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The map label for this gene is crtE [H]

Identifier: 108759145

GI number: 108759145

Start: 5827659

End: 5828552

Strand: Reverse

Name: crtE [H]

Synonym: MXAN_4644

Alternate gene names: 108759145

Gene position: 5828552-5827659 (Counterclockwise)

Preceding gene: 108763514

Following gene: 108761105

Centisome position: 63.77

GC content: 73.38

Gene sequence:

>894_bases
GTGGCAACGTTTCAACTGAACTCCTTCCTGGCCGCTCAGCAGGCGCGCGTCGAGGCCCTGCTGAACGAGCGCGTGGCGCG
GCTCGGGCCTTCCGGGACGCCGCCGCAGCTCGCGGAGGCCATGCGCTACTCCCTGCTGGCCGGCGGCAAGCGCCTGCGCC
CGGTGCTCTGCCTGGCCTTCGCGGACCTCGTGGCGCGCGGAAGCGCCGTATCGGCGGTGGCGGGCGACGCGGCGTGCGCG
CTGGAGTACGTGCACACGTACTCGCTGGTGCATGACGACCTGCCGGCGATGGACAACGACGACTACCGCCGGGGCCGGCT
CACCAACCACAAGGTGTACGGCGAGGCCATGGCCATCCTGGCGGGTGACGCGCTGTTGACGGAGGCCTTCACGCTGGTGG
CCAGTGGGCCGGAGAGCATGCGCGCCGCGCTGTGCCGGGAGCTGGCGGTGGCCTCGGGCGCGGCGGGCATGGTGGGCGGG
CAGGTGCTGGACACCGCCGAGGACCGGCCGTCCGCGCTGGACTACCTCATCCGGATGCACCGCATGAAGACGGGCGCCCT
CATCCGGGCCGCGTGCCGCATGGGCGTGCTGGCCAGCGGTGGAGACGCGGACGCATTGGCGCGCGCGGACACCTACGGTG
ACGCGGTGGGGCTGGCCTTCCAGATTGCCGATGACGTGCTGGACGTGACGGCCACGGCGGCGGAGCTGGGCAAGCCCGCG
GGCGCGGACGCCGCGGCCGGGCGCTTCACCTTCCCGGCGGTGGTGGGCCTGGAGGCGTCGCGGACGCTGGCGGACCAGAA
GGTGGCCGAGGCCATCGCGGCCGTACGCCCTCTGGAAGGCGAGGACGGGCCGCTGGCGGCGTTGGCGCGCTACACGGTGG
AGCGGAAGTCCTAA

Upstream 100 bases:

>100_bases
CCGCGGACTACTTCGTCAAGCCGCTGGACATGGACAAGCTCGTCAGCCGCATTCGCGAGCTTGTGCCCGCGCAGATTCCA
TAAGAGGAGCACGGACGCTC

Downstream 100 bases:

>100_bases
TGTCGGAGTTGCTGTCACGCATCGGCTCGCCCTCGGACGTCCGCGCACTTCCCGAGGAGGCACTGCCGCTCCTGTGCCAG
GAACTGCGCGAGGACATCAT

Product: geranylgeranyl diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MATFQLNSFLAAQQARVEALLNERVARLGPSGTPPQLAEAMRYSLLAGGKRLRPVLCLAFADLVARGSAVSAVAGDAACA
LEYVHTYSLVHDDLPAMDNDDYRRGRLTNHKVYGEAMAILAGDALLTEAFTLVASGPESMRAALCRELAVASGAAGMVGG
QVLDTAEDRPSALDYLIRMHRMKTGALIRAACRMGVLASGGDADALARADTYGDAVGLAFQIADDVLDVTATAAELGKPA
GADAAAGRFTFPAVVGLEASRTLADQKVAEAIAAVRPLEGEDGPLAALARYTVERKS

Sequences:

>Translated_297_residues
MATFQLNSFLAAQQARVEALLNERVARLGPSGTPPQLAEAMRYSLLAGGKRLRPVLCLAFADLVARGSAVSAVAGDAACA
LEYVHTYSLVHDDLPAMDNDDYRRGRLTNHKVYGEAMAILAGDALLTEAFTLVASGPESMRAALCRELAVASGAAGMVGG
QVLDTAEDRPSALDYLIRMHRMKTGALIRAACRMGVLASGGDADALARADTYGDAVGLAFQIADDVLDVTATAAELGKPA
GADAAAGRFTFPAVVGLEASRTLADQKVAEAIAAVRPLEGEDGPLAALARYTVERKS
>Mature_296_residues
ATFQLNSFLAAQQARVEALLNERVARLGPSGTPPQLAEAMRYSLLAGGKRLRPVLCLAFADLVARGSAVSAVAGDAACAL
EYVHTYSLVHDDLPAMDNDDYRRGRLTNHKVYGEAMAILAGDALLTEAFTLVASGPESMRAALCRELAVASGAAGMVGGQ
VLDTAEDRPSALDYLIRMHRMKTGALIRAACRMGVLASGGDADALARADTYGDAVGLAFQIADDVLDVTATAAELGKPAG
ADAAAGRFTFPAVVGLEASRTLADQKVAEAIAAVRPLEGEDGPLAALARYTVERKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=230, Percent_Identity=31.304347826087, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786623, Length=288, Percent_Identity=46.875, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1789578, Length=257, Percent_Identity=29.9610894941634, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17505681, Length=286, Percent_Identity=31.4685314685315, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319475, Length=231, Percent_Identity=29.004329004329, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651612, Length=242, Percent_Identity=30.1652892561983, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30891; Mature: 30759

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATFQLNSFLAAQQARVEALLNERVARLGPSGTPPQLAEAMRYSLLAGGKRLRPVLCLAF
CCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
ADLVARGSAVSAVAGDAACALEYVHTYSLVHDDLPAMDNDDYRRGRLTNHKVYGEAMAIL
HHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AGDALLTEAFTLVASGPESMRAALCRELAVASGAAGMVGGQVLDTAEDRPSALDYLIRMH
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHCCCHHHHCCCCCHHHHHHHHHHH
RMKTGALIRAACRMGVLASGGDADALARADTYGDAVGLAFQIADDVLDVTATAAELGKPA
HHHHHHHHHHHHHHCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GADAAAGRFTFPAVVGLEASRTLADQKVAEAIAAVRPLEGEDGPLAALARYTVERKS
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATFQLNSFLAAQQARVEALLNERVARLGPSGTPPQLAEAMRYSLLAGGKRLRPVLCLAF
CEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
ADLVARGSAVSAVAGDAACALEYVHTYSLVHDDLPAMDNDDYRRGRLTNHKVYGEAMAIL
HHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AGDALLTEAFTLVASGPESMRAALCRELAVASGAAGMVGGQVLDTAEDRPSALDYLIRMH
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHCCCHHHHCCCCCHHHHHHHHHHH
RMKTGALIRAACRMGVLASGGDADALARADTYGDAVGLAFQIADDVLDVTATAAELGKPA
HHHHHHHHHHHHHHCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GADAAAGRFTFPAVVGLEASRTLADQKVAEAIAAVRPLEGEDGPLAALARYTVERKS
CCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515931 [H]