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The map label for this gene is fadN [H]

Identifier: 108761054

GI number: 108761054

Start: 6416350

End: 6418728

Strand: Reverse

Name: fadN [H]

Synonym: MXAN_5136

Alternate gene names: 108761054

Gene position: 6418728-6416350 (Counterclockwise)

Preceding gene: 108763695

Following gene: 108762905

Centisome position: 70.23

GC content: 65.91

Gene sequence:

>2379_bases
ATGACGACGCGGATCCGCAAAGTGGCTGTGCTGGGCGCCGGAGTAATGGGCAGCGGCATCGCCGCGCACCTAGCCAACTC
GGGCGTGCGTGCGCTCCTCCTGGACATCGTTCCGCCCAAGGCCGCGCCGGGCGAGGACACCTCCTCGAAGGCGTTTCGCA
ACAAGTTCGCCCAGGGCGCGCTGGCCAACCTGCGCAAGCAGAAGCCGAGCCCCATCGTCTCTGGTGAGGTCTTCACCAAC
ATCGAGGTAGGCAACTTCGAGGACGACCTGCACCGCATCGCCGAGTGCGATTGGGTGGTGGAGGTGGTGAAGGAGGACCT
GAAGATCAAGCAGGACCTGTTCGCCAAGGTGGAGAAGCTCATCCGCCCGGGCACCATCGTGTCGTCCAACACCTCCGGCA
TGTCGATTGTGGGGATGACCGAGGGCCGCGGCGCGGAGTTCAAGAAGAACTTCCTGGTCACGCACTTCTTCAACCCCGTC
CGCTACATGAAGCTGCTGGAGCTGGTGGCCGGCAAGGAGACTGCCCCGGAGGTGCTCAAGACGCTGCACCGCTTTGGCGA
AGAGGTGCTGGGCAAGGGCATCGTCTACGGCAAGGACACCACCAACTTCATCGCGAACCGCATTGGCGTGTACGGGATGA
TGCGGACCATCGCCGCCATGGACAAGGCGGAGCTATCCATCGAAGAGGTGGACAAGATTTTCGGCCCGGCCATGGGCCGT
CCCAAGTCCGCCGTCTTCCGCACCGCGGACATCGTGGGCCTGGACACGTTCACCCACGTGGCGAAGAACTGTTACGACAC
GCTGACGCACGACGAAGAGCGTGACGTGTTCGCCAGCCCCGCCTTCCTCCAGAAGATGGTGGAGAAGGGCATGCTGGGCG
ACAAGAGCGGCGGCGGCTTCTACAAGAAGCAGGGCAAGGACATCCTCGCGCTCGACCTGAAGACGCTGGAGTACCGGCCG
CAGGCGAAGGTGCGCTACGAGTCGCTGGGCGCCGCGCGGGACATCGAGGACGTGCGCGAGCGCGTGGCCTCGGTGATGAA
CGCCGAGGACAAGGCGGCGAAGTTCGCCGAGGGCGTCACCCTGGACGTGCTGGCCTACACCAGCCGCCGCATCCCGGAGA
TCGCCGACGACGTGGTCAACGTGGACCGCGGCGTGCGCTGGGGCTTCGGTTGGGACTTGGGGCCCTTCGAGGTCTGGGAC
GCCTACGGCGTGAAGAAGGGCGTGGAGCGGATGAAGGCCCTGGGCCTGAAGCCAGCCGCGTGGGTGGAGGAGATGCTGGC
CGCGGGCCGCGCGTCCTTCTACGGCGTGGAGAACGGCAAGGACACGTACTGGGACATCCCGTCCAAGTCCGTGAAGGTGG
TGCCGGAGAACGCCCGCACGCAGCGCGTGGAGTACCTCAAGCGCGGCAACAAGAAGATCGCCGGCAACGACGGGGCCACG
CTGTGGGATTTGGGCGACGGCGCGACGCTGCTCGAGTTCCACACCAAGATGAACTCCATCGATGACCAGATCATCGAGAT
GATGAACACCGCGCTGGACGAGACGGAGAAGAACCACAAGGGCCTCGTCATCGGTAACGACGGCTCCAACTTCTCCGCGG
GCGCGAACATCGTGGCGCTGCTGTGGGCGGCCAAGAGCGGCGAGTTCGAGTCCATCCGCAAGCTGGTGACGGGCTTCCAG
GCCGTCAATCAGCGCATGCGCTACAGCCCGGTGCCGGTGGTGACGGCGCCCTTCAACCTCACGCTCGGCGGCGGCGCCGA
GGTGACGATGGGCGGCAACGCCATCCAGGCGAGCGCCGAGCTGTACATGGGCCTGGTGGAAGTGGGCGTGGGCCTCATCC
CGGGCGGCGGCGGCAACATGCAGTTGCTGCGCAACGTGTACGGCCCTTTCGGCACGGACAAGGACTTCGACTTCTTCCCC
TTCCTGAAGAAGATCTTCCTCACCATCGGCATGGCGAAGGTCGCCACCAGCGCCGAGGAGGCCCGCGAGGCGGGCTTCCT
GACGCAGGCGGATGGCATCAGCGCCAACCGGGACTTCCTGCTGTCCGACGCGAAGGCCCGCGTGCTGGGCATGGCGGACG
CCGGCTTCAAGGCGCCCCGTCCCACGCGCTTCCGCCTGCCGGGCACCAGCGGCGCGGCCACCATCGACATGATGCTCTAC
GACATGGAGCTCAACGGCCAGGTGAGCGCGCACGACCGGAAGATCGCCCAGAAGCTGGCGAAGGTGCTGACGGGTGGCAA
CACCAGCCCGTCGCTGCTCGTGACGGAGGAGCGCTTGCTGGAGCTGGAGGCGGAGGCCTTCCTGAGCCTGTGCGGCGAGG
AGAAGACCCAGGACCGCCTGCAGCACATGATCGAGAAGGGCAAGCCGCTGCGGAACTGA

Upstream 100 bases:

>100_bases
CTCTGGTGGCGAGTGTCCTGGCCGTCCGAACCGATTGACTTTCGGGTCAATCGCCTACATTTGTGCAATCCCCTCCTTCC
CAACAGGGAGCCTTTTCCAC

Downstream 100 bases:

>100_bases
CGGCCGGCCAGTATCCATAGGCTACTGAACCTGAGATTCGCTGAATGCCCGGGTGCCCCCCGGGCAAGGAGACATCAAAA
TGGCTGGTCGAGTCGTGATT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 792; Mature: 791

Protein sequence:

>792_residues
MTTRIRKVAVLGAGVMGSGIAAHLANSGVRALLLDIVPPKAAPGEDTSSKAFRNKFAQGALANLRKQKPSPIVSGEVFTN
IEVGNFEDDLHRIAECDWVVEVVKEDLKIKQDLFAKVEKLIRPGTIVSSNTSGMSIVGMTEGRGAEFKKNFLVTHFFNPV
RYMKLLELVAGKETAPEVLKTLHRFGEEVLGKGIVYGKDTTNFIANRIGVYGMMRTIAAMDKAELSIEEVDKIFGPAMGR
PKSAVFRTADIVGLDTFTHVAKNCYDTLTHDEERDVFASPAFLQKMVEKGMLGDKSGGGFYKKQGKDILALDLKTLEYRP
QAKVRYESLGAARDIEDVRERVASVMNAEDKAAKFAEGVTLDVLAYTSRRIPEIADDVVNVDRGVRWGFGWDLGPFEVWD
AYGVKKGVERMKALGLKPAAWVEEMLAAGRASFYGVENGKDTYWDIPSKSVKVVPENARTQRVEYLKRGNKKIAGNDGAT
LWDLGDGATLLEFHTKMNSIDDQIIEMMNTALDETEKNHKGLVIGNDGSNFSAGANIVALLWAAKSGEFESIRKLVTGFQ
AVNQRMRYSPVPVVTAPFNLTLGGGAEVTMGGNAIQASAELYMGLVEVGVGLIPGGGGNMQLLRNVYGPFGTDKDFDFFP
FLKKIFLTIGMAKVATSAEEAREAGFLTQADGISANRDFLLSDAKARVLGMADAGFKAPRPTRFRLPGTSGAATIDMMLY
DMELNGQVSAHDRKIAQKLAKVLTGGNTSPSLLVTEERLLELEAEAFLSLCGEEKTQDRLQHMIEKGKPLRN

Sequences:

>Translated_792_residues
MTTRIRKVAVLGAGVMGSGIAAHLANSGVRALLLDIVPPKAAPGEDTSSKAFRNKFAQGALANLRKQKPSPIVSGEVFTN
IEVGNFEDDLHRIAECDWVVEVVKEDLKIKQDLFAKVEKLIRPGTIVSSNTSGMSIVGMTEGRGAEFKKNFLVTHFFNPV
RYMKLLELVAGKETAPEVLKTLHRFGEEVLGKGIVYGKDTTNFIANRIGVYGMMRTIAAMDKAELSIEEVDKIFGPAMGR
PKSAVFRTADIVGLDTFTHVAKNCYDTLTHDEERDVFASPAFLQKMVEKGMLGDKSGGGFYKKQGKDILALDLKTLEYRP
QAKVRYESLGAARDIEDVRERVASVMNAEDKAAKFAEGVTLDVLAYTSRRIPEIADDVVNVDRGVRWGFGWDLGPFEVWD
AYGVKKGVERMKALGLKPAAWVEEMLAAGRASFYGVENGKDTYWDIPSKSVKVVPENARTQRVEYLKRGNKKIAGNDGAT
LWDLGDGATLLEFHTKMNSIDDQIIEMMNTALDETEKNHKGLVIGNDGSNFSAGANIVALLWAAKSGEFESIRKLVTGFQ
AVNQRMRYSPVPVVTAPFNLTLGGGAEVTMGGNAIQASAELYMGLVEVGVGLIPGGGGNMQLLRNVYGPFGTDKDFDFFP
FLKKIFLTIGMAKVATSAEEAREAGFLTQADGISANRDFLLSDAKARVLGMADAGFKAPRPTRFRLPGTSGAATIDMMLY
DMELNGQVSAHDRKIAQKLAKVLTGGNTSPSLLVTEERLLELEAEAFLSLCGEEKTQDRLQHMIEKGKPLRN
>Mature_791_residues
TTRIRKVAVLGAGVMGSGIAAHLANSGVRALLLDIVPPKAAPGEDTSSKAFRNKFAQGALANLRKQKPSPIVSGEVFTNI
EVGNFEDDLHRIAECDWVVEVVKEDLKIKQDLFAKVEKLIRPGTIVSSNTSGMSIVGMTEGRGAEFKKNFLVTHFFNPVR
YMKLLELVAGKETAPEVLKTLHRFGEEVLGKGIVYGKDTTNFIANRIGVYGMMRTIAAMDKAELSIEEVDKIFGPAMGRP
KSAVFRTADIVGLDTFTHVAKNCYDTLTHDEERDVFASPAFLQKMVEKGMLGDKSGGGFYKKQGKDILALDLKTLEYRPQ
AKVRYESLGAARDIEDVRERVASVMNAEDKAAKFAEGVTLDVLAYTSRRIPEIADDVVNVDRGVRWGFGWDLGPFEVWDA
YGVKKGVERMKALGLKPAAWVEEMLAAGRASFYGVENGKDTYWDIPSKSVKVVPENARTQRVEYLKRGNKKIAGNDGATL
WDLGDGATLLEFHTKMNSIDDQIIEMMNTALDETEKNHKGLVIGNDGSNFSAGANIVALLWAAKSGEFESIRKLVTGFQA
VNQRMRYSPVPVVTAPFNLTLGGGAEVTMGGNAIQASAELYMGLVEVGVGLIPGGGGNMQLLRNVYGPFGTDKDFDFFPF
LKKIFLTIGMAKVATSAEEAREAGFLTQADGISANRDFLLSDAKARVLGMADAGFKAPRPTRFRLPGTSGAATIDMMLYD
MELNGQVSAHDRKIAQKLAKVLTGGNTSPSLLVTEERLLELEAEAFLSLCGEEKTQDRLQHMIEKGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=305, Percent_Identity=30.8196721311475, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI296179427, Length=322, Percent_Identity=29.5031055900621, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI20127408, Length=418, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI261878539, Length=256, Percent_Identity=24.609375, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI68989263, Length=256, Percent_Identity=24.609375, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI115430219, Length=211, Percent_Identity=27.4881516587678, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1787661, Length=396, Percent_Identity=27.7777777777778, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790281, Length=300, Percent_Identity=25.6666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=217, Percent_Identity=27.1889400921659, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549919, Length=304, Percent_Identity=33.8815789473684, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=299, Percent_Identity=31.438127090301, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17508951, Length=442, Percent_Identity=27.6018099547511, Blast_Score=102, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17563036, Length=302, Percent_Identity=29.1390728476821, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17508953, Length=442, Percent_Identity=27.6018099547511, Blast_Score=102, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25144276, Length=297, Percent_Identity=28.956228956229, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=297, Percent_Identity=28.6195286195286, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=308, Percent_Identity=25.974025974026, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985930, Length=311, Percent_Identity=24.1157556270096, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45549573, Length=247, Percent_Identity=25.1012145748988, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19921000, Length=447, Percent_Identity=23.9373601789709, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583077, Length=447, Percent_Identity=23.7136465324385, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583079, Length=447, Percent_Identity=23.7136465324385, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI20129993, Length=235, Percent_Identity=24.2553191489362, Blast_Score=73, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 86409; Mature: 86278

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRIRKVAVLGAGVMGSGIAAHLANSGVRALLLDIVPPKAAPGEDTSSKAFRNKFAQGA
CCCCCEEHHHCCCCHHHCCHHHHHHCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
LANLRKQKPSPIVSGEVFTNIEVGNFEDDLHRIAECDWVVEVVKEDLKIKQDLFAKVEKL
HHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRPGTIVSSNTSGMSIVGMTEGRGAEFKKNFLVTHFFNPVRYMKLLELVAGKETAPEVLK
HCCCCEEECCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TLHRFGEEVLGKGIVYGKDTTNFIANRIGVYGMMRTIAAMDKAELSIEEVDKIFGPAMGR
HHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
PKSAVFRTADIVGLDTFTHVAKNCYDTLTHDEERDVFASPAFLQKMVEKGMLGDKSGGGF
CHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
YKKQGKDILALDLKTLEYRPQAKVRYESLGAARDIEDVRERVASVMNAEDKAAKFAEGVT
HHHCCCEEEEEEHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCE
LDVLAYTSRRIPEIADDVVNVDRGVRWGFGWDLGPFEVWDAYGVKKGVERMKALGLKPAA
EEEEHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
WVEEMLAAGRASFYGVENGKDTYWDIPSKSVKVVPENARTQRVEYLKRGNKKIAGNDGAT
HHHHHHHCCCHHEEECCCCCCCEECCCCCCEEEECCCHHHHHHHHHHCCCCEEECCCCCE
LWDLGDGATLLEFHTKMNSIDDQIIEMMNTALDETEKNHKGLVIGNDGSNFSAGANIVAL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEE
LWAAKSGEFESIRKLVTGFQAVNQRMRYSPVPVVTAPFNLTLGGGAEVTMGGNAIQASAE
EEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCEEEECCCHHHHHHH
LYMGLVEVGVGLIPGGGGNMQLLRNVYGPFGTDKDFDFFPFLKKIFLTIGMAKVATSAEE
HHHHHHHHCCEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AREAGFLTQADGISANRDFLLSDAKARVLGMADAGFKAPRPTRFRLPGTSGAATIDMMLY
HHHCCCEEECCCCCCCCCEEECCCCHHEEEECCCCCCCCCCCEEECCCCCCCEEEEEEEE
DMELNGQVSAHDRKIAQKLAKVLTGGNTSPSLLVTEERLLELEAEAFLSLCGEEKTQDRL
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHH
QHMIEKGKPLRN
HHHHHCCCCCCC
>Mature Secondary Structure 
TTRIRKVAVLGAGVMGSGIAAHLANSGVRALLLDIVPPKAAPGEDTSSKAFRNKFAQGA
CCCCEEHHHCCCCHHHCCHHHHHHCCCHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
LANLRKQKPSPIVSGEVFTNIEVGNFEDDLHRIAECDWVVEVVKEDLKIKQDLFAKVEKL
HHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IRPGTIVSSNTSGMSIVGMTEGRGAEFKKNFLVTHFFNPVRYMKLLELVAGKETAPEVLK
HCCCCEEECCCCCEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TLHRFGEEVLGKGIVYGKDTTNFIANRIGVYGMMRTIAAMDKAELSIEEVDKIFGPAMGR
HHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCC
PKSAVFRTADIVGLDTFTHVAKNCYDTLTHDEERDVFASPAFLQKMVEKGMLGDKSGGGF
CHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
YKKQGKDILALDLKTLEYRPQAKVRYESLGAARDIEDVRERVASVMNAEDKAAKFAEGVT
HHHCCCEEEEEEHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCE
LDVLAYTSRRIPEIADDVVNVDRGVRWGFGWDLGPFEVWDAYGVKKGVERMKALGLKPAA
EEEEHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
WVEEMLAAGRASFYGVENGKDTYWDIPSKSVKVVPENARTQRVEYLKRGNKKIAGNDGAT
HHHHHHHCCCHHEEECCCCCCCEECCCCCCEEEECCCHHHHHHHHHHCCCCEEECCCCCE
LWDLGDGATLLEFHTKMNSIDDQIIEMMNTALDETEKNHKGLVIGNDGSNFSAGANIVAL
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEE
LWAAKSGEFESIRKLVTGFQAVNQRMRYSPVPVVTAPFNLTLGGGAEVTMGGNAIQASAE
EEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCCEEEECCCHHHHHHH
LYMGLVEVGVGLIPGGGGNMQLLRNVYGPFGTDKDFDFFPFLKKIFLTIGMAKVATSAEE
HHHHHHHHCCEEECCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AREAGFLTQADGISANRDFLLSDAKARVLGMADAGFKAPRPTRFRLPGTSGAATIDMMLY
HHHCCCEEECCCCCCCCCEEECCCCHHEEEECCCCCCCCCCCEEECCCCCCCEEEEEEEE
DMELNGQVSAHDRKIAQKLAKVLTGGNTSPSLLVTEERLLELEAEAFLSLCGEEKTQDRL
EEECCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHH
QHMIEKGKPLRN
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]