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The map label for this gene is zraS [H]

Identifier: 108763472

GI number: 108763472

Start: 1254015

End: 1256507

Strand: Direct

Name: zraS [H]

Synonym: MXAN_1077

Alternate gene names: 108763472

Gene position: 1254015-1256507 (Clockwise)

Preceding gene: 108761780

Following gene: 108763819

Centisome position: 13.72

GC content: 71.92

Gene sequence:

>2493_bases
ATGAGTACCAAGCGCTACAGCGAGGCGGAGCTTCGCGCCCTCGTCGACACCTTCCGCAACCCCATGCTGGCGGTGGTGGA
GGGACGCGTGCTCGTGGCCAATGACGCCTATGTCGCGTTGCTCGGCCTGCAACGCGCCCAGGTGGAGGGCCGCTCCGTCA
TGGACTTCATCCAGCCGGAGGACCGCAGCCGCGTGGTCGAGCGCTACTGGCGGGTGGAGGCCGGTGCGCCGCTCCATGAG
GGCTCCCAGCTCTTCCAGGTCCCCTGCGCGGATGGCGTGGCCCGTGAGGTGGCAGTCACCGCGTCCCGCTTCGTGTTGGA
GCACGGGGGCGGGGGCCTGCTGCTCAATTGCGTGCCCATGGAGAACCGGCCGCCGGAGATGTCGGTGGCCGAGCGGCTGG
TGGAGACCTCCGCGGGGCTGGTGTCCGCGCACTCAGAGAACGCCGTCCGCCGCGTCGCCCTGAAGGGCCTGGAGGCCGCG
GGCTTCCGGGCCCGGCTGTTGCGCTGGGACGGCGAGGGACTGCTGGCTCGGGATGGGGAGCCCCTGCCGGAGGATGCGCG
CCTGGGGATGGAGTCGCTCGCGGACGGGCGTCCCGTCTTTGGCGGCTCGGACCAGGCCGCGCCCACCCACGTCTACCTGC
CCGTGGGCGGCCCCCAGGCCGAGGTGTTGTGGGTGGAGGGCCACTGGGTGGCGCCGCACCATGGCTCGGTGTTGATGCTC
TTCGCCAAGGTGGTGGGCGCCGCGCTGGCGGACGCGCGTGTGCAGGCGGAGAGCGCGCGCAGCCGCTGGGAGATGGAGGC
GGTCGCGCAGATGGCGCGCTTCGTCGCGCAGCCGTCTCCGCCCACGCAGGAGGACTTCCTGGAGCGCGTCGCTTCACTGC
TCCAGGCGGCCGCCGCGGCGCTGCACCTCTCGACGCCTCCCGAAGCCACGCTGACGCTGTCCTCACACGTGGGCTTTCAG
GACGCGGCGGACGCGCGCCGGCTCACGGGCGTGCTGTCGTGTGGCGCGGAGGGCGCGCTGTCCTCGTCCGCGGATGAGGC
CCCGCTGGTGGAGCAGTCCGGAGGGCGGTTGGGGGCGGGCGCGGCGGTGTGTCTGATTCGCGGCGGCGAGGTGTGCGGGA
TGCTCCAGGTGCTGCGCGCGCCGGGGAAGCCGTTCGACGAACGGGACCTGCGCCTGCTGGGCACGCTGTCGGAGTTGCTG
GTGACGCTGCTGGAGCAGCGCCGGCTGCGGGCCGAGTCCTCGCGCCAACTGGCCGAGACGCGCCTCCTGCTGGACCTGGC
GCGCACCACGTCCGGTGTGCTGGAGACGTCGAGCATCCTGGACGTGGCCGCCGACTTCCTCGTCCGCCTGCTGGACGTGT
CCAACTGCTACATCCTGCTGTACGACGAGGGCGCCCGGCTGCTGCGCGGCGCCGCGGCCTCCATCGCGCACCGCGACTAC
TTCCGCACGGTGGTGTTGCCCCTCCATGGAGACGGCCTGACGGCGCGCGTGGCGCGTGAGCGCAGGCCCATCGCGGTGGA
GGACGTGTCCTCCGCGGACGGAGGCTTCAACCCGGAGCTCGCGCACCGCTTCGACGAGAAGGCGCTGCTGGCGCTGCCGC
TCACCTCGCGCGAGGAGCTCATCGGCGTGGTGGTGGTGGACGACACGCGGGGCCCGCGCGCCTTCGGTCCGGAGCTCATC
GAGCTGGCGGAGGCCACGTGTGGCCAGCTGGCGTTGTCCATCGCCAACGCGCGCTTGTACGAGTCACTGTGGGCCAGCTA
CGCGGAGCTGGCCGCCACGCGCGCGGAGATGGTGAAGCGCGAGCGGCTGGCCGCGCTGGGCGAGCTGTCCGCGATTGTCG
CCCACGAGGTGCGCAATCCGCTGGGCGTCATCTTCAACGCGGTGGCCTCGCTGCGCCGGCTGTTGGTGCCGGGCGGGGAC
GCGGCCATGTTGCTCGACATCCTGGGGGAGGAGAGCGACCGGCTCAACCGCATCGTCGGTGACTTGCTGGACTACACGCG
TCCCAGGGACCCGGTGCTCCAGCAGGAGGACCTGGGCCGCGTGCTCCAGGATTCGCTGGAGGCCGCGCGGATGCAGGGCG
GCGGCGCGGACCGCTCCATCCGCATCCAATCCGACGTGGAGCCCGGCCTGCCGCCGGTACCCATGGACCGTCGCCTCATC
CGACAGGCGCTGGTCAACGTGGCGGTCAACGCCATCCAGTCCATGCCGCAGGGTGGACTCGTGCAGGTTCGCGCGCGCCG
TGAAGCCCACGCGGGGCGCGAGCAACTGCGCATCGATGTGGTGGACCAGGGCCCGGGCATCCCCGCCGAGCTGCTCCACC
GCGTCTTCGAGCCGTTCTTCACCACCAAGGCCCAGGGCACCGGCCTGGGGCTGGCCGTCGTCAGGCGCATCCTCGAGGAG
CACCGGGGCGAAATCGCCGTGGACAGTATTCCGGGGCGCGGTACCACCTTCACCTTCCGGCTGCCGTTCTCGCAGCCTCC
GTCCTTCCCATGA

Upstream 100 bases:

>100_bases
TGGTGGGGCAAAGCCGCAAGTTCGTCATCCCCCTGTCCGAATACTTCGACCGGGAGAAGGTCACGCTCCGGGTAGGAGAG
AAGCGGGTGCTGCGTCGCGG

Downstream 100 bases:

>100_bases
CCGACGCGAACACTCCGCCGACCCGAGGACGGCTCCTCGTCGTGGACGACCAGCGCAACATGCGCGCCACCACCGCCCTG
TTGTTGCGGGCGGAGAACTA

Product: sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 830; Mature: 829

Protein sequence:

>830_residues
MSTKRYSEAELRALVDTFRNPMLAVVEGRVLVANDAYVALLGLQRAQVEGRSVMDFIQPEDRSRVVERYWRVEAGAPLHE
GSQLFQVPCADGVAREVAVTASRFVLEHGGGGLLLNCVPMENRPPEMSVAERLVETSAGLVSAHSENAVRRVALKGLEAA
GFRARLLRWDGEGLLARDGEPLPEDARLGMESLADGRPVFGGSDQAAPTHVYLPVGGPQAEVLWVEGHWVAPHHGSVLML
FAKVVGAALADARVQAESARSRWEMEAVAQMARFVAQPSPPTQEDFLERVASLLQAAAAALHLSTPPEATLTLSSHVGFQ
DAADARRLTGVLSCGAEGALSSSADEAPLVEQSGGRLGAGAAVCLIRGGEVCGMLQVLRAPGKPFDERDLRLLGTLSELL
VTLLEQRRLRAESSRQLAETRLLLDLARTTSGVLETSSILDVAADFLVRLLDVSNCYILLYDEGARLLRGAAASIAHRDY
FRTVVLPLHGDGLTARVARERRPIAVEDVSSADGGFNPELAHRFDEKALLALPLTSREELIGVVVVDDTRGPRAFGPELI
ELAEATCGQLALSIANARLYESLWASYAELAATRAEMVKRERLAALGELSAIVAHEVRNPLGVIFNAVASLRRLLVPGGD
AAMLLDILGEESDRLNRIVGDLLDYTRPRDPVLQQEDLGRVLQDSLEAARMQGGGADRSIRIQSDVEPGLPPVPMDRRLI
RQALVNVAVNAIQSMPQGGLVQVRARREAHAGREQLRIDVVDQGPGIPAELLHRVFEPFFTTKAQGTGLGLAVVRRILEE
HRGEIAVDSIPGRGTTFTFRLPFSQPPSFP

Sequences:

>Translated_830_residues
MSTKRYSEAELRALVDTFRNPMLAVVEGRVLVANDAYVALLGLQRAQVEGRSVMDFIQPEDRSRVVERYWRVEAGAPLHE
GSQLFQVPCADGVAREVAVTASRFVLEHGGGGLLLNCVPMENRPPEMSVAERLVETSAGLVSAHSENAVRRVALKGLEAA
GFRARLLRWDGEGLLARDGEPLPEDARLGMESLADGRPVFGGSDQAAPTHVYLPVGGPQAEVLWVEGHWVAPHHGSVLML
FAKVVGAALADARVQAESARSRWEMEAVAQMARFVAQPSPPTQEDFLERVASLLQAAAAALHLSTPPEATLTLSSHVGFQ
DAADARRLTGVLSCGAEGALSSSADEAPLVEQSGGRLGAGAAVCLIRGGEVCGMLQVLRAPGKPFDERDLRLLGTLSELL
VTLLEQRRLRAESSRQLAETRLLLDLARTTSGVLETSSILDVAADFLVRLLDVSNCYILLYDEGARLLRGAAASIAHRDY
FRTVVLPLHGDGLTARVARERRPIAVEDVSSADGGFNPELAHRFDEKALLALPLTSREELIGVVVVDDTRGPRAFGPELI
ELAEATCGQLALSIANARLYESLWASYAELAATRAEMVKRERLAALGELSAIVAHEVRNPLGVIFNAVASLRRLLVPGGD
AAMLLDILGEESDRLNRIVGDLLDYTRPRDPVLQQEDLGRVLQDSLEAARMQGGGADRSIRIQSDVEPGLPPVPMDRRLI
RQALVNVAVNAIQSMPQGGLVQVRARREAHAGREQLRIDVVDQGPGIPAELLHRVFEPFFTTKAQGTGLGLAVVRRILEE
HRGEIAVDSIPGRGTTFTFRLPFSQPPSFP
>Mature_829_residues
STKRYSEAELRALVDTFRNPMLAVVEGRVLVANDAYVALLGLQRAQVEGRSVMDFIQPEDRSRVVERYWRVEAGAPLHEG
SQLFQVPCADGVAREVAVTASRFVLEHGGGGLLLNCVPMENRPPEMSVAERLVETSAGLVSAHSENAVRRVALKGLEAAG
FRARLLRWDGEGLLARDGEPLPEDARLGMESLADGRPVFGGSDQAAPTHVYLPVGGPQAEVLWVEGHWVAPHHGSVLMLF
AKVVGAALADARVQAESARSRWEMEAVAQMARFVAQPSPPTQEDFLERVASLLQAAAAALHLSTPPEATLTLSSHVGFQD
AADARRLTGVLSCGAEGALSSSADEAPLVEQSGGRLGAGAAVCLIRGGEVCGMLQVLRAPGKPFDERDLRLLGTLSELLV
TLLEQRRLRAESSRQLAETRLLLDLARTTSGVLETSSILDVAADFLVRLLDVSNCYILLYDEGARLLRGAAASIAHRDYF
RTVVLPLHGDGLTARVARERRPIAVEDVSSADGGFNPELAHRFDEKALLALPLTSREELIGVVVVDDTRGPRAFGPELIE
LAEATCGQLALSIANARLYESLWASYAELAATRAEMVKRERLAALGELSAIVAHEVRNPLGVIFNAVASLRRLLVPGGDA
AMLLDILGEESDRLNRIVGDLLDYTRPRDPVLQQEDLGRVLQDSLEAARMQGGGADRSIRIQSDVEPGLPPVPMDRRLIR
QALVNVAVNAIQSMPQGGLVQVRARREAHAGREQLRIDVVDQGPGIPAELLHRVFEPFFTTKAQGTGLGLAVVRRILEEH
RGEIAVDSIPGRGTTFTFRLPFSQPPSFP

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=41.4847161572052, Blast_Score=166, Evalue=5e-42,
Organism=Escherichia coli, GI1788549, Length=264, Percent_Identity=35.6060606060606, Blast_Score=157, Evalue=3e-39,
Organism=Escherichia coli, GI1790300, Length=218, Percent_Identity=33.9449541284404, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI145693157, Length=391, Percent_Identity=26.8542199488491, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789149, Length=254, Percent_Identity=27.1653543307087, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=230, Percent_Identity=30, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=26.1261261261261, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1786912, Length=306, Percent_Identity=29.0849673202614, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=227, Percent_Identity=29.5154185022026, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1786783, Length=255, Percent_Identity=28.6274509803922, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=219, Percent_Identity=28.310502283105, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=25.2252252252252, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1788713, Length=240, Percent_Identity=22.0833333333333, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1790861, Length=216, Percent_Identity=29.6296296296296, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=25.4464285714286, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 89653; Mature: 89521

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKRYSEAELRALVDTFRNPMLAVVEGRVLVANDAYVALLGLQRAQVEGRSVMDFIQPE
CCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEHHHHHHHCCCHHHHHHCCCC
DRSRVVERYWRVEAGAPLHEGSQLFQVPCADGVAREVAVTASRFVLEHGGGGLLLNCVPM
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEECCCEEEEEEEEC
ENRPPEMSVAERLVETSAGLVSAHSENAVRRVALKGLEAAGFRARLLRWDGEGLLARDGE
CCCCCCHHHHHHHHHHHCCHHCCCHHHHHHHHHHHCCHHCCCEEEEEEECCCEEEECCCC
PLPEDARLGMESLADGRPVFGGSDQAAPTHVYLPVGGPQAEVLWVEGHWVAPHHGSVLML
CCCHHHHCCHHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECEEECCCCCHHHHH
FAKVVGAALADARVQAESARSRWEMEAVAQMARFVAQPSPPTQEDFLERVASLLQAAAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LHLSTPPEATLTLSSHVGFQDAADARRLTGVLSCGAEGALSSSADEAPLVEQSGGRLGAG
HCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCC
AAVCLIRGGEVCGMLQVLRAPGKPFDERDLRLLGTLSELLVTLLEQRRLRAESSRQLAET
EEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLLDLARTTSGVLETSSILDVAADFLVRLLDVSNCYILLYDEGARLLRGAAASIAHRDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
FRTVVLPLHGDGLTARVARERRPIAVEDVSSADGGFNPELAHRFDEKALLALPLTSREEL
HEEEEEEECCCCCHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCE
IGVVVVDDTRGPRAFGPELIELAEATCGQLALSIANARLYESLWASYAELAATRAEMVKR
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLAALGELSAIVAHEVRNPLGVIFNAVASLRRLLVPGGDAAMLLDILGEESDRLNRIVG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHH
DLLDYTRPRDPVLQQEDLGRVLQDSLEAARMQGGGADRSIRIQSDVEPGLPPVPMDRRLI
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHH
RQALVNVAVNAIQSMPQGGLVQVRARREAHAGREQLRIDVVDQGPGIPAELLHRVFEPFF
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHH
TTKAQGTGLGLAVVRRILEEHRGEIAVDSIPGRGTTFTFRLPFSQPPSFP
CCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
STKRYSEAELRALVDTFRNPMLAVVEGRVLVANDAYVALLGLQRAQVEGRSVMDFIQPE
CCCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEHHHHHHHCCCHHHHHHCCCC
DRSRVVERYWRVEAGAPLHEGSQLFQVPCADGVAREVAVTASRFVLEHGGGGLLLNCVPM
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHEECCCEEEEEEEEC
ENRPPEMSVAERLVETSAGLVSAHSENAVRRVALKGLEAAGFRARLLRWDGEGLLARDGE
CCCCCCHHHHHHHHHHHCCHHCCCHHHHHHHHHHHCCHHCCCEEEEEEECCCEEEECCCC
PLPEDARLGMESLADGRPVFGGSDQAAPTHVYLPVGGPQAEVLWVEGHWVAPHHGSVLML
CCCHHHHCCHHHHCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECEEECCCCCHHHHH
FAKVVGAALADARVQAESARSRWEMEAVAQMARFVAQPSPPTQEDFLERVASLLQAAAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LHLSTPPEATLTLSSHVGFQDAADARRLTGVLSCGAEGALSSSADEAPLVEQSGGRLGAG
HCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCC
AAVCLIRGGEVCGMLQVLRAPGKPFDERDLRLLGTLSELLVTLLEQRRLRAESSRQLAET
EEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLLDLARTTSGVLETSSILDVAADFLVRLLDVSNCYILLYDEGARLLRGAAASIAHRDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
FRTVVLPLHGDGLTARVARERRPIAVEDVSSADGGFNPELAHRFDEKALLALPLTSREEL
HEEEEEEECCCCCHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCE
IGVVVVDDTRGPRAFGPELIELAEATCGQLALSIANARLYESLWASYAELAATRAEMVKR
EEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLAALGELSAIVAHEVRNPLGVIFNAVASLRRLLVPGGDAAMLLDILGEESDRLNRIVG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHH
DLLDYTRPRDPVLQQEDLGRVLQDSLEAARMQGGGADRSIRIQSDVEPGLPPVPMDRRLI
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHH
RQALVNVAVNAIQSMPQGGLVQVRARREAHAGREQLRIDVVDQGPGIPAELLHRVFEPFF
HHHHHHHHHHHHHHCCCCCEEEEEEHHHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHH
TTKAQGTGLGLAVVRRILEEHRGEIAVDSIPGRGTTFTFRLPFSQPPSFP
CCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]