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The map label for this gene is alsR [H]

Identifier: 108761305

GI number: 108761305

Start: 1992136

End: 1993041

Strand: Direct

Name: alsR [H]

Synonym: MXAN_1683

Alternate gene names: 108761305

Gene position: 1992136-1993041 (Clockwise)

Preceding gene: 108763878

Following gene: 108758073

Centisome position: 21.8

GC content: 69.54

Gene sequence:

>906_bases
ATGGAATTCCGTCAGCTCCAGCTCTTCGTCGCCGTGGCGGAGGAGTTGCACTTCGGACGCGCCGCCGCGCGCATCGGCAT
GGCCCAGCCGCCCTTCAGCCAGCAGATTCGCCGGCTGGAGTCCGAGCTGGGAGTCGAGCTGCTCACGCGCACGAGCCGCC
GGGTAGCCCTGACCGCCGCCGGGAGCCGCTTGCTGGAGGATGCGCGCGCGTTGCTGGCTCGGCGCGCGGATGTCATCCAT
TCGGTGCAGCAGGCGGCGAGTGGAGAGACAGGCACGCTGCGTGTCGGCTTCGCCGCGTCGTCTGCCTTCGGCGTGCTGCC
GGACATCGTGCTGCGCTTCCGCACGCGGTTCCCGAAGGTGAAGCTGGAGTTGGACGACAGCGAGACGCTGGATGTCGGCG
CCGCGCTCGTCTCGGGGGAGCTGGACATCGCCATCATCCGGGCGCCCTTCCGTCACGAAGGGCTCACCGTCGAGCGACTG
CTCCAGGAGCGCTTCGTGCTCGCCCTGCCAGCTCGACACCCGCGAGCCCGTCAACAGGTCGTCGCGCTGTCCTCACTGGC
GAACGAGCCGTTCGTGCTCTTTCCGCGTCACTCCGCGCCGGGCCTGCATGACCTGGTGACGAGCATGTGCCTGGGCGCGG
GTTTCTCTCCGAACATCCTCCAGGAAGCCAGCTCGTGGCCGTCCGTCGTTGGCATGGTGGAAGCGGGCCTGGGGCTGACC
ATCGCTCCCGCGTCCTCCCAGGCGCTGTGTCCCAAAGGGGTGGTGTTTCGCCCCCTGAGCGGCGCTCCCGGACACGCGGA
GCTGGTGGTGGCCTTCCCTGGAACGCGGCCCGCGCCCGCGGCGCAGCACTTCCGCGTCCTCGCGCATGAAGCCGTCTCCC
GCTCTGGCAGGCGTGCTTCTGACTGA

Upstream 100 bases:

>100_bases
GAGGGGAACGAAGGGGAATCGCATGCGCCGATGGTAGGAAGCGGCATCCTTCACGACCAATATATCTTTTGATGCGCATT
GAGATGGATATCGTCTCGAT

Downstream 100 bases:

>100_bases
GCGGCACTCGCGCCACGAGGCGCACGTCATGCGCGGAGGGAACGCCCTACATCCGTTCGCCAGGCAATCGACTGGCCTGC
TTCACCCAGGCGGCGAACTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEFRQLQLFVAVAEELHFGRAAARIGMAQPPFSQQIRRLESELGVELLTRTSRRVALTAAGSRLLEDARALLARRADVIH
SVQQAASGETGTLRVGFAASSAFGVLPDIVLRFRTRFPKVKLELDDSETLDVGAALVSGELDIAIIRAPFRHEGLTVERL
LQERFVLALPARHPRARQQVVALSSLANEPFVLFPRHSAPGLHDLVTSMCLGAGFSPNILQEASSWPSVVGMVEAGLGLT
IAPASSQALCPKGVVFRPLSGAPGHAELVVAFPGTRPAPAAQHFRVLAHEAVSRSGRRASD

Sequences:

>Translated_301_residues
MEFRQLQLFVAVAEELHFGRAAARIGMAQPPFSQQIRRLESELGVELLTRTSRRVALTAAGSRLLEDARALLARRADVIH
SVQQAASGETGTLRVGFAASSAFGVLPDIVLRFRTRFPKVKLELDDSETLDVGAALVSGELDIAIIRAPFRHEGLTVERL
LQERFVLALPARHPRARQQVVALSSLANEPFVLFPRHSAPGLHDLVTSMCLGAGFSPNILQEASSWPSVVGMVEAGLGLT
IAPASSQALCPKGVVFRPLSGAPGHAELVVAFPGTRPAPAAQHFRVLAHEAVSRSGRRASD
>Mature_301_residues
MEFRQLQLFVAVAEELHFGRAAARIGMAQPPFSQQIRRLESELGVELLTRTSRRVALTAAGSRLLEDARALLARRADVIH
SVQQAASGETGTLRVGFAASSAFGVLPDIVLRFRTRFPKVKLELDDSETLDVGAALVSGELDIAIIRAPFRHEGLTVERL
LQERFVLALPARHPRARQQVVALSSLANEPFVLFPRHSAPGLHDLVTSMCLGAGFSPNILQEASSWPSVVGMVEAGLGLT
IAPASSQALCPKGVVFRPLSGAPGHAELVVAFPGTRPAPAAQHFRVLAHEAVSRSGRRASD

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=37.8472222222222, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI2367136, Length=281, Percent_Identity=35.2313167259786, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=33.1034482758621, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790399, Length=262, Percent_Identity=34.3511450381679, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI145693105, Length=242, Percent_Identity=26.4462809917355, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI157672245, Length=245, Percent_Identity=31.0204081632653, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=29.7520661157025, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790208, Length=195, Percent_Identity=32.8205128205128, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787806, Length=302, Percent_Identity=24.8344370860927, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=29.1828793774319, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=30.2439024390244, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789506, Length=243, Percent_Identity=26.7489711934156, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787530, Length=255, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=28.8135593220339, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786401, Length=141, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788481, Length=240, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787589, Length=153, Percent_Identity=35.9477124183007, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082132, Length=205, Percent_Identity=27.8048780487805, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788296, Length=197, Percent_Identity=26.9035532994924, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790262, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.1463414634146, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788626, Length=276, Percent_Identity=27.1739130434783, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789204, Length=263, Percent_Identity=22.8136882129278, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=29.5081967213115, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787128, Length=130, Percent_Identity=30, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32332; Mature: 32332

Theoretical pI: Translated: 10.78; Mature: 10.78

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRQLQLFVAVAEELHFGRAAARIGMAQPPFSQQIRRLESELGVELLTRTSRRVALTAA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
GSRLLEDARALLARRADVIHSVQQAASGETGTLRVGFAASSAFGVLPDIVLRFRTRFPKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEE
KLELDDSETLDVGAALVSGELDIAIIRAPFRHEGLTVERLLQERFVLALPARHPRARQQV
EEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHEEECCCCCCHHHHHH
VALSSLANEPFVLFPRHSAPGLHDLVTSMCLGAGFSPNILQEASSWPSVVGMVEAGLGLT
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHCCCCEE
IAPASSQALCPKGVVFRPLSGAPGHAELVVAFPGTRPAPAAQHFRVLAHEAVSRSGRRAS
EECCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
D
C
>Mature Secondary Structure
MEFRQLQLFVAVAEELHFGRAAARIGMAQPPFSQQIRRLESELGVELLTRTSRRVALTAA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHH
GSRLLEDARALLARRADVIHSVQQAASGETGTLRVGFAASSAFGVLPDIVLRFRTRFPKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEE
KLELDDSETLDVGAALVSGELDIAIIRAPFRHEGLTVERLLQERFVLALPARHPRARQQV
EEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHEEECCCCCCHHHHHH
VALSSLANEPFVLFPRHSAPGLHDLVTSMCLGAGFSPNILQEASSWPSVVGMVEAGLGLT
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHCCCCEE
IAPASSQALCPKGVVFRPLSGAPGHAELVVAFPGTRPAPAAQHFRVLAHEAVSRSGRRAS
EECCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]