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The map label for this gene is selB [H]

Identifier: 108761780

GI number: 108761780

Start: 1252102

End: 1254018

Strand: Direct

Name: selB [H]

Synonym: MXAN_1076

Alternate gene names: 108761780

Gene position: 1252102-1254018 (Clockwise)

Preceding gene: 108761795

Following gene: 108763472

Centisome position: 13.7

GC content: 72.56

Gene sequence:

>1917_bases
ATGATTGTCGGGACGGCGGGCCACATCGACCATGGCAAGACGTCCCTGGTGAAGGTGCTCACCGGCATCGACACCGACCG
GCTGAAGGAAGAGAAGCGCCGCGGCATCACCCTGGAGCTGGGCTTCGCCCACCTGACGCTGGATGACGGCGCCGTGGCCG
GCGTGGTGGACGTCCCGGGCCACGAGCGCTTCGTGAAGGCCATGGCCGCTGGCTCCGGCGGCGTGGACCTGGTGGTGCTG
GTGGTGGCCGCGGACGAGGGCGTGATGCCCCAGACGCGCGAGCACCTGGACATCTGCCGGCTGCTGGGCGTGAGGGCCGG
CGTCATCGCCCTCACCAAGTCGGACACGCTGGCGGAGCTGGGCCCGGAGTGGCTCGCGCTGGTGGAGGCCGACCTGTCCG
CGCTCACCGTGGGGACCTTCCTGGAGTCGGCGCCCGTGGTGGCCTGCTCCGCCAGAACGGGTGCGGGATTGGACGCGCTG
CGCGCCGCGCTCACCCGGGCCGCGGCGGCGCTGCCCGAGCGGCCTTCGGAGGGCCCCGCCTTCTTGCCGGTCGACCGCGT
GTTCACCATCAAGGGCTTTGGCACGGTGGTGACGGGCACGCTGCTGTCGGGAGCGCTGGCGGTGGGTGACGCGGTGTCGC
TCCTGCCTGGGCTGCCCGGTCCGCTGCGCGTGCGCGGGGTGCAGCGTCATGGCGACGCCGTATCCGTCGTGGAGGCGGGG
CAGCGCGCGGCGGTGAACCTCACTGGCGTGGAGCCGGAGGCGTTGCGCCGGGGGATGGTGCTGGTGCGCGCGGGCGAGCT
GCCGGAGGCGCGCATGCTCGATGTCGAGTTGACGTTGCTGCCCGCGGCTCCGTCGCCGTTGCCTCGTCGCTCGAAGCTGC
TGCTGCACCTGGGCACCGCGCAGGTGGAGGCCACGGTGGCGCTGTTGGATGTGGAGCGGCTGGAGCCCGGCGAGACGACG
CTGGCGCAGTTGCGGCTGGGCGCGTCCGTGGGTGCGTTGGTGGGCCAGCGCTTCATCCTGCGCGGCGCGCGAGCCCTTCC
GGGGAGAGGCGCCACGGTGGCGGGAGGCCGCATCCTGTCCATCTCCCCGCCGAAGCGGCGCAAGGGCGGCGCGTCGGCGG
TAGCGCCCCTGCTGGAGGCGGACCCGGCGGGGCAGGTGGCCTGGCTGCTGCGGCAGGCGGGCTATCGCGGGCTGACGCAG
CCGGAGCTGTTCGGCCGCTCGGCGCTGGGGCCCCGGGTCCTCACGCGCGCGCTGGAGTTGCTGGGGGCGCGGGGCGGTGC
GCTCCTCATCGACCGGGAGCGGCGGCTGTACCTCTCCGGCGAGGTCTTCGAGGCGTTGCAGGGCCGCGCCCTGGCGCTGC
TGGCCACCTTCCATGAGCGCGAACCCTTGCGCGAAGGCCTGTCACGCGAGGAGCTGCGGCAGCGGCTGTCCTCCGCGCTG
GATGTTCGGGCGTTCCAGCGGGTGTTGCAGGCGCTGGTGGAAGGAGGACGGGTGGAACTGGAGCGGGACGTGGTACGCCT
CAAGGGGCGCGGCCGCACGCTGAGCCTGGGTGACACCGCTGCTCGGGCGCGGCTGGCGGCAGAGCTGTCCGCCGCGGCCC
TGGCGCCTCCCTCGCTTCCCGAACTGGAGCAGAAGCTCCAGCTCCCCGCCTCCCGGCTGCGTGAGCTGTTGGGCGTCATG
GTGGTGGAGGGGGCGGCGGTGCGCGTCTCGGAGGGCTTGTGGTTCGCGGCCGGGGCGCTGGCTTCACTGCGCGAGCGCCT
GGTTGCCCACCTGCGCGAGAAGAAGGAGATTACCACCCAGGATTTCAAGGAGATGGTGGGGCAAAGCCGCAAGTTCGTCA
TCCCCCTGTCCGAATACTTCGACCGGGAGAAGGTCACGCTCCGGGTAGGAGAGAAGCGGGTGCTGCGTCGCGGATGA

Upstream 100 bases:

>100_bases
CTCATGGTCTTCCCCTGGGACTACGAGCCGTCCACCGGCGACGCGCGCTTCGACGAGGACCCGGACAAGGCTGGCGCATG
AGCCTTGGCGCGGTGACGCC

Downstream 100 bases:

>100_bases
GTACCAAGCGCTACAGCGAGGCGGAGCTTCGCGCCCTCGTCGACACCTTCCGCAACCCCATGCTGGCGGTGGTGGAGGGA
CGCGTGCTCGTGGCCAATGA

Product: selenocysteine-specific translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MIVGTAGHIDHGKTSLVKVLTGIDTDRLKEEKRRGITLELGFAHLTLDDGAVAGVVDVPGHERFVKAMAAGSGGVDLVVL
VVAADEGVMPQTREHLDICRLLGVRAGVIALTKSDTLAELGPEWLALVEADLSALTVGTFLESAPVVACSARTGAGLDAL
RAALTRAAAALPERPSEGPAFLPVDRVFTIKGFGTVVTGTLLSGALAVGDAVSLLPGLPGPLRVRGVQRHGDAVSVVEAG
QRAAVNLTGVEPEALRRGMVLVRAGELPEARMLDVELTLLPAAPSPLPRRSKLLLHLGTAQVEATVALLDVERLEPGETT
LAQLRLGASVGALVGQRFILRGARALPGRGATVAGGRILSISPPKRRKGGASAVAPLLEADPAGQVAWLLRQAGYRGLTQ
PELFGRSALGPRVLTRALELLGARGGALLIDRERRLYLSGEVFEALQGRALALLATFHEREPLREGLSREELRQRLSSAL
DVRAFQRVLQALVEGGRVELERDVVRLKGRGRTLSLGDTAARARLAAELSAAALAPPSLPELEQKLQLPASRLRELLGVM
VVEGAAVRVSEGLWFAAGALASLRERLVAHLREKKEITTQDFKEMVGQSRKFVIPLSEYFDREKVTLRVGEKRVLRRG

Sequences:

>Translated_638_residues
MIVGTAGHIDHGKTSLVKVLTGIDTDRLKEEKRRGITLELGFAHLTLDDGAVAGVVDVPGHERFVKAMAAGSGGVDLVVL
VVAADEGVMPQTREHLDICRLLGVRAGVIALTKSDTLAELGPEWLALVEADLSALTVGTFLESAPVVACSARTGAGLDAL
RAALTRAAAALPERPSEGPAFLPVDRVFTIKGFGTVVTGTLLSGALAVGDAVSLLPGLPGPLRVRGVQRHGDAVSVVEAG
QRAAVNLTGVEPEALRRGMVLVRAGELPEARMLDVELTLLPAAPSPLPRRSKLLLHLGTAQVEATVALLDVERLEPGETT
LAQLRLGASVGALVGQRFILRGARALPGRGATVAGGRILSISPPKRRKGGASAVAPLLEADPAGQVAWLLRQAGYRGLTQ
PELFGRSALGPRVLTRALELLGARGGALLIDRERRLYLSGEVFEALQGRALALLATFHEREPLREGLSREELRQRLSSAL
DVRAFQRVLQALVEGGRVELERDVVRLKGRGRTLSLGDTAARARLAAELSAAALAPPSLPELEQKLQLPASRLRELLGVM
VVEGAAVRVSEGLWFAAGALASLRERLVAHLREKKEITTQDFKEMVGQSRKFVIPLSEYFDREKVTLRVGEKRVLRRG
>Mature_638_residues
MIVGTAGHIDHGKTSLVKVLTGIDTDRLKEEKRRGITLELGFAHLTLDDGAVAGVVDVPGHERFVKAMAAGSGGVDLVVL
VVAADEGVMPQTREHLDICRLLGVRAGVIALTKSDTLAELGPEWLALVEADLSALTVGTFLESAPVVACSARTGAGLDAL
RAALTRAAAALPERPSEGPAFLPVDRVFTIKGFGTVVTGTLLSGALAVGDAVSLLPGLPGPLRVRGVQRHGDAVSVVEAG
QRAAVNLTGVEPEALRRGMVLVRAGELPEARMLDVELTLLPAAPSPLPRRSKLLLHLGTAQVEATVALLDVERLEPGETT
LAQLRLGASVGALVGQRFILRGARALPGRGATVAGGRILSISPPKRRKGGASAVAPLLEADPAGQVAWLLRQAGYRGLTQ
PELFGRSALGPRVLTRALELLGARGGALLIDRERRLYLSGEVFEALQGRALALLATFHEREPLREGLSREELRQRLSSAL
DVRAFQRVLQALVEGGRVELERDVVRLKGRGRTLSLGDTAARARLAAELSAAALAPPSLPELEQKLQLPASRLRELLGVM
VVEGAAVRVSEGLWFAAGALASLRERLVAHLREKKEITTQDFKEMVGQSRKFVIPLSEYFDREKVTLRVGEKRVLRRG

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=382, Percent_Identity=32.1989528795811, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI54607086, Length=341, Percent_Identity=28.1524926686217, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI82546879, Length=454, Percent_Identity=25.7709251101322, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4503507, Length=261, Percent_Identity=25.6704980842912, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI45593140, Length=426, Percent_Identity=25.8215962441315, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI53729339, Length=215, Percent_Identity=34.8837209302326, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI53729337, Length=215, Percent_Identity=34.8837209302326, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI2367247, Length=644, Percent_Identity=31.5217391304348, Blast_Score=234, Evalue=2e-62,
Organism=Escherichia coli, GI1790412, Length=368, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789737, Length=368, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789559, Length=216, Percent_Identity=35.1851851851852, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1789108, Length=289, Percent_Identity=28.0276816608997, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25141371, Length=365, Percent_Identity=32.6027397260274, Blast_Score=129, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17556456, Length=399, Percent_Identity=29.5739348370927, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17506081, Length=261, Percent_Identity=30.2681992337165, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17565438, Length=350, Percent_Identity=24.8571428571429, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115532067, Length=344, Percent_Identity=25.8720930232558, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115532065, Length=344, Percent_Identity=25.8720930232558, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI32566629, Length=373, Percent_Identity=24.9329758713137, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994658, Length=215, Percent_Identity=30.6976744186047, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=375, Percent_Identity=31.2, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320863, Length=266, Percent_Identity=24.812030075188, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6325337, Length=324, Percent_Identity=26.2345679012346, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319594, Length=324, Percent_Identity=26.2345679012346, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324550, Length=184, Percent_Identity=28.804347826087, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281363316, Length=393, Percent_Identity=30.7888040712468, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17864358, Length=393, Percent_Identity=30.7888040712468, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19921738, Length=400, Percent_Identity=29.75, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19922690, Length=338, Percent_Identity=31.9526627218935, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922512, Length=401, Percent_Identity=25.6857855361596, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24654852, Length=401, Percent_Identity=25.6857855361596, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24647046, Length=261, Percent_Identity=26.8199233716475, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24647048, Length=261, Percent_Identity=26.8199233716475, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28572034, Length=175, Percent_Identity=34.8571428571429, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550900, Length=257, Percent_Identity=26.4591439688716, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 67780; Mature: 67780

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGTAGHIDHGKTSLVKVLTGIDTDRLKEEKRRGITLELGFAHLTLDDGAVAGVVDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEEEECCCCEEEEEECCC
HERFVKAMAAGSGGVDLVVLVVAADEGVMPQTREHLDICRLLGVRAGVIALTKSDTLAEL
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHH
GPEWLALVEADLSALTVGTFLESAPVVACSARTGAGLDALRAALTRAAAALPERPSEGPA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
FLPVDRVFTIKGFGTVVTGTLLSGALAVGDAVSLLPGLPGPLRVRGVQRHGDAVSVVEAG
EEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCEEHHHHCC
QRAAVNLTGVEPEALRRGMVLVRAGELPEARMLDVELTLLPAAPSPLPRRSKLLLHLGTA
CCEEEEECCCCHHHHHCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEECCH
QVEATVALLDVERLEPGETTLAQLRLGASVGALVGQRFILRGARALPGRGATVAGGRILS
HHEEEEEEEEHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEE
ISPPKRRKGGASAVAPLLEADPAGQVAWLLRQAGYRGLTQPELFGRSALGPRVLTRALEL
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHH
LGARGGALLIDRERRLYLSGEVFEALQGRALALLATFHEREPLREGLSREELRQRLSSAL
HCCCCCEEEEECCCEEEECHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHH
DVRAFQRVLQALVEGGRVELERDVVRLKGRGRTLSLGDTAARARLAAELSAAALAPPSLP
HHHHHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCH
ELEQKLQLPASRLRELLGVMVVEGAAVRVSEGLWFAAGALASLRERLVAHLREKKEITTQ
HHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
DFKEMVGQSRKFVIPLSEYFDREKVTLRVGEKRVLRRG
HHHHHHCCCCEEEEEHHHHCCCCEEEEEECHHHHHCCC
>Mature Secondary Structure
MIVGTAGHIDHGKTSLVKVLTGIDTDRLKEEKRRGITLELGFAHLTLDDGAVAGVVDVPG
CEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEEEECCCCEEEEEECCC
HERFVKAMAAGSGGVDLVVLVVAADEGVMPQTREHLDICRLLGVRAGVIALTKSDTLAEL
HHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHH
GPEWLALVEADLSALTVGTFLESAPVVACSARTGAGLDALRAALTRAAAALPERPSEGPA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
FLPVDRVFTIKGFGTVVTGTLLSGALAVGDAVSLLPGLPGPLRVRGVQRHGDAVSVVEAG
EEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCEEHHHHCC
QRAAVNLTGVEPEALRRGMVLVRAGELPEARMLDVELTLLPAAPSPLPRRSKLLLHLGTA
CCEEEEECCCCHHHHHCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEECCH
QVEATVALLDVERLEPGETTLAQLRLGASVGALVGQRFILRGARALPGRGATVAGGRILS
HHEEEEEEEEHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEE
ISPPKRRKGGASAVAPLLEADPAGQVAWLLRQAGYRGLTQPELFGRSALGPRVLTRALEL
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHH
LGARGGALLIDRERRLYLSGEVFEALQGRALALLATFHEREPLREGLSREELRQRLSSAL
HCCCCCEEEEECCCEEEECHHHHHHHCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHH
DVRAFQRVLQALVEGGRVELERDVVRLKGRGRTLSLGDTAARARLAAELSAAALAPPSLP
HHHHHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCH
ELEQKLQLPASRLRELLGVMVVEGAAVRVSEGLWFAAGALASLRERLVAHLREKKEITTQ
HHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
DFKEMVGQSRKFVIPLSEYFDREKVTLRVGEKRVLRRG
HHHHHHCCCCEEEEEHHHHCCCCEEEEEECHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]