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The map label for this gene is pkn1 [H]

Identifier: 108761219

GI number: 108761219

Start: 826731

End: 827777

Strand: Direct

Name: pkn1 [H]

Synonym: MXAN_0724

Alternate gene names: 108761219

Gene position: 826731-827777 (Clockwise)

Preceding gene: 108762229

Following gene: 108763857

Centisome position: 9.05

GC content: 72.87

Gene sequence:

>1047_bases
ATGTCCCGGTCGGACGTCACCACCTCCGTTCCCGTGTTCACCCAGACCTTCCGGTCCCCGTGTGGCTGTGTCCCCGCGCA
CGGGGGGGCCTGCGAGTGTCCGGCCCGGGCGGGCGCGCGTCGTGTGTCCATGGGGTGTCCGCCATCCTTCATGGTGCCGC
CCGCGAGGGAGGCCCCGCTCCCGTCCTCGGCGGCCTCGCTGGTGGGACAGCAGGTGGGCCACTTCCGGCTGCTGCGAGAG
CTGGGCCGGGGGAGCCTGGGCGTCGTGCTGCTCGCGGAGCACGCGCTCATCCAGAAGCGCGTGGCCATCCAGGTGCTTCA
CACGCACGTGACGCAGGACCCGGCGCAGGTCGCTCGGTTCCTTCAGGCGGCGCGCACGCTGACGCTCATCCAGCACGCGC
ACATCGTTTCGCTCTACGACCTGGGCATGCGCGACGGGCGTCCCTACCTCGTCAGGGAGTACCTGGAGGGACAGAGCCTG
ACCGCCTTCGCGAAGGGGCCGCTGGCGTCCGCGCTGGTGGTGGACCTGCTCACCCAGGTGTGTGACGCGCTGGGCGCCGC
GCATGCGCACGGCATCGCCCACGGCAGTCTCAATCCCGCCAGCATCTTCCTCATCCCCGATGCGAATGGCCGCCAGCACG
TGAAGCTGCTGGACTTCGGCATCGCCGGGTTGCTCCCTTCCCCCGATGGCGCCGCCGACCTGTCGGTGGCCGCTGACCTC
TTCGCCGTGGGCGTGCTGGGCGCGCTGCTGGTCTCGGGCCGGCTGTCCTCGCGCGGGCACGCGGCGGAGGAGCCGCCCCA
TGGCCACGCTCGGGAGGTGCCACCGCTGCCGGCGGGCATCCCGTCGGCGCTGTCACGCGTGCTGCTCAAGGCCATGGCGC
GCCGCCCGGGGGACCGTTATGCCAGTGCGGCCGAGCTGCGCGCGGCATTGCAGGCGTCGGTGGCGCTCGACGGCGGCGTG
GCGCATCCAGAGGCCCTGGAGCTGGAGCGGCTTCCCAGTTGGTACACGCTCCGGGGGCCGCCGGGGGCCGCGCCCGCCTC
CAGGTAG

Upstream 100 bases:

>100_bases
CTGTCACATCTTCCGAAACCCATTTCGCGCTGGCTCGTGCGTGGGCCCACTGGCTGCTGGCCGGAGCGGGGGCGCCTGTC
GCGCGAAGGACGTTGGCATC

Downstream 100 bases:

>100_bases
GGCGGCCTGGCTGTCTCGGCGGGGCGTCATGCCTTGCGTCTGGCGGGGCCCTCCTCGTTAATCCACTTCAGCTCCCATGG
CCTCCGACCCCGACGACAAG

Product: putative serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSRSDVTTSVPVFTQTFRSPCGCVPAHGGACECPARAGARRVSMGCPPSFMVPPAREAPLPSSAASLVGQQVGHFRLLRE
LGRGSLGVVLLAEHALIQKRVAIQVLHTHVTQDPAQVARFLQAARTLTLIQHAHIVSLYDLGMRDGRPYLVREYLEGQSL
TAFAKGPLASALVVDLLTQVCDALGAAHAHGIAHGSLNPASIFLIPDANGRQHVKLLDFGIAGLLPSPDGAADLSVAADL
FAVGVLGALLVSGRLSSRGHAAEEPPHGHAREVPPLPAGIPSALSRVLLKAMARRPGDRYASAAELRAALQASVALDGGV
AHPEALELERLPSWYTLRGPPGAAPASR

Sequences:

>Translated_348_residues
MSRSDVTTSVPVFTQTFRSPCGCVPAHGGACECPARAGARRVSMGCPPSFMVPPAREAPLPSSAASLVGQQVGHFRLLRE
LGRGSLGVVLLAEHALIQKRVAIQVLHTHVTQDPAQVARFLQAARTLTLIQHAHIVSLYDLGMRDGRPYLVREYLEGQSL
TAFAKGPLASALVVDLLTQVCDALGAAHAHGIAHGSLNPASIFLIPDANGRQHVKLLDFGIAGLLPSPDGAADLSVAADL
FAVGVLGALLVSGRLSSRGHAAEEPPHGHAREVPPLPAGIPSALSRVLLKAMARRPGDRYASAAELRAALQASVALDGGV
AHPEALELERLPSWYTLRGPPGAAPASR
>Mature_347_residues
SRSDVTTSVPVFTQTFRSPCGCVPAHGGACECPARAGARRVSMGCPPSFMVPPAREAPLPSSAASLVGQQVGHFRLLREL
GRGSLGVVLLAEHALIQKRVAIQVLHTHVTQDPAQVARFLQAARTLTLIQHAHIVSLYDLGMRDGRPYLVREYLEGQSLT
AFAKGPLASALVVDLLTQVCDALGAAHAHGIAHGSLNPASIFLIPDANGRQHVKLLDFGIAGLLPSPDGAADLSVAADLF
AVGVLGALLVSGRLSSRGHAAEEPPHGHAREVPPLPAGIPSALSRVLLKAMARRPGDRYASAAELRAALQASVALDGGVA
HPEALELERLPSWYTLRGPPGAAPASR

Specific function: Plays an essential role in proper timing of early development events [H]

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TPR repeat [H]

Homologues:

Organism=Homo sapiens, GI24308326, Length=157, Percent_Identity=28.6624203821656, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI193083127, Length=226, Percent_Identity=26.9911504424779, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI116089335, Length=157, Percent_Identity=29.2993630573248, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI193083125, Length=226, Percent_Identity=26.9911504424779, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI46852166, Length=226, Percent_Identity=26.9911504424779, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI193083129, Length=226, Percent_Identity=26.9911504424779, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33636756, Length=226, Percent_Identity=26.9911504424779, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI86990441, Length=214, Percent_Identity=25.7009345794392, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI254028234, Length=214, Percent_Identity=25.7009345794392, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI153791472, Length=226, Percent_Identity=25.2212389380531, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI254028237, Length=249, Percent_Identity=24.4979919678715, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI254028240, Length=249, Percent_Identity=24.4979919678715, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI254028232, Length=214, Percent_Identity=25.7009345794392, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI46877068, Length=205, Percent_Identity=24.8780487804878, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI94557301, Length=205, Percent_Identity=24.390243902439, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI133901970, Length=254, Percent_Identity=25.5905511811024, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901968, Length=252, Percent_Identity=25.3968253968254, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17568289, Length=252, Percent_Identity=23.4126984126984, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25152839, Length=161, Percent_Identity=24.8447204968944, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25152842, Length=161, Percent_Identity=24.8447204968944, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71995452, Length=184, Percent_Identity=24.4565217391304, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193208263, Length=213, Percent_Identity=24.8826291079812, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI193204599, Length=267, Percent_Identity=26.2172284644195, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538163, Length=159, Percent_Identity=30.188679245283, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320685, Length=186, Percent_Identity=26.3440860215054, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319825, Length=212, Percent_Identity=26.4150943396226, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550626, Length=159, Percent_Identity=30.188679245283, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553923, Length=184, Percent_Identity=26.6304347826087, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24639066, Length=184, Percent_Identity=26.6304347826087, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17137472, Length=184, Percent_Identity=26.6304347826087, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24643817, Length=244, Percent_Identity=26.6393442622951, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550904, Length=230, Percent_Identity=26.5217391304348, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550091, Length=230, Percent_Identity=26.5217391304348, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161077232, Length=168, Percent_Identity=27.3809523809524, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161077230, Length=168, Percent_Identity=27.3809523809524, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24655167, Length=168, Percent_Identity=27.3809523809524, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR009875
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07238 PilZ; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 36331; Mature: 36200

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSDVTTSVPVFTQTFRSPCGCVPAHGGACECPARAGARRVSMGCPPSFMVPPAREAPL
CCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCEEECCCCCCCCCCCCCCCCC
PSSAASLVGQQVGHFRLLRELGRGSLGVVLLAEHALIQKRVAIQVLHTHVTQDPAQVARF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQAARTLTLIQHAHIVSLYDLGMRDGRPYLVREYLEGQSLTAFAKGPLASALVVDLLTQV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEHHCCCHHHHHHHHHHHHH
CDALGAAHAHGIAHGSLNPASIFLIPDANGRQHVKLLDFGIAGLLPSPDGAADLSVAADL
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHH
FAVGVLGALLVSGRLSSRGHAAEEPPHGHAREVPPLPAGIPSALSRVLLKAMARRPGDRY
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
ASAAELRAALQASVALDGGVAHPEALELERLPSWYTLRGPPGAAPASR
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
SRSDVTTSVPVFTQTFRSPCGCVPAHGGACECPARAGARRVSMGCPPSFMVPPAREAPL
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCEEECCCCCCCCCCCCCCCCC
PSSAASLVGQQVGHFRLLRELGRGSLGVVLLAEHALIQKRVAIQVLHTHVTQDPAQVARF
CHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LQAARTLTLIQHAHIVSLYDLGMRDGRPYLVREYLEGQSLTAFAKGPLASALVVDLLTQV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEHHCCCHHHHHHHHHHHHH
CDALGAAHAHGIAHGSLNPASIFLIPDANGRQHVKLLDFGIAGLLPSPDGAADLSVAADL
HHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEHHHHHCCCCCCCCCHHHHHHHH
FAVGVLGALLVSGRLSSRGHAAEEPPHGHAREVPPLPAGIPSALSRVLLKAMARRPGDRY
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
ASAAELRAALQASVALDGGVAHPEALELERLPSWYTLRGPPGAAPASR
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1835671 [H]