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The map label for this gene is rnhA [H]

Identifier: 108762273

GI number: 108762273

Start: 2628106

End: 2628873

Strand: Reverse

Name: rnhA [H]

Synonym: MXAN_2265

Alternate gene names: 108762273

Gene position: 2628873-2628106 (Counterclockwise)

Preceding gene: 108760220

Following gene: 108758002

Centisome position: 28.76

GC content: 67.45

Gene sequence:

>768_bases
ATGGAGCACCGCCCGACCCTTGTCTTCGCTGATGGCGCCTGTTCAGGAAACCCTGGCCCGGGTGGCTGGGGGAGCATCAT
CGTCACGCCCGACGGGCTGGTGACGGAGCTGGGCGGACACGAGCCGGAGACCACCAACAACCGGATGGAGCTGACGGCCG
TGGGCAAGGCCCTGCGCCACCTGGAGCGCGCGCCGGGCCCCATCCACATCCACACGGACTCCACGTATGTGATTCAGGGA
GCTACCAAGTGGGCGTTCGGCTGGAGCCGGCGCGGGTGGAAGACGGCCGAGGGTGGCGAGGTCGCCAACGCCATCTATTG
GAAACGGCTGATGGCGCTCCTGGCGCAGCGCAAGGAGAGCCATGCCGCCGAGGCCGCCGCCGTCGCGTGGTTCTACATCC
GGGGCCACGTGGGCGTTCCCGGCAACGAGCGTGTGGACGCCATCGCCGTGGCCTATTCCAAGGGGCGTGACGCGAGGCTC
TACACCGGCCCGCTCCACGGCTACGGCGTGGCGGTGCACGACCTGCCGGAGGACATGTCACTGCCTCCAGAGAAGCCCAA
GGAACAGCGGGAGGCAGCGGCCAAGGCCTACTCCTACCTGAGCCAGGTGGGCAGCTCCGTGAAGCGCCACGCCTCCTGGG
CCGCGTGTGAGCGCCGGGTAAAAGGTGTGTCCGGCGCCCGTTTCAAGAAGACAAAGAGCGCGTTGGATGAAGCCAAAGTG
CTGGAGGACTGGGGCTTCAAGGGACAGGACGTCCCGTCGGAAGACTGA

Upstream 100 bases:

>100_bases
TTCGCGCGCGTCCGGCCGGGCCCCTCCCTGAGTGCCGTGCACTGAGCGCGCGGCCACCGCCGTCCTGGCGGGAGCACTTC
GCGCCGAATAGGGTGCCGGC

Downstream 100 bases:

>100_bases
GGCAGCCCCTCCAAGCCCATTGCCCCGCCGGTCCATTGCGCCTATGGGTCGGTGCCACTCCCATCCCGCGAGGACGCAGC
ATGGCTCAAGAGCCTCTCCA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MEHRPTLVFADGACSGNPGPGGWGSIIVTPDGLVTELGGHEPETTNNRMELTAVGKALRHLERAPGPIHIHTDSTYVIQG
ATKWAFGWSRRGWKTAEGGEVANAIYWKRLMALLAQRKESHAAEAAAVAWFYIRGHVGVPGNERVDAIAVAYSKGRDARL
YTGPLHGYGVAVHDLPEDMSLPPEKPKEQREAAAKAYSYLSQVGSSVKRHASWAACERRVKGVSGARFKKTKSALDEAKV
LEDWGFKGQDVPSED

Sequences:

>Translated_255_residues
MEHRPTLVFADGACSGNPGPGGWGSIIVTPDGLVTELGGHEPETTNNRMELTAVGKALRHLERAPGPIHIHTDSTYVIQG
ATKWAFGWSRRGWKTAEGGEVANAIYWKRLMALLAQRKESHAAEAAAVAWFYIRGHVGVPGNERVDAIAVAYSKGRDARL
YTGPLHGYGVAVHDLPEDMSLPPEKPKEQREAAAKAYSYLSQVGSSVKRHASWAACERRVKGVSGARFKKTKSALDEAKV
LEDWGFKGQDVPSED
>Mature_255_residues
MEHRPTLVFADGACSGNPGPGGWGSIIVTPDGLVTELGGHEPETTNNRMELTAVGKALRHLERAPGPIHIHTDSTYVIQG
ATKWAFGWSRRGWKTAEGGEVANAIYWKRLMALLAQRKESHAAEAAAVAWFYIRGHVGVPGNERVDAIAVAYSKGRDARL
YTGPLHGYGVAVHDLPEDMSLPPEKPKEQREAAAKAYSYLSQVGSSVKRHASWAACERRVKGVSGARFKKTKSALDEAKV
LEDWGFKGQDVPSED

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=157, Percent_Identity=29.9363057324841, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786408, Length=144, Percent_Identity=43.75, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115532542, Length=147, Percent_Identity=36.0544217687075, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137476, Length=151, Percent_Identity=31.1258278145695, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45552509, Length=151, Percent_Identity=31.1258278145695, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 27709; Mature: 27709

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHRPTLVFADGACSGNPGPGGWGSIIVTPDGLVTELGGHEPETTNNRMELTAVGKALRH
CCCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCEEEHHHHHHHHHH
LERAPGPIHIHTDSTYVIQGATKWAFGWSRRGWKTAEGGEVANAIYWKRLMALLAQRKES
HHHCCCCEEEECCCEEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HAAEAAAVAWFYIRGHVGVPGNERVDAIAVAYSKGRDARLYTGPLHGYGVAVHDLPEDMS
HHHHHHHEEEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCEEEECCCCCCC
LPPEKPKEQREAAAKAYSYLSQVGSSVKRHASWAACERRVKGVSGARFKKTKSALDEAKV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LEDWGFKGQDVPSED
HHHCCCCCCCCCCCC
>Mature Secondary Structure
MEHRPTLVFADGACSGNPGPGGWGSIIVTPDGLVTELGGHEPETTNNRMELTAVGKALRH
CCCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCEEEHHHHHHHHHH
LERAPGPIHIHTDSTYVIQGATKWAFGWSRRGWKTAEGGEVANAIYWKRLMALLAQRKES
HHHCCCCEEEECCCEEEEECCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HAAEAAAVAWFYIRGHVGVPGNERVDAIAVAYSKGRDARLYTGPLHGYGVAVHDLPEDMS
HHHHHHHEEEEEEEECCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCEEEECCCCCCC
LPPEKPKEQREAAAKAYSYLSQVGSSVKRHASWAACERRVKGVSGARFKKTKSALDEAKV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LEDWGFKGQDVPSED
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA