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The map label for this gene is pcm

Identifier: 108762574

GI number: 108762574

Start: 3960650

End: 3961288

Strand: Direct

Name: pcm

Synonym: MXAN_3407

Alternate gene names: 108762574

Gene position: 3960650-3961288 (Clockwise)

Preceding gene: 108763623

Following gene: 108758376

Centisome position: 43.33

GC content: 68.86

Gene sequence:

>639_bases
ATGGGTGACTGGGGAAGGGCCGACTACCTGTCGCGGCACGGCATCAAGGACGCGCGAGTCCTGGAGGCCATCGCTCGGCT
GAACCGCGCGGACTTCGTGCCGGAGGACCTGCGCGAAGAGGCGAGCGCGGACTCGCCGCTGCCCATCGGGCATGGGCAGA
CCATCAGCCAGCCCTACGTCGTGGCGCTGATGACGGAGGCGCTCCAGCTCCAGGGGGACGAGCGCGTCCTCGAAATCGGC
ACCGGCTCGGGCTACCAGACGGCGCTGCTGTCCCTGCTGTGCAGAGAGGTCTACTCCGTGGAAATCGTCCCCGAGCTGGC
CCAATCGGCGCGAGAGGTGTTGGGGCGGCAGGGCTTCGAAAACGTCTCGTTCCGGGAAGGAGACGGCTCACTGGGCTGGC
CGGACCAGGCGCCCTTCGACGCCATCCTCGCCGCCGCGGCGCCACCAGACGTTCCGCTTCAGCTCCTTTCACAGCTCAAG
CCGGGCGGGCGCATGATCATTCCGGTGGGGCCAAGGGGGGGCACCCAGCAACTGTTGCGCATCCAGCGAGCCCTCCGGCC
CGGAGAGGTGCCCCAGGTGGAGTCCCTGCTGTCGGTTCGCTTCGTTCCCATGACGGGGCAGCCGCTCTCGCAGGGGTGA

Upstream 100 bases:

>100_bases
GGAGAACCAGGGCCTCGTGAAGGCGCTCGAGGAACGCTGGGAAGGGCGGCTCGCGCTCGCACGGGTGGGGTAGGGCGCCT
GCCATGATTAGGCTAGGGGC

Downstream 100 bases:

>100_bases
CCTCCTGGGCTCGGGTGGCTCCTGACCCAGCGAGGCGGGAGGCAGGCTCTCTGTCCGCTTGCTCGCCATGTCGGCGGCGG
CCCGCTAACGTTCGCACATC

Product: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MGDWGRADYLSRHGIKDARVLEAIARLNRADFVPEDLREEASADSPLPIGHGQTISQPYVVALMTEALQLQGDERVLEIG
TGSGYQTALLSLLCREVYSVEIVPELAQSAREVLGRQGFENVSFREGDGSLGWPDQAPFDAILAAAAPPDVPLQLLSQLK
PGGRMIIPVGPRGGTQQLLRIQRALRPGEVPQVESLLSVRFVPMTGQPLSQG

Sequences:

>Translated_212_residues
MGDWGRADYLSRHGIKDARVLEAIARLNRADFVPEDLREEASADSPLPIGHGQTISQPYVVALMTEALQLQGDERVLEIG
TGSGYQTALLSLLCREVYSVEIVPELAQSAREVLGRQGFENVSFREGDGSLGWPDQAPFDAILAAAAPPDVPLQLLSQLK
PGGRMIIPVGPRGGTQQLLRIQRALRPGEVPQVESLLSVRFVPMTGQPLSQG
>Mature_211_residues
GDWGRADYLSRHGIKDARVLEAIARLNRADFVPEDLREEASADSPLPIGHGQTISQPYVVALMTEALQLQGDERVLEIGT
GSGYQTALLSLLCREVYSVEIVPELAQSAREVLGRQGFENVSFREGDGSLGWPDQAPFDAILAAAAPPDVPLQLLSQLKP
GGRMIIPVGPRGGTQQLLRIQRALRPGEVPQVESLLSVRFVPMTGQPLSQG

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=203, Percent_Identity=33.9901477832512, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1789100, Length=203, Percent_Identity=48.2758620689655, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71983477, Length=197, Percent_Identity=32.48730964467, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193207222, Length=195, Percent_Identity=31.2820512820513, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17981723, Length=213, Percent_Identity=33.8028169014084, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_MYXXD (Q1D6W9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631604.1
- ProteinModelPortal:   Q1D6W9
- SMR:   Q1D6W9
- STRING:   Q1D6W9
- GeneID:   4106325
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3407
- TIGR:   MXAN_3407
- eggNOG:   COG2518
- HOGENOM:   HBG699907
- OMA:   GYHAAVV
- PhylomeDB:   Q1D6W9
- BioCyc:   MXAN246197:MXAN_3407-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 22929; Mature: 22798

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 56-56

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDWGRADYLSRHGIKDARVLEAIARLNRADFVPEDLREEASADSPLPIGHGQTISQPYV
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHH
VALMTEALQLQGDERVLEIGTGSGYQTALLSLLCREVYSVEIVPELAQSAREVLGRQGFE
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NVSFREGDGSLGWPDQAPFDAILAAAAPPDVPLQLLSQLKPGGRMIIPVGPRGGTQQLLR
CCCEECCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHH
IQRALRPGEVPQVESLLSVRFVPMTGQPLSQG
HHHHCCCCCCHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
GDWGRADYLSRHGIKDARVLEAIARLNRADFVPEDLREEASADSPLPIGHGQTISQPYV
CCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHH
VALMTEALQLQGDERVLEIGTGSGYQTALLSLLCREVYSVEIVPELAQSAREVLGRQGFE
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NVSFREGDGSLGWPDQAPFDAILAAAAPPDVPLQLLSQLKPGGRMIIPVGPRGGTQQLLR
CCCEECCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHH
IQRALRPGEVPQVESLLSVRFVPMTGQPLSQG
HHHHCCCCCCHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA