Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 108762063

GI number: 108762063

Start: 3490257

End: 3491519

Strand: Reverse

Name: tyrS [H]

Synonym: MXAN_2976

Alternate gene names: 108762063

Gene position: 3491519-3490257 (Counterclockwise)

Preceding gene: 108761547

Following gene: 108757312

Centisome position: 38.2

GC content: 65.87

Gene sequence:

>1263_bases
ATGAATCCGGACGCGCTGCGCAAGGCGACCCCCGAGGAGCAGTTCGAAGAAGTGACCCGTGGCACGGTGGACCTCCACGT
GCCCGAGGACCTGAAGAAGAAGCTTCAGTACTCGTATGACACGGGCAAGCCGCTGGTCATCAAGGCGGGCTTCGACCCGA
GCCGGCCGGACCTGCACCTGGGCCACTCGCTGCTGCTCACGCGCATGCGGCGCTTCCAGGAGTTCGGCCACACGGTGGTG
TTCCTCATCGGTGACTTCACGGGGTTGATTGGCGACCCGACGGGCCGCAACGCCACGCGCCCGGCGCTCACGCGCGACGA
GGTGAAGGCCAACGCGGAGACCTACAAGAAGCAGGTCTTCAAGGTGTTGGACGAGTCCAAGACGCAGGTGCGCTTCAACT
CCAGCTGGCTGGACTCACTGGGGACGGAAGGGATGATCCGCCTGGCCTCGCGCTACTCCGTGCAGCGCATGCTGGAGCGC
GACGACTTCAAGAAGCGCTTCCGCGGCGAAGTCTCCATCTCCATCCACGAGTTCCTCTACCCGCTCCTGCAGGGCTACGA
CTCGGTGGTGCTCAAGGCGGACGTGGAGCTGGGCGCGACGGACCAGCTCTTCAACCTGCTGGTGGGCCGCCAGTTGATGA
AGGAAGAGGGCATGGCGCCCCAGGTCATCATGACGGGCCCCATCCTGGAGGGCCTCAACGCGAAGGCGGTTGACGGAAAG
ATTGTCGGCGACAAGATGTCCAAGAGCCTGGACAACTACGTGGGCATCGACGAGCCGGCGGACACCATCTTCGGCAAGTT
GATGAGCATCACCGACGACCTGATGTGGCGGTACTACGAGCTGCTCTCCGCGAAGACGCGGGCGGAGCTGGCGGAAATGC
GCGCCCAGGTGGAGTCCGGCGCGCTGCACCCCAAGGCGGTGAAGGTCGGCTTCGCGCAGGAGATGACGGCGCGCTTCCAG
GGCGAGGAGGCCGGGAAGAAGGCCGCCGAGGACTTCGAGAAGCGCTTCGCGAAGAAGGAGCTGTCCACGGACGAGCTGCC
CCTGGTGGAGGTGTCCCTGGGCGGCGCGGAGAAGCTGCCGGTGACGAAGCTGCTGCCGGAGTCGAAGCTGGTCGCGTCCG
CCACCGAGGCGCGCAAGCTGATGGCGCAGGGCGGCGTGCGCGTCAACGGCGAGAAGGTGCAGGACGTCAAGGCGGAGCTG
GGCGCCGGCGAGTACACAGTGCAGGTGGGCAAGCTGAAGGCAGCCCGCGTGAAGCTCGGTTGA

Upstream 100 bases:

>100_bases
GCCGGAGCATCCACCGCGTGCGTGAGCACCTGCCAGGCACCTGAAACCCGGTGGAGGAAGTGCGTCCACGGCTGGCGCAC
TTCGGGTAGCTTGCGGCGCC

Downstream 100 bases:

>100_bases
ATCTCCGGCCGGTGACGGCCGTCGCAGGCGCAGGACATGCCCCCCTGCCCCTCCTCTGAGGGGCACGGCGGGGACTGCTG
TAGACTCCCGTGCGCCATGC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNPDALRKATPEEQFEEVTRGTVDLHVPEDLKKKLQYSYDTGKPLVIKAGFDPSRPDLHLGHSLLLTRMRRFQEFGHTVV
FLIGDFTGLIGDPTGRNATRPALTRDEVKANAETYKKQVFKVLDESKTQVRFNSSWLDSLGTEGMIRLASRYSVQRMLER
DDFKKRFRGEVSISIHEFLYPLLQGYDSVVLKADVELGATDQLFNLLVGRQLMKEEGMAPQVIMTGPILEGLNAKAVDGK
IVGDKMSKSLDNYVGIDEPADTIFGKLMSITDDLMWRYYELLSAKTRAELAEMRAQVESGALHPKAVKVGFAQEMTARFQ
GEEAGKKAAEDFEKRFAKKELSTDELPLVEVSLGGAEKLPVTKLLPESKLVASATEARKLMAQGGVRVNGEKVQDVKAEL
GAGEYTVQVGKLKAARVKLG

Sequences:

>Translated_420_residues
MNPDALRKATPEEQFEEVTRGTVDLHVPEDLKKKLQYSYDTGKPLVIKAGFDPSRPDLHLGHSLLLTRMRRFQEFGHTVV
FLIGDFTGLIGDPTGRNATRPALTRDEVKANAETYKKQVFKVLDESKTQVRFNSSWLDSLGTEGMIRLASRYSVQRMLER
DDFKKRFRGEVSISIHEFLYPLLQGYDSVVLKADVELGATDQLFNLLVGRQLMKEEGMAPQVIMTGPILEGLNAKAVDGK
IVGDKMSKSLDNYVGIDEPADTIFGKLMSITDDLMWRYYELLSAKTRAELAEMRAQVESGALHPKAVKVGFAQEMTARFQ
GEEAGKKAAEDFEKRFAKKELSTDELPLVEVSLGGAEKLPVTKLLPESKLVASATEARKLMAQGGVRVNGEKVQDVKAEL
GAGEYTVQVGKLKAARVKLG
>Mature_420_residues
MNPDALRKATPEEQFEEVTRGTVDLHVPEDLKKKLQYSYDTGKPLVIKAGFDPSRPDLHLGHSLLLTRMRRFQEFGHTVV
FLIGDFTGLIGDPTGRNATRPALTRDEVKANAETYKKQVFKVLDESKTQVRFNSSWLDSLGTEGMIRLASRYSVQRMLER
DDFKKRFRGEVSISIHEFLYPLLQGYDSVVLKADVELGATDQLFNLLVGRQLMKEEGMAPQVIMTGPILEGLNAKAVDGK
IVGDKMSKSLDNYVGIDEPADTIFGKLMSITDDLMWRYYELLSAKTRAELAEMRAQVESGALHPKAVKVGFAQEMTARFQ
GEEAGKKAAEDFEKRFAKKELSTDELPLVEVSLGGAEKLPVTKLLPESKLVASATEARKLMAQGGVRVNGEKVQDVKAEL
GAGEYTVQVGKLKAARVKLG

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=449, Percent_Identity=24.2761692650334, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1787925, Length=376, Percent_Identity=28.1914893617021, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25145802, Length=230, Percent_Identity=31.304347826087, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325160, Length=382, Percent_Identity=25.130890052356, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI20130383, Length=440, Percent_Identity=24.7727272727273, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 46656; Mature: 46656

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: PS50889 S4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPDALRKATPEEQFEEVTRGTVDLHVPEDLKKKLQYSYDTGKPLVIKAGFDPSRPDLHL
CCCHHHHCCCCHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHH
GHSLLLTRMRRFQEFGHTVVFLIGDFTGLIGDPTGRNATRPALTRDEVKANAETYKKQVF
HHHHHHHHHHHHHHHCCEEEEEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KVLDESKTQVRFNSSWLDSLGTEGMIRLASRYSVQRMLERDDFKKRFRGEVSISIHEFLY
HHHHCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
PLLQGYDSVVLKADVELGATDQLFNLLVGRQLMKEEGMAPQVIMTGPILEGLNAKAVDGK
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCCCCE
IVGDKMSKSLDNYVGIDEPADTIFGKLMSITDDLMWRYYELLSAKTRAELAEMRAQVESG
EECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ALHPKAVKVGFAQEMTARFQGEEAGKKAAEDFEKRFAKKELSTDELPLVEVSLGGAEKLP
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
VTKLLPESKLVASATEARKLMAQGGVRVNGEKVQDVKAELGAGEYTVQVGKLKAARVKLG
HHHHCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHCCCCEEEEECCEEEEEECCC
>Mature Secondary Structure
MNPDALRKATPEEQFEEVTRGTVDLHVPEDLKKKLQYSYDTGKPLVIKAGFDPSRPDLHL
CCCHHHHCCCCHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHH
GHSLLLTRMRRFQEFGHTVVFLIGDFTGLIGDPTGRNATRPALTRDEVKANAETYKKQVF
HHHHHHHHHHHHHHHCCEEEEEEECHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KVLDESKTQVRFNSSWLDSLGTEGMIRLASRYSVQRMLERDDFKKRFRGEVSISIHEFLY
HHHHCCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
PLLQGYDSVVLKADVELGATDQLFNLLVGRQLMKEEGMAPQVIMTGPILEGLNAKAVDGK
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHHCCCCCCCCCCE
IVGDKMSKSLDNYVGIDEPADTIFGKLMSITDDLMWRYYELLSAKTRAELAEMRAQVESG
EECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ALHPKAVKVGFAQEMTARFQGEEAGKKAAEDFEKRFAKKELSTDELPLVEVSLGGAEKLP
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCC
VTKLLPESKLVASATEARKLMAQGGVRVNGEKVQDVKAELGAGEYTVQVGKLKAARVKLG
HHHHCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHCCCCEEEEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA