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The map label for this gene is adhA [H]

Identifier: 108762108

GI number: 108762108

Start: 520101

End: 521111

Strand: Direct

Name: adhA [H]

Synonym: MXAN_0456

Alternate gene names: 108762108

Gene position: 520101-521111 (Clockwise)

Preceding gene: 108762201

Following gene: 108761005

Centisome position: 5.69

GC content: 72.21

Gene sequence:

>1011_bases
ATGGAAGGAAGCATGCGCGCGATGGTGCTGCGCGAGGTCGGGCAGCCCCTGCATGAGACGCGGCTGCCCATTCCTCGCCC
CGGCCCGGAGGAGCTGTTGCTTCGCGTGCGCGCCTGCGCGGTCTGCCGCACCGACCTGCACGTCGTGGACGGTGAGCTGC
CGAAGCCCAAGCTGCCGCTGGTCCCAGGCCATGAAATCGTGGCCACGGTGGAGGCGGCGGGCGAGCGGGCGACGGCCATT
CCCGTGGGCACGCGAGTGGGCGTCCCCTGGCTCGGCTGGAGCTGCGGCCACTGCCGCTTCTGTCTGGCCGGCCAGGAGAA
CCTCTGCGAGCAGGCACGCTTCACGGGGTACCAACTGGATGGTGGCTACGCGGAGTTCACGGTGGCCCACCAGCGCTTCT
GCTTCCCCCTGCCGCCCGAGTACACCGACGTCCACGCCGCGCCGTTGATGTGCGCGGGCCTCATCGGCTTTCGCAGCCTC
CGCATGGCGGGGAGGGAGCGTCGTCTGTTGGGTTTCTACGGCTTCGGCGCCGCGGCCCACCTGCTCATCCAGGTCGCGCG
CCACCAAGGCCGGCGTGTCTTCGCCTTCACCCGGCCGGGGGACGTGGAGGGCCAACGGTTCGCGCGGGAGCTGGGCGCGG
AGTGGGCCGGGGATTCGGACACCGTGCCTCCGGAGCGGCTGGACGCGGCCATCCTCTTCGCGCCGGTGGGCGCGCTGGTG
CCCGCCGCGCTCCGGGCGGTGGACAAGGCCGGCGTGGTGGTGTGCGGCGGCATCCACATGAGCGACATCCCCGCGTTCCC
CTATGCGCTGCTGTGGGAGGAGCGGGTGGTGCGCTCGGTGGCGAACCTCACCCGGGCGGATGCGCTGGACTTCCTCGCGC
TCGCGCCCAAGGTGCCGGTGCGCACCCTGGTGCAAACCTTCCCACTGTCCGCCGCCAACGACGCCCTCACCGCGCTGAGG
CGAGGCCAGGTGCACGGCGCGGCGGTGCTGGAGGTGGCGGCCCTGGGTTGA

Upstream 100 bases:

>100_bases
ATGTGGCCGGGCCTGCTCGCGGGGGTGCAGATTTGAGGGGCCCCTCCCATCTTCCTCCCGGGTGCGCTGCTCTGGAGAGC
GCGGCGCCAGGGGGTGAAGC

Downstream 100 bases:

>100_bases
GCGCGGAGTCGGGCGGGCCTACATCCGCCTCTCAGGGTGGGCGGGGCAAATCGCCCCGCAGAGACTGCGCGGTGTCCCAT
TTCGCCGCAAACGCAGCGTG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MEGSMRAMVLREVGQPLHETRLPIPRPGPEELLLRVRACAVCRTDLHVVDGELPKPKLPLVPGHEIVATVEAAGERATAI
PVGTRVGVPWLGWSCGHCRFCLAGQENLCEQARFTGYQLDGGYAEFTVAHQRFCFPLPPEYTDVHAAPLMCAGLIGFRSL
RMAGRERRLLGFYGFGAAAHLLIQVARHQGRRVFAFTRPGDVEGQRFARELGAEWAGDSDTVPPERLDAAILFAPVGALV
PAALRAVDKAGVVVCGGIHMSDIPAFPYALLWEERVVRSVANLTRADALDFLALAPKVPVRTLVQTFPLSAANDALTALR
RGQVHGAAVLEVAALG

Sequences:

>Translated_336_residues
MEGSMRAMVLREVGQPLHETRLPIPRPGPEELLLRVRACAVCRTDLHVVDGELPKPKLPLVPGHEIVATVEAAGERATAI
PVGTRVGVPWLGWSCGHCRFCLAGQENLCEQARFTGYQLDGGYAEFTVAHQRFCFPLPPEYTDVHAAPLMCAGLIGFRSL
RMAGRERRLLGFYGFGAAAHLLIQVARHQGRRVFAFTRPGDVEGQRFARELGAEWAGDSDTVPPERLDAAILFAPVGALV
PAALRAVDKAGVVVCGGIHMSDIPAFPYALLWEERVVRSVANLTRADALDFLALAPKVPVRTLVQTFPLSAANDALTALR
RGQVHGAAVLEVAALG
>Mature_336_residues
MEGSMRAMVLREVGQPLHETRLPIPRPGPEELLLRVRACAVCRTDLHVVDGELPKPKLPLVPGHEIVATVEAAGERATAI
PVGTRVGVPWLGWSCGHCRFCLAGQENLCEQARFTGYQLDGGYAEFTVAHQRFCFPLPPEYTDVHAAPLMCAGLIGFRSL
RMAGRERRLLGFYGFGAAAHLLIQVARHQGRRVFAFTRPGDVEGQRFARELGAEWAGDSDTVPPERLDAAILFAPVGALV
PAALRAVDKAGVVVCGGIHMSDIPAFPYALLWEERVVRSVANLTRADALDFLALAPKVPVRTLVQTFPLSAANDALTALR
RGQVHGAAVLEVAALG

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=35.4545454545455, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4501933, Length=104, Percent_Identity=35.5769230769231, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=36.5384615384615, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4501929, Length=124, Percent_Identity=33.0645161290323, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI71743840, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262073058, Length=149, Percent_Identity=30.8724832214765, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI156627571, Length=326, Percent_Identity=26.6871165644172, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87081918, Length=317, Percent_Identity=29.9684542586751, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082401, Length=341, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786518, Length=230, Percent_Identity=34.3478260869565, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787863, Length=338, Percent_Identity=23.6686390532544, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790045, Length=214, Percent_Identity=29.4392523364486, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786552, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI226510992, Length=124, Percent_Identity=29.8387096774194, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788073, Length=234, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=307, Percent_Identity=25.7328990228013, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=25.2941176470588, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562582, Length=223, Percent_Identity=29.1479820627803, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=126, Percent_Identity=31.7460317460317, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=124, Percent_Identity=31.4516129032258, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=355, Percent_Identity=28.7323943661972, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324486, Length=360, Percent_Identity=27.7777777777778, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323729, Length=345, Percent_Identity=26.9565217391304, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319621, Length=358, Percent_Identity=27.0949720670391, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=149, Percent_Identity=34.8993288590604, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319949, Length=187, Percent_Identity=28.3422459893048, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=247, Percent_Identity=24.6963562753036, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=166, Percent_Identity=33.7349397590361, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=112, Percent_Identity=32.1428571428571, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36269; Mature: 36269

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGSMRAMVLREVGQPLHETRLPIPRPGPEELLLRVRACAVCRTDLHVVDGELPKPKLPL
CCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
VPGHEIVATVEAAGERATAIPVGTRVGVPWLGWSCGHCRFCLAGQENLCEQARFTGYQLD
CCCCHHEEEHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEC
GGYAEFTVAHQRFCFPLPPEYTDVHAAPLMCAGLIGFRSLRMAGRERRLLGFYGFGAAAH
CCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHH
LLIQVARHQGRRVFAFTRPGDVEGQRFARELGAEWAGDSDTVPPERLDAAILFAPVGALV
HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHCHHHHHHHHHHHH
PAALRAVDKAGVVVCGGIHMSDIPAFPYALLWEERVVRSVANLTRADALDFLALAPKVPV
HHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RTLVQTFPLSAANDALTALRRGQVHGAAVLEVAALG
HHHHHHCCCCCCHHHHHHHHHCCCCCHHHHEEEECC
>Mature Secondary Structure
MEGSMRAMVLREVGQPLHETRLPIPRPGPEELLLRVRACAVCRTDLHVVDGELPKPKLPL
CCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
VPGHEIVATVEAAGERATAIPVGTRVGVPWLGWSCGHCRFCLAGQENLCEQARFTGYQLD
CCCCHHEEEHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHCCCEEEC
GGYAEFTVAHQRFCFPLPPEYTDVHAAPLMCAGLIGFRSLRMAGRERRLLGFYGFGAAAH
CCEEEEEEHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHH
LLIQVARHQGRRVFAFTRPGDVEGQRFARELGAEWAGDSDTVPPERLDAAILFAPVGALV
HHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCHHHHCHHHHHHHHHHHH
PAALRAVDKAGVVVCGGIHMSDIPAFPYALLWEERVVRSVANLTRADALDFLALAPKVPV
HHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RTLVQTFPLSAANDALTALRRGQVHGAAVLEVAALG
HHHHHHCCCCCCHHHHHHHHHCCCCCHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]