGATGTGTACGGCGGCACCTTCCGCCTCTTCGACAA
GGTGTTCCGGCGGGCCGGGCTGCACTTCTCCTTCGTGGACCTGTCCAAGCCGGAGAACTTCGAGGCGGCGATTACGCCGA
AGACGAAGATGGTGTGGGTGGAGTCCCCCACCAACCCGATGCTCAAGCTCATCGACCTGGCGCGCATCGCCGAGGTCGCC
AAGAAGCGGAACATCCTCTCCGTCGCCGACAACACGTTCATGACGCCGTACTTCCAGCGCCCGCTGGACCTCGGCTTCGA
CGTGGTGGCGCACTCCACCACCAAGTACATCAACGGCCACAGCGACGTGGTGGGCGGCTTCGTCTGCACCAGCCGTGAGG
ACGTGGCAGAGAAGATGTACTTCCTCCAGAACGCGGTGGGCGGCGTGTCCGGCGCCTTCGACAGCTTCATGGTACTGCGC
GGCGTGAAGACGCTGCACGTGCGCATGGACCGCCACGCCTCCAACGCGATGAAGGTGGCGCAGTTCCTGGCGTCCCACCC
GAAGGTGAAGAAGGTCACCTACCCGGGTCTGGAGGCGCACCCGCAGCACGCGCTGGCGAAGCAGCAGATGTCCGGCTTTG
GCGGCATGGTGACCTTCGACATCCAGGGGGGCCTGGAGGCCGCCCGCACCTTCCTCAAGACGGTGAAGGTGTTCGCCTGC
GCCGAGTCGCTCGGCGGCGTCGAGTCCCTCATCGAGCACCCGGCCATCATGACCCACGCCTCCATTCCCAAGGAGACGCG
CGAGCAGCTCGGCATCACCGACGGCTTCATCCGCCTGTCGGTGGGCATCGAGGACGCGCGGGACCTGGTGGACGACCTGT
CCCAGGCGCTCGACGCCGCGAAGTAG

Upstream 100 bases:

>100_bases
GCTGGCGCCACGCGTTTTGCCCAAGGGGCGGGGCGTCACGGGAAGTTCGAATAGGCGGGTCCTGCTGCGGGCAGGGAGGG
ACTGTGTTAGTTCCCCCGGC

Downstream 100 bases:

>100_bases
CCGTCAGGGCCTCGCGCCCCTTCGGTCTCCAGGGCCTCCCCGCGCTCGCCTTTCCGGAAGCGCGCGGAGGCCCTTGTCAT
GTGGAGGCGGCGTGCTGATT

Product: Cys/Met metabolism PLP-dependent enzyme

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MRFDTLAIHAGQEPDPTTGAIMTPVYLTSTYVQDGPGEHKGYEYSRTQNPTRKALQDCLAALEGAKYGAAFASGLAGTDM
LMHMLDSGDHVVVSDDVYGGTFRLFDKVFRRAGLHFSFVDLSKPENFEAAITPKTKMVWVESPTNPMLKLIDLARIAEVA
KKRNILSVADNTFMTPYFQRPLDLGFDVVAHSTTKYINGHSDVVGGFVCTSREDVAEKMYFLQNAVGGVSGAFDSFMVLR
GVKTLHVRMDRHASNAMKVAQFLASHPKVKKVTYPGLEAHPQHALAKQQMSGFGGMVTFDIQGGLEAARTFLKTVKVFAC
AESLGGVESLIEHPAIMTHASIPKETREQLGITDGFIRLSVGIEDARDLVDDLSQALDAAK

Sequences:

>Translated_381_residues
MRFDTLAIHAGQEPDPTTGAIMTPVYLTSTYVQDGPGEHKGYEYSRTQNPTRKALQDCLAALEGAKYGAAFASGLAGTDM
LMHMLDSGDHVVVSDDVYGGTFRLFDKVFRRAGLHFSFVDLSKPENFEAAITPKTKMVWVESPTNPMLKLIDLARIAEVA
KKRNILSVADNTFMTPYFQRPLDLGFDVVAHSTTKYINGHSDVVGGFVCTSREDVAEKMYFLQNAVGGVSGAFDSFMVLR
GVKTLHVRMDRHASNAMKVAQFLASHPKVKKVTYPGLEAHPQHALAKQQMSGFGGMVTFDIQGGLEAARTFLKTVKVFAC
AESLGGVESLIEHPAIMTHASIPKETREQLGITDGFIRLSVGIEDARDLVDDLSQALDAAK
>Mature_381_residues
MRFDTLAIHAGQEPDPTTGAIMTPVYLTSTYVQDGPGEHKGYEYSRTQNPTRKALQDCLAALEGAKYGAAFASGLAGTDM
LMHMLDSGDHVVVSDDVYGGTFRLFDKVFRRAGLHFSFVDLSKPENFEAAITPKTKMVWVESPTNPMLKLIDLARIAEVA
KKRNILSVADNTFMTPYFQRPLDLGFDVVAHSTTKYINGHSDVVGGFVCTSREDVAEKMYFLQNAVGGVSGAFDSFMVLR
GVKTLHVRMDRHASNAMKVAQFLASHPKVKKVTYPGLEAHPQHALAKQQMSGFGGMVTFDIQGGLEAARTFLKTVKVFAC
AESLGGVESLIEHPAIMTHASIPKETREQLGITDGFIRLSVGIEDARDLVDDLSQALDAAK

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=380, Percent_Identity=55.5263157894737, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI299473759, Length=380, Percent_Identity=50.7894736842105, Blast_Score=357, Evalue=8e-99,
Organism=Homo sapiens, GI25453487, Length=379, Percent_Identity=49.6042216358839, Blast_Score=341, Evalue=7e-94,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=41.5343915343915, Blast_Score=315, Evalue=2e-87,
Organism=Escherichia coli, GI1789383, Length=396, Percent_Identity=29.2929292929293, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=382, Percent_Identity=54.4502617801047, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17560056, Length=382, Percent_Identity=52.0942408376963, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71980708, Length=379, Percent_Identity=38.5224274406332, Blast_Score=265, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=46.5116279069767, Blast_Score=355, Evalue=8e-99,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=33.256351039261, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321170, Length=322, Percent_Identity=28.5714285714286, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=339, Percent_Identity=29.2035398230088, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322970, Length=262, Percent_Identity=26.7175572519084, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922554, Length=381, Percent_Identity=51.9685039370079, Blast_Score=420, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41568; Mature: 41568

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDTLAIHAGQEPDPTTGAIMTPVYLTSTYVQDGPGEHKGYEYSRTQNPTRKALQDCLA
CCCCEEEEECCCCCCCCCCCEECHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALEGAKYGAAFASGLAGTDMLMHMLDSGDHVVVSDDVYGGTFRLFDKVFRRAGLHFSFVD
HHHCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEE
LSKPENFEAAITPKTKMVWVESPTNPMLKLIDLARIAEVAKKRNILSVADNTFMTPYFQR
CCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHC
PLDLGFDVVAHSTTKYINGHSDVVGGFVCTSREDVAEKMYFLQNAVGGVSGAFDSFMVLR
CHHCCHHHHHCCHHHHCCCCCHHHCCEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GVKTLHVRMDRHASNAMKVAQFLASHPKVKKVTYPGLEAHPQHALAKQQMSGFGGMVTFD
CHHHEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEE
IQGGLEAARTFLKTVKVFACAESLGGVESLIEHPAIMTHASIPKETREQLGITDGFIRLS
ECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCHHHHHHCCCCCCEEEEE
VGIEDARDLVDDLSQALDAAK
ECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFDTLAIHAGQEPDPTTGAIMTPVYLTSTYVQDGPGEHKGYEYSRTQNPTRKALQDCLA
CCCCEEEEECCCCCCCCCCCEECHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ALEGAKYGAAFASGLAGTDMLMHMLDSGDHVVVSDDVYGGTFRLFDKVFRRAGLHFSFVD
HHHCCCHHHHHHHCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEE
LSKPENFEAAITPKTKMVWVESPTNPMLKLIDLARIAEVAKKRNILSVADNTFMTPYFQR
CCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHC
PLDLGFDVVAHSTTKYINGHSDVVGGFVCTSREDVAEKMYFLQNAVGGVSGAFDSFMVLR
CHHCCHHHHHCCHHHHCCCCCHHHCCEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GVKTLHVRMDRHASNAMKVAQFLASHPKVKKVTYPGLEAHPQHALAKQQMSGFGGMVTFD
CHHHEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEE
IQGGLEAARTFLKTVKVFACAESLGGVESLIEHPAIMTHASIPKETREQLGITDGFIRLS
ECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHCCCCHHHHHHCCCCCCEEEEE
VGIEDARDLVDDLSQALDAAK
ECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]