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The map label for this gene is dxs

Identifier: 108761105

GI number: 108761105

Start: 5825908

End: 5827659

Strand: Reverse

Name: dxs

Synonym: MXAN_4643

Alternate gene names: 108761105

Gene position: 5827659-5825908 (Counterclockwise)

Preceding gene: 108759145

Following gene: 108757719

Centisome position: 63.76

GC content: 72.89

Gene sequence:

>1752_bases
ATGTCGGAGTTGCTGTCACGCATCGGCTCGCCCTCGGACGTCCGCGCACTTCCCGAGGAGGCACTGCCGCTCCTGTGCCA
GGAACTGCGCGAGGACATCATCTCCATCTGCGGCCGCGTGGGGGGCCACCTGGGGGCCTCCCTGGGCGCGGTGGAGCTCA
TCGTCGCGCTGCACCGCGTGTTCCATTCGCCGCAAGACGCGCTGCTGTTCGACGTGGGGCACCAGACGTACGCGCACAAG
CTCCTCACGGGCCGGCGTGACCGCATGCACACGCTGCGGCACGCGGGCGGCATCGCGCCGTTCCTGGACCCGCGGGAGAG
TCCTCACGACGCGCTGCTGGCTGGGCATTCATGCACGGCGGTGTCCGCGGCGCTGGGCGTGCTGGAGGGCCGGCGGCAGC
AGGGGCACCGGGGCCACGTGGTGGCGGTGTTGGGCGACGGCGGCCTCACGGGGGGCCTTACATTTGAAGGGCTCAACAAC
GCGGGGGGGAGCTCCCTGCCGTTGGTCGTCGTCCTCAACGACAACCAGATGTCCATCAGCGCCAACGTGGGGGCCATCCC
CGCGCTGCTGCGCACCCGCGAGGCGCGCGACTTCTTCGAAGGCCTGGGCTTCACCTACCTGGGCCCGGTGGATGGGCACG
ACCTGCCTGCGCTGATTCGCGCGCTGCGGGAGGCCCGTGCCTCGTCGCGGCCGGTGGTGGTGCACGCGCTGACGCTGAAG
GGGAAGGGCTTCCCGCCAGCGGAGGCCGACACGCAGACGCGTGGACATGCCATGGGCCCGTATGAGTGGCGGGACGGCAA
GCTGGTGCGCTCGCGCGGTGGCCAGCGGACCTTCAGCGAAGCCTTCGCGGCGGTGCTCGAGGACGCGATGGCCCGGGACC
CACGAGTGGTGGCGGTGACGCCCGCGATGTTGGAGGGCTCGGCGCTCAACGCGCTCAAGGCGCGCTTCCCGGACCGGGTG
CACGACGTGGGCATCGCGGAACAGCACGCCGTCACCTTCAGCGCGGGGCTGGCCTCGGCCGGCGCGCGGCCGGTGTGCTG
CATCTATTCGACCTTCCTCCAGCGCGCGTACGACCAGATCATCCACGACGTGTGCCTGCCGGGCCTGCCCGTCGTCTTCG
CCGTGGACCGCGCGGGGCTGGTGGGCGCGGATGGTGCGACGCACCAGGGCACCTACGACGTGGCGTCCCTGCGCCCGCTG
CCGGACCTGCACCTGTGGTCGCCCATGGTGGGGGAGGACCTGGCGCCTATGCTGGACACTGCCCTGGCGGCGCCGCACGC
CTCCGTCATCCGCTTCCCACGCGGCACGCTGCCGCCCCTGCCCGAAGGACTGGGCGCGGGCGAGGCACCGCTGCGGGGGG
CTCGCTGGCTGCTTCGCGCGGAGCAGCCCCGGCTGACGCTGGTGACGTTGGGGCCTTTGGGCATCGCCGCGCTGGAGGCC
GCGCGGGGCGAGCCCGGCTGGAGCGTGCTGGATGCGCGCTGCGCTTCGCCTCTGGATGAGGCCGCCTTGCTGGAGGCCGG
CCGGTCCGGTCATGTCGTGGTGGCCGAGGAGGGCACTACGCGCGGCGGGTTGGGCAGCGCGGTGCTGGAGCTCTTCGCGG
CGCACGGGCTGATGGCCCGCGTCCGGTTGATGGGCATGCCCGATGCGTTCGTTCCCCATGGGGACGCGCGGGTCCAGCGC
GCGGAGCAGGGGCTGGACGCGGAGGGTCTGCGGCGCGCGGGCCTCGCGCTGCTGGCAGGGGGCGGACGGTGA

Upstream 100 bases:

>100_bases
ACCAGAAGGTGGCCGAGGCCATCGCGGCCGTACGCCCTCTGGAAGGCGAGGACGGGCCGCTGGCGGCGTTGGCGCGCTAC
ACGGTGGAGCGGAAGTCCTA

Downstream 100 bases:

>100_bases
AGCCTCGCAAGGAGCGGTTGGACGTGCTGGTGGTGGAGCGCGGACTGGCCGAGTCGCGCACCAAGGCCCAGGCGCTCATC
CTGGCCGGCCAGGTGGTGGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 583; Mature: 582

Protein sequence:

>583_residues
MSELLSRIGSPSDVRALPEEALPLLCQELREDIISICGRVGGHLGASLGAVELIVALHRVFHSPQDALLFDVGHQTYAHK
LLTGRRDRMHTLRHAGGIAPFLDPRESPHDALLAGHSCTAVSAALGVLEGRRQQGHRGHVVAVLGDGGLTGGLTFEGLNN
AGGSSLPLVVVLNDNQMSISANVGAIPALLRTREARDFFEGLGFTYLGPVDGHDLPALIRALREARASSRPVVVHALTLK
GKGFPPAEADTQTRGHAMGPYEWRDGKLVRSRGGQRTFSEAFAAVLEDAMARDPRVVAVTPAMLEGSALNALKARFPDRV
HDVGIAEQHAVTFSAGLASAGARPVCCIYSTFLQRAYDQIIHDVCLPGLPVVFAVDRAGLVGADGATHQGTYDVASLRPL
PDLHLWSPMVGEDLAPMLDTALAAPHASVIRFPRGTLPPLPEGLGAGEAPLRGARWLLRAEQPRLTLVTLGPLGIAALEA
ARGEPGWSVLDARCASPLDEAALLEAGRSGHVVVAEEGTTRGGLGSAVLELFAAHGLMARVRLMGMPDAFVPHGDARVQR
AEQGLDAEGLRRAGLALLAGGGR

Sequences:

>Translated_583_residues
MSELLSRIGSPSDVRALPEEALPLLCQELREDIISICGRVGGHLGASLGAVELIVALHRVFHSPQDALLFDVGHQTYAHK
LLTGRRDRMHTLRHAGGIAPFLDPRESPHDALLAGHSCTAVSAALGVLEGRRQQGHRGHVVAVLGDGGLTGGLTFEGLNN
AGGSSLPLVVVLNDNQMSISANVGAIPALLRTREARDFFEGLGFTYLGPVDGHDLPALIRALREARASSRPVVVHALTLK
GKGFPPAEADTQTRGHAMGPYEWRDGKLVRSRGGQRTFSEAFAAVLEDAMARDPRVVAVTPAMLEGSALNALKARFPDRV
HDVGIAEQHAVTFSAGLASAGARPVCCIYSTFLQRAYDQIIHDVCLPGLPVVFAVDRAGLVGADGATHQGTYDVASLRPL
PDLHLWSPMVGEDLAPMLDTALAAPHASVIRFPRGTLPPLPEGLGAGEAPLRGARWLLRAEQPRLTLVTLGPLGIAALEA
ARGEPGWSVLDARCASPLDEAALLEAGRSGHVVVAEEGTTRGGLGSAVLELFAAHGLMARVRLMGMPDAFVPHGDARVQR
AEQGLDAEGLRRAGLALLAGGGR
>Mature_582_residues
SELLSRIGSPSDVRALPEEALPLLCQELREDIISICGRVGGHLGASLGAVELIVALHRVFHSPQDALLFDVGHQTYAHKL
LTGRRDRMHTLRHAGGIAPFLDPRESPHDALLAGHSCTAVSAALGVLEGRRQQGHRGHVVAVLGDGGLTGGLTFEGLNNA
GGSSLPLVVVLNDNQMSISANVGAIPALLRTREARDFFEGLGFTYLGPVDGHDLPALIRALREARASSRPVVVHALTLKG
KGFPPAEADTQTRGHAMGPYEWRDGKLVRSRGGQRTFSEAFAAVLEDAMARDPRVVAVTPAMLEGSALNALKARFPDRVH
DVGIAEQHAVTFSAGLASAGARPVCCIYSTFLQRAYDQIIHDVCLPGLPVVFAVDRAGLVGADGATHQGTYDVASLRPLP
DLHLWSPMVGEDLAPMLDTALAAPHASVIRFPRGTLPPLPEGLGAGEAPLRGARWLLRAEQPRLTLVTLGPLGIAALEAA
RGEPGWSVLDARCASPLDEAALLEAGRSGHVVVAEEGTTRGGLGSAVLELFAAHGLMARVRLMGMPDAFVPHGDARVQRA
EQGLDAEGLRRAGLALLAGGGR

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=41.2238325281804, Blast_Score=439, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_MYXXD (Q1D3G4)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632809.1
- ProteinModelPortal:   Q1D3G4
- SMR:   Q1D3G4
- STRING:   Q1D3G4
- GeneID:   4103694
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4643
- TIGR:   MXAN_4643
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   HATPDES
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 61356; Mature: 61225

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELLSRIGSPSDVRALPEEALPLLCQELREDIISICGRVGGHLGASLGAVELIVALHRV
CHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FHSPQDALLFDVGHQTYAHKLLTGRRDRMHTLRHAGGIAPFLDPRESPHDALLAGHSCTA
HCCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCHHH
VSAALGVLEGRRQQGHRGHVVAVLGDGGLTGGLTFEGLNNAGGSSLPLVVVLNDNQMSIS
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCCEEEE
ANVGAIPALLRTREARDFFEGLGFTYLGPVDGHDLPALIRALREARASSRPVVVHALTLK
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
GKGFPPAEADTQTRGHAMGPYEWRDGKLVRSRGGQRTFSEAFAAVLEDAMARDPRVVAVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEC
PAMLEGSALNALKARFPDRVHDVGIAEQHAVTFSAGLASAGARPVCCIYSTFLQRAYDQI
HHHHCCCHHHHHHHHCCHHHHHCCCCHHHHEEEECCHHCCCCCCHHHHHHHHHHHHHHHH
IHDVCLPGLPVVFAVDRAGLVGADGATHQGTYDVASLRPLPDLHLWSPMVGEDLAPMLDT
HHHHHCCCCCEEEEECCCCEECCCCCCCCCCCCHHHCCCCCCCHHCCCHHCCHHHHHHHH
ALAAPHASVIRFPRGTLPPLPEGLGAGEAPLRGARWLLRAEQPRLTLVTLGPLGIAALEA
HHHCCCHHHEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHH
ARGEPGWSVLDARCASPLDEAALLEAGRSGHVVVAEEGTTRGGLGSAVLELFAAHGLMAR
HCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
VRLMGMPDAFVPHGDARVQRAEQGLDAEGLRRAGLALLAGGGR
HHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCEEEEECCCC
>Mature Secondary Structure 
SELLSRIGSPSDVRALPEEALPLLCQELREDIISICGRVGGHLGASLGAVELIVALHRV
HHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FHSPQDALLFDVGHQTYAHKLLTGRRDRMHTLRHAGGIAPFLDPRESPHDALLAGHSCTA
HCCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHEECCCHHH
VSAALGVLEGRRQQGHRGHVVAVLGDGGLTGGLTFEGLNNAGGSSLPLVVVLNDNQMSIS
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCCEEEE
ANVGAIPALLRTREARDFFEGLGFTYLGPVDGHDLPALIRALREARASSRPVVVHALTLK
CCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
GKGFPPAEADTQTRGHAMGPYEWRDGKLVRSRGGQRTFSEAFAAVLEDAMARDPRVVAVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEC
PAMLEGSALNALKARFPDRVHDVGIAEQHAVTFSAGLASAGARPVCCIYSTFLQRAYDQI
HHHHCCCHHHHHHHHCCHHHHHCCCCHHHHEEEECCHHCCCCCCHHHHHHHHHHHHHHHH
IHDVCLPGLPVVFAVDRAGLVGADGATHQGTYDVASLRPLPDLHLWSPMVGEDLAPMLDT
HHHHHCCCCCEEEEECCCCEECCCCCCCCCCCCHHHCCCCCCCHHCCCHHCCHHHHHHHH
ALAAPHASVIRFPRGTLPPLPEGLGAGEAPLRGARWLLRAEQPRLTLVTLGPLGIAALEA
HHHCCCHHHEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEECCHHHHHHHH
ARGEPGWSVLDARCASPLDEAALLEAGRSGHVVVAEEGTTRGGLGSAVLELFAAHGLMAR
HCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
VRLMGMPDAFVPHGDARVQRAEQGLDAEGLRRAGLALLAGGGR
HHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA