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The map label for this gene is grpE [H]

Identifier: 108761636

GI number: 108761636

Start: 5329660

End: 5330289

Strand: Reverse

Name: grpE [H]

Synonym: MXAN_4331

Alternate gene names: 108761636

Gene position: 5330289-5329660 (Counterclockwise)

Preceding gene: 108760769

Following gene: 108763173

Centisome position: 58.32

GC content: 70.16

Gene sequence:

>630_bases
ATGGCCGGTAACACCCGCACCGACGCAGCCCCCGAAGCCCCCCAGCAGCCCCCCTCGGCCAATGGCGAGGGACCTGTTTC
CGCCGCCGAGGAGGCTTCCTCCCAGCAGCAGGCTCCGGAGGAGCACGCGGCTGCCGGTCAGGACGCGGAGCGGGAGCGGA
TGGTCGCGGAGCTGGAGACGCTTCGCAAGAAGTTCGACATCGCCGTCCGCGCGGTGCAGGCCGCGGAGAAGGACCGCGAG
GAGTTCAAGCAGCGCGTGACGCGGGAGCGTGAGCGCATGCTGGACGTGGAGCGCGGCAACGTGGCTGTCACGCTGCTGGA
GGCCATCGACGAGTTGGACCGGTGCCTGTCCGTCAGCGCCCAGGACACCTCGCCGCTGGCCGAGGGCGTCCGGATGATTC
GTGACGAGCTCTTGCGCAAGGCGCAGTCCACGGGCATCGAGCGCCTTCAGGTCGTCGGGCAGACCTTCGACCCGAACACG
GCCGATGCCGTCGACATGGAAGTGACCGCCACGCCGGACGACGACCACCGCATCGTCGCCGAGCTGCGTGCGGGCTACCG
GCTGAAGGACCGCGTCATCCGTCCGGCCCGGGTGAAGGTGGCGAAGTACGTCGCCCCCGTCCAGGCCTGA

Upstream 100 bases:

>100_bases
CCCGCGTTGACAGGGGCCGTCTCGCGGTTAGGTTCCGGGCAGCAGTGACTGCCTACCTTATCGCGCGAGACTGCGCATCC
ACCATCGCCTCAGGTTAGAC

Downstream 100 bases:

>100_bases
CGCCGCCGTCCAGGGCGCCCCCGTCACTCACGGGAAGGGGGCGCCGGGCCAGGCTGTTGAGTCCGCTCGACCCTGGTCCG
CCGTGTAGACTGCCGCTCCG

Product: putative co-chaperone GrpE

Products: NA

Alternate protein names: HSP-70 cofactor [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MAGNTRTDAAPEAPQQPPSANGEGPVSAAEEASSQQQAPEEHAAAGQDAERERMVAELETLRKKFDIAVRAVQAAEKDRE
EFKQRVTRERERMLDVERGNVAVTLLEAIDELDRCLSVSAQDTSPLAEGVRMIRDELLRKAQSTGIERLQVVGQTFDPNT
ADAVDMEVTATPDDDHRIVAELRAGYRLKDRVIRPARVKVAKYVAPVQA

Sequences:

>Translated_209_residues
MAGNTRTDAAPEAPQQPPSANGEGPVSAAEEASSQQQAPEEHAAAGQDAERERMVAELETLRKKFDIAVRAVQAAEKDRE
EFKQRVTRERERMLDVERGNVAVTLLEAIDELDRCLSVSAQDTSPLAEGVRMIRDELLRKAQSTGIERLQVVGQTFDPNT
ADAVDMEVTATPDDDHRIVAELRAGYRLKDRVIRPARVKVAKYVAPVQA
>Mature_208_residues
AGNTRTDAAPEAPQQPPSANGEGPVSAAEEASSQQQAPEEHAAAGQDAERERMVAELETLRKKFDIAVRAVQAAEKDREE
FKQRVTRERERMLDVERGNVAVTLLEAIDELDRCLSVSAQDTSPLAEGVRMIRDELLRKAQSTGIERLQVVGQTFDPNTA
DAVDMEVTATPDDDHRIVAELRAGYRLKDRVIRPARVKVAKYVAPVQA

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor. Unfolded

COG id: COG0576

COG function: function code O; Molecular chaperone GrpE (heat shock protein)

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grpE family [H]

Homologues:

None

Paralogues:

None

Copy number: 2359 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000740
- InterPro:   IPR013805
- InterPro:   IPR009012 [H]

Pfam domain/function: PF01025 GrpE [H]

EC number: NA

Molecular weight: Translated: 23012; Mature: 22881

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01071 GRPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNTRTDAAPEAPQQPPSANGEGPVSAAEEASSQQQAPEEHAAAGQDAERERMVAELET
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHH
LRKKFDIAVRAVQAAEKDREEFKQRVTRERERMLDVERGNVAVTLLEAIDELDRCLSVSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
QDTSPLAEGVRMIRDELLRKAQSTGIERLQVVGQTFDPNTADAVDMEVTATPDDDHRIVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHH
ELRAGYRLKDRVIRPARVKVAKYVAPVQA
HHHCCCHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AGNTRTDAAPEAPQQPPSANGEGPVSAAEEASSQQQAPEEHAAAGQDAERERMVAELET
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHH
LRKKFDIAVRAVQAAEKDREEFKQRVTRERERMLDVERGNVAVTLLEAIDELDRCLSVSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
QDTSPLAEGVRMIRDELLRKAQSTGIERLQVVGQTFDPNTADAVDMEVTATPDDDHRIVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHH
ELRAGYRLKDRVIRPARVKVAKYVAPVQA
HHHCCCHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA