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The map label for this gene is mutL

Identifier: 108761749

GI number: 108761749

Start: 4930779

End: 4932638

Strand: Reverse

Name: mutL

Synonym: MXAN_4026

Alternate gene names: 108761749

Gene position: 4932638-4930779 (Counterclockwise)

Preceding gene: 108759945

Following gene: 108761240

Centisome position: 53.97

GC content: 72.96

Gene sequence:

>1860_bases
ATGTCCCGGATTGCCCGTCTCAGCGACGTCCTCATCAACAAGATTGCCGCCGGCGAAGTGGTGGAACGCCCTGCCTCCGT
CGTGAAGGAGCTGGTGGAAAACGCCATCGACGCCGGTGCCGGTACGGTCCGCGTCGAGCTGGACGGTGGAGGCGTGGACC
GCATCATCGTGTCGGATGATGGGCACGGTATGGGACGCTCGGACGCCGTGGCGTGCCTGGAGCGCCACGCCACCAGCAAG
CTGCGCGAGCTGGACGACCTGTTCCACATCGACTCCATGGGGTTCCGGGGCGAGGCCATTCCCGCCATCGCATCCGTTTC
CCGGTTCACACTTCACTCCGCGGCCGCGAACTCCGAGGTGGGCACGCGGGTGTCGGTGGAGGGCGGTGGGCCACCGCTGG
TGGAGGACGCGCCGCCGCGGACGGGCACGGTCATGACTGTGGAGGACCTGTTCTTCAACGTGCCCGCGCGCCGCAAGTTC
CTGCGCCGGGGCGACACGGAGCTGAAGCACGCGGAGGAGGCCGTGGTGCGCCTGGCCCTGGCGTACCCGGAGGTGGGCTT
CTTCGCCTCGCACGAGGGCGGCACGCTCTTCTCCAGCGCGGCCTGCCCGGATGACCCGCGCGAGCGAATCGCCGCGGCGC
TGGGCTCCACGTCGCATCCGCACCTGTTCCCCGTGGAGGAGCGCCGGCTGGGCGTGGCCGTCACGGGGTTCGCCGCGTCG
CCCGAGTTCACATTCAACAACGCGCGCGGCCTCTACACCTTCGTCAACCGCCGCTACATCCGGGATCGCGGCCTCATTGG
CACTATTCAGCGCGCGTACCAGGACTTCCTCGCCGCCGGGCGCCAGCCCGTGGTGGTGCTGCACATCGACGTGGACCCGC
GCGCGGTGGACGTCAACGTGCACCCGCAGAAGCAGGAGGTCCGCTTCGCCGACGCCCGGGGTGTCCAGGAGGCGTTGACG
GCCGCGCTCAGCCGCATGCTGCGCGCCGCGCCGTGGCTGGGCTCGGGCGTGGAGGGCGCCGCGCCCCAGGCCGGCCAGCC
CATGGACGCCGCGCACTACGCGCACGCCGTGGAGCGCTTCCTCACCCGCGCCCAGGAAGCCGCGTGGGGCGGCCCGCTGC
CCACCGCCATGGACGCGCCGGGCCCCGGTCCAGGGGCGCCGTCCCTGGGGCCGCTGGGGCAGGGGGCTCGGCCGGGAGCG
CTGCCCTTCGCCGCCGCGGTGGGGCAGGCCCCCGCCTTCGGTCAGGCGCAGCCGCAACTCAACGAGGCACCTCCGCCGGG
CTACTTCGGCGCGCTGCGGCCCCTGGGCATGCTGGGGGGCCGCTTCCATGTCTGCGAGGGACCGGGGGGCACGCTGGTGG
TGATGGATCCGCACGCGGCGCTGGAGCGCGCGCGCCTGACGGGCTACCTGCGCGCGTTGGAGTCCGGCAAGCCGCCTCCG
GCGCCCACGCTCTTCGGCACCACGCTGGAGTTGCCCGTCGCGGCGGCCAAGGCTCTGGTGGAGGGCAGGGAAGCCCTGTC
CCGCCTGGGCTTCGACGTGGAGCCGTTCGGCGGCACCACGGTGGCGTTGAAGACGGTGCCGCCGGGACTGGAAGGGGCGG
ACGCGCGTTCGCTGCTGGAGGCCCTGGCGCGGGCGCTTCCGCCGAAGAGCGCGACGTTGGACACGGTGTCGCTGGCGGAG
GCGGTGCGGGTGATGGCGTGCCACGCAGCGAAGCAGGCCGGCGCCGTGCCGCTCTCCGACGCGCAGTTCCGCGCGCTGCT
CGGGGAGTTGGACCGGGCCGACTTCCACCCCACGTGCAGCCACGGCACGGTGGTGGTGTTGGAGATGCCCTTGCTGGAGC
TGGAGCGGCGCGCCCGCTGA

Upstream 100 bases:

>100_bases
GCGGCGTCGTGTGTTAGCCCAGCCGCCTGGGATTGTCAGCCGCCACCCATGTTGTGTTGCTGGACAACGTCGCCTGGGTG
GCGGAGGGTGTCCGGCCGCC

Downstream 100 bases:

>100_bases
GTGCCCCGAAAATTGACGGGGGGGGACCCCCTGTTACCGTGCGCCACACGCTTGTAGCACCCAGGCCAACCTCCGCAGCG
CACAGGAGCGGGCACATGCA

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSRIARLSDVLINKIAAGEVVERPASVVKELVENAIDAGAGTVRVELDGGGVDRIIVSDDGHGMGRSDAVACLERHATSK
LRELDDLFHIDSMGFRGEAIPAIASVSRFTLHSAAANSEVGTRVSVEGGGPPLVEDAPPRTGTVMTVEDLFFNVPARRKF
LRRGDTELKHAEEAVVRLALAYPEVGFFASHEGGTLFSSAACPDDPRERIAAALGSTSHPHLFPVEERRLGVAVTGFAAS
PEFTFNNARGLYTFVNRRYIRDRGLIGTIQRAYQDFLAAGRQPVVVLHIDVDPRAVDVNVHPQKQEVRFADARGVQEALT
AALSRMLRAAPWLGSGVEGAAPQAGQPMDAAHYAHAVERFLTRAQEAAWGGPLPTAMDAPGPGPGAPSLGPLGQGARPGA
LPFAAAVGQAPAFGQAQPQLNEAPPPGYFGALRPLGMLGGRFHVCEGPGGTLVVMDPHAALERARLTGYLRALESGKPPP
APTLFGTTLELPVAAAKALVEGREALSRLGFDVEPFGGTTVALKTVPPGLEGADARSLLEALARALPPKSATLDTVSLAE
AVRVMACHAAKQAGAVPLSDAQFRALLGELDRADFHPTCSHGTVVVLEMPLLELERRAR

Sequences:

>Translated_619_residues
MSRIARLSDVLINKIAAGEVVERPASVVKELVENAIDAGAGTVRVELDGGGVDRIIVSDDGHGMGRSDAVACLERHATSK
LRELDDLFHIDSMGFRGEAIPAIASVSRFTLHSAAANSEVGTRVSVEGGGPPLVEDAPPRTGTVMTVEDLFFNVPARRKF
LRRGDTELKHAEEAVVRLALAYPEVGFFASHEGGTLFSSAACPDDPRERIAAALGSTSHPHLFPVEERRLGVAVTGFAAS
PEFTFNNARGLYTFVNRRYIRDRGLIGTIQRAYQDFLAAGRQPVVVLHIDVDPRAVDVNVHPQKQEVRFADARGVQEALT
AALSRMLRAAPWLGSGVEGAAPQAGQPMDAAHYAHAVERFLTRAQEAAWGGPLPTAMDAPGPGPGAPSLGPLGQGARPGA
LPFAAAVGQAPAFGQAQPQLNEAPPPGYFGALRPLGMLGGRFHVCEGPGGTLVVMDPHAALERARLTGYLRALESGKPPP
APTLFGTTLELPVAAAKALVEGREALSRLGFDVEPFGGTTVALKTVPPGLEGADARSLLEALARALPPKSATLDTVSLAE
AVRVMACHAAKQAGAVPLSDAQFRALLGELDRADFHPTCSHGTVVVLEMPLLELERRAR
>Mature_618_residues
SRIARLSDVLINKIAAGEVVERPASVVKELVENAIDAGAGTVRVELDGGGVDRIIVSDDGHGMGRSDAVACLERHATSKL
RELDDLFHIDSMGFRGEAIPAIASVSRFTLHSAAANSEVGTRVSVEGGGPPLVEDAPPRTGTVMTVEDLFFNVPARRKFL
RRGDTELKHAEEAVVRLALAYPEVGFFASHEGGTLFSSAACPDDPRERIAAALGSTSHPHLFPVEERRLGVAVTGFAASP
EFTFNNARGLYTFVNRRYIRDRGLIGTIQRAYQDFLAAGRQPVVVLHIDVDPRAVDVNVHPQKQEVRFADARGVQEALTA
ALSRMLRAAPWLGSGVEGAAPQAGQPMDAAHYAHAVERFLTRAQEAAWGGPLPTAMDAPGPGPGAPSLGPLGQGARPGAL
PFAAAVGQAPAFGQAQPQLNEAPPPGYFGALRPLGMLGGRFHVCEGPGGTLVVMDPHAALERARLTGYLRALESGKPPPA
PTLFGTTLELPVAAAKALVEGREALSRLGFDVEPFGGTTVALKTVPPGLEGADARSLLEALARALPPKSATLDTVSLAEA
VRVMACHAAKQAGAVPLSDAQFRALLGELDRADFHPTCSHGTVVVLEMPLLELERRAR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=332, Percent_Identity=31.0240963855422, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=27.5862068965517, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=27.5862068965517, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=26.2996941896024, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI189458898, Length=327, Percent_Identity=26.2996941896024, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=26.5625, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI263191589, Length=243, Percent_Identity=26.7489711934156, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI310128480, Length=320, Percent_Identity=25.9375, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI91992162, Length=252, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI91992160, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=7e-14,
Organism=Escherichia coli, GI1790612, Length=322, Percent_Identity=41.9254658385093, Blast_Score=232, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=31.5950920245399, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=358, Percent_Identity=24.8603351955307, Blast_Score=128, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=376, Percent_Identity=31.1170212765957, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=356, Percent_Identity=23.5955056179775, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=352, Percent_Identity=24.1477272727273, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136968, Length=343, Percent_Identity=31.4868804664723, Blast_Score=173, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17136970, Length=348, Percent_Identity=24.7126436781609, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_MYXXD (Q1D568)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632205.1
- ProteinModelPortal:   Q1D568
- SMR:   Q1D568
- STRING:   Q1D568
- GeneID:   4105492
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4026
- TIGR:   MXAN_4026
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- PhylomeDB:   Q1D568
- BioCyc:   MXAN246197:MXAN_4026-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 65221; Mature: 65090

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIARLSDVLINKIAAGEVVERPASVVKELVENAIDAGAGTVRVELDGGGVDRIIVSDD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCC
GHGMGRSDAVACLERHATSKLRELDDLFHIDSMGFRGEAIPAIASVSRFTLHSAAANSEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GTRVSVEGGGPPLVEDAPPRTGTVMTVEDLFFNVPARRKFLRRGDTELKHAEEAVVRLAL
CCEEEECCCCCCCCCCCCCCCCCEEEHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AYPEVGFFASHEGGTLFSSAACPDDPRERIAAALGSTSHPHLFPVEERRLGVAVTGFAAS
HCCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEECCCC
PEFTFNNARGLYTFVNRRYIRDRGLIGTIQRAYQDFLAAGRQPVVVLHIDVDPRAVDVNV
CCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEC
HPQKQEVRFADARGVQEALTAALSRMLRAAPWLGSGVEGAAPQAGQPMDAAHYAHAVERF
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LTRAQEAAWGGPLPTAMDAPGPGPGAPSLGPLGQGARPGALPFAAAVGQAPAFGQAQPQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
NEAPPPGYFGALRPLGMLGGRFHVCEGPGGTLVVMDPHAALERARLTGYLRALESGKPPP
CCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
APTLFGTTLELPVAAAKALVEGREALSRLGFDVEPFGGTTVALKTVPPGLEGADARSLLE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHH
ALARALPPKSATLDTVSLAEAVRVMACHAAKQAGAVPLSDAQFRALLGELDRADFHPTCS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCC
HGTVVVLEMPLLELERRAR
CCEEEEEECCHHHHHHHCC
>Mature Secondary Structure 
SRIARLSDVLINKIAAGEVVERPASVVKELVENAIDAGAGTVRVELDGGGVDRIIVSDD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCC
GHGMGRSDAVACLERHATSKLRELDDLFHIDSMGFRGEAIPAIASVSRFTLHSAAANSEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GTRVSVEGGGPPLVEDAPPRTGTVMTVEDLFFNVPARRKFLRRGDTELKHAEEAVVRLAL
CCEEEECCCCCCCCCCCCCCCCCEEEHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AYPEVGFFASHEGGTLFSSAACPDDPRERIAAALGSTSHPHLFPVEERRLGVAVTGFAAS
HCCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEECCCC
PEFTFNNARGLYTFVNRRYIRDRGLIGTIQRAYQDFLAAGRQPVVVLHIDVDPRAVDVNV
CCCEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEEEC
HPQKQEVRFADARGVQEALTAALSRMLRAAPWLGSGVEGAAPQAGQPMDAAHYAHAVERF
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LTRAQEAAWGGPLPTAMDAPGPGPGAPSLGPLGQGARPGALPFAAAVGQAPAFGQAQPQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCC
NEAPPPGYFGALRPLGMLGGRFHVCEGPGGTLVVMDPHAALERARLTGYLRALESGKPPP
CCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCC
APTLFGTTLELPVAAAKALVEGREALSRLGFDVEPFGGTTVALKTVPPGLEGADARSLLE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHH
ALARALPPKSATLDTVSLAEAVRVMACHAAKQAGAVPLSDAQFRALLGELDRADFHPTCS
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCC
HGTVVVLEMPLLELERRAR
CCEEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA