Click here to switch to the map view.

The map label for this gene is cbs [H]

Identifier: 108762019

GI number: 108762019

Start: 5122156

End: 5123148

Strand: Reverse

Name: cbs [H]

Synonym: MXAN_4171

Alternate gene names: 108762019

Gene position: 5123148-5122156 (Counterclockwise)

Preceding gene: 108760958

Following gene: 108757949

Centisome position: 56.05

GC content: 68.58

Gene sequence:

>993_bases
ATGGCGCCTCGCATTGGAACGCTCTGGGACTCCGTCGGAAACACCCCGCTGCTGCGCATCGGCTCGCTGAGCCGGCAGAC
GGGGTGTGAAATCCTCGCGAAGGCCGAGTTCATGAACCCCGGCGGCAGCATCAAGGACCGCGCCGCGAAGGGGATGATTC
AGTGCGCCGAGGCGCAGGGCCTGCTGAAGCCGGGCGGCGCCATCTTCGAGGGCACCGCGGGCAACACCGGCATCGGCCTG
GGGCTCTTGGGCCGCGAGCGCGGGTACCGCGTGGTCGTCACCATGCCGGACAACCAGGCCCGCGAGAAGTACGAGCTACT
GGAGGCCATGGGCGTGGAGGTCCGAAAGGTCCCCGCGGTGCCCTTCGCCAATCCGAACCACTTCTTCCACCAGGCCCGCG
TGCTGGCGGAAGCGCAGGGCGGCTTCTGGGCGAACCAGTTCGAGAACCCGGCCAACGGCGACTACCACTACGAGACGACG
GGCCCTGAAATCTGGGAGCAGTGCGAGGGCCGCGTGGACGTGCTGGTGGCGTCCGTGGGCAGCGGTGGGACGATGGGCGG
CGTCAGCCGTTACCTGAAGGAGAAGAACCCCGCCGTGCGCGTGGTGTTGGTGGACCCGCCGGGCTCGGGCCTCTTCACCT
ACGTGCGCGAAGGGCGCATGGAAGGGCCCGGTTCTTCCATCACCGAGGGCATTGGCATCATGCGCCTCACGGAGAACTTC
CGCCGGGCCCAGGTGGACGAGGCCATGCGCCTGGGGGACCAGGACATGGTGGAGATGCTCTACCACCTGGCGCGCGAGGA
CGCGCTGGTGGTGGGCACATCGGCGGCCCTCAACGTGCGCGCCGCGTGGGAGCTGGCGCGGCGTCATCGGGGCGAGGGGC
TGCGCATCGTCACCTTCCTGTGCGACCACGGCAGCCGCTACGCGTCGAAGGTGTTCAACCCGGAGTTCCTCGCGTCCAAG
CAGTTGGAGGTGAGGCCGCTTCCCGTGGATTGA

Upstream 100 bases:

>100_bases
CGGCCCGCGCGGCGAAGTTGGATCCGGTGGAGGCCATGCGGGCGGATTGAGGGCGGTGGTTCCCGGTGACGGGCGCCACC
CTTCGCGTTAAGCACAGCCC

Downstream 100 bases:

>100_bases
CAGTGCGGGGTACTCGGGTGGTCGTGCTGCAATTCAACACCCTGGGACTGCAATGACTCTCCCTTGAGTCTGTGACGTCT
GCTGTTACAGAGCGAGTCAC

Product: cysteine synthase A

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MAPRIGTLWDSVGNTPLLRIGSLSRQTGCEILAKAEFMNPGGSIKDRAAKGMIQCAEAQGLLKPGGAIFEGTAGNTGIGL
GLLGRERGYRVVVTMPDNQAREKYELLEAMGVEVRKVPAVPFANPNHFFHQARVLAEAQGGFWANQFENPANGDYHYETT
GPEIWEQCEGRVDVLVASVGSGGTMGGVSRYLKEKNPAVRVVLVDPPGSGLFTYVREGRMEGPGSSITEGIGIMRLTENF
RRAQVDEAMRLGDQDMVEMLYHLAREDALVVGTSAALNVRAAWELARRHRGEGLRIVTFLCDHGSRYASKVFNPEFLASK
QLEVRPLPVD

Sequences:

>Translated_330_residues
MAPRIGTLWDSVGNTPLLRIGSLSRQTGCEILAKAEFMNPGGSIKDRAAKGMIQCAEAQGLLKPGGAIFEGTAGNTGIGL
GLLGRERGYRVVVTMPDNQAREKYELLEAMGVEVRKVPAVPFANPNHFFHQARVLAEAQGGFWANQFENPANGDYHYETT
GPEIWEQCEGRVDVLVASVGSGGTMGGVSRYLKEKNPAVRVVLVDPPGSGLFTYVREGRMEGPGSSITEGIGIMRLTENF
RRAQVDEAMRLGDQDMVEMLYHLAREDALVVGTSAALNVRAAWELARRHRGEGLRIVTFLCDHGSRYASKVFNPEFLASK
QLEVRPLPVD
>Mature_329_residues
APRIGTLWDSVGNTPLLRIGSLSRQTGCEILAKAEFMNPGGSIKDRAAKGMIQCAEAQGLLKPGGAIFEGTAGNTGIGLG
LLGRERGYRVVVTMPDNQAREKYELLEAMGVEVRKVPAVPFANPNHFFHQARVLAEAQGGFWANQFENPANGDYHYETTG
PEIWEQCEGRVDVLVASVGSGGTMGGVSRYLKEKNPAVRVVLVDPPGSGLFTYVREGRMEGPGSSITEGIGIMRLTENFR
RAQVDEAMRLGDQDMVEMLYHLAREDALVVGTSAALNVRAAWELARRHRGEGLRIVTFLCDHGSRYASKVFNPEFLASKQ
LEVRPLPVD

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=328, Percent_Identity=38.109756097561, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI295821200, Length=328, Percent_Identity=38.109756097561, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI4557415, Length=328, Percent_Identity=38.109756097561, Blast_Score=204, Evalue=9e-53,
Organism=Escherichia coli, GI2367138, Length=324, Percent_Identity=34.8765432098765, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788754, Length=328, Percent_Identity=33.2317073170732, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17535051, Length=307, Percent_Identity=39.413680781759, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17562970, Length=322, Percent_Identity=36.9565217391304, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=37.7483443708609, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=322, Percent_Identity=36.9565217391304, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI115535073, Length=301, Percent_Identity=38.8704318936877, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=32.6219512195122, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147552, Length=332, Percent_Identity=31.3253012048193, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=236, Percent_Identity=34.7457627118644, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17539800, Length=353, Percent_Identity=26.628895184136, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=332, Percent_Identity=25.6024096385542, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=40.7407407407407, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6321594, Length=325, Percent_Identity=34.1538461538462, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=33.9563862928349, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=33.9563862928349, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 35959; Mature: 35827

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00165 DEHYDRATASE_SER_THR ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRIGTLWDSVGNTPLLRIGSLSRQTGCEILAKAEFMNPGGSIKDRAAKGMIQCAEAQG
CCCCCCHHHHHCCCCCEEEECCCCCHHCHHEEEEHEECCCCCCHHHHHHHHHHHHHHHCC
LLKPGGAIFEGTAGNTGIGLGLLGRERGYRVVVTMPDNQAREKYELLEAMGVEVRKVPAV
CCCCCCCEEECCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCEEECCCC
PFANPNHFFHQARVLAEAQGGFWANQFENPANGDYHYETTGPEIWEQCEGRVDVLVASVG
CCCCCHHHHHHHHHHHHHCCCEEHHHCCCCCCCCEEEECCCHHHHHHHCCCEEEEEEECC
SGGTMGGVSRYLKEKNPAVRVVLVDPPGSGLFTYVREGRMEGPGSSITEGIGIMRLTENF
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RRAQVDEAMRLGDQDMVEMLYHLAREDALVVGTSAALNVRAAWELARRHRGEGLRIVTFL
HHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCEEHHHHHHHHHHHCCCCEEEEEEE
CDHGSRYASKVFNPEFLASKQLEVRPLPVD
ECCCCHHHHHCCCHHHHCCCCCEEECCCCC
>Mature Secondary Structure 
APRIGTLWDSVGNTPLLRIGSLSRQTGCEILAKAEFMNPGGSIKDRAAKGMIQCAEAQG
CCCCCHHHHHCCCCCEEEECCCCCHHCHHEEEEHEECCCCCCHHHHHHHHHHHHHHHCC
LLKPGGAIFEGTAGNTGIGLGLLGRERGYRVVVTMPDNQAREKYELLEAMGVEVRKVPAV
CCCCCCCEEECCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHCCCEEECCCC
PFANPNHFFHQARVLAEAQGGFWANQFENPANGDYHYETTGPEIWEQCEGRVDVLVASVG
CCCCCHHHHHHHHHHHHHCCCEEHHHCCCCCCCCEEEECCCHHHHHHHCCCEEEEEEECC
SGGTMGGVSRYLKEKNPAVRVVLVDPPGSGLFTYVREGRMEGPGSSITEGIGIMRLTENF
CCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RRAQVDEAMRLGDQDMVEMLYHLAREDALVVGTSAALNVRAAWELARRHRGEGLRIVTFL
HHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCEEHHHHHHHHHHHCCCCEEEEEEE
CDHGSRYASKVFNPEFLASKQLEVRPLPVD
ECCCCHHHHHCCCHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]